Sidney Altman

Professor

  • 10589 Citations
  • 53 h-Index
1970 …2019
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Research Output 1970 2019

2019

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

Miroshnichenko, S. K., Patutina, O. A., Burakova, E. A., Chelobanov, B. P., Fokina, A. A., Vlassov, V. V., Altman, S., Zenkova, M. A. & Stetsenko, D. A., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1229-1234 6 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Ribonuclease H
Oligodeoxyribonucleotides
Oligonucleotides
RNA Cleavage
2018

Modified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P

Novopashina, D. S., Nazarov, A. S., Vorobjeva, M. A., Kuprushkin, M. S., Davydova, A. S., Lomzov, A. A., Pyshnyi, D. V., Altman, S. & Venyaminova, A. G., Nov 1 2018, In : Molecular Biology. 52, 6, p. 905-912 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
Oligonucleotides
Bacterial RNA
Hydrolysis

Modified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P

Novopashina, D. S., Nazarov, A. S., Vorobjeva, M. A., Kuprushkin, M. S., Davydova, A. S., Lomzov, A. A., Pyshnyi, D. V., Altman, S. & Venyaminova, A. G., Nov 1 2018, In : Molekuliarnaia biologiia. 52, 6, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Cleavage
Oligonucleotides
Bacterial RNA
Hydrolysis
2017
31 Citations (Scopus)

Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity

Terekhov, S. S., Smirnov, I. V., Stepanova, A. V., Bobik, T. V., Mokrushina, Y. A., Ponomarenko, N. A., Belogurov, A. A., Rubtsova, M. P., Kartseva, O. V., Gomzikova, M. O., Moskovtsev, A. A., Bukatin, A. S., Dubina, M. V., Kostryukova, E. S., Babenko, V. V., Vakhitova, M. T., Manolov, A. I., Malakhova, M. V., Kornienko, M. A., Tyakht, A. V. & 5 othersVanyushkina, A. A., Ilina, E. N., Masson, P., Gabibov, A. G. & Altman, S., Mar 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. 2550-2555 6 p.

Research output: Contribution to journalArticle

Microfluidics
Biodiversity
Paraoxon
Butyrylcholinesterase
Forensic Anthropology

The origin of life, “the World of RNA,” and the problem of antibiotic resistance

Altman, S., Nov 1 2017, In : Herald of the Russian Academy of Sciences. 87, 6, p. 474-479 6 p.

Research output: Contribution to journalArticle

chemistry
Ministry of Education
medicine
genetic engineering
biochemistry
2016
16 Citations (Scopus)

Aptamers against pathogenic microorganisms

Davydova, A., Vorobjeva, M., Pyshnyi, D., Altman, S., Vlassov, V. & Venyaminova, A., Nov 1 2016, In : Critical Reviews in Microbiology. 42, 6, p. 847-865 19 p.

Research output: Contribution to journalReview article

Nucleic Acids
Molecular Medicine
Modern 1601-history
Biotechnology
Virion
21 Citations (Scopus)

Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses

Liu, Y., Padmanabhan, J., Cheung, B., Liu, J., Chen, Z., Scanley, B. E., Wesolowski, D., Pressley, M., Broadbridge, C. C., Altman, S., Schwarz, U. D., Kyriakides, T. R. & Schroers, J., May 27 2016, In : Scientific Reports. 6, 26950.

Research output: Contribution to journalArticle

Glass
2015
11 Citations (Scopus)

Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III

Serruya, R., Orlovetskie, N., Reiner, R., Dehtiar-Zilber, Y., Wesolowski, D., Altman, S. & Jarrous, N., Apr 24 2015, In : Nucleic Acids Research. 43, 11, p. 5442-5450 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Polymerase III
Ribonucleoproteins
Cell Extracts
rRNA Genes
7 Citations (Scopus)

Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum

Garg, A., Wesolowski, D., Alonso, D., Deitsch, K. W., Ben Mamoun, C. & Altman, S., Sep 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 38, p. 11935-11940 6 p.

Research output: Contribution to journalArticle

RNA Splicing
Morpholinos
RNA Stability
Chloroquine
Protein Biosynthesis
1 Citation (Scopus)

Twenty years

Altman, S., Apr 1 2015, In : RNA. 21, 4, p. 513-514 2 p.

Research output: Contribution to journalShort survey

21st Century History
20th Century History
RNA
2014
6 Citations (Scopus)

Antibiotics present and future

Altman, S., Jan 3 2014, In : FEBS Letters. 588, 1, p. 1-2 2 p.

Research output: Contribution to journalReview article

Anti-Bacterial Agents
Morpholinos
Peptides
Research
Surveys and Questionnaires
2013
22 Citations (Scopus)

A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model

Sawyer, A. J., Wesolowski, D., Gandotra, N., Stojadinovic, A., Izadjoo, M., Altman, S. & Kyriakides, T. R., 2013, In : International Journal of Pharmaceutics. 453, 2, p. 651-655 5 p.

Research output: Contribution to journalArticle

Morpholinos
Staphylococcus aureus
Messenger RNA
Skin
Peptides
20 Citations (Scopus)
Cell-Penetrating Peptides
Morpholinos
Anti-Bacterial Agents
Peptides
Genes
22 Citations (Scopus)

Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum

Augagneur, Y., Jaubert, L., Schiavoni, M., Pachikara, N., Garg, A., Usmani-Brown, S., Wesolowski, D., Zeller, S., Ghosal, A., Cornillot, E., Said, H. M., Kumar, P., Altman, S. & Ben Mamoun, C., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20558-20567 10 p.

Research output: Contribution to journalArticle

Functional analysis
Falciparum Malaria
Parasites
Plasmodium falciparum
Cell membranes
8 Citations (Scopus)

The RNA-protein world

Altman, S., May 2013, In : RNA. 19, 5, p. 589-590 2 p.

Research output: Contribution to journalReview article

RNA
Proteins
Chromosomes
Gene Expression
2012
24 Citations (Scopus)

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

Augagneur, Y., Wesolowski, D., Tae, H. S., Altman, S. & Mamoun, C. B., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6235-6240 6 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Morpholinos
Parasites
Messenger RNA
Antimalarials
580 Citations (Scopus)

RNA therapeutics: Beyond RNA interference and antisense oligonucleotides

Kole, R., Krainer, A. R. & Altman, S., Feb 2012, In : Nature Reviews Drug Discovery. 11, 2, p. 125-140 16 p.

Research output: Contribution to journalReview article

Antisense Oligonucleotides
RNA Interference
Oligonucleotides
RNA
Down-Regulation

U.S. basic research: Still number one?

Altman, S., Sep 28 2012, In : Science. 337, 6102, p. 1605 1 p.

Research output: Contribution to journalLetter

National Institutes of Health (U.S.)
Biomedical Research
Research
2011
28 Citations (Scopus)

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Wesolowski, D., Tae, H. S., Gandotra, N., Llopis, P., Shen, N. & Altman, S., Oct 4 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16582-16587 6 p.

Research output: Contribution to journalArticle

Morpholinos
Bacteria
Peptides
Nucleic Acids
Genes
2 Citations (Scopus)

Inactivation of expression of two genes in Saccharomyces cerevisiae with the external guide sequence methodology

Cheng, X., Ko, J. H. & Altman, S., Mar 2011, In : RNA. 17, 3, p. 544-549 6 p.

Research output: Contribution to journalArticle

Ribonuclease P
Saccharomyces cerevisiae
RNA
Gene Expression
Yeasts
17 Citations (Scopus)

Ribonuclease P

Altman, S., Oct 27 2011, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 366, 1580, p. 2936-2941 6 p.

Research output: Contribution to journalReview article

Ribonuclease P
ribonucleases
RNA
enzyme
Molecules
11 Citations (Scopus)

RNA binding properties of conserved protein subunits of human RNase P

Reiner, R., Alfiya-Mor, N., Berrebi-Demma, M., Wesolowski, D., Altman, S. & Jarrous, N., Jul 2011, In : Nucleic Acids Research. 39, 13, p. 5704-5714 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
RNA
Transfer RNA
Catalytic Domain
2010
5 Citations (Scopus)

History of RNase P and overview of its catalytic activity

Altman, S., 2010, Ribonuclease P. Vol. 10. p. 1-15 15 p. (Protein Reviews; vol. 10).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ribonuclease P
Catalyst activity
Catalytic RNA
Escherichia coli
History
28 Citations (Scopus)

Inhibition of gene expression by RNase P

Lundblad, E. W. & Altman, S., Jul 31 2010, In : New Biotechnology. 27, 3, p. 212-221 10 p.

Research output: Contribution to journalReview article

Ribonuclease P
RNA
Gene expression
RNA Cleavage
Prokaryotic Cells
1 Citation (Scopus)

Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA

Xiao, G., Wesolowski, D., Izadjoo, M. & Altman, S., Nov 2010, In : RNA. 16, 11, p. 2218-2225 8 p.

Research output: Contribution to journalArticle

Morpholinos
RNA
Messenger RNA
Ribonuclease P
Guide RNA
2009
31 Citations (Scopus)

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

Shen, N., Ko, J. H., Xiao, G., Wesolowski, D., Shan, G., Geller, B., Lzadjoo, M. & Altman, S., May 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 20, p. 8163-8168 6 p.

Research output: Contribution to journalArticle

Guide RNA
Morpholinos
Technology
Gene Expression
Oligonucleotides
2008
8 Citations (Scopus)

Inhibition of expression in Escherichia coli of a virulence regulator MglB of Francisella tularensis using external guide sequence technology

Xiao, G., Lundblad, E. W., Izadjoo, M. & Altman, S., Nov 13 2008, In : PLoS One. 3, 11, e3719.

Research output: Contribution to journalArticle

Francisella tularensis
Escherichia coli
Virulence
virulence
screening
14 Citations (Scopus)

Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P

Ko, J. H., Izadjoo, M. & Altman, S., Aug 2008, In : RNA. 14, 8, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

Ribonuclease P
Yersinia pestis
Virulence
Escherichia coli
Gene Expression
16 Citations (Scopus)
Ribonuclease P
RNA
Escherichia coli
Messenger RNA
Gels
28 Citations (Scopus)

RNase P cleaves the adenine riboswitch and stabilizes pbuE mRNA in Bacillus subtilis

Seif, E. & Altman, S., Jun 2008, In : RNA. 14, 6, p. 1237-1243 7 p.

Research output: Contribution to journalArticle

Riboswitch
Ribonuclease P
Adenine
Bacillus subtilis
Messenger RNA
2007
27 Citations (Scopus)

A noncoding RNA in Saccharomyces cerevisiae is an RNase P substrate

Yang, L. & Altman, S., May 2007, In : RNA. 13, 5, p. 682-690 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
Reading Frames
Untranslated RNA
Antisense RNA
Saccharomyces cerevisiae
2 Citations (Scopus)

An overview of the RNA world - For now

Altman, S., Jul 1 2007, In : Biological Chemistry. 388, 7, p. 663-664 2 p.

Research output: Contribution to journalComment/debate

Ribonuclease P
Ribosomes
RNA
47 Citations (Scopus)

A view of RNase P

Altman, S., 2007, In : Molecular BioSystems. 3, 9, p. 604-607 4 p.

Research output: Contribution to journalArticle

Ribonuclease P
Crystallography
Eukaryota
Yeast
Catalyst activity

Foreword

Altman, S., Jan 1 2007, MicroRNAs: From Basic Science to Disease Biology. Cambridge University Press, p. xxv-xxvi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

MicroRNAs
RNA
Regulator Genes
Eukaryota
Computer Simulation
23 Citations (Scopus)
Ribonuclease P
Nucleotide Motifs
RNA
Bacteria
Riboswitch
2005
2 Citations (Scopus)

Analysis of putative RNase P RNA from orthopoxviruses

Yang, L., Wesolowski, D., Li, Y. & Altman, S., Dec 2 2005, In : Journal of Molecular Biology. 354, 3, p. 529-535 7 p.

Research output: Contribution to journalArticle

Orthopoxvirus
Ribonuclease P
RNA
Vaccinia
HeLa Cells
22 Citations (Scopus)

An open letter to Elias Zerhouni [1]

Altman, S., Bassler, B. L., Beckwith, J., Belfort, M., Berg, H. C., Bloom, B., Brenchley, J. E., Campbell, A., Collier, R. J., Connell, N., Cozzarelli, N. R., Craig, N. L., Darst, S., Ebright, R. H., Elledge, S. J., Falkow, S., Galan, J. E., Gottesman, M., Gourse, R., Grindley, N. D. F. & 30 othersGross, C. A., Grossman, A., Hochschild, A., Howe, M., Hurwitz, J., Isberg, R. R., Kaplan, S., Kornberg, A., Kustu, S. G., Landick, R. C., Landy, A., Levy, S. B., Losick, R., Long, S. R., Maloy, S. R., Mekalanos, J. J., Neidhardt, F. C., Pace, N. R., Ptashne, M., Roberts, J. W., Roth, J. R., Rothman-Denes, L. B., Salyers, A., Schaechter, M., Shapiro, L., Silhavy, T. J., Simon, M. I., Walker, G., Yanofsky, C. & Zinder, N., Mar 4 2005, In : Science. 307, 5714, p. 1409-1410 2 p.

Research output: Contribution to journalLetter

Foreword

Altman, S., 2005, Non-viral Gene Therapy: Gene Design and Delivery. Springer-Verlag Tokyo, p. V

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

3 Citations (Scopus)

Masters of DNA.

Altman, S., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 14361-14365 5 p.

Research output: Contribution to journalArticle

20th Century History
England
DNA
5 Citations (Scopus)

Regulated expression of functional external guide sequences in mammalian cells using a U6 RNA polymerase III promoter

Kovrigina, E., Yang, L., Pfund, E. & Altman, S., Oct 2005, In : RNA. 11, 10, p. 1588-1595 8 p.

Research output: Contribution to journalArticle

Ribonuclease P
RNA Polymerase III
Protein Subunits
Lamin Type A
Ecdysone
66 Citations (Scopus)

RNase P cleaves transient structures in some riboswitches

Altman, S., Wesolowski, D., Guerrier-Takada, C. & Li, Y., Aug 9 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 32, p. 11284-11289 6 p.

Research output: Contribution to journalArticle

Riboswitch
Ribonuclease P
Escherichia coli
Aspergillus nidulans
5' Untranslated Regions
3 Citations (Scopus)

Using ethics to fight bioterrorism [1] (multiple letters)

Frankel, M. S., Li, L., Green, S. K., Rath, J., Jank, B., Perman, B., Agre, P. C., Altman, S., Curl, R. F., Wiesel, T. N., West-Eberhard, M. J., Somerville, M. & Atlas, R., Aug 12 2005, In : Science. 309, 5737, p. 1012-1017 6 p.

Research output: Contribution to journalLetter

2004
23 Citations (Scopus)

Disruption of type III secretion in Salmonella enterica serovar typhimurium by external guide sequences

McKinney, J. S., Zhang, H., Kubori, T., Galán, J. E. & Altman, S., 2004, In : Nucleic Acids Research. 32, 2, p. 848-854 7 p.

Research output: Contribution to journalArticle

Salmonella enterica
Messenger RNA
Salmonella
Ribonuclease P
Oligonucleotides
21 Citations (Scopus)
Ribonuclease P
Protein Subunits
Small Interfering RNA
Messenger RNA
Transfection
36 Citations (Scopus)

In search of RNase P RNA from microbial genomes

Li, Y. & Altman, S., Oct 2004, In : RNA. 10, 10, p. 1533-1540 8 p.

Research output: Contribution to journalArticle

Microbial Genome
Ribonuclease P
RNA
Orthopoxvirus
Archaea
35 Citations (Scopus)

Polarity effects in the lactose operon of Escherichia coli

Li, Y. & Altman, S., May 21 2004, In : Journal of Molecular Biology. 339, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
Lac Operon
Escherichia coli
Reporter Genes
Temperature
2003
75 Citations (Scopus)
Endoribonucleases
Ribonuclease P
Operon
Gene Expression
Messenger RNA
17 Citations (Scopus)

Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P

Kovrigina, E., Wesolowski, D. & Altman, S., Feb 18 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 4, p. 1598-1602 5 p.

Research output: Contribution to journalArticle

Ribonuclease P
Protein Subunits
Genes
Transfection
Proteins
2 Citations (Scopus)

RNA Processing: A Postdoc in a Great Laboratory

Altman, S., Dec 2003, In : Genetics. 165, 4, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

21st Century History
20th Century History
Catalytic RNA
RNA
United Kingdom
28 Citations (Scopus)

The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli

Li, Y., Cole, K. & Altman, S., May 1 2003, In : RNA. 9, 5, p. 518-532 15 p.

Research output: Contribution to journalArticle

Ribonuclease P
Escherichia coli
Gene Expression
Mutation
Intergenic DNA