(Flinn-JL) Establishment of a high throughput protein production center to empower translational research in Arizona (ASUF 30005389) Establishment of a high throughput protein production center to empower translational research in Arizona Proteins are the biomolecular machines that drive all important life functions in biology. Proteins orchestrate the cellular processes of life through their interaction and manipulation of other biomolecules. Moreover, most diseases are caused by protein malfunction, and nearly all drugs target and modify protein function, or are themselves proteins. The completion of the human genome has provided us with the powerful opportunity to understand the roles of all proteins and how their dysfunction contributes to disease. The last decade has witnessed dramatic advances in the field of proteomics, which broadly includes understanding the composition, structure, and function of all proteins in biological systems, and how the various components collectively contribute to phenotype. Arizona investigators have played key roles in these advances and there exists here at ASU a critical mass of expertise that could build a unique and world class translational proteomics program. This proposal focuses on developing a key technological capability necessary to realize this vision, which is currently absent in Arizona, and indeed exists in only limited form anywhere. That is, in order to study proteins, we must first produce them. At present, in modern biology, the demand for protein for use in research and commercial uses far outstrips the available supply. Thus, an automated protein production pipeline is essential to empower translational research in Arizona.
|Effective start/end date||10/1/14 → 9/30/19|
- Flinn Foundation: $1,000,000.00
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