Early Family Prevention of Adolescent Alcohol Drug Use and Psychopathology

Project: Research project

Description

Professor Thomas Dishion serves as MPI of the entire project and thus oversees the data collection and research activity at all three sites, in collaboration with Drs. Shaw and Wilson. This application proposes to conduct follow-up assessments of 731 children through adolescence (age 13.5 and 15.5) that include the collection of DNA, observations of family interaction, parent, youth and teacher report of adjustment and peer environments. The Early Steps multisite sample was recruited from WIC centers in three geographically, socioeconomically, and ethnically diverse communities: Pittsburgh, PA, Charlottesville, VA, and Eugene, OR. To increase risk of later ADU, eligibility was restricted to WIC families with additional socioeconomic (i.e., low parental education), family (i.e., maternal stress), and child (i.e., toddler conduct problems) risk factors. The children and families were initially assessed at age 2 and then yearly until age 10, using a multi-agent and - method strategy including direct observations of family interaction in most years. Families were randomly assigned to yearly offerings of the FCU intervention, including adapted and tailored family management interventions. Dr. Dishion will specifically support the data collection at the University of Oregon, supervise and support data analysis and scientific report writing, and code the family interaction videotapes of family interaction from all three data collection sites within the ASU environment. Associate Professor Kathryn Lemery-Chalfants role on the project is to coordinate the genetic component of the study (Aim 4). She will oversee DNA collection, biosample management, assays, and genetic data management. She will design and conduct/supervise the statistical analyses that address Aim 4, examining the role of genetics in moderating the effects of the intervention, as well as explicating meditational pathways from genes through early problem behaviors to adolescent alcohol and drug use. She will also present results at professional conferences and produce papers for developmental, clinical, and behavioral genetic audiences. Research Professor Jenn-Yun Tein serves as the methodologist for the study. She has primary responsibility for statistical model building and testing.
StatusActive
Effective start/end date5/1/143/31/20

Funding

  • HHS-NIH: National Institute on Drug Abuse (NIDA): $3,720,504.00

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Psychopathology
Pharmaceutical Preparations
Behavioral Genetics
Social Adjustment
Underage Drinking
Videotape Recording
DNA
Statistical Models
Research
Mothers
Education
Genes