The long-term objective of this work is to develop nano-machine technology for observing and interacting with the human body at the cellular level. The projects focus is a remotely powered and controlled artificial electrocyte (electric-organ cell) able to perform high precision neuro-stimulation. The same machine could also be used as a nano-sensor that would be delivered to its target by chemical tags or during surgical intervention. Such sensors may reveal never before seen intimate details of the transmission of neural signals and of their pathological interruption. The nano-machine will be self-assembled using the DNA origami approach. The power and command for the components is to be provided through light that is amplified by on-board tuned photonic antennas. The supplement grant will improve the chance of success of the project by expediting research tasks related to the analysis and development of the photonic antennas enhancement effect on energy transfer to the nano-machine. In addition the depth of the research scope will be increased to include the effect this same photonic antennas will have on the Frster Resonant Energy Transfer between the energy gathering molecules and the proton pumps. This latter investigation will provide a technical foundation for the future development of other nano-devices that rely on resonant field enhancement for their functionality.
|Effective start/end date||7/1/08 → 6/30/13|
- HHS: National Institutes of Health (NIH): $1,150,205.00