Evaluation of the Anti-aging Properties of Product B Evaluation of the Anti-aging Properties of Product B Project Summary Increased production of reactive oxygen species (ROS) is thought to be a key factor of aging. Reactive oxygen species are byproducts formed in the mitochondria of cells when substrates, like glucose and fatty acids, are used for energy. Other cellular sources of ROS include plasma and nuclear membranes and peroxisomes. While ROS play several important physiological roles in the body, high ROS concentrations create localized oxidative stress that contributes to tissue damage, cardiovascular disease, cancer, and aging. Obesity, autoimmune disorders such as rheumatoid arthritis or vitiligo, and hyperglycemia are common examples of conditions associated with excess ROS production. Excess ROS production leads to oxidative stress when there are insufficient concentrations of antioxidants available to counteract the ROS (Beckman and Aims, 1998). Antioxidants are either produced endogenously or consumed in the diet. To promote healthy aging, simple, inexpensive, and easily adopted diet strategies are needed to raise antioxidant protection in tissues and reduce the deleterious effects of oxidative stress. The proposed trial will examine the impact of daily ingestion of Product B on antioxidant status (total antioxidant capacity, red blood cell superoxide dismutase, catalase, and glutathione peroxidase activities) in addition to markers of oxidative stress and inflammation (thiobarbituric acid reactive substances (TBARS), interleukin-6 and urine 8-isoprostanes) in male college students. Trial exclusion criteria will include plant allergies, active disease states, anticipated changes in diet or physical activity level, and current use of supplements. Participants will ingest 4 capsules of Product B per day for 12 weeks. Participants will be 18 40 years of age and maintain their normal diet and physical activity patterns during the trial.
|Effective start/end date||8/1/13 → 11/30/14|
- INDUSTRY: Domestic Company: $111,171.00
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