• 17022 Citations
  • 55 h-Index
20022024
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Research Output 2002 2019

2019
1 Citation (Scopus)

Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

Velazquez, R., Meechoovet, B., Ow, A., Foley, C., Shaw, A., Smith, B., Oddo, S., Hulme, C. & Dunckley, T., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Alzheimer Disease
Neurofibrillary Tangles
Pathology
Amyloid Plaques
Amyloid beta-Protein Precursor

Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice

Vartak, R. S., Rodin, A. & Oddo, S., Nov 2019, In : Neurobiology of Aging. 83, p. 105-113 9 p.

Research output: Contribution to journalArticle

Autophagy
Sirolimus
Alzheimer Disease
Memory Disorders
Amyloid
1 Citation (Scopus)

Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation

Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W. & Oddo, S., Dec 1 2019, In : Aging Cell. 18, 6, e13037.

Research output: Contribution to journalArticle

Open Access
Microglia
Choline
Alzheimer Disease
Pathology
Food
4 Citations (Scopus)

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

Velazquez, R., Ferreira, E., Winslow, W., Dave, N., Piras, I. S., Naymik, M., Huentelman, M. J., Tran, A., Caccamo, A. & Oddo, S., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Homocysteine
Choline
Alzheimer Disease
Mothers
Pathology
2018
12 Citations (Scopus)

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

Velazquez, R., Ferreira, E., Tran, A., Turner, E. C., Belfiore, R., Branca, C. & Oddo, S., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Dependovirus
Memory Disorders
Hippocampus
Learning
Microtubule Proteins

Corrigendum to “Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease” [Neurobiol. Aging 58 (2017) 1–13](S0197458017301999)(10.1016/j.neurobiolaging.2017.06.003)

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., May 1 2018, In : Neurobiology of Aging. 65, p. 235-238 4 p.

Research output: Contribution to journalComment/debate

Publications
Actins
Alzheimer Disease
Ointments
Insulin
11 Citations (Scopus)

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease

Caccamo, A., Belfiore, R. & Oddo, S., Aug 1 2018, In : Neurobiology of Aging. 68, p. 59-67 9 p.

Research output: Contribution to journalArticle

Sirolimus
Alzheimer Disease
Insulin
Genetic Hybridization
Prosencephalon
13 Citations (Scopus)

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

Belfiore, R., Rodin, A., Ferreira, E., Velazquez, R., Branca, C., Caccamo, A. & Oddo, S., Jan 1 2018, (Accepted/In press) In : Aging Cell. e12873.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Hippocampus
Entorhinal Cortex
Memory Disorders
2017
24 Citations (Scopus)

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., Oct 1 2017, In : Neurobiology of Aging. 58, p. 1-13 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Insulin
Insulin Resistance
Central Nervous System
Vascular Resistance

Corrigendum to “Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease” [Neurobiol. Aging 58 (2017) 1–13] (S0197458017301999) (10.1016/j.neurobiolaging.2017.06.003))

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., Oct 1 2017, In : Neurobiology of Aging. 58, p. 241 1 p.

Research output: Contribution to journalComment/debate

Ointments
Alzheimer Disease
Insulin
corrigendum
21 Citations (Scopus)

Dyrk1 inhibition improves Alzheimer's disease-like pathology

Branca, C., Shaw, D. M., Belfiore, R., Gokhale, V., Shaw, A. Y., Foley, C., Smith, B., Hulme, C., Dunckley, T., Meechoovet, B., Caccamo, A. & Oddo, S., Oct 1 2017, In : Aging Cell. 16, 5, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Amyloid beta-Protein Precursor
Phosphorylation
Inhibition (Psychology)
15 Citations (Scopus)

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Branca, C., Ferreira, E., Nguyen, T. V., Doyle, K., Caccamo, A. & Oddo, S., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4823-4835 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Interferon-gamma
Brain
Animal Models
Antioxidant Response Elements
23 Citations (Scopus)

mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease

Norambuena, A., Wallrabe, H., McMahon, L., Silva, A., Swanson, E., Khan, S. S., Baerthlein, D., Kodis, E., Oddo, S., Mandell, J. W. & Bloom, G. S., Feb 1 2017, In : Alzheimer's and Dementia. 13, 2, p. 152-167 16 p.

Research output: Contribution to journalArticle

Amyloid
Cell Cycle
Alzheimer Disease
Insulin
Brain
60 Citations (Scopus)

Necroptosis activation in Alzheimer's disease

Caccamo, A., Branca, C., Piras, I. S., Ferreira, E., Huentelman, M. J., Liang, W. S., Readhead, B., Dudley, J. T., Spangenberg, E. E., Green, K. N., Belfiore, R., Winslow, W. & Oddo, S., Sep 1 2017, In : Nature Neuroscience. 20, 9, p. 1236-1246 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Protein Kinases
Necrosis
Phosphotransferases
1 Citation (Scopus)

Paving the Way for New Clinical Trials for Alzheimer's Disease

Branca, C. & Oddo, S., Jan 15 2017, In : Biological Psychiatry. 81, 2, p. 88-89 2 p.

Research output: Contribution to journalComment/debate

Alzheimer Disease
Clinical Trials
2016
5 Citations (Scopus)

Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer's disease

Ferreira, E., Shaw, D. M. & Oddo, S., Jul 5 2016, In : Translational Psychiatry. 6, 7, e849.

Research output: Contribution to journalArticle

Hippocampus
Alzheimer Disease
Learning
Proteins
RNA Transport
35 Citations (Scopus)

p62 improves AD-like pathology by increasing autophagy

Caccamo, A., Ferreira, E., Branca, C. & Oddo, S., Aug 30 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Autophagy
Alzheimer Disease
Pathology
Frontotemporal Lobar Degeneration
Neurofibrillary Tangles
13 Citations (Scopus)

Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease

Velazquez, R., Shaw, D. M., Caccamo, A. & Oddo, S., Jul 13 2016, In : Molecular Neurodegeneration. 11, 1, 52.

Research output: Contribution to journalArticle

Alzheimer Disease
Proline
Sirolimus
Therapeutics
Proteasome Endopeptidase Complex
2015
23 Citations (Scopus)

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

Mastroeni, D., Delvaux, E., Nolz, J., Tan, Y., Grover, A., Oddo, S. & Coleman, P., Dec 1 2015, In : Neurobiology of Aging. 36, 12, p. 3121-3129 9 p.

Research output: Contribution to journalArticle

Epigenomics
Alzheimer Disease
Cell Nucleus
Histones
Lysine

Genetically modified rodent models: A new generation of translational cognitive science

Oddo, S. & Kitazawa, M., 2015, In : Neuromethods. 94, p. 259-283 25 p.

Research output: Contribution to journalArticle

Cognitive Science
Rodentia
Data storage equipment
Learning
Brain

Genetically modified rodent models: A new generation of translational cognitive science

Oddo, S. & Kitazawa, M., Mar 10 2015, The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York, p. 259-283 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cognitive Science
Rodentia
rodents
learning
Learning
53 Citations (Scopus)

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

Richardson, A., Galvan, V., Lin, A. L. & Oddo, S., Aug 1 2015, In : Experimental Gerontology. 68, p. 51-58 8 p.

Research output: Contribution to journalArticle

Sirolimus
Alzheimer Disease
Aging of materials
Research
Cerebrovascular Circulation
12 Citations (Scopus)

Reduced protein turnover mediates functional deficits in transgenic mice expressing the 25 kDa C-terminal fragment of TDP-43

Caccamo, A., Shaw, D. M., Guarino, F., Messina, A., Walker, A. W. & Oddo, S., Apr 28 2015, In : Human Molecular Genetics. 24, 16, p. 4625-4635 11 p., ddv193.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Amyotrophic Lateral Sclerosis
Transgenic Mice
Autophagy
Proteasome Endopeptidase Complex
44 Citations (Scopus)

Reducing ribosomal protein S6 kinase 1 expression improves spatial memory and synaptic plasticity in a mouse model of Alzheimer’s disease

Caccamo, A., Branca, C., Talboom, J. S., Shaw, D. M., Turner, D., Ma, L., Messina, A., Huang, Z., Wu, J. & Oddo, S., Oct 14 2015, In : Journal of Neuroscience. 35, 41, p. 14042-14056 15 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Neuronal Plasticity
Alzheimer Disease
Memory Disorders
Amyloid
16 Citations (Scopus)

The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease

Talboom, J. S., Velazquez, R. & Oddo, S., Jan 1 2015, In : npj Aging and Mechanisms of Disease. 1, 1, 15008.

Research output: Contribution to journalReview article

Sirolimus
Alzheimer Disease
Neurodegenerative Diseases
Cognitive Aging
Population
2014
20 Citations (Scopus)
DNA-Binding Proteins
Transgenic Mice
aspartyl-arginyl-valyl-tyrosyl-isoleucyl-histidyl-prolyl-phenylalanyl-histidyl-leucyl-valyl-isoleucyl-histidine
Frontotemporal Lobar Degeneration
Phenotype
26 Citations (Scopus)

Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease

Branca, C., Wisely, E. V., Hartman, L. K., Caccamo, A. & Oddo, S., Dec 1 2014, In : Neurobiology of Aging. 35, 12, p. 2726-2735 10 p.

Research output: Contribution to journalArticle

Adrenergic Antagonists
Alzheimer Disease
Adrenergic Receptors
Amyloidogenic Proteins
Neuropathology
86 Citations (Scopus)

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

Caccamo, A., De Pinto, V., Messina, A., Branca, C. & Oddo, S., 2014, In : Journal of Neuroscience. 34, 23, p. 7988-7998 11 p.

Research output: Contribution to journalArticle

Sirolimus
Transcriptome
Alzheimer Disease
Autophagy
Amyloid Plaques
12 Citations (Scopus)

Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies

Wisely, E. V., Xiang, Y. K. & Oddo, S., 2014, In : Human Molecular Genetics. 23, 15, p. 4024-4034 11 p., ddu116.

Research output: Contribution to journalArticle

Tauopathies
Genetic Suppression
Adrenergic Receptors
Pathology
Transgenic Mice
42 Citations (Scopus)

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

Orr, M. E., Salinas, A., Buffenstein, R. & Oddo, S., Jun 2014, In : Neurobiology of Aging. 35, 6, p. 1233-1242 10 p.

Research output: Contribution to journalArticle

Sirolimus
Sucrose
Alzheimer Disease
Pathology
Diet
21 Citations (Scopus)

Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents

Edrey, Y. H., Oddo, S., Cornelius, C., Caccamo, A., Calabrese, V. & Buffenstein, R., Feb 2014, In : Journal of Neuroscience Research. 92, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

Mole Rats
Amyloid
Rodentia
Brain
Heat-Shock Proteins
2013
34 Citations (Scopus)

Amyloid beta and the longest-lived rodent: The naked mole-rat as a model for natural protection from alzheimer's disease

Edrey, Y. H., Medina, D. X., Gaczynska, M., Osmulski, P. A., Oddo, S., Caccamo, A. & Buffenstein, R., Oct 2013, In : Neurobiology of Aging. 34, 10, p. 2352-2360 9 p.

Research output: Contribution to journalArticle

Mole Rats
Amyloid
Rodentia
Alzheimer Disease
Poisons
62 Citations (Scopus)

Autophagic/lysosomal dysfunction in Alzheimer's disease

Orr, M. E. & Oddo, S., 2013, In : Alzheimer's Research and Therapy. 5, 5, 53.

Research output: Contribution to journalArticle

Alzheimer Disease
Autophagy
Organelles
Poisons
Hydrolases
24 Citations (Scopus)
DNA-Binding Proteins
Transgenic Mice
Glucocorticoids
Glutathione
Frontotemporal Dementia
175 Citations (Scopus)

mTOR regulates tau phosphorylation and degradation: Implications for Alzheimer's disease and other tauopathies

Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López-Aranda, M. F., Silva, A. J. & Oddo, S., Jun 2013, In : Aging Cell. 12, 3, p. 370-380 11 p.

Research output: Contribution to journalArticle

Tauopathies
Sirolimus
Alzheimer Disease
Phosphorylation
Pathology
52 Citations (Scopus)

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease

Walker, M. P., Laferla, F. M., Oddo, S. & Brewer, G. J., Jun 2013, In : Age. 35, 3, p. 519-531 13 p.

Research output: Contribution to journalArticle

Histone Code
Epigenomics
Alzheimer Disease
Neurons
Acetylation
46 Citations (Scopus)

Β2 adrenergic receptor, protein kinase a (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in alzheimer disease models

Wang, D., Fu, Q., Zhou, Y., Xu, B., Shi, Q., Igwe, B., Matt, L., Hell, J. W., Wisely, E. V., Oddo, S. & Xiang, Y. K., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10298-10307 10 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Pathology
Adrenergic Receptors
Protein Kinases
Alzheimer Disease
2012
34 Citations (Scopus)

BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of alzheimer's disease: Differential aβ antibody labeling of early-onset axon terminal pathology

Cai, Y., Zhang, X. M., MacKlin, L. N., Cai, H., Luo, X. G., Oddo, S., Laferla, F. M., Struble, R. G., Rose, G. M., Patrylo, P. R. & Yan, X. X., Feb 2012, In : Neurotoxicity Research. 21, 2, p. 160-174 15 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid Plaques
Presynaptic Terminals
Pathology
Amyloid
23 Citations (Scopus)

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

Yan, X. X., Cai, Y., Shelton, J., Deng, S. H., Luo, X. G., Oddo, S., LaFerla, F. M., Cai, H., Rose, G. M. & Patrylo, P. R., Nov 14 2012, In : PLoS One. 7, 11, e48782.

Research output: Contribution to journalArticle

neuropathology
Temporal Lobe Epilepsy
epilepsy
Alzheimer disease
Alzheimer Disease
35 Citations (Scopus)

Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43

Caccamo, A., Majumder, S. & Oddo, S., Jan 2012, In : American Journal of Pathology. 180, 1, p. 293-302 10 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
DNA-Binding Proteins
Transgenic Mice
Frontotemporal Dementia
Amyotrophic Lateral Sclerosis
2401 Citations (Scopus)

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. 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Research output: Contribution to journalArticle

Autophagy
Guidelines
Lysosomes
Eukaryota
Research Personnel
122 Citations (Scopus)

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

Majumder, S., Caccamo, A., Medina, D. X., Benavides, A. D., Javors, M. A., Kraig, E., Strong, R., Richardson, A. & Oddo, S., Apr 2012, In : Aging Cell. 11, 2, p. 326-335 10 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Sirolimus
Interleukin-1
Memory Disorders
Learning
19 Citations (Scopus)

Sortilin is required for toxic action of Aβ oligomers (AβOs): Extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways

Takamura, A., Sato, Y., Watabe, D., Okamoto, Y., Nakata, T., Kawarabayashi, T., Oddo, S., Laferla, F. M., Shoji, M. & Matsubara, E., Dec 10 2012, In : Life Sciences. 91, 23-24, p. 1177-1186 10 p.

Research output: Contribution to journalArticle

Toxic Actions
Oligomers
Apoptosis
Degradation
Endocytosis
87 Citations (Scopus)

The role of mTOR signaling in Alzheimer disease

Oddo, S., Jan 1 2012, In : Frontiers in Bioscience - Scholar. 4 S, 3, p. 941-952 12 p.

Research output: Contribution to journalArticle

Sirolimus
Alzheimer Disease
Learning
Data storage equipment
Memory Disorders
48 Citations (Scopus)

Toxic role of K + channel oxidation in mammalian brain

Cotella, D., Hernandez-Enriquez, B., Wu, X., Li, R., Pan, Z., Leveille, J., Link, C. D., Oddo, S. & Sesti, F., Mar 21 2012, In : Journal of Neuroscience. 32, 12, p. 4133-4144 12 p.

Research output: Contribution to journalArticle

Poisons
Alzheimer Disease
Brain
Oxidants
Apoptosis
2011
204 Citations (Scopus)

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

Majumder, S., Richardson, A., Strong, R. & Oddo, S., Sep 28 2011, In : PLoS One. 6, 9, e25416.

Research output: Contribution to journalArticle

autophagy
Autophagy
Sirolimus
Alzheimer disease
Alzheimer Disease
137 Citations (Scopus)

Methylene blue reduces Aβ levels and rescues early cognitive deficit by increasing proteasome activity

Medina, D. X., Caccamo, A. & Oddo, S., Mar 2011, In : Brain Pathology. 21, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

Methylene Blue
Proteasome Endopeptidase Complex
Alzheimer Disease
Pathology
Phase II Clinical Trials
103 Citations (Scopus)

Naturally secreted amyloid-β increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

Caccamo, A., Maldonado, M. A., Majumder, S., Medina, D. X., Holbein, W., Magrí, A. & Oddo, S., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 8924-8932 9 p.

Research output: Contribution to journalArticle

Sirolimus
Amyloid
Proline
Substrates
Alzheimer Disease
8 Citations (Scopus)

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular Beta-Amyloid peptides

Bianchi, F. T., Camera, P., Ala, U., Imperiale, D., Migheli, A., Boda, E., Tempia, F., Berto, G., Bosio, Y., Oddo, S., LaFerla, F. M., Taraglio, S., Dotti, C. G. & Di Cunto, F., 2011, In : PLoS One. 6, 7, e22370.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid beta-Peptides
amyloid
collagen
Collagen
2010
106 Citations (Scopus)

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., Laferla, F. M., Spencer, T. A., Hickey, W. F. & Chang, T. Y., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3081-3086 6 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Pathology
Brain
Hydroxymethylglutaryl CoA Reductases