• 1606 Citations
  • 19 h-Index
20092021
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Research Output 2009 2019

2019
5 Citations (Scopus)

Extracellular vesicles as cancer liquid biopsies: From discovery, validation, to clinical application

Zhao, Z., Fan, J., Hsu, Y. M. S., Lyon, C. J., Ning, B. & Hu, Y., Jan 1 2019, In : Lab on a Chip. 19, 7, p. 1114-1140 27 p.

Research output: Contribution to journalReview article

Biopsy
Biomarkers
Tumor Biomarkers
Liquids
Neoplasms

MALDI-TOF mass spectrometry-based quantification of C-peptide in diabetes patients

Wan, M. H., Wang, Y., Zhan, L., Fan, J. & Hu, T. Y., Jan 1 2019, (Accepted/In press) In : European Journal of Mass Spectrometry.

Research output: Contribution to journalArticle

C-Peptide
Medical problems
Ionization
peptides
Mass spectrometry

Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection

Deng, Z., Zhao, Z., Ning, B., Basilio, J., Mann, K., Fu, J., Gu, Y., Ye, Y., Wu, X., Fan, J., Chiao, P. & Hu, Y., Jan 1 2019, In : Nano Research.

Research output: Contribution to journalArticle

Hydroxylation
Bradykinin
Peptides
Blood
Prolyl Hydroxylases

Nickel affinity: A sensible approach for extracellular vesicles isolation?

Hu, T. Y., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalComment/debate

Open Access
Nickel
Extracellular Vesicles
7 Citations (Scopus)

Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer

Zou, R., Cao, W., Chong, L., Hua, W., Xu, H., Mao, Y., Page, J., Shi, R., Xia, Y., Hu, Y., Zhang, W. & Ouyang, Z., Jan 2 2019, In : Analytical Chemistry. 91, 1, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

Mass spectrometers
Tissue
Lipids
Ionization
Diagnostic products

Rapid Lipid-Based Approach for Normalization of Quantum-Dot-Detected Biomarker Expression on Extracellular Vesicles in Complex Biological Samples

Rodrigues, M., Richards, N., Ning, B., Lyon, C. J. & Hu, T. Y., Jan 1 2019, (Accepted/In press) In : Nano Letters.

Research output: Contribution to journalArticle

biomarkers
Biomarkers
Lipids
Semiconductor quantum dots
lipids

Tumor-derived exosomes (TDEs): How to avoid the sting in the tail

Wan, M. H., Ning, B., Spiegel, S., Lyon, C. J. & Hu, Y., Jan 1 2019, In : Medicinal Research Reviews.

Research output: Contribution to journalReview article

Open Access
Exosomes
Bites and Stings
Neoplasms
Phenotype
Half-Life

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Wan, M., Amrollahi, P., Sun, D., Lyon, C. & Hu, T. Y., May 24 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Open Access
Exosomes
Tumors
Microscopes
Scattering
Imaging techniques
2018
5 Citations (Scopus)

A low cost mobile phone dark-field microscope for nanoparticle-based quantitative studies

Sun, D. & Hu, Y., Jan 15 2018, In : Biosensors and Bioelectronics. 99, p. 513-518 6 p.

Research output: Contribution to journalArticle

Cell Phones
Mobile phones
Nanoparticles
Microscopes
Costs and Cost Analysis
2 Citations (Scopus)

Antigen 85B peptidomic analysis allows species-specific mycobacterial identification

Zhang, W., Shu, Q., Zhao, Z., Fan, J., Lyon, C. J., Zelazny, A. M. & Hu, Y., Jan 8 2018, In : Clinical Proteomics. 15, 1, 1.

Research output: Contribution to journalArticle

Antigens
Peptides
Nontuberculous Mycobacteria
Mycobacterium
Lung
8 Citations (Scopus)

Chemoresistance transmission via exosome-Mediated EphA2 transfer in pancreatic cancer

Fan, J., Wei, Q., Koay, E. J., Liu, Y., Ning, B., Bernard, P. W., Zhang, N., Han, H., Katz, M. H., Zhao, Z. & Hu, Y., Jan 1 2018, In : Theranostics. 8, 21, p. 5986-5994 9 p.

Research output: Contribution to journalArticle

Exosomes
Pancreatic Neoplasms
gemcitabine
Cell Line
Eph Family Receptors
3 Citations (Scopus)

Clinical evaluation of a blood assay to diagnose paucibacillary tuberculosis via bacterial antigens

Liu, C., Lyon, C. J., Bu, Y., Deng, Z., Walters, E., Li, Y., Zhang, L., Hesseling, A. C., Graviss, E. A. & Hu, Y., May 1 2018, In : Clinical Chemistry. 64, 5, p. 791-800 10 p.

Research output: Contribution to journalArticle

Bacterial Antigens
Mass spectrometry
Assays
Tuberculosis
Blood
15 Citations (Scopus)

Role of extracellular vesicles in viral and bacterial infections: Pathogenesis, diagnostics, and therapeutics

Rodrigues, M., Fan, J., Lyon, C., Wan, M. & Hu, Y., Jan 1 2018, In : Theranostics. 8, 10, p. 2709-2721 13 p.

Research output: Contribution to journalReview article

Virus Diseases
Bacterial Infections
Exosomes
Therapeutics
Cell Communication
2017
3 Citations (Scopus)

Aptamer internalization via endocytosis inducing s-phase arrest and priming maver-1 lymphoma cells for cytarabine chemotherapy

Li, H., Yang, S., Yu, G., Shen, L., Fan, J., Xu, L., Zhang, H., Zhao, N., Zeng, Z., Hu, Y., Wen, J. & Zu, Y., Jan 1 2017, In : Theranostics. 7, 5, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Cytarabine
Endocytosis
Lymphoma
Drug Therapy
S Phase
2 Citations (Scopus)

Circulating Peptidome and Tumor-Resident Proteolysis

Fan, J., Ning, B., Lyon, C. J. & Hu, Y., Jan 1 2017, Enzymes. Academic Press, p. 1-25 25 p. (Enzymes; vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteolysis
Tumors
Peptide Hydrolases
Neoplasms
Tumor Biomarkers
81 Citations (Scopus)

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring

Liang, K., Liu, F., Fan, J., Sun, D., Liu, C., Lyon, C. J., Bernard, D. W., Li, Y., Yokoi, K., Katz, M. H., Koay, E. J., Zhao, Z. & Hu, Y., Apr 10 2017, In : Nature Biomedical Engineering. 1, 4, 0021.

Research output: Contribution to journalArticle

Tumors
Assays
Plasmas
Monitoring
Biomarkers
2 Citations (Scopus)

Plasma Levels of Complement Factor i and C4b Peptides Are Associated with HIV Suppression

Wu, B., Ouyang, Z., Lyon, C. J., Zhang, W., Clift, T., Bone, C. R., Li, B., Zhao, Z., Kimata, J. T., Yu, X. G. & Hu, Y., Dec 8 2017, In : ACS Infectious Diseases. 3, 12, p. 880-885 6 p.

Research output: Contribution to journalArticle

HIV
Peptides
Complement C4b
Complement Factor I
Biomarkers

Preface

Hu, Y. & Tamanoi, F., Jan 1 2017, In : Enzymes. 42, p. xi

Research output: Contribution to journalEditorial

26 Citations (Scopus)

Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring

Liu, C., Zhao, Z., Fan, J., Lyon, C. J., Wu, H. J., Nedelkov, D., Zelazny, A. M., Olivier, K. N., Cazares, L. H., Holland, S. M., Graviss, E. A. & Hu, Y., Apr 11 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15, p. 3969-3974 6 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Mass Spectrometry
Peptides
Tuberculosis
Sensitivity and Specificity
2 Citations (Scopus)

Rapid diagnosis of new and relapse tuberculosis by quantification of a circulating antigen in HIV-infected adults in the Greater Houston metropolitan area

Fan, J., Zhang, H., Nguyen, D. T., Lyon, C. J., Mitchell, C. D., Zhao, Z., Graviss, E. A. & Hu, Y., Nov 1 2017, In : BMC Medicine. 15, 1, 188.

Research output: Contribution to journalArticle

HIV Antigens
Tuberculosis
Recurrence
Mycobacterium tuberculosis
Serum
2016
27 Citations (Scopus)

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis

Mi, Y., Mu, C., Wolfram, J., Deng, Z., Hu, Y., Liu, X., Blanco, E., Shen, H. & Ferrari, M., Apr 20 2016, In : Advanced healthcare materials. 5, 8, p. 936-946 11 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Lung
Liposomes
Composite materials

Can sugarcoated fingerprints be used to identify lurking viruses?

Hu, Y., Jul 1 2016, In : Proteomics. 16, 13, p. 1947-1948 2 p.

Research output: Contribution to journalComment/debate

Dermatoglyphics
Biomarkers
Viruses
Proteomics
T-cells
13 Citations (Scopus)

Chemical-sensitive graphene modulator with a memory effect for internet-of-things applications

Huang, H., Tao, L., Liu, F., Ji, L., Hu, Y., Cheng, M. M. C., Chen, P. Y. & Akinwande, D., Jan 1 2016, In : Microsystems and Nanoengineering. 2, 16018.

Research output: Contribution to journalArticle

Graphite
Graphene
Modulators
modulators
graphene
12 Citations (Scopus)

Correlation of serum hepcidin levels with disease progression in hepatitis B virus-related disease assessed by nanopore film based assay

Wang, J., Dong, A., Liu, G., Anderson, G. J., Hu, Y., Shi, J., Hu, Y. & Nie, G., Oct 3 2016, In : Scientific Reports. 6, 34252.

Research output: Contribution to journalArticle

Nanopores
Hepcidins
Virus Diseases
Hepatitis B virus
Disease Progression
96 Citations (Scopus)

Identification and quantitation of lipid C=C location isomers: A shotgun lipidomics approach enabled by photochemical reaction

Ma, X., Chong, L., Tian, R., Shi, R., Hu, Y., Ouyang, Z. & Xia, Y., Mar 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 10, p. 2573-2578 6 p.

Research output: Contribution to journalArticle

Firearms
Glycerophospholipids
Lipids
Tandem Mass Spectrometry
Complex Mixtures
12 Citations (Scopus)

Intergenic variable-number tandem-repeat polymorphism upstream of rocA alters toxin production and enhances virulence in Streptococcus pyogenes

Zhu, L., Olsen, R. J., Horstmann, N., Shelburne, S. A., Fan, J., Hu, Y. & Musser, J. M., Jan 1 2016, In : Infection and Immunity. 84, 7, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

Minisatellite Repeats
Streptococcus pyogenes
Virulence
NAD+ Nucleosidase
Necrotizing Fasciitis
2 Citations (Scopus)

Mesoporous silica chip: enabled peptide profiling as an effective platform for controlling bio-sample quality and optimizing handling procedure

Liang, K., Wu, H., Hu, Y. & Li, Y., Nov 22 2016, In : Clinical Proteomics. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Molecular Weight
Molecular weight
Peptides
Biological Preservation

Nanotechnology toward advancing personalized medicine

Sakamoto, J. H., Godin, B., Hu, Y., Blanco, E., van de Ven, A. L., Vellaichamy, A., Murphy, M. B., La Francesca, S., Schuenemeyer, T., Given, B., Meyn, A. & Ferrari, M., May 2 2016, Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk. Pan Stanford Publishing Pte. Ltd., Vol. 2. p. 1347-1411 65 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanofluidics
Nanomedicine
Medical nanotechnology
Plasma diagnostics
Precision Medicine
1 Citation (Scopus)

Noise reduction method for quantifying nanoparticle light scattering in low magnification dark-field microscope far-field images

Sun, D., Fan, J., Liu, C., Liu, Y., Bu, Y., Lyon, C. J. & Hu, Y., Jan 1 2016, In : Analytical Chemistry. 88, 24, p. 12001-12005 5 p.

Research output: Contribution to journalArticle

Noise abatement
Light scattering
Microscopes
Nanoparticles
Assays
24 Citations (Scopus)

One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA

Khaled, S. Z., Cevenini, A., Yazdi, I. K., Parodi, A., Evangelopoulos, M., Corbo, C., Scaria, S., Hu, Y., Haddix, S. G., Corradetti, B., Salvatore, F. & Tasciotti, E., May 1 2016, In : Biomaterials. 87, p. 57-68 12 p.

Research output: Contribution to journalArticle

RNA
Nanoparticles
Small Interfering RNA
Hydrogel
Hydrogels
3 Citations (Scopus)

Power Normalization for Mass Spectrometry Data Analysis and Analytical Method Assessment

Du, Y. M., Hu, Y., Xia, Y. & Ouyang, Z., Mar 15 2016, In : Analytical Chemistry. 88, 6, p. 3156-3163 8 p.

Research output: Contribution to journalArticle

Mass spectrometry
Biomarkers
Sugars
Support vector machines
Bacteria
4 Citations (Scopus)

Predictive value of serum bradykinin and desArg9-bradykinin levels for chemotherapeutic responses in active tuberculosis patients: A retrospective case series

Qian, X., Nguyen, D. T. M., Li, Y., Lyu, J., Graviss, E. A. & Hu, Y., Dec 1 2016, In : Tuberculosis. 101, p. S109-S118

Research output: Contribution to journalArticle

Bradykinin
Tuberculosis
Serum
Therapeutics
Biomarkers
4 Citations (Scopus)

Profiling of cross-functional peptidases regulated circulating peptides in BRCA1 mutant breast cancer

Fan, J., Tea, M. K. M., Yang, C., Ma, L., Meng, Q. H., Hu, Y., Singer, C. F. & Ferrari, M., May 6 2016, In : Journal of Proteome Research. 15, 5, p. 1534-1545 12 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Breast Neoplasms
Peptides
Tissue Kallikreins
Carboxypeptidase B2
34 Citations (Scopus)

Sequential co-delivery of miR-21 inhibitor followed by burst release doxorubicin using NIR-responsive hollow gold nanoparticle to enhance anticancer efficacy

Ren, Y., Wang, R., Gao, L., Li, K., Zhou, X., Guo, H., Liu, C., Han, D., Tian, J., Ye, Q., Hu, Y., Sun, D., Yuan, X. & Zhang, N., Apr 28 2016, In : Journal of Controlled Release. 228, p. 74-86 13 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Doxorubicin
MicroRNAs
Radiation
2015
6 Citations (Scopus)

Circulating Peptidome to Indicate the Tumor-resident Proteolysis

Deng, Z., Li, Y., Fan, J., Wang, G., Li, Y., Zhang, Y., Cai, G., Shen, H., Ferrari, M. & Hu, Y., Mar 19 2015, In : Scientific Reports. 5, 9327.

Research output: Contribution to journalArticle

Proteolysis
Metalloproteases
Neoplasms
Peptide Hydrolases
Ovarian Neoplasms
3 Citations (Scopus)

Hepcidin levels in hyperprolactinemic women monitored by nanopore thin film based assay: Correlation with pregnancy-associated hormone prolactin

Wang, J., Liu, G., Xu, Z., Dai, J., Song, P., Shi, J., Hu, Y., Hu, Z., Nie, G., Chang, Y. Z. & Zhao, Y., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 4, p. 871-878 8 p.

Research output: Contribution to journalArticle

Nanopores
Hepcidins
Hormones
Prolactin
Assays
2014
13 Citations (Scopus)

Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps

Wu, H. J., Li, Y., Fan, J., Deng, Z., Hu, Z., Liu, X., Graviss, E. A., Ferrari, M., Ma, X. & Hu, Y., Feb 18 2014, In : Analytical Chemistry. 86, 4, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

Antibodies
Screening
Disease control
Nanopores
Fractionation
164 Citations (Scopus)

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

Zhang, P., Wei, Y., Wang, L. I., Debeb, B. G., Yuan, Y., Zhang, J., Yuan, J., Wang, M., Chen, D., Sun, Y., Woodward, W. A., Liu, Y., Dean, D. C., Liang, H., Hu, Y., Ang, K. K., Hung, M. C., Chen, J. & Ma, L., Jan 1 2014, In : Nature Cell Biology. 16, 9, p. 864-875 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
DNA Damage
Breast Neoplasms
Recombinational DNA Repair
Neoplastic Stem Cells
21 Citations (Scopus)

Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer

Li, Y., Li, Y., Chen, T., Kuklina, A. S., Bernard, P., Esteva, F. J., Shen, H., Ferrari, M. & Hu, Y., Jan 1 2014, In : Clinical Chemistry. 60, 1, p. 233-242 10 p.

Research output: Contribution to journalArticle

Lysine Carboxypeptidase
Early Detection of Cancer
Breast Neoplasms
Peptides
Tumors
13 Citations (Scopus)

Lab-on-chip device for single cell trapping and analysis

Shah, P., Zhu, X., Chen, C., Hu, Y. & Li, C. Z., Feb 1 2014, In : Biomedical Microdevices. 16, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Assays
Equipment and Supplies
Lab-on-a-chip
Electrophoresis
85 Citations (Scopus)

MiR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

Zhang, P., Wang, L., Rodriguez-Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., Woodward, W. A., Liang, H., Yang, X., Lopez-Berestein, G., Sood, A. K., Hu, Y., Ang, K. K., Chen, J. & Ma, L., Jan 1 2014, In : Nature Communications. 5, 5671.

Research output: Contribution to journalArticle

boxes
Zinc
Tumors
tumors
zinc
3 Citations (Scopus)

Multidisciplinary efforts driving translational theranostics

Hu, Y., Jan 1 2014, In : Theranostics. 4, 12, p. 1209-1210 2 p.

Research output: Contribution to journalEditorial

Language
Theranostic Nanomedicine
Therapeutics
12 Citations (Scopus)

Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids

Fan, J., Niu, S., Dong, A., Shi, J., Wu, H. J., Fine, D. H., Tian, Y., Zhou, C., Liu, X., Sun, T., Anderson, G. J., Ferrari, M., Nie, G., Hu, Y. & Zhao, Y., Jan 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 5, p. 879-888 10 p.

Research output: Contribution to journalArticle

Nanopores
Hepcidins
Peptides
Fluids
Biomarkers
14 Citations (Scopus)

Nanotechnologies in glycoproteomics

Zhao, H., Li, Y. & Hu, Y., Jan 1 2014, In : Clinical Proteomics. 11, 1, 21.

Research output: Contribution to journalReview article

Nanotechnology
Glycopeptides
Mass spectrometry
Mass Spectrometry
Biomarkers
16 Citations (Scopus)

RFID tag helix antenna sensors for wireless drug dosage monitoring

Huang, H., Zhao, P., Chen, P. Y., Ren, Y., Liu, X., Ferrari, M., Hu, Y. & Akinwande, D., Jan 1 2014, In : IEEE Journal of Translational Engineering in Health and Medicine. 2, 1, 1700108.

Research output: Contribution to journalArticle

Drug dosage
Radio frequency identification (RFID)
Antennas
Drug delivery
Monitoring
2013
13 Citations (Scopus)

Bacteriophage associated silicon particles: Design and characterization of a novel theranostic vector with improved payload carrying potential

Srinivasan, S., Alexander, J. F., Driessen, W. H., Leonard, F., Hu, Y., Liu, X., Arap, W., Pasqualini, R., Ferrari, M. & Godin, B., Oct 21 2013, In : Journal of Materials Chemistry B. 1, 39, p. 5218-5229 12 p.

Research output: Contribution to journalArticle

Bacteriophages
Silicon
Nanoparticles
Therapeutics
Macromolecules
114 Citations (Scopus)

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Wang, Z., Wu, H. J., Fine, D., Schmulen, J., Hu, Y., Godin, B., Zhang, J. X. J. & Liu, X., Aug 7 2013, In : Lab on a Chip. 13, 15, p. 2879-2882 4 p.

Research output: Contribution to journalArticle

Nanowires
Microfluidics
Lab-On-A-Chip Devices
Lipids
Exosomes

Dual band electrically small non-uniform pitch ellipsoidal helix antenna for cardiac pacemakers

Huang, H., Chen, P. Y., Ferrari, M., Hu, Y. & Akinwande, D., Jan 1 2013, BioWireleSS 2013 - Proceedings: 2013 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems - 2013 IEEE Radio and Wireless Week, RWW 2013. IEEE Computer Society, p. 148-150 3 p. 6613704

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pacemakers
Antennas
Frequency bands
Natural frequencies
Sintering
1 Citation (Scopus)

Dual band electrically small non-uniform pitch ellipsoidal helix antenna for cardiac pacemakers

Huang, H., Chen, P. Y., Ferrari, M., Hu, Y. & Akinwande, D., Apr 15 2013, 2013 IEEE 13th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems, SiRF 2013 - RWW 2013. p. 225-227 3 p. 6489487

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pacemakers
Antennas
Frequency bands
Natural frequencies
Sintering

Dual band electrically small non-uniform pitch ellipsoidal helix antenna for cardiac pacemakers

Huang, H., Chen, P. Y., Ferrari, M., Hu, Y. & Akinwande, D., Apr 15 2013, PAWR 2013 - Proceedings: 2013 IEEE Topical Conference on Power Amplifiers for Wireless and Radio Applications - 2013 IEEE Radio and Wireless Week, RWW 2013. p. 154-156 3 p. 6490220

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pacemakers
Antennas
Frequency bands
Natural frequencies
Sintering