A Wearable Wireless System for Real-Time Monitoring of Chemical Toxicants Supplement: A Wearable Wirele3ss System for Real-Time Monitoring of Chemical Toxicants The "parent" grants of this opportunity fund project are to develop a wearable particulate detector (led by RTI) and a wireless chemical sensor (led by ASU), for the GEl Exposure Biology Program. Building upon the individual successes of the two projects, the two teams in this project will develop an integrated sensor system that can simultaneously detect both particulate and chemical levels in a single device. A key feature of the integration is the versatile ASU data uplink and user-friendly graphic interface facilitated by cell phone technologies. The integration will: 1) reduce the burden for a child to carry multiple devices; 2) simplify the task of researchers to synchronize and analyze data from different sensors; and 3) minimize the overall weight, size, and cost of the sensor, making it more practical for large-scale population studies. The ASU and RTI teams will work with epidemiologists at USC to pilot test both the validity and utility the sensor system in the Los Angeles area. The three teams have developed a collaboration in the Los Angeles-Ventura National Children's Study (NCS) center to test un-integrated particulate and chemical sensors, and our recently submitted response to an NCS' call for pilot project letters of intent has passed the first screening of proposals. The project will leverage the existing collaboration and potentially lead to work with a much wider range of NCS Centers. The goal of the opportunity fund project is to optimize this integrated personal-level device to measure a range of acute and chronic pollutant stressors from mobile sources for use in the epidemiologic studies focused on pregnant women and children. The project will expedite the development of the integrated instrument and determine .suitability for broader use in NCS Centers. The specific aims are to: Develop mechanical interface between the outlet of the particulate detector and the inlet of the chemical sensor while maintaining sample integrity and meeting the flow rate requirements for both the particulate and chemical detections (mos. 1-2; ASU/RTI) Develop microcontroller-based and Bluetooth enabled circuit to read the output signals of the photodiode and filter differential pressure sensor of the particulate detector, and the frequency counters of the chemical sensor (mos. 3-4; ASU/RTI) After pre-pilot breadboard performance testing, design, and develop a new housing to encompass all the components of the integrated sensor into a wearable format (mos. 1-4; ASU) Modify the user interface (cell phone) software to include particulate detection (mos. 4-5; ASU) Complete an integrated device for the initial integration pilot testing (mos. 6-8; ASU/RTIIUSC) Validate the system performance using commercially available GC/MS for volatile chemicals and referee aerosol monitors both in laboratory and in field trials aboard an instrumented mobile platform in locations of high and low traffic emissions (mos. 9-10; ASU/RTI/USC) Perform a final feasibility test in a convenience sample of Los Angeles children wearing the device for five consecutive days and evaluate participant burden, instrument performance, and comparison with exposures estimated from ambient concentrations and time-activity patterns of the children using traditional methods based on central site monitors (mos. 11-12; USC)
|Effective start/end date||9/1/08 → 5/31/13|
- HHS: National Institutes of Health (NIH): $1,869,483.00
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