Effects of maqui berry extract on cytokine reduction in elderly obese adults Effects of maqui berry extract on cytokine reduction in elderly obese adults Natural products have been used medicinally for centuries. Omega-3 fatty acids found in marine oils are one such class. Another class is plant products such as flavonoids, natural phenolic compounds with beneficial health effects including anti-oxidative, anti-inflammatory, and anti-carcinogenic properties. Anthocyanins, a subclass of flavonoids, are plant pigments that provide the rich color of many plants, fruits, and flowers. Health benefits of anthocyanins have been widely reported in the research literature, particularly for disease conditions associated with oxidative stress, such as cardiovascular and neurodegenerative diseases1. Emerging evidence suggests that anthocyanins may also modulate gut microbiota, which can impact a wide variety of health conditions2. Maqui berries (Aristotelia chilensis), indigenous to Chile, have one of the highest concentrations of anthocyanins in the plant world; moreover, the dominant anthocyanin in maqui berries is delphinidin. Delphinidin is more bioavailable than most flavonoids, with intact molecules absorbed in appreciable amounts in less than an hour after consumption3. Systemic effects of delphinidin include reduced inflammation due to downregulation of NF-kB,4,5, the transcription factor that initiates the generation of pro-inflammatory cytokines.6,7 The omega-3 fatty acid eicosapentaenoic acid [EPA], a component of omega-3 fatty acid concentrates, also has anti-inflammatory properties. There is much empirical evidence demonstrating beneficial effects of EPA supplementation, linked mainly to reductions in inflammation.8 The anti-inflammatory properties of EPA include the inhibition of gene expression and the mitigation of the inflammatory cascade initiated by arachidonic acid.9,10 It has been demonstrated the dietary supplementation with EPA-rich marine oil concentrations also reduces cytokine levels.11,12 We believe there may be a synergistic interaction of these two distinct natural products, which will enhance the reduction of cytokine production. Goal: To determine the effect of maqui extract plus omega-3 fatty acids compared to a placebo in reducing inflammatory cytokine levels in older, obese adults.
|Effective start/end date||5/17/21 → 5/16/23|
- Inflammation Research Foundation: $94,540.00
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