• 7732 Citations
  • 32 h-Index
20052020
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Research Output 2005 2019

  • 7732 Citations
  • 32 h-Index
  • 54 Article
  • 2 Comment/debate
  • 2 Letter
  • 1 Review article
Article
26 Citations (Scopus)

Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering

Joseph, J. S., Liu, W., Kunken, J., Weiss, T. M., Tsuruta, H. & Cherezov, V., Dec 2011, In : Methods. 55, 4, p. 342-349 8 p.

Research output: Contribution to journalArticle

Crystallization
X ray scattering
Membrane Proteins
Throughput
X-Rays
15 Citations (Scopus)

Crystallization of membrane proteins in lipidic mesophases

Liu, W. & Cherezov, V., Mar 2011, In : Journal of Visualized Experiments. 49, e2501.

Research output: Contribution to journalArticle

Crystallization
Membrane Proteins
Proteins
Membranes
Crystals

Crystallization of membrane proteins in lipidic mesophases.

Liu, W. & Cherezov, V., 2011, In : Journal of visualized experiments : JoVE. 49

Research output: Contribution to journalArticle

Crystallization
Membrane Proteins
Proteins
Membranes
Crystals
17 Citations (Scopus)

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes

Santos, J. S., Asmar-Rovira, G. A., Han, G. W., Liu, W., Syeda, R., Cherezov, V., Baker, K. A., Stevens, R. C. & Montal, M., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 43063-43070 8 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Membrane Lipids
Crystal structure
Sensors
Electric potential
4 Citations (Scopus)

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

Audet, M., White, K. L., Breton, B., Zarzycka, B., Han, G. W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katritch, V., Cherezov, V., Hanson, M. A. & Stevens, R. C., Jan 1 2019, In : Nature Chemical Biology. 15, 1, p. 11-17 7 p.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Misoprostol
Dinoprostone
Induced Labor
Myometrium
361 Citations (Scopus)

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Ke, J., Tan, M. H. E., Zhang, C., Moeller, A., West, G. M., Pascal, B. D., Van Eps, N., Caro, L. N. & 52 others, Vishnivetskiy, S. A., Lee, R. J., Suino-Powell, K. M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G. J., Messerschmidt, M., Gati, C., Zatsepin, N., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C. E., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C. S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H. N., Spence, J., Fromme, P., Weierstall, U., Ernst, O. P., Katritch, V., Gurevich, V. V., Griffin, P. R., Hubbell, W. L., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Jul 30 2015, In : Nature. 523, 7562, p. 561-567 7 p.

Research output: Contribution to journalArticle

Arrestin
Rhodopsin
Lasers
X-Rays
G-Protein-Coupled Receptors
57 Citations (Scopus)

Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis

Fairman, J. W., Dautin, N., Wojtowicz, D., Liu, W., Noinaj, N., Barnard, T. J., Udho, E., Przytycka, T. M., Cherezov, V. & Buchanan, S. K., Jul 3 2012, In : Structure. 20, 7, p. 1233-1243 11 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Virulence Factors
Gram-Negative Bacteria
Peptide Hydrolases
Membranes
35 Citations (Scopus)

Development of an automated high throughput LCP-FRAP assay to guide membrane protein crystallization in lipid mesophases

Xu, F., Liu, W., Hanson, M. A., Stevens, R. C. & Cherezov, V., Apr 6 2011, In : Crystal Growth and Design. 11, 4, p. 1193-1201 9 p.

Research output: Contribution to journalArticle

Photobleaching
Crystallization
Lipids
lipids
Assays

Erratum: The monoolein-cholesterol cubic phase: Characterization by NMR spectroscopy (Biophysical Journal (2012) (390a))

Gater, D., Saurel, O., Réat, V., Jolibois, F., Liu, W., Cherezov, V. & Milon, A., Mar 21 2012, In : Biophysical Journal. 102, 6, p. 1469 1 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Cholesterol
monoolein

Erratum: Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes (Journal Of Biological Chemistry (2012) 287 (43063-43070))

Santos, J. S., Asmar-Rovira, G. A., Han, G. W., Liu, W., Syeda, R., Cherezov, V., Baker, K. A., Stevens, R. C. & Montal, M., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3476 1 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Membrane Lipids
Crystal structure
1 Citation (Scopus)

FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death

Li, D. Z., Liu, S. F., Zhu, L., Wang, Y. X., Chen, Y. X., Liu, J., Hu, G., Yu, X., Li, J., Zhang, J., Wu, Z. X., Lu, H., Liu, W. & Liu, B., 2017, In : Oncotarget. 8, 57, p. 97178-97186 9 p.

Research output: Contribution to journalArticle

Telophase
Anaphase
Genomic Instability
Cell Death
Histone Code
32 Citations (Scopus)

Femtosecond crystallography of membrane proteins in the lipidic cubic phase

Liu, W., Wacker, D., Wang, C., Abola, E. & Cherezov, V., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130314.

Research output: Contribution to journalArticle

crystallography
Crystallography
membrane proteins
Membrane Proteins
membrane
180 Citations (Scopus)

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

Chun, E., Thompson, A. A., Liu, W., Roth, C. B., Griffith, M. T., Katritch, V., Kunken, J., Xu, F., Cherezov, V., Hanson, M. A. & Stevens, R. C., Jun 6 2012, In : Structure. 20, 6, p. 967-976 10 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Crystallization
Adenosine A2A Receptors
Adrenergic Agents
Proteins
6 Citations (Scopus)

GPCR crystallization using lipidic cubic phase technique

Yin, X., Xu, H., Hanson, M. & Liu, W., 2014, In : Current Pharmaceutical Biotechnology. 15, 10, p. 971-979 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Crystallization
Drug Delivery Systems
Pharmaceutical Preparations
Lasers
39 Citations (Scopus)

Gramicidin structure and disposition in highly curved membranes

Liu, W. & Caffrey, M., Apr 2005, In : Journal of Structural Biology. 150, 1, p. 23-40 18 p.

Research output: Contribution to journalArticle

Gramicidin
Crystallization
Membranes
Peptides
Membrane Proteins
73 Citations (Scopus)

High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment

Tiefenbrunn, T., Liu, W., Chen, Y., Katritch, V., Stout, C. D., Fee, J. A. & Cherezov, V., 2011, In : PLoS One. 6, 7, e22348.

Research output: Contribution to journalArticle

Thermus thermophilus
Electron Transport Complex IV
cytochrome-c oxidase
protons
Protons
1 Citation (Scopus)

High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

Martin-Garcia, J. M., Zhu, L., Mendez, D., Lee, M. Y., Chun, E., Li, C., Hu, H., Subramanian, G., Kissick, D., Ogata, C., Henning, R., Ishchenko, A., Dobson, Z., Zhang, S., Weierstall, U., Spence, J., Fromme, P., Zatsepin, N., Fischetti, R. F., Cherezov, V. & 1 others, Liu, W., Jan 1 2019, In : IUCrJ. 6, p. 412-425 14 p.

Research output: Contribution to journalArticle

Open Access
Crystallography
Microcrystals
Synchrotrons
microcrystals
Synchrotron radiation
32 Citations (Scopus)

In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin

Cherezov, V., Liu, W., Derrick, J. P., Luan, B., Aksimentiev, A., Katritch, V. & Caffrey, M., Apr 2008, In : Proteins: Structure, Function and Genetics. 71, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

Proteoglycans
Polysaccharides
Crystal structure
Binding Sites
N-Acetylneuraminic Acid
80 Citations (Scopus)

In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution

Cherezov, V., Yamashita, E., Liu, W., Zhalnina, M., Cramer, W. A. & Caffrey, M., Dec 8 2006, In : Journal of Molecular Biology. 364, 4, p. 716-734 19 p.

Research output: Contribution to journalArticle

Vitamin B 12
Membrane Proteins
Colicins
Energy Transfer
Electron Spin Resonance Spectroscopy
38 Citations (Scopus)

Interactions of tryptophan, tryptophan peptides, and tryptophan alkyl esters at curved membrane interfaces

Liu, W. & Caffrey, M., Oct 3 2006, In : Biochemistry. 45, 39, p. 11713-11726 14 p.

Research output: Contribution to journalArticle

Tryptophan
Esters
Membranes
Peptides
Glycerophospholipids
44 Citations (Scopus)

LCP-Tm: An assay to measure and understand stability of membrane proteins in a membrane environment

Liu, W., Hanson, M. A., Stevens, R. C. & Cherezov, V., Apr 21 2010, In : Biophysical Journal. 98, 8, p. 1539-1548 10 p.

Research output: Contribution to journalArticle

Membrane Proteins
Membranes
Fluorescence
Bacteriorhodopsins
Protein Denaturation
286 Citations (Scopus)

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In : Nature Communications. 5, 3309.

Research output: Contribution to journalArticle

Crystallography
injectors
crystallography
Membrane Proteins
membranes
47 Citations (Scopus)

Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

Batyuk, A., Galli, L., Ishchenko, A., Han, G. W., Gati, C., Popov, P. A., Lee, M. Y., Stauch, B., White, T. A., Barty, A., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Pu, M., Liu, Z. J., Nelson, G., James, D., Li, C., Zhao, Y. & 7 others, Spence, J., Liu, W., Fromme, P., Katritch, V., Weierstall, U., Stevens, R. C. & Cherezov, V., Sep 1 2016, In : Science advances. 2, 9, e1600292.

Research output: Contribution to journalArticle

Lasers
X-Rays
Electrons
Adenosine A2A Receptors
Crystallography

Overview of Biochemical Assays in Lipidic Cubic Phase

Lan, Z., Lee, M. Y., Chun, E., Liu, B. & Liu, W., Jan 1 2018, (Accepted/In press) In : Trends in Biochemical Sciences.

Research output: Contribution to journalArticle

Assays
Membrane Proteins
7 Citations (Scopus)

Preparation and delivery of protein microcrystals in lipidic cubic phase for serial femtosecond crystallography

Ishchenko, A., Cherezov, V. & Liu, W., Sep 20 2016, In : Journal of Visualized Experiments. 2016, 115, e54463.

Research output: Contribution to journalArticle

Crystallography
Microcrystals
Proteins
Crystals
Synchrotrons
66 Citations (Scopus)

Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography

Liu, W., Ishchenko, A. & Cherezov, V., 2014, In : Nature Protocols. 9, 9, p. 2123-2134 12 p.

Research output: Contribution to journalArticle

Crystallography
Microcrystals
X ray lasers
Free electron lasers
Crystals

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response 06 Biological Sciences 0601 Biochemistry and Cell Biology

Du, S. C., Zhu, L., Wang, Y. X., Liu, J., Zhang, D., Chen, Y. L., Peng, Q., Liu, W. & Liu, B., Jan 3 2019, In : Cancer Cell International. 19, 1, 4.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Hypoxia-Inducible Factor 1
Biological Science Disciplines
Biochemistry
Cell Biology
5 Citations (Scopus)

Serial femtosecond crystallography datasets from G protein-coupled receptors

White, T. A., Barty, A., Liu, W., Ishchenko, A., Zhang, H., Gati, C., Zatsepin, N., Basu, S., Oberthur, D., Metz, M., Beyerlein, K. R., Yoon, C. H., Yefanov, O. M., James, D., Wang, D., Messerschmidt, M., Koglin, J. E., Boutet, S., Weierstall, U. & Cherezov, V., Aug 1 2016, In : Scientific data. 3, 160057.

Research output: Contribution to journalArticle

G Protein
Crystallography
Femtosecond
Receptor
Proteins
276 Citations (Scopus)

Serial femtosecond crystallography of G protein-coupled receptors

Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T. A., Basu, S. & 13 others, Fromme, R., Kupitz, C., Rendek, K. N., Grotjohann, I., Fromme, P., Kirian, R., Beyerlein, K. R., White, T. A., Chapman, H. N., Caffrey, M., Spence, J., Stevens, R. C. & Cherezov, V., 2013, In : Science. 342, 6165, p. 1521-1524 4 p.

Research output: Contribution to journalArticle

Protein
Laser
Damage
Temperature
Radiation

Serial femtosecond crystallography of membrane proteins

Zhu, L., Weierstall, U., Cherezov, V. & Liu, W., 2016, In : Advances in Experimental Medicine and Biology. 922, p. 151-160 10 p.

Research output: Contribution to journalArticle

Crystallography
Membrane Proteins
X ray lasers
Free electron lasers
X Ray Crystallography
33 Citations (Scopus)

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

Fromme, R., Ishchenko, A., Metz, M., Chowdhury, S. R., Basu, S., Boutet, S., Fromme, P., White, T. A., Barty, A., Spence, J., Weierstall, U., Liu, W. & Cherezov, V., Sep 1 2015, In : IUCrJ. 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
Microcrystals
proteins
Proteins
8 Citations (Scopus)

Serial femtosecond X-ray diffraction of enveloped virus microcrystals

Lawrence, R. M., Conrad, C. E., Zatsepin, N., Grant, T. D., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Coe, J., Spence, J., Weierstall, U., Liu, W., Fromme, P., Cherezov, V. & Hogue, B., Jul 1 2015, In : Structural Dynamics. 2, 4, 041720.

Research output: Contribution to journalArticle

Microcrystals
microcrystals
viruses
Viruses
X ray diffraction
31 Citations (Scopus)

Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

Martin-Garcia, J. M., Conrad, C. E., Nelson, G., Stander, N., Zatsepin, N., Zook, J., Zhu, L., Geiger, J., Chun, E., Kissick, D., Hilgart, M. C., Ogata, C., Ishchenko, A., Nagaratnam, N., Roy-Chowdhury, S., Coe, J., Subramanian, G., Schaffer, A., James, D., Ketwala, G. & 10 others, Venugopalan, N., Xu, S., Corcoran, S., Ferguson, D., Weierstall, U., Spence, J., Cherezov, V., Fromme, P., Fischetti, R. F. & Liu, W., 2017, In : IUCrJ. 4, p. 439-454 16 p.

Research output: Contribution to journalArticle

Crystallography
Microcrystals
Synchrotrons
microcrystals
Phycocyanin
3 Citations (Scopus)

Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source

Lan, T. Y., Wierman, J. L., Tate, M. W., Philipp, H. T., Martin-Garcia, J. M., Zhu, L., Kissick, D., Fromme, P., Fischetti, R. F., Liu, W., Elser, V. & Gruner, S. M., Jan 1 2018, In : IUCrJ. 5, p. 548-558 11 p.

Research output: Contribution to journalArticle

Microcrystals
Synchrotrons
Storage rings
microcrystals
synchrotrons
541 Citations (Scopus)

Structural basis for allosteric regulation of GPCRS by sodium ions

Liu, W., Chun, E., Thompson, A. A., Chubukov, P., Xu, F., Katritch, V., Han, G. W., Roth, C. B., Heitman, L. H., IJzerman, A. P., Cherezov, V. & Stevens, R. C., Jul 13 2012, In : Science. 337, 6091, p. 232-236 5 p.

Research output: Contribution to journalArticle

Allosteric Regulation
G-Protein-Coupled Receptors
Sodium
Ions
Cholesterol
91 Citations (Scopus)

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J., Boutet, S., Messerschmidt, M., Williams, G. J., Gati, C., Yefanov, O. M., White, T. A., Oberthuer, D. & 16 others, Metz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptides
Analgesics
Opiate Alkaloids
phenylalanylphenylalanine
284 Citations (Scopus)

Structural basis for molecular recognition at serotonin receptors

Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X. P., Vardy, E., McCorvy, J. D., Gao, X., Zhou, X. E., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B. L. & 3 others, Cherezov, V., Stevens, R. C. & Xu, H. E., 2013, In : Science. 340, 6132, p. 610-614 5 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Serotonin
Receptor, Serotonin, 5-HT2B
Dihydroergotamine
Ergotamine
68 Citations (Scopus)

Structural basis for selectivity and diversity in angiotensin II receptors

Zhang, H., Han, G. W., Batyuk, A., Ishchenko, A., White, K. L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M. T., Hollenstein, K., Tolstikova, A., White, T. A., Hunter, M. S., Weierstall, U., Liu, W., Babaoglu, K., Moore, E. L., Katz, R. D., Shipman, J. M., Garcia-Calvo, M. & 6 others, Sharma, S., Sheth, P., Soisson, S. M., Stevens, R. C., Katritch, V. & Cherezov, V., Apr 20 2017, In : Nature. 544, 7650, p. 327-332 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Ligands
Arrestins
Structure-Activity Relationship
Renin-Angiotensin System
378 Citations (Scopus)

Structural features for functional selectivity at serotonin receptors

Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X. P., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F. Y., Liu, W., Xu, H. E., Cherezov, V., Roth, B. L. & Stevens, R. C., 2013, In : Science. 340, 6132, p. 615-619 5 p.

Research output: Contribution to journalArticle

Ergotamine
Serotonin Receptors
G-Protein-Coupled Receptors
Receptor, Serotonin, 5-HT2B
Ergolines
15 Citations (Scopus)

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G. W., Basu, S., Patel, N., Messerschmidt, M., Weierstall, U., Liu, W., Katritch, V., Roth, B. L., Stevens, R. C. & Cherezov, V., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8223-8228 6 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2B
G-Protein-Coupled Receptors
Serotonin Receptors
Monoclonal Antibodies
Antibodies
56 Citations (Scopus)

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors

Lane, J. R., Chubukov, P., Liu, W., Canals, M., Cherezov, V., Abagyan, R., Stevens, R. C. & Katritch, V., Dec 2013, In : Molecular Pharmacology. 84, 6, p. 794-807 14 p.

Research output: Contribution to journalArticle

Dopamine Receptors
Allosteric Site
Ligands
Dopamine
G-Protein-Coupled Receptors
168 Citations (Scopus)

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

Zhang, H., Unal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N., James, D., Wang, D., Nelson, G., Weierstall, U., Sawaya, M. R., Xu, Q., Messerschmidt, M., Williams, G. J., Boutet, S., Yefanov, O. M., White, T. A., Wang, C., Ishchenko, A., Tirupula, K. C. & 8 others, Desnoyer, R., Coe, J., Conrad, C. E., Fromme, P., Stevens, R. C., Katritch, V., Karnik, S. S. & Cherezov, V., Nov 6 2014, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Crystallography
Angiotensin Receptors
Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
70 Citations (Scopus)

Structure of the full-length glucagon class B G-protein-coupled receptor

Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., De Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G. W., Grant, T. D., Sierra, R. G., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X. & 13 others, Geng, Z., Dong, Y., Song, G., Griffin, P. R., Lau, J., Cherezov, V., Yang, H., Hanson, M. A., Stevens, R. C., Zhao, Q., Jiang, H., Wang, M. W. & Wu, B., Jun 8 2017, In : Nature. 546, 7657, p. 259-264 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Glucagon
Glucagon Receptors
Deuterium
Molecular Dynamics Simulation
816 Citations (Scopus)

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist

Chien, E. Y. T., Liu, W., Zhao, Q., Katritch, V., Han, G. W., Hanson, M. A., Shi, L., Newman, A. H., Javitch, J. A., Cherezov, V. & Stevens, R. C., Nov 19 2010, In : Science. 330, 6007, p. 1091-1095 5 p.

Research output: Contribution to journalArticle

eticlopride
Dopamine D3 Receptors
Dopamine
G-Protein-Coupled Receptors
Amides
256 Citations (Scopus)

Structure of the human glucagon class B G-protein-coupled receptor

Siu, F. Y., He, M., De Graaf, C., Han, G. W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J. S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M. W. & Stevens, R. C., 2013, In : Nature. 499, 7459, p. 444-449 6 p.

Research output: Contribution to journalArticle

Glucagon Receptors
G-Protein-Coupled Receptors
Glucagon
Ligands
Glucose
533 Citations (Scopus)

Structure of the human histamine H 1 receptor complex with doxepin

Shimamura, T., Shiroishi, M., Weyand, S., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R., Cherezov, V., Liu, W., Han, G. W., Kobayashi, T., Stevens, R. C. & Iwata, S., Jul 7 2011, In : Nature. 475, 7354, p. 65-72 8 p.

Research output: Contribution to journalArticle

Doxepin
Histamine
Anions
Hypersensitivity
Biogenic Amines
318 Citations (Scopus)

Structure of the human smoothened receptor bound to an antitumour agent

Wang, C., Wu, H., Katritch, V., Han, G. W., Huang, X. P., Liu, W., Siu, F. Y., Roth, B. L., Cherezov, V. & Stevens, R. C., May 16 2013, In : Nature. 497, 7449, p. 338-343 6 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
G-Protein-Coupled Receptors
Transducers
Disulfides
Embryonic Development
590 Citations (Scopus)

Structure of the human κ-opioid receptor in complex with JDTic

Wu, H., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X. P., Carroll, F. I., Mascarella, S. W., Westkaemper, R. B., Mosier, P. D., Roth, B. L., Cherezov, V. & Stevens, R. C., May 17 2012, In : Nature. 485, 7398, p. 327-332 6 p.

Research output: Contribution to journalArticle

Opioid Receptors
salvinorin A
Ligands
Morphinans
Physiological Phenomena
329 Citations (Scopus)

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H., Vardy, E., Huang, X. P., Trapella, C., Guerrini, R., Calo, G., Roth, B. L., Cherezov, V. & Stevens, R. C., May 17 2012, In : Nature. 485, 7398, p. 395-399 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
G-Protein-Coupled Receptors
Peptides
Ligands
Pharmacology
26 Citations (Scopus)

Successful Strategies to Determine High-Resolution Structures of GPCRs

Xiang, J., Chun, E., Liu, C., Jing, L., Al-Sahouri, Z., Zhu, L. & Liu, W., 2016, (Accepted/In press) In : Trends in Pharmacological Sciences.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Crystallization
Ligands
Protein Engineering
Human Genome