• 1117 Citations
  • 17 h-Index
20052020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1117 Citations
  • 17 h-Index
  • 25 Article
  • 5 Review article
  • 2 Comment/debate
  • 2 Patent
2020

Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Garami, A., Shimansky, Y. P., Rumbus, Z., Vizin, R. C. L., Farkas, N., Hegyi, J., Szakacs, Z., Solymar, M., Csenkey, A., Chiche, D. A., Kapil, R., Kyle, D. J., Van Horn, W. D., Hegyi, P. & Romanovsky, A. A., Apr 2020, In : Pharmacology and Therapeutics. 208, 107474.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

PIRT the TRP channel regulating protein binds calmodulin and cholesterol-like ligands

Sisco, N. J., Luu, D. D., Kim, M. & Van Horn, W. D., Mar 2020, In : Biomolecules. 10, 3, 478.

Research output: Contribution to journalArticle

Open Access

Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies

Journigan, V. B., Feng, Z., Rahman, S., Wang, Y., Amin, A. R. M. R., Heffner, C. E., Bachtel, N., Wang, S., Gonzalez-Rodriguez, S., Fernández-Carvajal, A., Fernández-Ballester, G., Hilton, J. K., Van Horn, W. D., Ferrer-Montiel, A., Xie, X. Q. & Rahman, T., Feb 5 2020, In : ACS chemical neuroscience. 11, 3, p. 268-290 23 p.

Research output: Contribution to journalArticle

2019

Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation

Sisco, N. J., Helsell, C. V. M. & Van Horn, W. D., Dec 1 2019, In : Scientific reports. 9, 1, 14128.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels

Hilton, J. K., Kim, M. & Van Horn, W., Jun 18 2019, In : Accounts of chemical research. 52, 6, p. 1643-1652 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels

Hilton, J. K., Salehpour, T., Sisco, N. J., Rath, P. & Van Horn, W. D., Jun 15 2018, In : Journal of Biological Chemistry. 293, 24, p. 9423-9434 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A parallel stranded G-quadruplex composed of threose nucleic acid (TNA)

Liao, J. Y., Anosova, I., Bala, S., Van Horn, W. & Chaput, J. C., Mar 1 2017, In : Biopolymers. 107, 3, e22999.

Research output: Contribution to journalArticle

5 Scopus citations

New pieces to an old puzzle: Identifying the warfarin-binding site that prevents clotting

Hilton, J. K. & Van Horn, W., Jan 5 2017, In : Nature Structural and Molecular Biology. 24, 1, p. 5-6 2 p.

Research output: Contribution to journalComment/debate

2016

Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain

Rath, P., Hilton, J. K., Sisco, N. J. & Van Horn, W., Jan 19 2016, In : Biochemistry. 55, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural basis for KCNE3 modulation of potassium recycling in epithelia

Kroncke, B. M., Van Horn, W., Smith, J., Kang, C. B., Welch, R. C., Song, Y., Nannemann, D. P., Taylor, K. C., Sisco, N. J., George, A. L., Meiler, J., Vanoye, C. G. & Sanders, C. R., Sep 1 2016, In : Science advances. 2, 9, e1501228.

Research output: Contribution to journalArticle

20 Scopus citations

Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes

Anosova, I., Kowal, E. A., Sisco, N. J., Sau, S., Liao, J. Y., Bala, S., Rozners, E., Egli, M., Chaput, J. C. & Van Horn, W., Sep 15 2016, In : ChemBioChem. 17, 18, p. 1705-1708 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Heat-sensing protein switch based on TRPV1

Van Horn, W., Jun 19 2015

Research output: Patent

NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins

Zook, J., Mo, G., Sisco, N. J., Craciunescu, F. M., Hansen, D., Baravati, B., Cherry, B., Sykes, K., Wachter, R., Van Horn, W. & Fromme, P., Jun 3 2015, In : Structure. 23, 6, p. 1116-1122 7 p., 3165.

Research output: Contribution to journalArticle

4 Scopus citations

SURVEY AND SUMMARY the structural diversity of artificial genetic polymers

Anosova, I., Kowal, E. A., Dunn, M. R., Chaput, J. C., Van Horn, W. & Egli, M., 2015, In : Nucleic Acids Research. 44, 3, p. 1007-1021 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Understanding thermosensitive transient receptor potential channels as versatile polymodal cellular sensors

Hilton, J. K., Rath, P., Helsell, C. V. M., Beckstein, O. & Van Horn, W., Apr 21 2015, In : Biochemistry. 54, 15, p. 2401-2413 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel

Peng, D., Kim, J. H., Kroncke, B. M., Law, C. L., Xia, Y., Droege, K. D., Van Horn, W. D., Vanoye, C. G. & Sanders, C. R., Apr 1 2014, In : Biochemistry. 53, 12, p. 2032-2042 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

VKORC1 ER mislocalization causes rare disease

Van Horn, W. D., Aug 21 2014, In : Blood. 124, 8, p. 1215-1216 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2013
20 Scopus citations

The quiet renaissance of protein nuclear magnetic resonance

Barrett, P. J., Chen, J., Cho, M. K., Kim, J. H., Lu, Z., Mathew, S., Peng, D., Song, Y., Van Horn, W., Zhuang, T., Sönnichsen, F. D. & Sanders, C. R., Feb 26 2013, In : Biochemistry. 52, 8, p. 1303-1320 18 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Bicelles at low concentrations

Lu, Z., Van Horn, W. D., Chen, J., Mathew, S., Zent, R. & Sanders, C. R., Apr 2 2012, In : Molecular Pharmaceutics. 9, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis

Shi, M., Pedchenko, V., Greer, B. H., Van Horn, W. D., Santoro, S. A., Sanders, C. R., Hudson, B. G., Eichman, B. F., Zent, R. & Pozzi, A., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35139-35152 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Prokaryotic diacylglycerol kinase and undecaprenol kinase

Van Horn, W. D. & Sanders, C. R., Jun 9 2012, In : Annual Review of Biophysics. 41, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

40 Scopus citations

The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol

Barrett, P. J., Song, Y., Van Horn, W. D., Hustedt, E. J., Schafer, J. M., Hadziselimovic, A., Beel, A. J. & Sanders, C. R., Jun 1 2012, In : Science. 336, 6085, p. 1168-1171 4 p.

Research output: Contribution to journalArticle

286 Scopus citations
2011

Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel

Van Horn, W. D., Vanoye, C. G. & Sanders, C. R., Apr 1 2011, In : Current Opinion in Structural Biology. 21, 2, p. 283-291 9 p.

Research output: Contribution to journalReview article

24 Scopus citations
2010

Functional delivery of a membrane protein into oocyte membranes using bicelles

Kang, C., Vanoye, C. G., Welch, R. C., Van Horn, W. D. & Sanders, C. R., Feb 2 2010, In : Biochemistry. 49, 4, p. 653-655 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins

Van Horn, W. D., Beel, A. J., Kang, C. & Sanders, C. R., Feb 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Recent advances in the application of solution NMR spectroscopy to multi-span integral membrane proteins

Kim, H. J., Howell, S. C., Van Horn, W. D., Jeon, Y. H. & Sanders, C. R., Nov 1 2009, In : Progress in Nuclear Magnetic Resonance Spectroscopy. 55, 4, p. 335-360 26 p.

Research output: Contribution to journalReview article

124 Scopus citations

Reverse micelle encapsulation as a model for intracellular crowding

Van Horn, W. D., Ogilvie, M. E. & Flynn, P. F., Jun 17 2009, In : Journal of the American Chemical Society. 131, 23, p. 8030-8039 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase

Van Horn, W. D., Kim, H. J., Ellis, C. D., Hadziselimovic, A., Sulistijo, E. S., Karra, M. D., Tian, C., Sönnichsen, F. D. & Sanders, C. R., Jun 26 2009, In : Science. 324, 5935, p. 1726-1729 4 p.

Research output: Contribution to journalArticle

171 Scopus citations
2008

Use of reverse micelles in membrane protein structural biology

van Horn, W. D., Ogilvie, M. E. & Flynn, P. F., Mar 1 2008, In : Journal of Biomolecular NMR. 40, 3, p. 203-211 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

NMR Studies of Encapsulated Macromolecules

Flynn, P. F., Simorellis, A. K. & Van Horn, W., 2007, In : Annual Reports on NMR Spectroscopy. 62, p. 179-219 41 p.

Research output: Contribution to journalArticle

5 Scopus citations
2006

Dynamics of low temperature induced water shedding from AOT reverse micelles

Simorellis, A. K., Van Horn, W. D. & Flynn, P. F., Apr 19 2006, In : Journal of the American Chemical Society. 128, 15, p. 5082-5090 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2005

Low-temperature studies of encapsulated proteins

Van Horn, W. D., Simorellis, A. K. & Flynn, P. F., Oct 5 2005, In : Journal of the American Chemical Society. 127, 39, p. 13553-13560 8 p.

Research output: Contribution to journalArticle

47 Scopus citations