Statement of Work This grant seeks to determine whether the BDNF SNP is related to extent of behavioral gains from a regimen of stroke rehabilitation therapy. We are in the process of initiating an additional study. Recall that dystonia is suspected of being a diagnosis of pathological plasticity, and that the BDNF SNP, known to significantly modify brain plasticity in humans, was abnormally distributed in persons with this diagnosis. We now seek to determine whether the BDNF SNP is normally distributed in patients with a different diagnosis that is also suspected to arise from pathological brain plasticity, post--stroke pain. This study will examine patients with post--stroke plasticity and determine whether the proportion of such patients with the BDNF SNP differs from non--pain stroke controls and from healthy controls, with both control groups being age--matched and ethnicity--matched.
|Effective start/end date||1/18/11 → 2/28/13|
- HHS: National Institutes of Health (NIH): $544,502.00