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Research Output 1996 2019

2019
3 Citations (Scopus)

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

Audet, M., White, K. L., Breton, B., Zarzycka, B., Han, G. W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katritch, V., Cherezov, V., Hanson, M. A. & Stevens, R. C., Jan 1 2019, In : Nature Chemical Biology. 15, 1, p. 11-17 7 p.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Misoprostol
Dinoprostone
Induced Labor
Myometrium

Erratum to: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor (Nature Chemical Biology, (2019), 15, 1, (11-17), 10.1038/s41589-018-0160-y)

Audet, M., White, K. L., Breton, B., Zarzycka, B., Han, G. W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katritch, V., Cherezov, V., Hanson, M. A. & Stevens, R. C., Feb 1 2019, In : Nature Chemical Biology. 15, 2, 1 p.

Research output: Contribution to journalComment/debate

Prostaglandin Receptors
Misoprostol
Moscow
Russia
Dinoprostone

High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

Martin-Garcia, J. M., Zhu, L., Mendez, D., Lee, M. Y., Chun, E., Li, C., Hu, H., Subramanian, G., Kissick, D., Ogata, C., Henning, R., Ishchenko, A., Dobson, Z., Zhang, S., Weierstall, U., Spence, J., Fromme, P., Zatsepin, N., Fischetti, R. F., Cherezov, V. & 1 others, Liu, W., Jan 1 2019, In : IUCrJ. 6, p. 412-425 14 p.

Research output: Contribution to journalArticle

Open Access
Crystallography
Microcrystals
Synchrotrons
microcrystals
Synchrotron radiation

Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency

Yun, J. H., Li, X., Park, J. H., Wang, Y., Ohki, M., Jin, Z., Lee, W., Park, S. Y., Hu, H., Li, C., Zatsepin, N., Hunter, M. S., Sierra, R. G., Koralek, J., Yoon, C. H., Cho, H. S., Weierstall, U., Tang, L., Liu, H. & Lee, W., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 794-804 11 p.

Research output: Contribution to journalArticle

Chlorides
Pumps
Rhodopsin
X ray lasers
Temperature

Publisher Correction: Structural basis of ligand recognition at the human MT 1 melatonin receptor (Nature, (2019), 569, 7755, (284-288), 10.1038/s41586-019-1141-3)

Stauch, B., Johansson, L. C., McCorvy, J. D., Patel, N., Han, G. W., Huang, X. P., Gati, C., Batyuk, A., Slocum, S. T., Ishchenko, A., Brehm, W., White, T. A., Michaelian, N., Madsen, C., Zhu, L., Grant, T. D., Grandner, J. M., Shiriaeva, A., Olsen, R. H. J., Tribo, A. R. & 7 others, Yous, S., Stevens, R. C., Weierstall, U., Katritch, V., Roth, B. L., Liu, W. & Cherezov, V., May 16 2019, In : Nature. 569, 7756, p. E6

Research output: Contribution to journalComment/debate

Open Access
Melatonin Receptors
History
Ligands
2 Citations (Scopus)

Structural basis of ligand recognition at the human MT 1 melatonin receptor

Stauch, B., Johansson, L. C., McCorvy, J. D., Patel, N., Han, G. W., Huang, X. P., Gati, C., Batyuk, A., Slocum, S. T., Ishchenko, A., Brehm, W., White, T. A., Michaelian, N., Madsen, C., Zhu, L., Grant, T. D., Grandner, J. M., Shiriaeva, A., Olsen, R. H. J., Tribo, A. R. & 7 others, Yous, S., Stevens, R. C., Weierstall, U., Katritch, V., Roth, B. L., Liu, W. & Cherezov, V., May 9 2019, In : Nature. 569, 7755, p. 284-288 5 p.

Research output: Contribution to journalLetter

Melatonin Receptors
Ligands
S 20098
Melatonin
Serotonin
1 Citation (Scopus)

XFEL structures of the human MT 2 melatonin receptor reveal the basis of subtype selectivity

Johansson, L. C., Stauch, B., McCorvy, J. D., Han, G. W., Patel, N., Huang, X. P., Batyuk, A., Gati, C., Slocum, S. T., Li, C., Grandner, J. M., Hao, S., Olsen, R. H. J., Tribo, A. R., Zaare, S., Zhu, L., Zatsepin, N., Weierstall, U., Yous, S., Stevens, R. C. & 4 others, Liu, W., Roth, B. L., Katritch, V. & Cherezov, V., May 9 2019, In : Nature. 569, 7755, p. 289-292 4 p.

Research output: Contribution to journalLetter

Melatonin Receptors
Lasers
X-Rays
Electrons
Ligands
1 Citation (Scopus)

X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis

Jensen, S. C., Sullivan, B., Hartzler, D. A., Aguilar, J. M., Awel, S., Bajt, S., Basu, S., Bean, R., Chapman, H. N., Conrad, C., Frank, M., Fromme, R., Martin-Garcia, J. M., Grant, T. D., Heymann, M., Hunter, M. S., Ketawala, G., Kirian, R., Knoska, J., Kupitz, C. & 23 others, Li, X., Liang, M., Lisova, S., Mariani, V., Mazalova, V., Messerschmidt, M., Moran, M., Nelson, G., Oberthür, D., Schaffer, A., Sierra, R. G., Vaughn, N., Weierstall, U., Wiedorn, M. O., Xavier, P. L., Yang, J. H., Yefanov, O., Zatsepin, N., Aquila, A., Fromme, P., Boutet, S., Seidler, G. T. & Pushkar, Y., Feb 7 2019, In : Journal of Physical Chemistry Letters. 10, 3, p. 441-446 6 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
free electron lasers
Electronic structure
electronic structure
2018
3 Citations (Scopus)
X ray absorption spectroscopy
Cobalt
Ground state
absorption spectroscopy
cobalt
20 Citations (Scopus)

Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography

Olmos, J. L., Pandey, S., Martin-Garcia, J. M., Calvey, G., Katz, A., Knoska, J., Kupitz, C., Hunter, M. S., Liang, M., Oberthuer, D., Yefanov, O., Wiedorn, M., Heyman, M., Holl, M., Pande, K., Barty, A., Miller, M. D., Stern, S., Roy-Chowdhury, S., Coe, J. & 30 others, Nagaratnam, N., Zook, J., Verburgt, J., Norwood, T., Poudyal, I., Xu, D., Koglin, J., Seaberg, M. H., Zhao, Y., Bajt, S., Grant, T., Mariani, V., Nelson, G., Subramanian, G., Bae, E., Fromme, R., Fung, R., Schwander, P., Frank, M., White, T. A., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Chapman, H. N., Pollack, L., Tremblay, L., Ourmazd, A., Phillips, G. N. & Schmidt, M., May 31 2018, In : BMC Biology. 16, 1, 59.

Research output: Contribution to journalArticle

crystallography
Crystallography
Diptera
X-radiation
X-Rays

Erratum to: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor (Nature Chemical Biology, (2019), 15, 1, (11-17), 10.1038/s41589-018-0160-y)

Audet, M., White, K. L., Breton, B., Zarzycka, B., Han, G. W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katritch, V., Cherezov, V., Hanson, M. A. & Stevens, R. C., Jan 1 2018, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Misoprostol
Moscow
Russia
Dinoprostone
7 Citations (Scopus)

Femtosecond X-ray diffraction from an aerosolized beam of protein nanocrystals

Awel, S., Kirian, R., Wiedorn, M. O., Beyerlein, K. R., Roth, N., Horke, D. A., Oberthür, D., Knoska, J., Mariani, V., Morgan, A., Adriano, L., Tolstikova, A., Xavier, P. L., Yefanov, O., Aquila, A., Barty, A., Roy-Chowdhury, S., Hunter, M. S., James, D., Robinson, J. S. & 5 others, Weierstall, U., Rode, A. V., Bajt, S., Küpper, J. & Chapman, H. N., Feb 1 2018, In : Journal of Applied Crystallography. 51, 1, p. 133-139 7 p.

Research output: Contribution to journalArticle

X-Ray Diffraction
Nanoparticles
Nanocrystals
Granulovirus
Jet Injections
33 Citations (Scopus)

Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser

Nogly, P., Weinert, T., James, D., Carbajo, S., Ozerov, D., Furrer, A., Gashi, D., Borin, V., Skopintsev, P., Jaeger, K., Nass, K., Båth, P., Bosman, R., Koglin, J., Seaberg, M., Lane, T., Kekilli, D., Brünle, S., Tanaka, T., Wu, W. & 12 others, Milne, C., White, T., Barty, A., Weierstall, U., Panneels, V., Nango, E., Iwata, S., Hunter, M., Schapiro, I., Schertler, G., Neutze, R. & Standfuss, J., Jul 13 2018, In : Science. 361, 6398, eaat0094.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Proton Pumps
Schiff Bases
Ion Transport
Protein Binding

Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

Lee, D. B., Kim, J. M., Seok, J. H., Lee, J. H., Jo, J. D., Mun, J. Y., Conrad, C., Coe, J., Nelson, G., Hogue, B., White, T. A., Zatsepin, N., Weierstall, U., Barty, A., Chapman, H., Fromme, P., Spence, J., Chung, M. S., Oh, C. H. & Kim, K. H., Dec 1 2018, In : Scientific Reports. 8, 1, 2541.

Research output: Contribution to journalArticle

supersaturation
crystallography
microcrystals
free electron lasers
evaporation
2017
27 Citations (Scopus)

Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

Gati, C., Oberthuer, D., Yefanov, O., Bunker, R. D., Stellato, F., Chiu, E., Yeh, S. M., Aquila, A., Basu, S., Bean, R., Beyerlein, K. R., Botha, S., Boutet, S., DePonte, D. P., Doak, R. B., Fromme, R., Galli, L., Grotjohann, I., James, D. R., Kupitz, C. & 17 others, Lomb, L., Messerschmidt, M., Nass, K., Rendek, K., Shoeman, R. L., Wang, D., Weierstall, U., White, T. A., Williams, G. J., Zatsepin, N., Fromme, P., Spence, J., Goldie, K. N., Jehle, J. A., Metcalf, P., Barty, A. & Chapman, H. N., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2247-2252 6 p.

Research output: Contribution to journalArticle

Granulovirus
Lasers
X-Rays
Electrons
Radiation
1 Citation (Scopus)

CHAPTER 17: High Viscosity Microstream Sample Delivery for Serial Femtosecond Crystallography

Weierstall, U., 2017, Thermoelectric Materials and Devices. 18 ed. Royal Society of Chemistry, Vol. 2017-January. p. 337-347 11 p. (RSC Energy and Environment Series; vol. 2017-January, no. 18).

Research output: Chapter in Book/Report/Conference proceedingChapter

crystallography
Crystallography
X ray lasers
viscosity
Free electron lasers
1 Citation (Scopus)

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Crystallography
corrigendum
3 Citations (Scopus)

Diffraction data of core-shell nanoparticles from an X-ray free electron laser

Li, X., Chiu, C. Y., Wang, H. J., Kassemeyer, S., Botha, S., Shoeman, R. L., Lawrence, R. M., Kupitz, C., Kirian, R., James, D., Wang, DI., Nelson, G., Messerschmidt, M., Boutet, S., Williams, G. J., Hartmann, E., Jafarpour, A., Foucar, L. M., Barty, A., Chapman, H. & 13 others, Liang, M., Menzel, A., Wang, F., Basu, S., Fromme, R., Doak, R. B., Fromme, P., Weierstall, U., Huang, M. H., Spence, J., Schlichting, I., Hogue, B. & Liu, H., Apr 11 2017, In : Scientific data. 4, 170048.

Research output: Contribution to journalArticle

X ray lasers
X-ray Laser
Free Electron Laser
Free electron lasers
Nanoparticles
32 Citations (Scopus)

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific Reports. 7, 44628.

Research output: Contribution to journalArticle

liquid flow
injectors
nozzles
crystallography
room temperature
28 Citations (Scopus)

Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

Martin-Garcia, J. M., Conrad, C. E., Nelson, G., Stander, N., Zatsepin, N., Zook, J., Zhu, L., Geiger, J., Chun, E., Kissick, D., Hilgart, M. C., Ogata, C., Ishchenko, A., Nagaratnam, N., Roy-Chowdhury, S., Coe, J., Subramanian, G., Schaffer, A., James, D., Ketwala, G. & 10 others, Venugopalan, N., Xu, S., Corcoran, S., Ferguson, D., Weierstall, U., Spence, J., Cherezov, V., Fromme, P., Fischetti, R. F. & Liu, W., 2017, In : IUCrJ. 4, p. 439-454 16 p.

Research output: Contribution to journalArticle

Crystallography
Microcrystals
Synchrotrons
microcrystals
Phycocyanin
60 Citations (Scopus)

Structural basis for selectivity and diversity in angiotensin II receptors

Zhang, H., Han, G. W., Batyuk, A., Ishchenko, A., White, K. L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M. T., Hollenstein, K., Tolstikova, A., White, T. A., Hunter, M. S., Weierstall, U., Liu, W., Babaoglu, K., Moore, E. L., Katz, R. D., Shipman, J. M., Garcia-Calvo, M. & 6 others, Sharma, S., Sheth, P., Soisson, S. M., Stevens, R. C., Katritch, V. & Cherezov, V., Apr 20 2017, In : Nature. 544, 7650, p. 327-332 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Ligands
Arrestins
Structure-Activity Relationship
Renin-Angiotensin System
36 Citations (Scopus)

Structural enzymology using X-ray free electron lasers

Kupitz, C., Olmos, J. L., Holl, M., Tremblay, L., Pande, K., Pandey, S., Oberthür, D., Hunter, M., Liang, M., Aquila, A., Tenboer, J., Calvey, G., Katz, A., Chen, Y., Wiedorn, M. O., Knoska, J., Meents, A., Majriani, V., Norwood, T., Poudyal, I. & 30 others, Grant, T., Miller, M. D., Xu, W., Tolstikova, A., Morgan, A., Metz, M., Martin-Gracia, J., Zook, J. D., Roy-Chowdhury, S., Coe, J., Nagaratnam, N., Meza, D., Fromme, R., Basu, S., Frank, M., White, T., Barty, A., Bajt, S., Yefanov, O., Chapman, H. N., Zatsepin, N., Nelson, G., Weierstall, U., Spence, J., Schwander, P., Pollack, L., Fromme, P., Ourmazd, A., Phillips, G. N. & Schmidt, M., Jul 1 2017, In : Structural Dynamics. 4, 4, 044003.

Research output: Contribution to journalArticle

enzymology
X ray lasers
Crystallography
Ceftriaxone
Free electron lasers
14 Citations (Scopus)

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G. W., Basu, S., Patel, N., Messerschmidt, M., Weierstall, U., Liu, W., Katritch, V., Roth, B. L., Stevens, R. C. & Cherezov, V., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8223-8228 6 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2B
G-Protein-Coupled Receptors
Serotonin Receptors
Monoclonal Antibodies
Antibodies
65 Citations (Scopus)

Structure of the full-length glucagon class B G-protein-coupled receptor

Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., De Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G. W., Grant, T. D., Sierra, R. G., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X. & 13 others, Geng, Z., Dong, Y., Song, G., Griffin, P. R., Lau, J., Cherezov, V., Yang, H., Hanson, M. A., Stevens, R. C., Zhao, Q., Jiang, H., Wang, M. W. & Wu, B., Jun 8 2017, In : Nature. 546, 7657, p. 259-264 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Glucagon
Glucagon Receptors
Deuterium
Molecular Dynamics Simulation
72 Citations (Scopus)

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Stagno, J. R., Liu, Y., Bhandari, Y. R., Conrad, C. E., Panja, S., Swain, M., Fan, L., Nelson, G., Li, C., Wendel, D. R., White, T. A., Coe, J. D., Wiedorn, M. O., Knoska, J., Oberthuer, D., Tuckey, R. A., Yu, P., Dyba, M., Tarasov, S. G., Weierstall, U. & 18 others, Grant, T. D., Schwieters, C. D., Zhang, J., Ferré-D'Amaré, A. R., Fromme, P., Draper, D. E., Liang, M., Hunter, M. S., Boutet, S., Tan, K., Zuo, X., Ji, X., Barty, A., Zatsepin, N., Chapman, H. N., Spence, J., Woodson, S. A. & Wang, Y. X., Jan 12 2017, In : Nature. 541, 7636, p. 242-246 5 p.

Research output: Contribution to journalArticle

Riboswitch
Crystallography
Lasers
X-Rays
RNA
2016
149 Citations (Scopus)

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

Pande, K., Hutchison, C. D. M., Groenhof, G., Aquila, A., Robinson, J. S., Tenboer, J., Basu, S., Boutet, S., DePonte, D. P., Liang, M., White, T. A., Zatsepin, N., Yefanov, O., Morozov, D., Oberthuer, D., Gati, C., Subramanian, G., James, D., Zhao, Y., Koralek, J. & 24 others, Brayshaw, J., Kupitz, C., Conrad, C., Roy-Chowdhury, S., Coe, J. D., Metz, M., Xavier, P. L., Grant, T. D., Koglin, J. E., Ketawala, G., Fromme, R., Srajer, V., Henning, R., Spence, J., Ourmazd, A., Schwander, P., Weierstall, U., Frank, M., Fromme, P., Barty, A., Chapman, H. N., Moffat, K., Van Thor, J. J. & Schmidt, M., May 6 2016, In : Science. 352, 6286, p. 725-729 5 p.

Research output: Contribution to journalArticle

Light
Crystallography
Proteins
Photons
X-Rays
34 Citations (Scopus)

Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography

Nogly, P., Panneels, V., Nelson, G., Gati, C., Kimura, T., Milne, C., Milathianaki, D., Kubo, M., Wu, W., Conrad, C., Coe, J., Bean, R., Zhao, Y., Båth, P., Dods, R., Harimoorthy, R., Beyerlein, K. R., Rheinberger, J., James, D., DePonte, D. & 20 others, Li, C., Sala, L., Williams, G. J., Hunter, M. S., Koglin, J. E., Berntsen, P., Nango, E., Iwata, S., Chapman, H. N., Fromme, P., Frank, M., Abela, R., Boutet, S., Barty, A., White, T. A., Weierstall, U., Spence, J., Neutze, R., Schertler, G. & Standfuss, J., Aug 22 2016, In : Nature Communications. 7, 12314.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Crystallography
injectors
crystallography
delivery
68 Citations (Scopus)

Macromolecular diffractive imaging using imperfect crystals

Ayyer, K., Yefanov, O. M., Oberthür, D., Roy-Chowdhury, S., Galli, L., Mariani, V., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Schaffer, A., Dörner, K., James, D., Kupitz, C., Metz, M., Nelson, G., Xavier, P. L., Beyerlein, K. R., Schmidt, M., Sarrou, I. & 14 others, Spence, J., Weierstall, U., White, T. A., Yang, J. H., Zhao, Y., Liang, M., Aquila, A., Hunter, M. S., Robinson, J. S., Koglin, J. E., Boutet, S., Fromme, P., Barty, A. & Chapman, H. N., Feb 10 2016, In : Nature. 530, 7589, p. 202-206 5 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
Crystallography
X Ray Crystallography
Cell Size
X-Ray Diffraction
1 Citation (Scopus)

Measurements of transmitted electron beam extinction through Si crystal membranes

Nanni, E. A., Li, R. K., Limborg, C., Shen, X., Weathersby, S., Graves, W., Kirian, R., Spence, J. & Weierstall, U., 2016, IPAC 2016 - Proceedings of the 7th International Particle Accelerator Conference. Joint Accelerator Conferences Website (JACoW), p. 1611-1614 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

extinction
electron beams
membranes
crystals
modulation
43 Citations (Scopus)

Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

Batyuk, A., Galli, L., Ishchenko, A., Han, G. W., Gati, C., Popov, P. A., Lee, M. Y., Stauch, B., White, T. A., Barty, A., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Pu, M., Liu, Z. J., Nelson, G., James, D., Li, C., Zhao, Y. & 7 others, Spence, J., Liu, W., Fromme, P., Katritch, V., Weierstall, U., Stevens, R. C. & Cherezov, V., Sep 1 2016, In : Science advances. 2, 9, e1600292.

Research output: Contribution to journalArticle

Lasers
X-Rays
Electrons
Adenosine A2A Receptors
Crystallography
5 Citations (Scopus)

Serial femtosecond crystallography datasets from G protein-coupled receptors

White, T. A., Barty, A., Liu, W., Ishchenko, A., Zhang, H., Gati, C., Zatsepin, N., Basu, S., Oberthur, D., Metz, M., Beyerlein, K. R., Yoon, C. H., Yefanov, O. M., James, D., Wang, D., Messerschmidt, M., Koglin, J. E., Boutet, S., Weierstall, U. & Cherezov, V., Aug 1 2016, In : Scientific data. 3, 160057.

Research output: Contribution to journalArticle

G Protein
Crystallography
Femtosecond
Receptor
Proteins

Serial femtosecond crystallography of membrane proteins

Zhu, L., Weierstall, U., Cherezov, V. & Liu, W., 2016, In : Advances in Experimental Medicine and Biology. 922, p. 151-160 10 p.

Research output: Contribution to journalArticle

Crystallography
Membrane Proteins
X ray lasers
Free electron lasers
X Ray Crystallography
25 Citations (Scopus)

Three-dimensional-printed gas dynamic virtual nozzles for x-ray laser sample delivery

Nelson, G., Kirian, R., Weierstall, U., Zatsepin, N., Faragó, T., Baumbach, T., Wilde, F., Niesler, F. B. P., Zimmer, B., Ishigami, I., Hikita, M., Bajt, S., Yeh, S. R., Rousseau, D. L., Chapman, H. N., Spence, J. & Heymann, M., May 30 2016, In : Optics Express. 24, 11, p. 11515-11530 16 p.

Research output: Contribution to journalArticle

x ray lasers
gas dynamics
nozzles
delivery
free electron lasers
19 Citations (Scopus)

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

Zhou, X. E., Gao, X., Barty, A., Kang, Y., He, Y., Liu, W., Ishchenko, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Suino-Powell, K. M., Boutet, S., Williams, G. J., Wang, M., Li, D., Caffrey, M., Chapman, H. N., Spence, J. & 6 others, Fromme, P., Weierstall, U., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Apr 12 2016, In : Scientific data. 3, 201621.

Research output: Contribution to journalArticle

X ray lasers
X-ray Laser
Free Electron Laser
Free electron lasers
Femtosecond
2015
60 Citations (Scopus)

A novel inert crystal delivery medium for serial femtosecond crystallography

Conrad, C. E., Basu, S., James, D., Wang, D., Schaffer, A., Roy-Chowdhury, S., Zatsepin, N., Aquila, A., Coe, J., Gati, C., Hunter, M. S., Koglin, J. E., Kupitz, C., Nelson, G., Subramanian, G., White, T. A., Zhao, Y., Zook, J., Boutet, S., Cherezov, V. & 4 others, Spence, J., Fromme, R., Weierstall, U. & Fromme, P., Jul 1 2015, In : IUCrJ. 2, p. 421-430 10 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
delivery
Sepharose
proteins
2 Citations (Scopus)

Biphasic droplet-based sample delivery of protein crystals for serial femtosecond crystallography with an x-ray free electron laser

Echelmeier, A., Nelson, G., Abdallah, B. G., James, D., Roy-Chowdhury, S., Tolstikova, A., Mariani, V., Kirian, R., Oberthüer, D., Dörner, K., Fromme, P., Chapman, H. N., Weierstall, U., Spence, J. & Ros, A., 2015, MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 1374-1376 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Crystallography
Free electron lasers
X ray lasers
Proteins
X rays
345 Citations (Scopus)

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Ke, J., Tan, M. H. E., Zhang, C., Moeller, A., West, G. M., Pascal, B. D., Van Eps, N., Caro, L. N. & 52 others, Vishnivetskiy, S. A., Lee, R. J., Suino-Powell, K. M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G. J., Messerschmidt, M., Gati, C., Zatsepin, N., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C. E., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C. S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H. N., Spence, J., Fromme, P., Weierstall, U., Ernst, O. P., Katritch, V., Gurevich, V. V., Griffin, P. R., Hubbell, W. L., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Jul 30 2015, In : Nature. 523, 7562, p. 561-567 7 p.

Research output: Contribution to journalArticle

Arrestin
Rhodopsin
Lasers
X-Rays
G-Protein-Coupled Receptors
91 Citations (Scopus)

Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

Nogly, P., James, D., Wang, D., White, T. A., Zatsepin, N., Shilova, A., Nelson, G., Liu, H., Johansson, L., Heymann, M., Jaeger, K., Metz, M., Wickstrand, C., Wu, W., Båth, P., Berntsen, P., Oberthuer, D., Panneels, V., Cherezov, V., Chapman, H. & 7 others, Schertler, G., Neutze, R., Spence, J., Moraes, I., Burghammer, M., Standfuss, J. & Weierstall, U., Feb 26 2015, In : IUCrJ. 2, p. 168-176 9 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Crystallography
Synchrotrons
Synchrotron radiation
crystallography
8 Citations (Scopus)

Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction

Abdallah, B. G., Zatsepin, N., Roy-Chowdhury, S., Coe, J., Conrad, C. E., Dörner, K., Sierra, R. G., Stevenson, H. P., Camacho-Alanis, F., Grant, T. D., Nelson, G., James, D., Calero, G., Wachter, R., Spence, J., Weierstall, U., Fromme, P. & Ros, A., Jul 1 2015, In : Structural Dynamics. 2, 4, 041719.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
classifying
Sorting
Microfluidics
33 Citations (Scopus)

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

Fromme, R., Ishchenko, A., Metz, M., Chowdhury, S. R., Basu, S., Boutet, S., Fromme, P., White, T. A., Barty, A., Spence, J., Weierstall, U., Liu, W. & Cherezov, V., Sep 1 2015, In : IUCrJ. 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
Microcrystals
proteins
Proteins
7 Citations (Scopus)

Serial femtosecond X-ray diffraction of enveloped virus microcrystals

Lawrence, R. M., Conrad, C. E., Zatsepin, N., Grant, T. D., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Coe, J., Spence, J., Weierstall, U., Liu, W., Fromme, P., Cherezov, V. & Hogue, B., Jul 1 2015, In : Structural Dynamics. 2, 4, 041720.

Research output: Contribution to journalArticle

Microcrystals
microcrystals
viruses
Viruses
X ray diffraction
88 Citations (Scopus)

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J., Boutet, S., Messerschmidt, M., Williams, G. J., Gati, C., Yefanov, O. M., White, T. A., Oberthuer, D. & 16 others, Metz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptides
Analgesics
Opiate Alkaloids
phenylalanylphenylalanine
20 Citations (Scopus)

Ternary structure reveals mechanism of a membrane diacylglycerol kinase

Li, D., Stansfeld, P. J., Sansom, M. S. P., Keogh, A., Vogeley, L., Howe, N., Lyons, J. A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N., Cherezov, V., Liu, W., Bandaru, S., English, N. J. & 10 others, Gati, C., Barty, A., Yefanov, O., Chapman, H. N., Diederichs, K., Messerschmidt, M., Boutet, S., Williams, G. J., Seibert, M. M. & Caffrey, M., Dec 17 2015, In : Nature Communications. 6, 10140.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
adenosine triphosphate
Adenosine Triphosphate
membranes
Membranes
2014
41 Citations (Scopus)

Double-focusing mixing jet for XFEL study of chemical kinetics

Wang, D., Weierstall, U., Pollack, L. & Spence, J., Nov 1 2014, In : Journal of Synchrotron Radiation. 21, p. 1364-1366 3 p.

Research output: Contribution to journalArticle

Reaction kinetics
reaction kinetics
X-Rays
Equipment and Supplies
Motion Pictures
5 Citations (Scopus)

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

vaccines
human immunodeficiency virus
Vaccines
Crystallization
Viruses
273 Citations (Scopus)

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In : Nature Communications. 5, 3309.

Research output: Contribution to journalArticle

Crystallography
injectors
crystallography
Membrane Proteins
membranes
55 Citations (Scopus)
crystallography
Crystallography
Free electron lasers
X-radiation
X-Rays
255 Citations (Scopus)

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

Kupitz, C., Basu, S., Grotjohann, I., Fromme, R., Zatsepin, N., Rendek, K. N., Hunter, M. S., Shoeman, R. L., White, T. A., Wang, D., James, D., Yang, J. H., Cobb, D. E., Reeder, B., Sierra, R. G., Liu, H., Barty, A., Aquila, A. L., Deponte, D., Kirian, R. & 39 others, Bari, S., Bergkamp, J. J., Beyerlein, K. R., Bogan, M. J., Caleman, C., Chao, T. C., Conrad, C. E., Davis, K. M., Fleckenstein, H., Galli, L., Hau-Riege, S. P., Kassemeyer, S., Laksmono, H., Liang, M., Lomb, L., Marchesini, S., Martin, A. V., Messerschmidt, M., Milathianaki, D., Nass, K., Ros, A., Roy-Chowdhury, S., Schmidt, K., Seibert, M., Steinbrener, J., Stellato, F., Yan, L., Yoon, C., Moore, T., Moore, A., Pushkar, Y., Williams, G. J., Boutet, S., Doak, R. B., Weierstall, U., Frank, M., Chapman, H. N., Spence, J. & Fromme, P., Sep 11 2014, In : Nature. 513, 7517, p. 261-265 5 p.

Research output: Contribution to journalArticle

Crystallography
Photosystem II Protein Complex
Lasers
X-Rays
Photosynthesis
163 Citations (Scopus)

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

Zhang, H., Unal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N., James, D., Wang, D., Nelson, G., Weierstall, U., Sawaya, M. R., Xu, Q., Messerschmidt, M., Williams, G. J., Boutet, S., Yefanov, O. M., White, T. A., Wang, C., Ishchenko, A., Tirupula, K. C. & 8 others, Desnoyer, R., Coe, J., Conrad, C. E., Fromme, P., Stevens, R. C., Katritch, V., Karnik, S. S. & Cherezov, V., Nov 6 2014, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Crystallography
Angiotensin Receptors
Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
205 Citations (Scopus)

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

Tenboer, J., Basu, S., Zatsepin, N., Pande, K., Milathianaki, D., Frank, M., Hunter, M., Boutet, S., Williams, G. J., Koglin, J. E., Oberthuer, D., Heymann, M., Kupitz, C., Conrad, C., Coe, J., Roy-Chowdhury, S., Weierstall, U., James, D., Wang, D., Grant, T. & 16 others, Barty, A., Yefanov, O., Scales, J., Gati, C., Seuring, C., Srajer, V., Henning, R., Schwander, P., Fromme, R., Ourmazd, A., Moffat, K., Van Thor, J. J., Spence, J., Fromme, P., Chapman, H. N. & Schmidt, M., Dec 5 2014, In : Science. 346, 6214, p. 1242-1246 5 p.

Research output: Contribution to journalArticle

Crystallography
Electrons
Light
Bacterial Proteins
Proteins