ECM-Mimetic Nanoscaffolds and Autologous Adipose Tissue-Derived Stem Cells for Engineered POP Soft Tissue Repair ECM-Mimetic Nanoscaffolds and Autologous Adipose Tissue-Derived Stem Cells for Engineered POP Soft Tissue Repair PROJECT SUMMARY Pelvic organ prolapse (POP) is a major health problem that negatively impacts quality of life in women. Augmentation methods using synthetic and biological meshes implanted in the vaginal wall have not improved surgical success rates. Two major factors that influence surgical success rates using implants are: 1) compromised vaginal wall structure that promotes decreased biomechanical strength and susceptibility to POP; 2) the lack of regenerative/restorative capacity in the implant-augmented vaginal wall. Hypothesis: Autologous adipose tissue-derived mesenchymal stem cells delivered in extracellular matrix (ECM)-mimetic nanoscaffolds can be developed to alter vaginal wall fibroblast phenotypes so that the capacity to regenerate healthy vaginal wall tissue is restored. The proposed work is a result of 2012 and 2013 funding from the Mayo Center for Regenerative Medicine Accelerated Regenerative Medicine Program. CRM funding has greatly assisted this multidisciplinary Mayo-ASU team in gaining critical insights into the complex biological regenerative heuristics associated with normal and prolapsed vaginal wall. This knowledge has been systematically exploited to further the development of regenerative ECM-mimetic implant components with potential to improve structural integrity and biomechanical strength in the vaginal wall. The proposed work is a logical extension of the studies completed to date by this multi-disciplinary and multi-institutional team and seeks to explore the combination of autologous stem cell therapy and 3-D ECM-mimetic scaffold augmentation to develop and characterize ex vivo vaginal wall tissue replacement constructs (scaffolds seeded with autologous stem cells)
|Effective start/end date||1/1/14 → 12/31/14|
- Mayo Clinic: Center for Regenerative Medicine: $69,608.00
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