Enhancing the Quality of Optical Colonoscopy

Project: Research project

Project Details

Description

Enhancing the Quality of Optical Colonoscopy Enhancing the Quality of Optical Colonoscopy Abstract Colorectal cancer (CRC) is the second leading cause of cancer death in the United States [1]. More than 80% CRC arise from adenomatous polyps (precancerous abnormal growths inside of the colon), making CRC amenable to screening and prevention. The primary modality for screening and prevention of CRC is (optical) colonoscopy [2]. However, a signifi-cant number of polyps are missed during colonoscopy in clinical practicethe pooled miss-rate for all polyps is 22% (95% CI, 19%26%) [37]. Therefore, there is a clinical need to reduce the polyp miss-rate with colonoscopy. To address this clinical need, we propose to establish a new collaboration between ASU and Mayo Clinic. The Mayo Clinic team is renowned for diagnosing and treating CRC, and is among the first in recognizing the urgent need to improve polyp detec-tion rates with colonoscopy [12,35,36]. The ASU team is a recognized leader in biomedical informatics for enhancing medical diagnosis through computer-physician synergy [79]: In addition to their strong publication record, they hold 29 US patents [39-67], and their research has led to two FDA-approved systems. Through the integration of the clinical ex-pertise at Mayo Clinic and the informatics expertise at ASU, the significance of this project lies in the systematic investi-gation of an informatics-based approach for enhancing the quality of colonoscopy for the first time. An expected outcome from this research is a set of novel algorithms that enhance the quality of colonoscopy by attentively alerting colonosco-pists to possible polyps during the procedure and simultaneously achieving multiple clinical objectives in colonoscopy quality control (3.1). This research has an important clinical impact because ensuring high quality of colonoscopy is essential in reducing the mortality associated with CRC, and even a modest reduction of the polyp miss-rate in colonosco-py can generate measurable clinical benefits given the large patient population: beginning at age 50, both men and women are recommen
StatusFinished
Effective start/end date1/1/148/3/15

Funding

  • ASU: Mayo Seed Grant: $65,000.00

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