• 10609 Citations
  • 53 h-Index
1970 …2019
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Research Output 1970 2019

1994
57 Citations (Scopus)
Ribonuclease P
Holoenzymes
Escherichia coli
Gels
RNA
47 Citations (Scopus)

Kinetic and thermodynamic analysis of RNA-protein interactions in the RNase P holoenzyme from escherichia colf

Talbot, S. J. & Altman, S., 1994, In : Biochemistry. 33, 6, p. 1406-1411 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Escherichia
Monovalent Cations
Holoenzymes
Divalent Cations
78 Citations (Scopus)

Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P

Yuan, Y. & Altman, S., Mar 4 1994, In : Science. 263, 5151, p. 1269-1273 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Precursors
RNA
Messenger RNA
Oligoribonucleotides
77 Citations (Scopus)
Ribonuclease P
RNA Precursors
RNA
Escherichia coli
Catalytic RNA
1993
27 Citations (Scopus)

A physical assay for and kinetic analysis of the interactions between M1 RNA and tRNA precursor substrates

Guerrier-Takada, C. & Altman, S., 1993, In : Biochemistry. 32, 28, p. 7152-7161 10 p.

Research output: Contribution to journalArticle

RNA Precursors
Assays
RNA
Kinetics
Substrates
Biochemistry
RNA Precursors
Assays
Kinetics
Substrates
25 Citations (Scopus)

Nucleotide Sequences of the RNA Subunit of RNase P from Several Mammals

Altman, S., Wesolowski, D. & Puranam, R. S., Nov 1993, In : Genomics. 18, 2, p. 418-422 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Mammals
RNA
Primates
Rodentia
47 Citations (Scopus)

Pathway of activation by magnesium ions of substrates for the catalytic subunit of RNase P from Escherichia coli

Perreault, J. P. & Altman, S., 1993, In : Journal of Molecular Biology. 230, 3, p. 750-756 7 p.

Research output: Contribution to journalArticle

Ribonuclease P
Magnesium
Catalytic Domain
Ions
Escherichia coli
134 Citations (Scopus)

Recent studies of ribonuclease P

Altman, S., Kirsebom, L. & Talbot, S., 1993, In : FASEB Journal. 7, 1, p. 7-14 8 p.

Research output: Contribution to journalReview article

Ribonuclease P
ribonucleases
RNA
protein subunits
Biosynthesis
81 Citations (Scopus)

RNA enzyme-directed gene therapy

Altman, S., 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 23, p. 10898-10900 3 p.

Research output: Contribution to journalComment/debate

Molecular Sequence Data
Catalytic RNA
RNA Viruses
Hydrogen Bonding
Genetic Therapy
1992
57 Citations (Scopus)
RNA Cleavage
Metals
Ions
Nucleotides
Poly U
84 Citations (Scopus)

Important 2′-hydroxyl groups in model substrates for M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli

Perreault, J. P. & Altman, S., Jul 20 1992, In : Journal of Molecular Biology. 226, 2, p. 399-409 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Hydroxyl Radical
Catalytic Domain
RNA
45 Citations (Scopus)

Reconstitution of enzymatic activity from fragments of M1 RNA

Guerrier-Takada, C. & Altman, S., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 4, p. 1266-1270 5 p.

Research output: Contribution to journalArticle

RNA
Ribonuclease P
Catalytic RNA
Substrate Specificity
Catalytic Domain
118 Citations (Scopus)

Targeted cleavage of mRNA by human RNase P

Yuan, Y., Hwang, E. S. & Altman, S., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 17, p. 8006-8010 5 p.

Research output: Contribution to journalArticle

Oligoribonucleotides
Ribonuclease P
Messenger RNA
Chloramphenicol O-Acetyltransferase
RNA Precursors
46 Citations (Scopus)

Targeted cleavage of mRNA in vitro by RNase P from Escherichia coli

Li, Y., Guerrier-Takada, C. & Altman, S., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 8, p. 3185-3189 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Galactosidases
Escherichia coli
Messenger RNA
Guide RNA
1991
118 Citations (Scopus)

Kinetics of the processing of the precursor to 4·5 S RNA, a naturally occurring substrate for RNase P from Escherichia coli

Peck-Miller, K. A. & Altman, S., Sep 5 1991, In : Journal of Molecular Biology. 221, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Precursors
RNA
Escherichia coli
RNA Cleavage
1 Citation (Scopus)

LA RIBONUCLEASE P: UNE VERITABLE ENZYME A ARN IN VITRO

Perreault, J. P. & Altman, S., 1991, In : Medecine/Sciences. 7, 8, p. 847-850 4 p.

Research output: Contribution to journalShort survey

Ribonuclease P
RNA
Enzymes
In Vitro Techniques
39 Citations (Scopus)

Multiple cis-acting elements are required for RNA polymerase III transcription of the gene encoding H1 RNA, the RNA component of human RNase P

Hannon, G. J., Chubb, A., Maroney, P. A., Hannon, G., Altman, S. & Nilsen, T. W., Dec 5 1991, In : Journal of Biological Chemistry. 266, 34, p. 22796-22799 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Polymerase III
Gene encoding
Transcription
RNA
94 Citations (Scopus)
Ribonuclease P
Catalytic Domain
RNA Cleavage
Metals
RNA
1990
24 Citations (Scopus)

Enzymatic cleavage of RNA by RNA

Altman, S., Aug 1990, In : Bioscience Reports. 10, 4, p. 317-337 21 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
Catalytic RNA
Escherichia coli
RNA
38 Citations (Scopus)

Enzymatic Cleavage of RNA by RNA (Nobel Lecture)

Altman, S., 1990, In : Angewandte Chemie - International Edition. 29, 7, p. 749-758 10 p.

Research output: Contribution to journalReview article

RNA
Ribonuclease P
Proteins
Biochemistry
Transesterification
235 Citations (Scopus)

External guide sequence for an RNA enzyme

Forster, A. C. & Altman, S., 1990, In : Science. 249, 4970, p. 783-786 4 p.

Research output: Contribution to journalArticle

Guide RNA
Ribonuclease P
RNA
Enzymes
RNA Cleavage
41 Citations (Scopus)

Interaction of RNAse P from Escherichia coli with pseudoknotted structures in viral RNAs

Mans, R. M. W., Guerrier-Takada, C., Altman, S. & Pieij, C. W. A., Jun 25 1990, In : Nucleic Acids Research. 18, 12, p. 3479-3487 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
Tymovirus
Viral RNA
RNA
Escherichia coli
15 Citations (Scopus)

Preparation and characterization of RNase P from Escherichia coli

Baer, M. F., Arnez, J. G., Guerrier-Takada, C., Vioque, A. & Altman, S., 1990, In : Methods in Enzymology. 181, p. 569-582 14 p.

Research output: Contribution to journalArticle

Ribonuclease P
Escherichia coli
39 Citations (Scopus)

Protection from chemical modification of nucleotides in complexes of M1 RNA, the catalytic subunit of RNase P from E coli, and tRNA precursors

Knap, A. K., Wesolowski, D. & Altman, S., 1990, In : Biochimie. 72, 11, p. 779-790 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
RNA Precursors
Chemical modification
Escherichia coli
45 Citations (Scopus)

Ribonuclease

Altman, S., 1990, In : Journal of Biological Chemistry. 265, 33, p. 20053-20056 4 p.

Research output: Contribution to journalReview article

Nucleic Acid Sequence Homology
Molecular Sequence Data
23S Ribosomal RNA
Nucleic acid sequences
Endoribonucleases
113 Citations (Scopus)

Similar cage-shaped structures for the RNA components of all ribonuclease P and ribonuclease MRP enzymes

Forster, A. C. & Altman, S., Aug 10 1990, In : Cell. 62, 3, p. 407-409 3 p.

Research output: Contribution to journalLetter

Nucleic Acid Sequence Homology
Molecular Sequence Data
Fungal Genes
Endoribonucleases
Bacterial RNA
86 Citations (Scopus)

Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P

Baer, M., Nilsen, T. W., Costigan, C. & Altman, S., Jan 11 1990, In : Nucleic Acids Research. 18, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

Ribonuclease P
Transcription
RNA
Clone
Genomics
21 Citations (Scopus)

Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P

Baer, M., Nilsen, T. W., Costigan, C. & Altman, S., Jun 25 1990, In : Nucleic Acids Research. 18, 12, p. 3688 1 p.

Research output: Contribution to journalComment/debate

Ribonuclease P
Transcription
RNA
Genes
Gene
1989
27 Citations (Scopus)

An immunological determinant of RNase P protein is conserved between Escherichia coli and humans

Mamula, M. J., Baer, M., Craft, J. & Altman, S., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 22, p. 8717-8721 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Escherichia coli
Proteins
Escherichia coli Proteins
Protein Subunits
30 Citations (Scopus)

Catalysis by the RNA subunit of RNase P - a minireview

Altman, S., Baer, M. F., Bartkiewicz, M., Gold, H., Guerrier-Takada, C., Kirsebom, L. A., Lumelsky, N. & Peck, K., Oct 15 1989, In : Gene. 82, 1, p. 63-64 2 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalysis
RNA
RNA Precursors
Transfer RNA
37 Citations (Scopus)

Characterization in vitro of the defect in a temperature-sensitive mutant of the protein subunit of RNase P from Escherichia coli

Baer, M. F., Wesolowski, D. & Altman, S., 1989, In : Journal of Bacteriology. 171, 12, p. 6862-6866 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Holoenzymes
Protein Subunits
Mutant Proteins
RNA
130 Citations (Scopus)

Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

Bartkiewicz, M., Gold, H. & Altman, S., Apr 1989, In : Genes and Development. 3, 4, p. 488-499 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
HeLa Cells
RNA
Schizosaccharomyces
DNA
26 Citations (Scopus)

Reaction in vitro of some mutants of RNase P with wild-type and temperature-sensitive substrates

Kirsebom, L. A. & Altman, S., Jun 20 1989, In : Journal of Molecular Biology. 207, 4, p. 837-840 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Precursors
Transfer RNA
Temperature
Base Pairing
142 Citations (Scopus)

Ribonuclease P: an enzyme with a catalytic RNA subunit.

Altman, S., 1989, In : Advances in Enzymology and Related Areas of Molecular Biology. 62, p. 1-36 36 p.

Research output: Contribution to journalReview article

Endoribonucleases
Bacterial RNA
Ribonuclease P
Macromolecular Substances
Catalytic RNA
108 Citations (Scopus)

Specific interactions in RNA enzyme-substrate complexes

Guerrier-Takada, C., Lumelsky, N. & Altman, S., 1989, In : Science. 246, 4937, p. 1578-1584 7 p.

Research output: Contribution to journalArticle

RNA
Enzymes
Nucleotides
RNA Precursors
Ribonuclease P
1988
57 Citations (Scopus)

Antibodies in human serum that precipitate ribonuclease P

Gold, H. A., Craft, J., Hardin, J. A., Bartkiewicz, M. & Altman, S., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 15, p. 5483-5487 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Antibodies
RNA
Serum
Endoribonucleases
58 Citations (Scopus)

Differential effects of mutations in the protein and RNA moieties of RNase P on the efficiency of suppression by various tRNA suppressors

Kirsebom, L. A., Baer, M. F. & Altman, S., Dec 20 1988, In : Journal of Molecular Biology. 204, 4, p. 879-888 10 p.

Research output: Contribution to journalArticle

Ribonuclease P
Transfer RNA
Gene Components
RNA
Mutation
75 Citations (Scopus)

Novel reactions of RNAase P with a tRNA-like structure in turnip yellow mosaic virus RNA

Guerrier-Takada, C., van Belkum, A., Pleii, C. W. A. & Altman, S., Apr 22 1988, In : Cell. 53, 2, p. 267-272 6 p.

Research output: Contribution to journalArticle

Tymovirus
Transfer RNA
Viruses
RNA
Catalytic RNA
138 Citations (Scopus)

Protein-RNA interactions in the RNase P holoenzyme from Escherichia coli

Vioque, A., Arnez, J. & Altman, S., Aug 20 1988, In : Journal of Molecular Biology. 202, 4, p. 835-848 14 p.

Research output: Contribution to journalArticle

Ribonuclease P
Holoenzymes
RNA
Escherichia coli
Proteins
36 Citations (Scopus)

Selection and characterization of randomly produced mutants in the gene coding for M1 RNA

Lumelsky, N. & Altman, S., Aug 5 1988, In : Journal of Molecular Biology. 202, 3, p. 443-454 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA
Genes
Ribonuclease T1
Denaturing Gradient Gel Electrophoresis
22 Citations (Scopus)

The recognition by RNaseP of precursor tRNAs

Baer, M. F., Reilly, R. M., McCorkle, G. M., Hai, T. Y., Altman, S. & RajBhandary, U. L., 1988, In : Journal of Biological Chemistry. 263, 5, p. 2344-2351 8 p.

Research output: Contribution to journalArticle

RNA Precursors
RNA
Escherichia coli
Mutation
RNA, Transfer, Tyr
1987
34 Citations (Scopus)

Characteristics of ribonuclease P from various organisms

Lawrence, N., Wesolowski, D., Gold, H., Bartkiewicz, M., Guerrier-Takada, C., McClain, W. H. & Altman, S., 1987, In : Cold Spring Harbor Symposia on Quantitative Biology. 52, p. 233-238 6 p.

Research output: Contribution to journalArticle

ribonucleases
organisms
10 Citations (Scopus)

Concepts in biochemistry: RNA's as catalysts: A new class of enzymes

McCorkle, G. M. & Altman, S., 1987, In : Journal of Chemical Education. 64, 3, p. 221-226 6 p.

Research output: Contribution to journalReview article

Biochemistry
biochemistry
RNA
Catalysts
Enzymes
22 Citations (Scopus)
Ribonuclease P
Catalytic RNA
Catalytic Domain
Escherichia coli
Enzymes
208 Citations (Scopus)

Model substrates for an RNA enzyme

Mcclain, W. H., Guerrier-Takada, C. & Altman, S., 1987, In : Science. 238, 4826, p. 527-530 4 p.

Research output: Contribution to journalArticle

RNA Precursors
RNA
Enzymes
Ribonuclease P
Catalytic RNA
135 Citations (Scopus)

Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA

Kaneda, S., Takeishi, K., Ayusawa, D., Shimizu, K., Seno, T. & Altman, S., Feb 11 1987, In : Nucleic Acids Research. 15, 3, p. 1259-1270 12 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
5' Untranslated Regions
CDNA
Mutant
Messenger RNA
3 Citations (Scopus)

Suppressor and novel mutants of bacteriophage T4 tRNAGly

McClain, W. H., Foss, K., Schneider, J., Guerrier-Takada, C. & Altman, S., Jan 5 1987, In : Journal of Molecular Biology. 193, 1, p. 223-226 4 p.

Research output: Contribution to journalArticle

RNA, Transfer, Gly
Bacteriophage T4
Base Pairing
RNA Precursors
Ribonuclease P
1986
19 Citations (Scopus)

Affinity chromatography with an immobilized RNA enzyme

Vioque, A. & Altman, S., 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 16, p. 5904-5908 5 p.

Research output: Contribution to journalArticle

Immobilized Nucleic Acids
Immobilized Enzymes
Affinity Chromatography
Ribonuclease P
RNA
47 Citations (Scopus)

Enzymatic cleavage of RNA by RNA

Altman, S., Baer, M., Guerrier-Takada, C. & Vioque, A., 1986, In : Trends in Biochemical Sciences. 11, 12, p. 515-518 4 p.

Research output: Contribution to journalReview article

RNA Cleavage
RNA
Enzymes
Ribonuclease P
Biosynthesis