• 10669 Citations
  • 53 h-Index
1970 …2019
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Research Output 1970 2019

2002
16 Citations (Scopus)
Exoribonucleases
Ribonuclease P
Protein Subunits
RNA Precursors
Transfer RNA

Difficult problems, difficult thoughts

Altman, S., Aug 1 2002, In : Biochimie. 84, 8, p. 691-692 2 p.

Research output: Contribution to journalComment/debate

27 Citations (Scopus)

Elucidation of structure-function relationships in the protein subunit of bacterial RNase P using a genetic complementation approach

Jovanovic, M., Sanchez, R., Altman, S. & Gopalan, V., Dec 1 2002, In : Nucleic Acids Research. 30, 23, p. 5065-5073 9 p.

Research output: Contribution to journalReview article

Ribonuclease P
Protein Subunits
Transfer RNA
Catalytic RNA
Ribonucleoproteins
15 Citations (Scopus)
Ribonuclease P
HeLa Cells
RNA
Proteins
Enzymes
36 Citations (Scopus)

Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P

Guerrier-Takada, C., Eder, P. S., Gopalan, V. & Altman, S., 2002, In : RNA. 8, 3, p. 290-295 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA-Binding Proteins
Protein Subunits
RNA
HeLa Cells
83 Citations (Scopus)

RNase P: Variations and uses

Gopalan, V., Vioque, A. & Altman, S., Mar 1 2002, In : Journal of Biological Chemistry. 277, 9, p. 6759-6762 4 p.

Research output: Contribution to journalShort survey

Endoribonucleases
Ribonuclease P
Catalytic RNA
Bacteria
Animals
23 Citations (Scopus)

Tightly regulated gene expression system in Salmonella enterica serovar Typhimurium

McKinney, J., Guerrier-Takada, C., Galán, J. & Altman, S., Nov 2002, In : Journal of Bacteriology. 184, 21, p. 6056-6059 4 p.

Research output: Contribution to journalArticle

Bacterial Chromosomes
Arabinose
Salmonella enterica
RNA
Gene Expression
2001
28 Citations (Scopus)

A subunit of human nuclear RNase P has ATPase activity

Li, Y. & Altman, S., Jan 16 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 2, p. 441-444 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
Adenosine Triphosphatases
RNA
ATP-Binding Cassette Transporters
Protein Subunits
14 Citations (Scopus)

Characterization of RNase P from Thermotoga maritima

Paul, R., Lazarevand, D. & Altman, S., Feb 15 2001, In : Nucleic Acids Research. 29, 4, p. 880-885 6 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Ribonuclease P
Protein Subunits
Holoenzymes
Temperature
47 Citations (Scopus)

Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P

Jarrous, N., Reiner, R., Wesolowski, D., Mann, H., Guerrier-Takada, C. & Altman, S., 2001, In : RNA. 7, 8, p. 1153-1164 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
Ribonucleoproteins
Protein Subunits
RNA Precursors
MHC Class I Genes
46 Citations (Scopus)

Human ribonuclease P

Jarrous, N. & Altman, S., 2001, In : Methods in Enzymology. 342, p. 93-100 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
28 Citations (Scopus)

Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes

McKinney, J., Guerrier-Takada, C., Wesolowski, D. & Altman, S., Jun 5 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 12, p. 6605-6610 6 p.

Research output: Contribution to journalArticle

Essential Genes
Nucleotides
Escherichia coli
Ribonuclease P
Microbial Viability
54 Citations (Scopus)

Protein-protein interactions with subunits of human nuclear RNase P

Altman, T. & Altman, S., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 920-925 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Two-Hybrid System Techniques
Gene Library
HeLa Cells
HSP27 Heat-Shock Proteins
53 Citations (Scopus)

Protein-RNA interactions in the subunits of human nuclear RNase P

Jiang, T., Guerrier-Takada, C. & Altman, S., 2001, In : RNA. 7, 7, p. 937-941 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA
Holoenzymes
Two-Hybrid System Techniques
Proteins
2000
17 Citations (Scopus)

Evidence for helical unwinding of an RNA substrate by the RNA enzyme RNase P: Use of an interstrand disulfide crosslink in substrate

Krummel, D. A. P., Kent, O., MacMillan, A. M. & Altman, S., Feb 4 2000, In : Journal of Molecular Biology. 295, 5, p. 1113-1118 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Disulfides
RNA
Enzymes
Escherichia coli
44 Citations (Scopus)

Inactivation of gene expression using ribonuclease P and external guide sequences

Guerrier-Takada, C. & Altman, S., 2000, In : Methods in Enzymology. 313, p. 442-456 15 p.

Research output: Contribution to journalArticle

Ribonuclease P
Gene expression
47 Citations (Scopus)

Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe

Biswas, R., Ledman, D. W., Fox, R. O., Altman, S. & Gopalan, V., Feb 11 2000, In : Journal of Molecular Biology. 296, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Protein Interaction Mapping
Ribonuclease P
Edetic Acid
Disulfides
RNA
23 Citations (Scopus)

The road to RNase P

Altman, S., 2000, In : Nature Structural Biology. 7, 10, p. 827-828 2 p.

Research output: Contribution to journalShort survey

Endoribonucleases
Ribonuclease P
Catalytic RNA
Transfer RNA
9 Citations (Scopus)

Varieties of RNase P: A nomenclature problem?

Altman, S., Gopalan, V. & Vioque, A., 2000, In : RNA. 6, 12, p. 1689-1694 6 p.

Research output: Contribution to journalReview article

Neoplasm RNA
Neoplasm Proteins
Fungal RNA
Archaeal RNA
Molecular Sequence Data
1999

Common courtesy [3]

Altman, S., Sep 3 1999, In : Science. 285, 5433, p. 1492 1 p.

Research output: Contribution to journalLetter

76 Citations (Scopus)

Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P

Jarrous, N., Wolenski, J. S., Wesolowski, D., Lee, C. & Altman, S., Aug 9 1999, In : Journal of Cell Biology. 146, 3, p. 559-571 13 p.

Research output: Contribution to journalArticle

Coiled Bodies
Ribonuclease P
Ribonucleoproteins
Protein Subunits
RNA Precursors
19 Citations (Scopus)

Mapping RNA - Protein interactions in ribonuclease P from Escherichia coli using electron paramagnetic resonance spectroscopy

Gopalan, V., Kühne, H., Biswas, R., Li, H., Brudvig, G. W. & Altman, S., Feb 9 1999, In : Biochemistry. 38, 6, p. 1705-1714 10 p.

Research output: Contribution to journalArticle

Protein Interaction Mapping
Ribonuclease P
Electron Spin Resonance Spectroscopy
Escherichia coli
Paramagnetic resonance
23 Citations (Scopus)

Multiple binding modes of substrate to the catalytic RNA subunit of RNase P from Escherichia coli

Pomeranz Krummel, D. A. & Altman, S., Aug 1999, In : RNA. 5, 8, p. 1021-1033 13 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Catalytic Domain
RNA
Escherichia coli
45 Citations (Scopus)

Rpp14 and Rpp29, two protein subunits of human ribonuclease P

Jarrous, N., Eder, P. S., Wesolowski, D. & Altman, S., Feb 1999, In : RNA. 5, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
HeLa Cells
Enzymes
Yeasts
20 Citations (Scopus)
Catalytic RNA
Ribonuclease P
RNA
Escherichia coli
Site-Directed Mutagenesis
1998
42 Citations (Scopus)

Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P

Jarrous, N., Eder, P. S., Guerrier-Takada, C., Hoog, C. & Altman, S., Apr 1998, In : RNA. 4, 4, p. 407-417 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
Holoenzymes
Proteins
Ribonucleoproteins
88 Citations (Scopus)
Ribonuclease P
Orthomyxoviridae
Cultured Cells
Nucleocapsid
Messenger RNA
2 Citations (Scopus)

Improving the efficiency of antisense and EGS methods

Salavati, R. & Altman, S., 1998, In : Antisense and Nucleic Acid Drug Development. 8, 1, p. 63-65 3 p.

Research output: Contribution to journalArticle

Guide RNA
Antisense RNA
Exonucleases
Gene Silencing
RNA
31 Citations (Scopus)
Ribonuclease P
RNA Precursors
Protein Subunits
Saccharomyces cerevisiae
Yeasts
1997
67 Citations (Scopus)

Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coli

Gopalan, V., Baxevanis, A. D., Landsman, D. & Altman, S., Apr 11 1997, In : Journal of Molecular Biology. 267, 4, p. 818-829 12 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
Escherichia coli
Proteins
Catalysis
91 Citations (Scopus)

Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P

Eder, P. S., Kekuda, R., Stolc, V. & Altman, S., Feb 18 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 4, p. 1101-1106 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Antigens
Peptides
RNA
Complementary DNA
Ribonuclease P
RNA Precursors
Protein Subunits
Saccharomyces cerevisiae
Genes
34 Citations (Scopus)

Fluorescence properties of a tryptophan residue in an aromatic core of the protein subunit of ribonuclease P from Escherichia coli

Gopalan, V., Golbik, R., Schreiber, G., Fersht, A. R. & Altman, S., Apr 11 1997, In : Journal of Molecular Biology. 267, 4, p. 765-769 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
Tryptophan
Fluorescence
Escherichia coli
67 Citations (Scopus)

Phenotypic conversion of drug-resistant bacteria to drug sensitivity

Guerrier-Takada, C., Salavati, R. & Altman, S., Aug 5 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 16, p. 8468-8472 5 p.

Research output: Contribution to journalArticle

Bacteria
Oligoribonucleotides
Ribonuclease P
Pharmaceutical Preparations
Synthetic Genes
30 Citations (Scopus)
Ribonuclease P
RNA Precursors
Protein Subunits
Saccharomyces cerevisiae
Ribonucleases
43 Citations (Scopus)
Ribonuclease P
RNA Precursors
Protein Subunits
Saccharomyces cerevisiae
Ribonucleases

Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence

Yuan, Y., Guerrier-Takada, C., Altman, S. & Liu, F., 1997, In : Biotechnology Advances. 15, 3-4, p. 681-682 2 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
RNA
Oligoribonucleotides
Anticodon
44 Citations (Scopus)

The protein cofactor allows the sequence of an RNase P ribozyme to diversify by maintaining the catalytically active structure of the enzyme

Kim, J. J., Kilani, A. F., Zhan, X., Altman, S. & Liu, F., Jun 1997, In : RNA. 3, 6, p. 613-623 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Ribonucleoproteins
RNA
Enzymes
1996
16 Citations (Scopus)

Cleavage by RNase P of gene N mRNA reduces bacteriophage λ burst size

Li, Y. & Altman, S., 1996, In : Nucleic Acids Research. 24, 5, p. 835-842 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
Bacteriophages
RNA
Messenger RNA
Genes
62 Citations (Scopus)

Mapping in three dimensions of regions in a catalytic RNA protected from attack by an Fe(II)-EDTA reagent

Westhof, E., Wesolowski, D. & Altman, S., May 17 1996, In : Journal of Molecular Biology. 258, 4, p. 600-613 14 p.

Research output: Contribution to journalArticle

Catalytic RNA
RNA
Ribonuclease P
Computer Security
Holoenzymes
44 Citations (Scopus)

Requirements for cleavage by a modified RNase P of a small model substrate

Liu, F. & Altman, S., 1996, In : Nucleic Acids Research. 24, 14, p. 2690-2696 7 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA
Catalytic RNA
Cytosine
Oligonucleotides
11 Citations (Scopus)

The RNA subunit of ribonuclease P from the zebrafish, Danio rerio

Eder, P. S., Srinivasan, A., Fishman, M. C. & Altman, S., 1996, In : Journal of Biological Chemistry. 271, 35, p. 21031-21036 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Zebrafish
RNA
Transcription
Reverse Transcription
1995
82 Citations (Scopus)

Artificial regulation of gene expression in Escherichia coli by RNase P

Guerrier-Takada, C., Li, Y. & Altman, S., Nov 21 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 24, p. 11115-11119 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Synthetic Genes
Gene Expression Regulation
Plasmids
Escherichia coli

Artificial regulation of gene expression in Escherichia coli by RNase P

Guerrier-Takada, C., Li Ying, Y. & Altman, S., 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 24, p. 1115-1119 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Synthetic Genes
Gene Expression Regulation
Escherichia coli
1 Citation (Scopus)

Characterization of RNA with unusual electrophoretic mobility from tissues of patients with Crohn's disease

Lundberg, U., West, A. B. & Altman, S., Sep 11 1995, In : FEBS Letters. 371, 3, p. 345-350 6 p.

Research output: Contribution to journalArticle

Electrophoretic mobility
Crohn Disease
RNA
Tissue
Viroids
103 Citations (Scopus)

Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli

Liu, F. & Altman, S., 1995, In : Genes and Development. 9, 4, p. 471-480 10 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Viral Genes
Thymidine Kinase
Catalytic Domain
66 Citations (Scopus)

Processing of the precursor to the catalytic RNA subunit of RNase P from Escherichia coli

Lundberg, U. & Altman, S., 1995, In : RNA. 1, 3, p. 327-334 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Catalytic Domain
RNA
Escherichia coli
27 Citations (Scopus)

RNase P in research and therapy

Altman, S., 1995, In : Bio/Technology. 13, 4, p. 327-329 3 p.

Research output: Contribution to journalArticle

Endoribonucleases
Ribonuclease P
Catalytic RNA
RNA Precursors
Structure-Activity Relationship
67 Citations (Scopus)

Substrate recognition by human RNase P: Identification of small, model substrates for the enzyme

Yuan, Y. & Altman, S., 1995, In : EMBO Journal. 14, 1, p. 159-168 10 p.

Research output: Contribution to journalArticle

Ribonuclease P
Transfer RNA
Identification (control systems)
Nucleotides
Substrates
1994
79 Citations (Scopus)

Differential evolution of substrates for an RNA enzyme in the presence and absence of its protein cofactor

Liu, F. & Altman, S., Jul 1 1994, In : Cell. 77, 7, p. 1093-1100 8 p.

Research output: Contribution to journalArticle

Catalytic RNA
RNA
Substrates
Enzymes
Proteins