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Research Output 1993 2019

  • 1240 Citations
  • 19 h-Index
  • 46 Article
  • 2 Chapter
  • 2 Comment/debate
2019
Virology
Vaccinia virus
Virion
Names
HIV-1
2018

Erratum to: Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity (Scientific Reports, (2017), 7, 1, (10419), 10.1038/s41598-017-10571-z)

Larrimore, K. E., Kazan, I. C., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Bolia, A., Brimijoin, S., Zhan, C. G., Ozkan, S. & Leket-Mor, T., Dec 1 2018, In : Scientific Reports. 8, 1, 17223.

Research output: Contribution to journalComment/debate

Butyrylcholinesterase
Cholinesterases
Hydrolases
Cocaine
2017
1 Citation (Scopus)

A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles

Meador, L. R., Kessans, S. A., Kilbourne, J., Kibler, K., Pantaleo, G., Roderiguez, M. E., Blattman, J., Jacobs, B. & Leket-Mor, T., Jul 1 2017, In : Virology. 507, p. 242-256 15 p.

Research output: Contribution to journalArticle

Vaccinia virus
Virion
HIV-1
Epitopes
T-Lymphocytes
4 Citations (Scopus)

Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide

Deb, A., Johnson, W. A., Kline, A. P., Scott, B. J., Meador, L. R., Srinivas, D., Martin-Garcia, J. M., Dörner, K., Borges, C., Misra, R., Hogue, B., Fromme, P. & Leket-Mor, T., Feb 1 2017, In : PLoS One. 12, 2, e0172529.

Research output: Contribution to journalArticle

viral proteins
Viral Proteins
Protein Sorting Signals
Human immunodeficiency virus 1
signal peptide
6 Citations (Scopus)

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Larrimore, K. E., Kazan, I. C., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Bolia, A., Brimijoin, S., Zhan, C. G., Ozkan, S. & Leket-Mor, T., Dec 1 2017, In : Scientific Reports. 7, 1, 10419.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cholinesterases
Hydrolases
Cocaine
Enzymes
2016
6 Citations (Scopus)

Immunological Characterization of Plant-Based HIV-1 Gag/Dgp41 Virus-Like Particles

Kessans, S. A., Linhart, M. D., Meador, L. R., Kilbourne, J., Hogue, B., Fromme, P., Matoba, N. & Leket-Mor, T., 2016, In : PLoS One. 11, 3, p. e0151842

Research output: Contribution to journalArticle

virus-like particles
Human immunodeficiency virus 1
Viruses
Virion
HIV-1
2015
2 Citations (Scopus)

Biophysical characterization of a vaccine candidate against HIV-1: The transmembrane and membrane proximal domains of HIV-1 gp41 as a maltose binding protein fusion

Gong, Z., Martin-Garcia, J. M., Daskalova, S. M., Craciunescu, F. M., Song, L., Dörner, K., Hansen, D., Yang, J. H., LaBaer, J., Hogue, B., Leket-Mor, T. & Fromme, P., Aug 21 2015, In : PLoS One. 10, 8, e0136507.

Research output: Contribution to journalArticle

Maltose-Binding Proteins
maltose
Human immunodeficiency virus 1
HIV-1
binding proteins
18 Citations (Scopus)

Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story

Leket-Mor, T., Nov 29 2015, In : Biotechnology Letters. 37, 11, p. 2147-2150 4 p.

Research output: Contribution to journalArticle

Glucosylceramidase
United States Food and Drug Administration
Biological Products
Drug products
Foot

Mucosal Vaccines from Plant Biotechnology

Mason, H., Thuenemann, E., Kiyono, H., Kessans, S., Matoba, N. & Leket-Mor, T., Apr 1 2015, Mucosal Immunology: Fourth Edition. Elsevier Inc., Vol. 2-2. p. 1271-1289 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biotechnology
Vaccines
Genetically Modified Plants
Antigens
Plant Antigens
14 Citations (Scopus)

The case for plant-made veterinary immunotherapeutics

Topp, E., Irwin, R., McAllister, T., Lessard, M., Joensuu, J. J., Kolotilin, I., Conrad, U., Stöger, E., Leket-Mor, T., Warzecha, H., Hall, J. C., McLean, M. D., Cox, E., Devriendt, B., Potter, A., Depicker, A., Virdi, V., Holbrook, L., Doshi, K., Dussault, M. & 5 others, Friendship, R., Yarosh, O., Yoo, H. S., MacDonald, J. & Menassa, R., Sep 29 2015, (Accepted/In press) In : Biotechnology Advances.

Research output: Contribution to journalArticle

Vaccines
Animal Diseases
Animals
Antibiotics
Disease control
2014
5 Citations (Scopus)

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

vaccines
human immunodeficiency virus
Vaccines
Crystallization
Viruses
30 Citations (Scopus)

Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue

Schneider, J. D., Castilho, A., Neumann, L., Altmann, F., Loos, A., Kannan, L., Leket-Mor, T. & Steinkellner, H., 2014, In : Biotechnology Journal. 9, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Glycosylation
Polysaccharides
Proteins
Extracellular Fluid
4 Citations (Scopus)

Meeting report VLPNPV: Session 5: Plant based technology

Meador, L. R. & Leket-Mor, T., Oct 1 2014, In : Human Vaccines and Immunotherapeutics. 10, 10, p. 3068-3073 6 p.

Research output: Contribution to journalArticle

Virion
Technology
Nanoparticles
Virus-Like Particle Vaccines
Plant Viruses
25 Citations (Scopus)

Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana

Schneider, J. D., Marillonnet, S., Castilho, A., Gruber, C., Werner, S., Mach, L., Klimyuk, V., Leket-Mor, T. & Steinkellner, H., 2014, In : Plant Biotechnology Journal. 12, 7, p. 832-839 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Nicotiana benthamiana
cholinesterase
glycosylation
Glycosylation
3 Citations (Scopus)

Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41

Gong, Z., Kessans, S. A., Song, L., Dörner, K., Lee, H. H., Meador, L. R., LaBaer, J., Hogue, B., Leket-Mor, T. & Fromme, P., Nov 1 2014, In : Protein Science. 23, 11, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Purification
HIV-1
Membranes
Neutralizing Antibodies
Glycoproteins
2013
19 Citations (Scopus)

Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed in Nicotiana benthamiana

Kessans, S. A., Linhart, M. D., Matoba, N. & Leket-Mor, T., Aug 2013, In : Plant Biotechnology Journal. 11, 6, p. 681-690 10 p.

Research output: Contribution to journalArticle

virus-like particles
Nicotiana benthamiana
Human immunodeficiency virus 1
Virion
Tobacco
10 Citations (Scopus)

Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

Larrimore, K. E., Barcus, M., Kannan, L., Gao, Y., Zhan, C. G., Brimijoin, S. & Leket-Mor, T., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 217-220 4 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Hydrolases
Cocaine
Recurrence
Cocaine-Related Disorders
4 Citations (Scopus)

Reversal of Succinylcholine Induced Apnea with an Organophosphate Scavenging Recombinant Butyrylcholinesterase

Geyer, B. C., Larrimore, K. E., Kilbourne, J., Kannan, L. & Leket-Mor, T., Mar 11 2013, In : PLoS One. 8, 3, e59159.

Research output: Contribution to journalArticle

Butyrylcholinesterase
suxamethonium
apnea
Succinylcholine
Organophosphates
5 Citations (Scopus)

The Arabidopsis thaliana ortholog of a purported maize cholinesterase gene encodes a GDSL-lipase

Muralidharan, M., Buss, K., Larrimore, K. E., Segerson, N. A., Kannan, L. & Leket-Mor, T., 2013, In : Plant Molecular Biology. 81, 6, p. 565-576 12 p.

Research output: Contribution to journalArticle

cholinesterase
Cholinesterases
Acetylcholinesterase
Lipase
Arabidopsis
2012
4 Citations (Scopus)

Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle

Geyer, B. C., Ben Ari, S., Barbash, S., Kilbourne, J., Leket-Mor, T. & Soreq, H., Feb 2012, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1823, 2, p. 368-378 11 p.

Research output: Contribution to journalArticle

Tristetraprolin
Paraoxon
Cholinergic Agents
Inflammation
Muscles
2011
6 Citations (Scopus)

Humoral immunogenicity of an HIV-1 envelope residue 649-684 membrane-proximal region peptide fused to the plague antigen F1-V

Matoba, N., Shah, N. R. & Leket-Mor, T., Aug 5 2011, In : Vaccine. 29, 34, p. 5584-5590 7 p.

Research output: Contribution to journalArticle

Plague
plague
Human immunodeficiency virus 1
HIV-1
Immunization
2010
56 Citations (Scopus)

Plant-derived human butyrylcholinesterase, but not an organophosphorous- compound hydrolyzing variant thereof, protects rodents against nerve agents

Geyer, B. C., Kannan, L., Garnaud, P. E., Broomfield, C. A., Cadieux, C. L., Cherni, I., Hodgins, S. M., Kasten, S. A., Kelley, K., Kilbourne, J., Oliver, Z. P., Otto, T. C., Puffenberger, I., Reeves, T. E., Robbins, N., Woods, R. R., Soreq, H., Lenz, D. E., Cerasoli, D. M. & Leket-Mor, T., Nov 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 47, p. 20251-20256 6 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Acid Anhydride Hydrolases
Acetylcholinesterase
Pesticides
Rodentia
40 Citations (Scopus)

Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase

Geyer, B. C., Kannan, L., Cherni, I., Woods, R. R., Soreq, H. & Leket-Mor, T., Oct 2010, In : Plant Biotechnology Journal. 8, 8, p. 873-886 14 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
cholinesterase
Genetically Modified Plants
transgenic plants
Enzymes
2009
41 Citations (Scopus)

Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR 649-684

Matoba, N., Kajiura, H., Cherni, I., Doran, J. D., Bomsel, M., Fujiyama, K. & Leket-Mor, T., Feb 2009, In : Plant Biotechnology Journal. 7, 2, p. 129-145 17 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
Vaccines
vaccines
G(M1) Ganglioside
1 Citation (Scopus)

Organophosphate intoxication: Molecular consequences, mechanisms and solutions

Geyer, B. C., Evron, T., Soreq, H. & Leket-Mor, T., 2009, Handbook of Toxicology of Chemical Warfare Agents. Elsevier Inc., p. 691-717 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Organophosphates
Cholinergic Agents
Acetylcholinesterase
Cholinesterase Inhibitors
Neuromuscular Junction
2 Citations (Scopus)

P02-10. Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1

Kessans, S. A., Frater, J., Matoba, N. & Leket-Mor, T., Sep 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

2 Citations (Scopus)

P12-16. Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB-MPR

Matoba, N., Cherni, I., Kessans, S., Frater, J., Preston, K., Bomsel, M. & Leket-Mor, T., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

HIV-1
Vaccines
2008
28 Citations (Scopus)

Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility

Mor, I., Sklan, E. H., Podoly, E., Pick, M., Kirschner, M., Yogev, L., Bar-Sheshet Itach, S., Schreiber, L., Geyer, B., Leket-Mor, T., Grisaru, D. & Soreq, H., Apr 2008, In : Journal of Cellular and Molecular Medicine. 12, 2, p. 479-495 17 p.

Research output: Contribution to journalArticle

Sperm Motility
Acetylcholinesterase
Germ Cells
Spermatozoa
Cells
85 Citations (Scopus)

Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology

Berson, A., Knobloch, M., Hanan, M., Diamant, S., Sharoni, M., Schuppli, D., Geyer, B. C., Ravid, R., Leket-Mor, T., Nitsch, R. M. & Soreq, H., Jan 2008, In : Brain. 131, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Amyloid
Pathology
Alzheimer Disease
Cholinergic Agents
29 Citations (Scopus)

Hairy-root organ cultures for the production of human acetylcholinesterase

Woods, R. R., Geyer, B. C. & Leket-Mor, T., Dec 23 2008, In : BMC Biotechnology. 8, 95.

Research output: Contribution to journalArticle

Organ Culture Techniques
Acetylcholinesterase
Enzymes
Genetically Modified Plants
Cell Culture Techniques
8 Citations (Scopus)

Increased organophosphate scavenging in a butyrylcholinesterase mutant

Geyer, B. C., Woods, R. R. & Leket-Mor, T., Sep 25 2008, In : Chemico-Biological Interactions. 175, 1-3, p. 376-379 4 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Organophosphates
Scavenging
Cocaine
Hydrolases
16 Citations (Scopus)

Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes

Matoba, N., Griffin, T. A., Mittman, M., Doran, J. D., Alfsen, A., Montefiori, D. C., Hanson, C. V., Bornsel, M. & Leket-Mor, T., May 2008, In : Current HIV Research. 6, 3, p. 218-229 12 p.

Research output: Contribution to journalArticle

Transcytosis
Cholera Toxin
HIV-1
Epitopes
Membranes
2007
19 Citations (Scopus)

Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults

Evron, T., Greenberg, D., Leket-Mor, T. & Soreq, H., Apr 20 2007, In : Toxicology. 233, 1-3 SPEC. ISS., p. 97-107 11 p.

Research output: Contribution to journalArticle

Paraoxon
Acetylcholinesterase
Gene expression
Lipopolysaccharides
Chemical Warfare Agents
32 Citations (Scopus)

Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath

Evron, T., Geyer, B. C., Cherni, I., Muralidharan, M., Kilbourne, J., Fletcher, S. P., Soreq, H. & Leket-Mor, T., Sep 2007, In : FASEB Journal. 21, 11, p. 2961-2969 9 p.

Research output: Contribution to journalArticle

Organophosphate Poisoning
Organophosphates
organophosphorus compounds
Acetylcholinesterase
acetylcholinesterase
17 Citations (Scopus)

Translational control of recombinant human acetylcholinesterase accumulation in plants

Geyer, B. C., Fletcher, S. P., Griffin, T. A., Lopker, M. J., Soreq, H. & Leket-Mor, T., May 30 2007, In : BMC Biotechnology. 7, 27.

Research output: Contribution to journalArticle

Acetylcholinesterase
Codon
Gene Expression
Messenger RNA
GC Rich Sequence
2006
43 Citations (Scopus)

Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649-684, a mucosal subunit HIV/AIDS vaccine candidate

Matoba, N., Geyer, B. C., Kilbourne, J., Alfsen, A., Bomsel, M. & Leket-Mor, T., Jun 5 2006, In : Vaccine. 24, 23, p. 5047-5055 9 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Subunit Vaccines
Humoral Immunity
humoral immunity
cholera toxin
31 Citations (Scopus)

Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies

Saldaña, S., Guadarrama, F. E., Olivera Flores, T. D. J., Arias, N., López, S., Arias, C., Ruiz-Medrano, R., Mason, H., Leket-Mor, T., Richter, L., Arntzen, C. J. & Gómez Lim, M. A., 2006, In : Viral Immunology. 19, 1, p. 42-53 12 p.

Research output: Contribution to journalArticle

Rotavirus
Capsid Proteins
Lycopersicon esculentum
Fruit
Virion
2005
4 Citations (Scopus)

(32) Characterizing pea acetylcholinesterase

Muralidharan, M., Soreq, H. & Leket-Mor, T., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 406-407 2 p.

Research output: Contribution to journalArticle

Cholinesterases
Peas
Neurology
Acetylcholinesterase
Cholinergic Agents
24 Citations (Scopus)

Purification of transgenic plant-derived recombinant human acetylcholinesterase-R

Geyer, B. C., Muralidharan, M., Cherni, I., Doran, J., Fletcher, S. P., Evron, T., Soreq, H. & Leket-Mor, T., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 331-334 4 p.

Research output: Contribution to journalArticle

Genetically Modified Plants
Acetylcholinesterase
Purification
Plant Proteins
Cell culture
2004
67 Citations (Scopus)

A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs

Matoba, N., Magérus, A., Geyer, B. C., Zhang, Y., Muralidharan, M., Alfsen, A., Arntzen, C. J., Bomsel, M. & Leket-Mor, T., Sep 14 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 37, p. 13584-13589 6 p.

Research output: Contribution to journalArticle

Galactosylceramides
Transcytosis
Subunit Vaccines
HIV-1
Mucosal Administration
12 Citations (Scopus)

Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants

Fletcher, S. P., Geyer, B. C., Smith, A., Evron, T., Joshi, L., Soreq, H. & Leket-Mor, T., May 2004, In : Plant Molecular Biology. 55, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

cholinesterase
Genetically Modified Plants
Cholinesterase Inhibitors
Cholinesterases
tissue distribution
2003
Biotechnology
Proteins
Plant Cells
Bioengineering
61 Citations (Scopus)

Geminivirus vectors for high-level expression of foreign proteins in plant cells

Leket-Mor, T., Moon, Y. S., Palmer, K. E. & Mason, H., Feb 20 2003, In : Biotechnology and Bioengineering. 81, 4, p. 430-437 8 p.

Research output: Contribution to journalArticle

Geminiviridae
Plant Cells
Viruses
Proteins
Biolistics
2002
183 Citations (Scopus)

Edible plant vaccines: Applications for prophylactic and therapeutic molecular medicine

Mason, H., Warzecha, H., Leket-Mor, T. & Arntzen, C. J., 2002, In : Trends in Molecular Medicine. 8, 7, p. 324-329 6 p.

Research output: Contribution to journalArticle

Edible Vaccines
Molecular Medicine
Edible Plants
Vaccines
Technology
2001
52 Citations (Scopus)

Expression of recombinant human acetylcholinesterase in transgenic tomato plants

Leket-Mor, T., Sternfeld, M., Soreq, H., Arntzen, C. J. & Mason, H., Nov 5 2001, In : Biotechnology and Bioengineering. 75, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Genetically Modified Plants
Lycopersicon esculentum
Acetylcholinesterase
Proteins
Enzymes
1998
56 Citations (Scopus)

Perspective: Edible vaccines - A concept coming of age

Leket-Mor, T., Gómez-Lim, M. A. & Palmer, K. E., Nov 1 1998, In : Trends in Microbiology. 6, 11, p. 449-453 5 p.

Research output: Contribution to journalArticle

Edible Vaccines
Plant Antigens
Vaccines
Genetically Modified Plants
Developing Countries
1997
8 Citations (Scopus)

The fate of cytochrome b559 during anaerobic photoinhibition and its recovery processes

Leket-Mor, T., Hundal, T., Ohad, I. & Andersson, B., 1997, In : Photosynthesis Research. 53, 2-3, p. 205-213 9 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
photoinhibition
cytochromes
photosystem II
Recovery
1995
21 Citations (Scopus)
Chlamydomonas reinhardtii
Plastids
Chromosomes
Genes
Operon
1994
126 Citations (Scopus)

The ctpA gene encodes the C-terminal processing protease for the D1 protein of the photosystem II reaction center complex

Anbudurai, P. R., Leket-Mor, T., Ohad, I., Shestakov, S. V. & Pakrasi, H. B., Aug 16 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 17, p. 8082-8086 5 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
Peptide Hydrolases
Genes
Water
Proteins
1993
10 Citations (Scopus)

The manganese stabilising protein (MSP) of Prochlorothrix hollandica is a hydrophobic membrane-bound protein

Leket-Mor, T., Post, A. F. & Ohad, I., Mar 1 1993, In : BBA - Bioenergetics. 1141, 2-3, p. 206-212 7 p.

Research output: Contribution to journalArticle

Prochlorothrix
Manganese
Membrane Proteins
Cyanobacteria
Photosystem II Protein Complex