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1970 …2019
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Research Output 1970 2019

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Article
2019

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

Miroshnichenko, S. K., Patutina, O. A., Burakova, E. A., Chelobanov, B. P., Fokina, A. A., Vlassov, V. V., Altman, S., Zenkova, M. A. & Stetsenko, D. A., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1229-1234 6 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Ribonuclease H
Oligodeoxyribonucleotides
Oligonucleotides
RNA Cleavage
2018

Modified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P

Novopashina, D. S., Nazarov, A. S., Vorobjeva, M. A., Kuprushkin, M. S., Davydova, A. S., Lomzov, A. A., Pyshnyi, D. V., Altman, S. & Venyaminova, A. G., Nov 1 2018, In : Molekuliarnaia biologiia. 52, 6, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
Oligonucleotides
Bacterial RNA
Hydrolysis

Modified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P

Novopashina, D. S., Nazarov, A. S., Vorobjeva, M. A., Kuprushkin, M. S., Davydova, A. S., Lomzov, A. A., Pyshnyi, D. V., Altman, S. & Venyaminova, A. G., Nov 1 2018, In : Molecular Biology. 52, 6, p. 905-912 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
Oligonucleotides
Bacterial RNA
Hydrolysis
2017
31 Citations (Scopus)

Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity

Terekhov, S. S., Smirnov, I. V., Stepanova, A. V., Bobik, T. V., Mokrushina, Y. A., Ponomarenko, N. A., Belogurov, A. A., Rubtsova, M. P., Kartseva, O. V., Gomzikova, M. O., Moskovtsev, A. A., Bukatin, A. S., Dubina, M. V., Kostryukova, E. S., Babenko, V. V., Vakhitova, M. T., Manolov, A. I., Malakhova, M. V., Kornienko, M. A., Tyakht, A. V. & 5 othersVanyushkina, A. A., Ilina, E. N., Masson, P., Gabibov, A. G. & Altman, S., Mar 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. 2550-2555 6 p.

Research output: Contribution to journalArticle

Microfluidics
Biodiversity
Paraoxon
Butyrylcholinesterase
Forensic Anthropology

The origin of life, “the World of RNA,” and the problem of antibiotic resistance

Altman, S., Nov 1 2017, In : Herald of the Russian Academy of Sciences. 87, 6, p. 474-479 6 p.

Research output: Contribution to journalArticle

chemistry
Ministry of Education
medicine
genetic engineering
biochemistry
2016
21 Citations (Scopus)

Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses

Liu, Y., Padmanabhan, J., Cheung, B., Liu, J., Chen, Z., Scanley, B. E., Wesolowski, D., Pressley, M., Broadbridge, C. C., Altman, S., Schwarz, U. D., Kyriakides, T. R. & Schroers, J., May 27 2016, In : Scientific Reports. 6, 26950.

Research output: Contribution to journalArticle

Glass
2015
11 Citations (Scopus)

Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III

Serruya, R., Orlovetskie, N., Reiner, R., Dehtiar-Zilber, Y., Wesolowski, D., Altman, S. & Jarrous, N., Apr 24 2015, In : Nucleic Acids Research. 43, 11, p. 5442-5450 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Polymerase III
Ribonucleoproteins
Cell Extracts
rRNA Genes
7 Citations (Scopus)

Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum

Garg, A., Wesolowski, D., Alonso, D., Deitsch, K. W., Ben Mamoun, C. & Altman, S., Sep 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 38, p. 11935-11940 6 p.

Research output: Contribution to journalArticle

RNA Splicing
Morpholinos
RNA Stability
Chloroquine
Protein Biosynthesis
2013
22 Citations (Scopus)

A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model

Sawyer, A. J., Wesolowski, D., Gandotra, N., Stojadinovic, A., Izadjoo, M., Altman, S. & Kyriakides, T. R., 2013, In : International Journal of Pharmaceutics. 453, 2, p. 651-655 5 p.

Research output: Contribution to journalArticle

Morpholinos
Staphylococcus aureus
Messenger RNA
Skin
Peptides
20 Citations (Scopus)
Cell-Penetrating Peptides
Morpholinos
Anti-Bacterial Agents
Peptides
Genes
22 Citations (Scopus)

Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum

Augagneur, Y., Jaubert, L., Schiavoni, M., Pachikara, N., Garg, A., Usmani-Brown, S., Wesolowski, D., Zeller, S., Ghosal, A., Cornillot, E., Said, H. M., Kumar, P., Altman, S. & Ben Mamoun, C., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20558-20567 10 p.

Research output: Contribution to journalArticle

Functional analysis
Falciparum Malaria
Parasites
Plasmodium falciparum
Cell membranes
2012
24 Citations (Scopus)

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

Augagneur, Y., Wesolowski, D., Tae, H. S., Altman, S. & Mamoun, C. B., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6235-6240 6 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Morpholinos
Parasites
Messenger RNA
Antimalarials
2011
28 Citations (Scopus)

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Wesolowski, D., Tae, H. S., Gandotra, N., Llopis, P., Shen, N. & Altman, S., Oct 4 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16582-16587 6 p.

Research output: Contribution to journalArticle

Morpholinos
Bacteria
Peptides
Nucleic Acids
Genes
2 Citations (Scopus)

Inactivation of expression of two genes in Saccharomyces cerevisiae with the external guide sequence methodology

Cheng, X., Ko, J. H. & Altman, S., Mar 2011, In : RNA. 17, 3, p. 544-549 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Saccharomyces cerevisiae
RNA
Gene Expression
Yeasts
11 Citations (Scopus)

RNA binding properties of conserved protein subunits of human RNase P

Reiner, R., Alfiya-Mor, N., Berrebi-Demma, M., Wesolowski, D., Altman, S. & Jarrous, N., Jul 2011, In : Nucleic Acids Research. 39, 13, p. 5704-5714 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
RNA
Transfer RNA
Catalytic Domain
2010
1 Citation (Scopus)

Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA

Xiao, G., Wesolowski, D., Izadjoo, M. & Altman, S., Nov 2010, In : RNA. 16, 11, p. 2218-2225 8 p.

Research output: Contribution to journalArticle

Morpholinos
RNA
Messenger RNA
Ribonuclease P
Guide RNA
2009
31 Citations (Scopus)

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

Shen, N., Ko, J. H., Xiao, G., Wesolowski, D., Shan, G., Geller, B., Lzadjoo, M. & Altman, S., May 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 20, p. 8163-8168 6 p.

Research output: Contribution to journalArticle

Guide RNA
Morpholinos
Technology
Gene Expression
Oligonucleotides
2008
8 Citations (Scopus)

Inhibition of expression in Escherichia coli of a virulence regulator MglB of Francisella tularensis using external guide sequence technology

Xiao, G., Lundblad, E. W., Izadjoo, M. & Altman, S., Nov 13 2008, In : PLoS One. 3, 11, e3719.

Research output: Contribution to journalArticle

Francisella tularensis
Escherichia coli
Virulence
virulence
screening
14 Citations (Scopus)

Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P

Ko, J. H., Izadjoo, M. & Altman, S., Aug 2008, In : RNA. 14, 8, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

Ribonuclease P
Yersinia pestis
Virulence
Escherichia coli
Gene Expression
16 Citations (Scopus)
Ribonuclease P
RNA
Escherichia coli
Messenger RNA
Gels
28 Citations (Scopus)

RNase P cleaves the adenine riboswitch and stabilizes pbuE mRNA in Bacillus subtilis

Seif, E. & Altman, S., Jun 2008, In : RNA. 14, 6, p. 1237-1243 7 p.

Research output: Contribution to journalArticle

Riboswitch
Ribonuclease P
Adenine
Bacillus subtilis
Messenger RNA
2007
27 Citations (Scopus)

A noncoding RNA in Saccharomyces cerevisiae is an RNase P substrate

Yang, L. & Altman, S., May 2007, In : RNA. 13, 5, p. 682-690 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
Reading Frames
Untranslated RNA
Antisense RNA
Saccharomyces cerevisiae
47 Citations (Scopus)

A view of RNase P

Altman, S., 2007, In : Molecular BioSystems. 3, 9, p. 604-607 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
Crystallography
Eukaryota
Yeast
Catalyst activity
23 Citations (Scopus)
Ribonuclease P
Nucleotide Motifs
RNA
Bacteria
Riboswitch
2005
2 Citations (Scopus)

Analysis of putative RNase P RNA from orthopoxviruses

Yang, L., Wesolowski, D., Li, Y. & Altman, S., Dec 2 2005, In : Journal of Molecular Biology. 354, 3, p. 529-535 7 p.

Research output: Contribution to journalArticle

Orthopoxvirus
Ribonuclease P
RNA
Vaccinia
HeLa Cells
3 Citations (Scopus)

Masters of DNA.

Altman, S., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 14361-14365 5 p.

Research output: Contribution to journalArticle

20th Century History
England
DNA
5 Citations (Scopus)

Regulated expression of functional external guide sequences in mammalian cells using a U6 RNA polymerase III promoter

Kovrigina, E., Yang, L., Pfund, E. & Altman, S., Oct 2005, In : RNA. 11, 10, p. 1588-1595 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Polymerase III
Protein Subunits
Lamin Type A
Ecdysone
66 Citations (Scopus)

RNase P cleaves transient structures in some riboswitches

Altman, S., Wesolowski, D., Guerrier-Takada, C. & Li, Y., Aug 9 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 32, p. 11284-11289 6 p.

Research output: Contribution to journalArticle

Riboswitch
Ribonuclease P
Escherichia coli
Aspergillus nidulans
5' Untranslated Regions
2004
23 Citations (Scopus)

Disruption of type III secretion in Salmonella enterica serovar typhimurium by external guide sequences

McKinney, J. S., Zhang, H., Kubori, T., Galán, J. E. & Altman, S., 2004, In : Nucleic Acids Research. 32, 2, p. 848-854 7 p.

Research output: Contribution to journalArticle

Salmonella enterica
Messenger RNA
Salmonella
Ribonuclease P
Oligonucleotides
21 Citations (Scopus)
Ribonuclease P
Protein Subunits
Small Interfering RNA
Messenger RNA
Transfection
36 Citations (Scopus)

In search of RNase P RNA from microbial genomes

Li, Y. & Altman, S., Oct 2004, In : RNA. 10, 10, p. 1533-1540 8 p.

Research output: Contribution to journalArticle

Microbial Genome
Ribonuclease P
RNA
Orthopoxvirus
Archaea
35 Citations (Scopus)

Polarity effects in the lactose operon of Escherichia coli

Li, Y. & Altman, S., May 21 2004, In : Journal of Molecular Biology. 339, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
Lac Operon
Escherichia coli
Reporter Genes
Temperature
2003
75 Citations (Scopus)
Endoribonucleases
Ribonuclease P
Operon
Gene Expression
Messenger RNA
17 Citations (Scopus)

Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P

Kovrigina, E., Wesolowski, D. & Altman, S., Feb 18 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 4, p. 1598-1602 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
Genes
Transfection
Proteins
28 Citations (Scopus)

The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli

Li, Y., Cole, K. & Altman, S., May 1 2003, In : RNA. 9, 5, p. 518-532 15 p.

Research output: Contribution to journalArticle

Ribonuclease P
Escherichia coli
Gene Expression
Mutation
Intergenic DNA
2002
16 Citations (Scopus)
Exoribonucleases
Ribonuclease P
Protein Subunits
RNA Precursors
Transfer RNA
15 Citations (Scopus)
Ribonuclease P
HeLa Cells
RNA
Proteins
Enzymes
35 Citations (Scopus)

Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P

Guerrier-Takada, C., Eder, P. S., Gopalan, V. & Altman, S., 2002, In : RNA. 8, 3, p. 290-295 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA-Binding Proteins
Protein Subunits
RNA
HeLa Cells
22 Citations (Scopus)

Tightly regulated gene expression system in Salmonella enterica serovar Typhimurium

McKinney, J., Guerrier-Takada, C., Galán, J. & Altman, S., Nov 2002, In : Journal of Bacteriology. 184, 21, p. 6056-6059 4 p.

Research output: Contribution to journalArticle

Bacterial Chromosomes
Arabinose
Salmonella enterica
RNA
Gene Expression
2001
28 Citations (Scopus)

A subunit of human nuclear RNase P has ATPase activity

Li, Y. & Altman, S., Jan 16 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 2, p. 441-444 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
Adenosine Triphosphatases
RNA
ATP-Binding Cassette Transporters
Protein Subunits
14 Citations (Scopus)

Characterization of RNase P from Thermotoga maritima

Paul, R., Lazarevand, D. & Altman, S., Feb 15 2001, In : Nucleic Acids Research. 29, 4, p. 880-885 6 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Ribonuclease P
Protein Subunits
Holoenzymes
Temperature
47 Citations (Scopus)

Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P

Jarrous, N., Reiner, R., Wesolowski, D., Mann, H., Guerrier-Takada, C. & Altman, S., 2001, In : RNA. 7, 8, p. 1153-1164 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
Ribonucleoproteins
Protein Subunits
RNA Precursors
MHC Class I Genes
44 Citations (Scopus)

Human ribonuclease P

Jarrous, N. & Altman, S., 2001, In : Methods in Enzymology. 342, p. 93-100 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
28 Citations (Scopus)

Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes

McKinney, J., Guerrier-Takada, C., Wesolowski, D. & Altman, S., Jun 5 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 12, p. 6605-6610 6 p.

Research output: Contribution to journalArticle

Essential Genes
Nucleotides
Escherichia coli
Ribonuclease P
Microbial Viability
54 Citations (Scopus)

Protein-protein interactions with subunits of human nuclear RNase P

Altman, T. & Altman, S., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 920-925 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Two-Hybrid System Techniques
Gene Library
HeLa Cells
HSP27 Heat-Shock Proteins
53 Citations (Scopus)

Protein-RNA interactions in the subunits of human nuclear RNase P

Jiang, T., Guerrier-Takada, C. & Altman, S., 2001, In : RNA. 7, 7, p. 937-941 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA
Holoenzymes
Two-Hybrid System Techniques
Proteins
2000
17 Citations (Scopus)

Evidence for helical unwinding of an RNA substrate by the RNA enzyme RNase P: Use of an interstrand disulfide crosslink in substrate

Krummel, D. A. P., Kent, O., MacMillan, A. M. & Altman, S., Feb 4 2000, In : Journal of Molecular Biology. 295, 5, p. 1113-1118 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Disulfides
RNA
Enzymes
Escherichia coli
44 Citations (Scopus)

Inactivation of gene expression using ribonuclease P and external guide sequences

Guerrier-Takada, C. & Altman, S., 2000, In : Methods in Enzymology. 313, p. 442-456 15 p.

Research output: Contribution to journalArticle

Ribonuclease P
Gene expression
47 Citations (Scopus)

Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe

Biswas, R., Ledman, D. W., Fox, R. O., Altman, S. & Gopalan, V., Feb 11 2000, In : Journal of Molecular Biology. 296, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Protein Interaction Mapping
Ribonuclease P
Edetic Acid
Disulfides
RNA
1999
76 Citations (Scopus)

Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P

Jarrous, N., Wolenski, J. S., Wesolowski, D., Lee, C. & Altman, S., Aug 9 1999, In : Journal of Cell Biology. 146, 3, p. 559-571 13 p.

Research output: Contribution to journalArticle

Coiled Bodies
Ribonuclease P
Ribonucleoproteins
Protein Subunits
RNA Precursors