Salvatore Oddo

Associate Professor

  • 17139 Citations
  • 55 h-Index
20022024
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Research Output 2002 2019

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Article
2009
119 Citations (Scopus)

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study

Ouellet, M., Emond, V., Chen, C. T., Julien, C., Bourasset, F., Oddo, S., LaFerla, F., Bazinet, R. P. & Calon, F., Dec 2009, In : Neurochemistry International. 55, 7, p. 476-482 7 p.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Docosahexaenoic Acids
Blood-Brain Barrier
Perfusion
Brain
26 Citations (Scopus)

Genetically altering aβ distribution from the brain to the vasculature ameliorates tau pathology

Oddo, S., Caccamo, A., Cheng, D. & Laferla, F. M., Jul 2009, In : Brain Pathology. 19, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Pathology
Brain
Genes
Apolipoproteins E
166 Citations (Scopus)

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

McAlpine, F. E., Lee, J. K., Harms, A. S., Ruhn, K. A., Blurton-Jones, M., Hong, J., Das, P., Golde, T. E., LaFerla, F. M., Oddo, S., Blesch, A. & Tansey, M. G., Apr 2009, In : Neurobiology of Disease. 34, 1, p. 163-177 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Alzheimer Disease
Tumor Necrosis Factor-alpha
Pathology
Central Nervous System
58 Citations (Scopus)

Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

Guan, H., Liu, Y., Daily, A., Police, S., Kim, M. H., Oddo, S., LaFerla, F. M., Pauly, J. R., Murphy, M. P. & Hersh, L. B., May 1 2009, In : Journal of Neuroscience Research. 87, 6, p. 1462-1473 12 p.

Research output: Contribution to journalArticle

Neprilysin
Amyloid
Alzheimer Disease
Brain
Peptides
103 Citations (Scopus)

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

Caccamo, A., Majumder, S., Deng, J. J., Bai, Y., Thornton, F. B. & Oddo, S., Oct 2 2009, In : Journal of Biological Chemistry. 284, 40, p. 27416-27424 9 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Intermediate Filaments
Autophagy
Molecular mass
Sirolimus
61 Citations (Scopus)

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

Bourasset, F., Ouellet, M., Tremblay, C., Julien, C., Do, T. M., Oddo, S., LaFerla, F. & Calon, F., Mar 2009, In : Neuropharmacology. 56, 4, p. 808-813 6 p.

Research output: Contribution to journalArticle

Transgenic Mice
Alzheimer Disease
Brain
Blood Vessels
Blood-Brain Barrier
59 Citations (Scopus)

Validation of a 2-day water maze protocol in mice

Gulinello, M., Gertner, M., Mendoza, G., Schoenfeld, B. P., Oddo, S., LaFerla, F., Choi, C. H., McBride, S. M. J. & Faber, D. S., Jan 23 2009, In : Behavioural Brain Research. 196, 2, p. 220-227 8 p.

Research output: Contribution to journalArticle

Water
Locomotion
Alzheimer Disease
Transgenes
Neurodegenerative Diseases
2008
99 Citations (Scopus)

Blocking Aβ42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: A mechanistic link between Aβ and tau pathology

Oddo, S., Caccamo, A., Tseng, B., Cheng, D., Vasilevko, V., Cribbs, D. H. & LaFerla, F. M., Nov 19 2008, In : Journal of Neuroscience. 28, 47, p. 12163-12175 13 p.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Shock
Alzheimer Disease
Hot Temperature
Pathology
129 Citations (Scopus)

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice

Janelsins, M. C., Mastrangelo, M. A., Park, K. M., Sudol, K. L., Narrow, W. C., Oddo, S., LaFerla, F. M., Callahan, L. M., Federoff, H. J. & Bowers, W. J., Dec 2008, In : American Journal of Pathology. 173, 6, p. 1768-1782 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Tumor Necrosis Factor-alpha
Neurons
Amyloid
Transgenic Mice
160 Citations (Scopus)

Congo red and thioflavin-T analogs detect Aβ oligomers

Maezawa, I., Hong, H. S., Liu, R., Wu, C. Y., Cheng, R. H., Kung, M. P., Kung, H. F., Lam, K. S., Oddo, S., LaFerla, F. M. & Jin, L. W., Jan 2008, In : Journal of Neurochemistry. 104, 2, p. 457-468 12 p.

Research output: Contribution to journalArticle

Congo Red
Oligomers
Ligands
Alzheimer Disease
Amyloid
167 Citations (Scopus)

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

McKee, A. C., Carreras, I., Hossain, L., Ryu, H., Klein, W. L., Oddo, S., LaFerla, F. M., Jenkins, B. G., Kowall, N. W. & Dedeoglu, A., May 1 2008, In : Brain Research. 1207, p. 225-236 12 p.

Research output: Contribution to journalArticle

Ibuprofen
Memory Disorders
Aptitude
Confocal Microscopy
Transgenic Mice
241 Citations (Scopus)

Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's Ddisease

Rodríguez, J. J., Jones, V. C., Tabuchi, M., Allan, S. M., Knight, E. M., LaFerla, F. M., Oddo, S. & Verkhratsky, A., Aug 13 2008, In : PLoS One. 3, 8, e2935.

Research output: Contribution to journalArticle

neurogenesis
Neurogenesis
Dentate Gyrus
Alzheimer disease
Transgenic Mice
100 Citations (Scopus)

Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice

Lopez, J. R., Lyckman, A., Oddo, S., LaFerla, F. M., Querfurth, H. W. & Shtifman, A., Apr 2008, In : Journal of Neurochemistry. 105, 1, p. 262-271 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Neurons
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Homeostasis
Amyloidogenic Proteins
155 Citations (Scopus)

The ubiquitin-proteasome system in Alzheimer's disease

Oddo, S., Apr 2008, In : Journal of Cellular and Molecular Medicine. 12, 2, p. 363-373 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Alzheimer Disease
Neurodegenerative diseases
Neurodegenerative Diseases
2007
176 Citations (Scopus)

Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

Clinton, L. K., Billings, L. M., Green, K. N., Caccamo, A., Ngo, J., Oddo, S., McGaugh, J. L. & LaFerla, F. M., Oct 2007, In : Neurobiology of Disease. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Sex Characteristics
Cognition
Corticosterone
Water
Phenotype
115 Citations (Scopus)

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Cole, A. R., Noble, W., Aalten, L. V., Plattner, F., Meimaridou, R., Hogan, D., Taylor, M., LaFrancois, J., Gunn-Moore, F., Verkhratsky, A., Oddo, S., Laferla, F., Giese, K. P., Dineley, K. T., Duff, K., Richardson, J. C., Yan, S. D., Hanger, D. P., Allan, S. M. & Sutherland, C., Nov 2007, In : Journal of Neurochemistry. 103, 3, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Disease Progression
Alzheimer Disease
Cyclin-Dependent Kinase 5
Amyloid beta-Protein Precursor
61 Citations (Scopus)

Genetically augmenting tau levels does not modulate the onset or progression of Aβ pathology in transgenic mice

Oddo, S., Caccamo, A., Cheng, D., Jouleh, B., Torp, R. & LaFerla, F. M., Aug 2007, In : Journal of Neurochemistry. 102, 4, p. 1053-1063 11 p.

Research output: Contribution to journalArticle

Pathology
Transgenic Mice
Alzheimer Disease
Amyloid
Tauopathies
1244 Citations (Scopus)

Intracellular amyloid-β in Alzheimer's disease

LaFerla, F. M., Green, K. N. & Oddo, S., Jul 2007, In : Nature Reviews Neuroscience. 8, 7, p. 499-509 11 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Peptides
Transgenic Mice
Disease Progression
151 Citations (Scopus)

Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles

Caccamo, A., Oddo, S., Tran, L. X. & LaFerla, F. M., May 2007, In : American Journal of Pathology. 170, 5, p. 1669-1675 7 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Memory Disorders
Short-Term Memory
Lithium
Phosphorylation
156 Citations (Scopus)

Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid

Giménez-Llort, L., Blázquez, G., Cañete, T., Johansson, B., Oddo, S., Tobeña, A., LaFerla, F. M. & Fernández-Teruel, A., 2007, In : Neuroscience and Biobehavioral Reviews. 31, 1, p. 125-147 23 p.

Research output: Contribution to journalArticle

Behavioral Symptoms
Amyloid
Alzheimer Disease
Cholinergic Agents
Technology Transfer
112 Citations (Scopus)

Neural stem cells improve memory in an inducible mouse model of neuronal loss

Yamasaki, T. R., Blurton-Jones, M., Morrissette, D. A., Kitazawa, M., Oddo, S. & LaFerla, F. M., Oct 31 2007, In : Journal of Neuroscience. 27, 44, p. 11925-11933 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cells
Memory Disorders
Brain Diseases
Tetracycline
205 Citations (Scopus)

Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice

Carroll, J. C., Rosario, E. R., Chang, L., Stanczyk, F. Z., Oddo, S., LaFerla, F. M. & Pike, C. J., Nov 28 2007, In : Journal of Neuroscience. 27, 48, p. 13357-13365 9 p.

Research output: Contribution to journalArticle

Progesterone
Alzheimer Disease
Estrogens
Neuropathology
Hormones
2006
182 Citations (Scopus)

A dynamic relationship between intracellular and extracellular pools of Aβ

Oddo, S., Caccamo, A., Smith, I. F., Green, K. N. & LaFerla, F. M., Jan 2006, In : American Journal of Pathology. 168, 1, p. 184-194 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid Plaques
Amyloid
Immunotherapy
Antibodies
109 Citations (Scopus)

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease

Rosario, E. R., Carroll, J. C., Oddo, S., LaFerla, F. M. & Pike, C. J., Dec 20 2006, In : Journal of Neuroscience. 26, 51, p. 13384-13389 6 p.

Research output: Contribution to journalArticle

Transgenic Mice
Androgens
Alzheimer Disease
Dihydrotestosterone
Neuropathology
214 Citations (Scopus)

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice

Stutzmann, G. E., Smith, I., Caccamo, A., Oddo, S., LaFerla, F. M. & Parker, I., 2006, In : Journal of Neuroscience. 26, 19, p. 5180-5189 10 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Young Adult
Alzheimer Disease
Endoplasmic Reticulum
Mutation
320 Citations (Scopus)

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

Caccamo, A., Oddo, S., Billings, L. M., Green, K. N., Martinez-Coria, H., Fisher, A. & LaFerla, F. M., Mar 2 2006, In : Neuron. 49, 5, p. 671-682 12 p.

Research output: Contribution to journalArticle

Transgenic Mice
Pathology
Cognition
Dicyclomine
Muscarinic Agonists
241 Citations (Scopus)

Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

Oddo, S., Vasilevko, V., Caccamo, A., Kitazawa, M., Cribbs, D. H. & LaFerla, F. M., Dec 22 2006, In : Journal of Biological Chemistry. 281, 51, p. 39413-39423 11 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Amyloid
Transgenic Mice
Alzheimer Disease
Immunization
322 Citations (Scopus)

Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: A link between Aβ and tau pathology

Oddo, S., Caccamo, A., Tran, L., Lambert, M. P., Glabe, C. G., Klein, W. L. & LaFerla, F. M., Jan 20 2006, In : Journal of Biological Chemistry. 281, 3, p. 1599-1604 6 p.

Research output: Contribution to journalArticle

Oligomerization
Pathology
Amyloid
Alzheimer Disease
Oligomers
107 Citations (Scopus)

The role of nicotinic acetylcholine receptors in Alzheimer's disease

Oddo, S. & LaFerla, F. M., Mar 2006, In : Journal of Physiology Paris. 99, 2-3, p. 172-179 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Alzheimer Disease
Cholinergic Agents
tau Proteins
Neurofibrillary Tangles
2005
246 Citations (Scopus)

Age- and region-dependent alterations in Aβ-degrading enzymes: Implications for Aβ-induced disorders

Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y. & LaFerla, F. M., May 2005, In : Neurobiology of Aging. 26, 5, p. 645-654 10 p.

Research output: Contribution to journalArticle

Insulysin
Neprilysin
Alzheimer Disease
Enzymes
Inclusion Body Myositis
292 Citations (Scopus)

Alzheimer's disease: Aβ, tau and synaptic dysfunction

LaFerla, F. M. & Oddo, S., Apr 2005, In : Trends in Molecular Medicine. 11, 4, p. 170-176 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Alzheimer Disease
Neurofibrillary Tangles
Neuronal Plasticity
Amyloid Plaques
155 Citations (Scopus)

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

Oddo, S., Caccamo, A., Green, K. N., Liang, K., Tran, L., Chen, Y., Leslie, F. M. & LaFerla, F. M., Feb 22 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 8, p. 3046-3051 6 p.

Research output: Contribution to journalArticle

Nicotine
Alzheimer Disease
Pathology
Nicotinic Receptors
Phosphorylation
156 Citations (Scopus)
Entorhinal Cortex
Chemokine CCL2
Alzheimer Disease
Tumor Necrosis Factor-alpha
Hippocampus
116 Citations (Scopus)

Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease

Smith, I. F., Hitt, B., Green, K. N., Oddo, S. & LaFerla, F. M., Sep 2005, In : Journal of Neurochemistry. 94, 6, p. 1711-1718 8 p.

Research output: Contribution to journalArticle

Caffeine
Alzheimer Disease
Neurons
Presenilin-1
Ryanodine Receptor Calcium Release Channel
870 Citations (Scopus)

Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L. & LaFerla, F. M., Mar 3 2005, In : Neuron. 45, 5, p. 675-688 14 p.

Research output: Contribution to journalArticle

Transgenic Mice
Alzheimer Disease
Pathology
Memory Disorders
Amygdala
422 Citations (Scopus)

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease

Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N. & LaFerla, F. M., Sep 28 2005, In : Journal of Neuroscience. 25, 39, p. 8843-8853 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Lipopolysaccharides
Alzheimer Disease
Pathology
Inflammation
2004
673 Citations (Scopus)

Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H. & LaFerla, F. M., Aug 5 2004, In : Neuron. 43, 3, p. 321-332 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Immunotherapy
Alzheimer Disease
Pathology
Neurofibrillary Tangles
380 Citations (Scopus)

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T. & Cotman, C. W., Jul 2004, In : Journal of Clinical Investigation. 114, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Caspases
Alzheimer Disease
Pathology
Glycogen Synthase Kinase 3
80 Citations (Scopus)

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

Shakkottai, V. G., Chou, C. H., Oddo, S., Sailer, C. A., Knaus, H. G., Gutman, G. A., Barish, M. E., LaFerla, F. M. & Chandy, K. G., Feb 2004, In : Journal of Clinical Investigation. 113, 4, p. 582-590 9 p.

Research output: Contribution to journalArticle

Cerebellar Nuclei
Cerebellar Ataxia
Small-Conductance Calcium-Activated Potassium Channels
Riluzole
Apamin
2003
635 Citations (Scopus)

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Oddo, S., Caccamo, A., Kitazawa, M., Tseng, B. P. & LaFerla, F. M., Dec 2003, In : Neurobiology of Aging. 24, 8, p. 1063-1070 8 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Pathology
Hippocampus
Presenilin-1
2534 Citations (Scopus)

Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y. & LaFerla, F. M., Jul 31 2003, In : Neuron. 39, 3, p. 409-421 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Neuronal Plasticity
Transgenes
Neurofibrillary Tangles
Amyloid Plaques
2002
92 Citations (Scopus)

Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle

Sugarman, M. C., Yamasaki, T. R., Oddo, S., Echegoyen, J. C., Murphy, M. P., Golde, T. E., Jannatipour, M., Leissring, M. A. & LaFerla, F. M., Apr 30 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 9, p. 6334-6339 6 p.

Research output: Contribution to journalArticle

Inclusion Body Myositis
Amyloid beta-Protein Precursor
Skeletal Muscle
Phenotype
Transgenic Mice