• 1127 Citations
  • 17 h-Index
20052020

Research output per year

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Research Output

  • 1127 Citations
  • 17 h-Index
  • 25 Article
  • 5 Review article
  • 2 Comment/debate
  • 2 Patent
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Article
2020

PIRT the TRP channel regulating protein binds calmodulin and cholesterol-like ligands

Sisco, N. J., Luu, D. D., Kim, M. & Van Horn, W. D., Mar 2020, In : Biomolecules. 10, 3, 478.

Research output: Contribution to journalArticle

Open Access

Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies

Journigan, V. B., Feng, Z., Rahman, S., Wang, Y., Amin, A. R. M. R., Heffner, C. E., Bachtel, N., Wang, S., Gonzalez-Rodriguez, S., Fernández-Carvajal, A., Fernández-Ballester, G., Hilton, J. K., Van Horn, W. D., Ferrer-Montiel, A., Xie, X. Q. & Rahman, T., Feb 5 2020, In : ACS chemical neuroscience. 11, 3, p. 268-290 23 p.

Research output: Contribution to journalArticle

2019

Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation

Sisco, N. J., Helsell, C. V. M. & Van Horn, W. D., Dec 1 2019, In : Scientific reports. 9, 1, 14128.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels

Hilton, J. K., Kim, M. & Van Horn, W., Jun 18 2019, In : Accounts of chemical research. 52, 6, p. 1643-1652 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels

Hilton, J. K., Salehpour, T., Sisco, N. J., Rath, P. & Van Horn, W. D., Jun 15 2018, In : Journal of Biological Chemistry. 293, 24, p. 9423-9434 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A parallel stranded G-quadruplex composed of threose nucleic acid (TNA)

Liao, J. Y., Anosova, I., Bala, S., Van Horn, W. & Chaput, J. C., Mar 1 2017, In : Biopolymers. 107, 3, e22999.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain

Rath, P., Hilton, J. K., Sisco, N. J. & Van Horn, W., Jan 19 2016, In : Biochemistry. 55, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural basis for KCNE3 modulation of potassium recycling in epithelia

Kroncke, B. M., Van Horn, W., Smith, J., Kang, C. B., Welch, R. C., Song, Y., Nannemann, D. P., Taylor, K. C., Sisco, N. J., George, A. L., Meiler, J., Vanoye, C. G. & Sanders, C. R., Sep 1 2016, In : Science advances. 2, 9, e1501228.

Research output: Contribution to journalArticle

20 Scopus citations

Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes

Anosova, I., Kowal, E. A., Sisco, N. J., Sau, S., Liao, J. Y., Bala, S., Rozners, E., Egli, M., Chaput, J. C. & Van Horn, W., Sep 15 2016, In : ChemBioChem. 17, 18, p. 1705-1708 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

SURVEY AND SUMMARY the structural diversity of artificial genetic polymers

Anosova, I., Kowal, E. A., Dunn, M. R., Chaput, J. C., Van Horn, W. & Egli, M., Jan 1 2016, In : Nucleic acids research. 44, 3, p. 1007-1021 15 p.

Research output: Contribution to journalArticle

57 Scopus citations
2015

NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins

Zook, J., Mo, G., Sisco, N. J., Craciunescu, F. M., Hansen, D., Baravati, B., Cherry, B., Sykes, K., Wachter, R., Van Horn, W. & Fromme, P., Jun 3 2015, In : Structure. 23, 6, p. 1116-1122 7 p., 3165.

Research output: Contribution to journalArticle

4 Scopus citations

Understanding thermosensitive transient receptor potential channels as versatile polymodal cellular sensors

Hilton, J. K., Rath, P., Helsell, C. V. M., Beckstein, O. & Van Horn, W., Apr 21 2015, In : Biochemistry. 54, 15, p. 2401-2413 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel

Peng, D., Kim, J. H., Kroncke, B. M., Law, C. L., Xia, Y., Droege, K. D., Van Horn, W. D., Vanoye, C. G. & Sanders, C. R., Apr 1 2014, In : Biochemistry. 53, 12, p. 2032-2042 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

The quiet renaissance of protein nuclear magnetic resonance

Barrett, P. J., Chen, J., Cho, M. K., Kim, J. H., Lu, Z., Mathew, S., Peng, D., Song, Y., Van Horn, W., Zhuang, T., Sönnichsen, F. D. & Sanders, C. R., Feb 26 2013, In : Biochemistry. 52, 8, p. 1303-1320 18 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Bicelles at low concentrations

Lu, Z., Van Horn, W. D., Chen, J., Mathew, S., Zent, R. & Sanders, C. R., Apr 2 2012, In : Molecular Pharmaceutics. 9, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis

Shi, M., Pedchenko, V., Greer, B. H., Van Horn, W. D., Santoro, S. A., Sanders, C. R., Hudson, B. G., Eichman, B. F., Zent, R. & Pozzi, A., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35139-35152 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol

Barrett, P. J., Song, Y., Van Horn, W. D., Hustedt, E. J., Schafer, J. M., Hadziselimovic, A., Beel, A. J. & Sanders, C. R., Jun 1 2012, In : Science. 336, 6085, p. 1168-1171 4 p.

Research output: Contribution to journalArticle

289 Scopus citations
2010

Functional delivery of a membrane protein into oocyte membranes using bicelles

Kang, C., Vanoye, C. G., Welch, R. C., Van Horn, W. D. & Sanders, C. R., Feb 2 2010, In : Biochemistry. 49, 4, p. 653-655 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins

Van Horn, W. D., Beel, A. J., Kang, C. & Sanders, C. R., Feb 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Reverse micelle encapsulation as a model for intracellular crowding

Van Horn, W. D., Ogilvie, M. E. & Flynn, P. F., Jun 17 2009, In : Journal of the American Chemical Society. 131, 23, p. 8030-8039 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase

Van Horn, W. D., Kim, H. J., Ellis, C. D., Hadziselimovic, A., Sulistijo, E. S., Karra, M. D., Tian, C., Sönnichsen, F. D. & Sanders, C. R., Jun 26 2009, In : Science. 324, 5935, p. 1726-1729 4 p.

Research output: Contribution to journalArticle

171 Scopus citations
2008

Use of reverse micelles in membrane protein structural biology

van Horn, W. D., Ogilvie, M. E. & Flynn, P. F., Mar 1 2008, In : Journal of Biomolecular NMR. 40, 3, p. 203-211 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

NMR Studies of Encapsulated Macromolecules

Flynn, P. F., Simorellis, A. K. & Van Horn, W., 2007, In : Annual Reports on NMR Spectroscopy. 62, p. 179-219 41 p.

Research output: Contribution to journalArticle

5 Scopus citations
2006

Dynamics of low temperature induced water shedding from AOT reverse micelles

Simorellis, A. K., Van Horn, W. D. & Flynn, P. F., Apr 19 2006, In : Journal of the American Chemical Society. 128, 15, p. 5082-5090 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2005

Low-temperature studies of encapsulated proteins

Van Horn, W. D., Simorellis, A. K. & Flynn, P. F., Oct 5 2005, In : Journal of the American Chemical Society. 127, 39, p. 13553-13560 8 p.

Research output: Contribution to journalArticle

47 Scopus citations