Idiopathic Subglottic Stenosis Tissue and Deep Sequencing Study

Project: Research project

Project Details


Idiopathic Subglottic Stenosis Tissue and Deep Sequencing Study Idiopathic Subglottic Stenosis Tissue and Deep Sequencing Study ABSTRACT Idiopathic subglottic stenosis (ISGS) is a severely debilitating disease requiring multiple surgeries and possibly a permanent tracheostomy. The cause of the disease is unknown and there has been little research on this disorder. Unfortunately, the research that has been done is inconclusive but suggests the etiology is likely multifactorial. The goal of this study is to definitively determine the etiology of this disease. It is designed to analyze multiple factors and determine which are responsible for disease progression. The study contains four components and consists of two groups, ISGS group and Control group. There will be at least 11 subjects in each group. The first component is a survey designed to evaluate specific historical factors thought to contribute to ISGS. The second includes a biopsy of the stenotic area and the normal trachea in the ISGS group. In the Control group, a biopsy will be taken from the normal trachea. Specimens will be sent for histological analysis, tissue culture, and deep DNA/RNA sequencing. This is the first time sequencing will be performed for ISGS. The third component is blood analysis to evaluate for the presence of systemic disease indicators and hormone levels. The last component is three-channel 24-hour pH probe study to evaluate for the presence of laryngopharyngeal reflux. This multifactorial evaluation of a complex disease process allows for a more thorough and encompassing means by which to study this disorder. This approach has never before been applied to the study of ISGS.
Effective start/end date1/1/1312/31/14


  • ASU: Mayo Seed Grant: $23,953.00


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