Clinical Application of Telomere Length Calculations for Early Detection of Premalignant colon lesions and Colorectal Cancer

Project: Research project

Project Details

Description

Clinical Application of Telomere Length Calculations for Early Detection of Premalignant colon lesions and Colorectal Cancer Combining Landsat and MODIS to Assess Urbanization and its Impacts on Select Major Cities in the Mekong Region Urbanization represents a significant component of land cover and land use change (LCLUCC) that has important yet undocumented impacts on the local, regional, and continental climate in most parts of the world, especially in Southeast Asia (SAE) where urbanization is fragmented and embedded in forested environments. We propose to develop a land cover and land use modeling framework and use NASAs MODIS and Landsat data to assess the impacts of this land transformation on surface climate and the potential feedbacks from these changes on atmospheric, hydrologic, biological, and socio-economic properties within select cities and surrounding regions. We will focus on five major cities in the Lower Mekong SubregionPhnom Penh, Cambodia; Vientiane, Laos; Yangon, Myanmar; Bangkok, Thailand; and Hanoi, Vietnam. Threaded together by the Mekong River, these cities are experiencing unprecedented rapid urban development and economic growth, resulting in rapid and large-scale alterations from naturally vegetated landscape to built-up areas. These changes have significantly increased regional vulnerability to climate change. Emerging risks are compounded for those who live in areas that lack essential infrastructure and services such as informal settlements or where there is inadequate provision for adaptation and in hazardous areas. Moreover, urbanization and climate change interactions have led to concentrations of urban populations in low-income nations with weak adaptive capacity. Hence, serious attention needs to be paid to areas that are under immense pressure of an emerging global and regional economy, disaster risks, population growth, and urban infrastructure development in connection to climate change. We propose to develop two observation-based and two scenario-based maps characterizing distant-past (pre-urban, e.g., 1850), recent-past (2001), present (2010) and near-future (2030) LCLUCC including urbanized areas. Here we define pre-urban as hypothetically representing an undated land cover free of anthropogenic urban transformation. For each of the land cover maps, we will compute a set of biophysical parameters required by the land surface and climate models that address the earth system energetic, hydrological, and biological cycles. We will then use these maps in a NASA modeling system and carry out annual simulations for each of the four scenarios thereby providing an unprecedented set of surface climate variables at scales ranging from diurnal to annual and from local to regional over the entire SEA regions. This research will advance our understanding of urbanization as a form of land use, the mechanisms by which it affects surface climate and the environment and the feedbacks of these changes at local, regional and continental scales in an attempt to address the following questions: 1) what is the local and regional impact of existing impervious surface on the select cities in Mekong region current climate; 2) what is the aggregate impact of urbanization on the regions climate since pre-urbanization era in terms of carbon loss, freshwater gain and surface temperature changes; 3) to what extent can the urban chain amplify the land-climate interactions; 4) what are the observed trends and patterns of urban expansion in the capital cities of Mekong SEA and how are they likely to continue in the near-future; 5) what is the impact of urban growth on near-future climate of Mekong region; 6) will urbanization exacerbate the projected climate warming, through the urban heat island effect, in cities; 7) what are the socio-economic consequences for populations and to what extent can these consequences be mitigated; and 8) what alternate building, land-use planning, and infrastructure scenarios can be realized through policy, economic incentives, altered public and private investment, enhanced developer and consumer awareness, and more effective implementation in Greater Mekong Region metropolitan regions? Summer Residency Program: Clinical Application of Telomere Length Calculations for Early Detection of Prema
StatusFinished
Effective start/end date7/12/178/21/17

Funding

  • Mayo Clinic Rochester: $7,024.00

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