Inhibitors of p90Rsk

The long term goals of this work include the development of an understanding of the role(s) of the ser/thr protein kinase Rsk family in signal transduction within the mitogenactivated protein kinase (MAPK) pathway, and the identification of new classes of potential antitumor agents. The immediate objectives include -chemical synthesis of analogues of a group of kaempferol glycosides shown to mediate hightly selective inhibition of Rsk2 -synthesis of analogues of a second class of inhibitors identified from the NCI repository by in silico screening -identification of additional naturally occurring inhibitors of p90 Rsk that have different types of chemical structures and properties