A Survey of Coccidiomycosis Among Employees at Mayo Clinic Arizona During a Major Construction Project (The Big Dig)

Project: Research project

Project Details

Description

A Survey of Coccidiomycosis Among Employees at Mayo Clinic Arizona During a Major Construction Project (The Big Dig) Cocci positivity pre and post big dig The specific AIMS of this line of investigation are the following: 1. To prospectively identify Mayo Clinic employees on the Phoenix and Scottsdale campuses who have never acquired coccidioidomycosis (using an in vitro assay of cellular immunity to Coccidioides), and are thus at risk for acquisition of coccidioidomycosis. 2. To prospectively identify Mayo Clinic employees on the Phoenix and Scottsdale campuses who acquire coccidioidomycosis during the study period. 3. To compare the rate of such infection acquisition among employees at each campus. The Lake Laboratory will screen individual blood samples for pre-existing cellular immunity to Coccidioides sp. antigens from participants in A Survey of Coccidioidomycosis Acquisition Among Employees at During a Major Construction Project (The Big Dig)". Peripheral blood lymphocytes will be stimulated with a Coccidioidal antigen preparation followed by assessment of activation by flow cytometry. 9-12 months after the first screen, blood samples will be screened again for cellular immunity to Coccidioides sp. antigens in the same manner as above. Data will be reported to Dr. Janis Blair at Mayo Clinic Hospital. The rate of conversion of cellular immunity (negative to positive) will be calculated for each site, then compared between sites. Epidemiological analysis of risk factors associated with cellular immunity conversion will conducted collaboratively by Drs. Blair and Lake.
StatusFinished
Effective start/end date12/9/1112/8/13

Funding

  • Mayo Clinic Arizona: $42,000.00

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