14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity

14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity 14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity. Project Title: 14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity ASU Principal Investigator: Michael R. Sierks Statement of Work In this project, we will characterize the height distribution of samples of 14-3-3 provided by UAB by Atomic Force Microscopy. We will also determine whether the 14-3-3 samples bind to various different morphologies of alpha-synuclein, again using Atomic Force Microscopy.