Research Output 1989 2017

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2017
1 Citations

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Yang, M., Dent, M., Lai, H., Sun, H. & Chen, Q. 2017 (Accepted/In press) In : Vaccine.

Research output: Research - peer-reviewArticle

Zika virus
neutralization
immunization
immune response
proteins

Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

Yang, M., Lai, H., Sun, H. & Chen, Q. Dec 1 2017 In : Scientific Reports. 7, 1, 7679

Research output: Research - peer-reviewArticle

Viral Envelope Proteins
Virion
Protein Domains
Zika Virus
Hepatitis B Core Antigens
2016
Agrobacterium
MicroRNAs
Tobacco
Antibodies
Agrobacterium tumefaciens
3 Citations

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

Dent, M., Hurtado, J., Paul, A. M., Sun, H., Lai, H., Yang, M., Esqueda, A., Bai, F., Steinkellner, H. & Chen, Q. Dec 1 2016 In : Journal of General Virology. 97, 12, p. 3280-3290 11 p., 000635

Research output: Research - peer-reviewArticle

Antibody-Dependent Enhancement
Dengue Virus
Monoclonal Antibodies
Infection
Glycosylation
2015
8 Citations

Gene delivery into plant cells for recombinant protein production

Chen, Q. & Lai, H. 2015 In : BioMed Research International. 2015, 932161

Research output: Research - peer-reviewArticle

Plant Cells
Recombinant Proteins
Genes
Scalability
Costs
5 Citations

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

Chen, Q. May 1 2015 In : Biotechnology Journal. 10, 5, p. 671-680 10 p.

Research output: Research - peer-reviewArticle

West Nile Virus Vaccines
Vaccines
Costs and Cost Analysis
West Nile virus
Economics
7 Citations

Purification of monoclonal antibody against Ebola GP1 protein expressed in Nicotiana benthamiana

Fulton, A., Lai, H., Chen, Q. & Zhang, C. Apr 10 2015 In : Journal of Chromatography A. 1389, p. 128-132 5 p.

Research output: Research - peer-reviewArticle

Plant Proteins
Chromatography
Polyelectrolytes
Purification
Monoclonal Antibodies
2014
15 Citations

A plant-produced antigen elicits potent immune responses against west nile virus in mice

He, J., Peng, L., Lai, H., Hurtado, J., Stahnke, J. & Chen, Q. 2014 In : BioMed Research International. 2014, 952865

Research output: Research - peer-reviewArticle

Plant Antigens
Viruses
Vaccines
West Nile virus
Endoplasmic Reticulum
21 Citations

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus

He, J., Lai, H., Engle, M., Gorlatov, S., Gruber, C., Steinkellner, H., Diamond, M. S. & Chen, Q. Mar 27 2014 In : PLoS One. 9, 3, e93541

Research output: Research - peer-reviewArticle

Plantibodies
West Nile virus
Monoclonal Antibodies
Therapeutics
therapeutics
4 Citations

Plant-made biologics

Chen, Q., Santi, L. & Zhang, C. 2014 In : BioMed Research International. 2014, 418064

Research output: Research - peer-reviewArticle

21 Citations

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Loos, A., Diamond, M. S. & Chen, Q. 2014 In : Plant Biotechnology Journal. 12, 8, p. 1098-1107 10 p.

Research output: Research - peer-reviewArticle

West Nile virus
monoclonal antibodies
Monoclonal Antibodies
therapeutics
glycosylation
2013
31 Citations

Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins

Leuzinger, K., Dent, M., Hurtado, J., Stahnke, J., Lai, H., Zhou, X. & Chen, Q. 2013 In : Journal of visualized experiments : JoVE. 77

Research output: Research - peer-reviewArticle

Recombinant Proteins
Proteins
Recombinant proteins
Syringes
Infiltration
41 Citations

Plant-derived virus-like particles as vaccines

Chen, Q. & Lai, H. Jan 2013 In : Human Vaccines and Immunotherapeutics. 9, 1, p. 26-49 24 p.

Research output: Research - peer-reviewArticle

Virus-Like Particle Vaccines
Plant Viruses
Virion
Vaccines
Safety
2012
19 Citations
West Nile virus
Costs and Cost Analysis
Viruses
Costs
Scalability
58 Citations
Norwalk virus
bioprocessing
virus-like particles
coat proteins
manufacturing
41 Citations

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Lai, H., He, J., Engle, M., Diamond, M. S. & Chen, Q. Jan 2012 In : Plant Biotechnology Journal. 10, 1, p. 95-104 10 p.

Research output: Research - peer-reviewArticle

Lettuce
Replicon
Virion
Monoclonal Antibodies
Proteins
2011
36 Citations

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. S. & Herbst-Kralovetz, M. M. Dec 20 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Research - peer-reviewArticle

Ebolavirus
Subunit Vaccines
Antigen-Antibody Complex
Ebola Hemorrhagic Fever
Viruses
51 Citations

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Phoolcharoen, W., Bhoo, S. H., Lai, H., Ma, J., Arntzen, C. J., Chen, Q. & Mason, H. S. Sep 2011 In : Plant Biotechnology Journal. 9, 7, p. 807-816 10 p.

Research output: Research - peer-reviewArticle

antigen-antibody complex
Nicotiana benthamiana
Antigen-Antibody Complex
Tobacco
Ebolavirus
55 Citations

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

Chen, Q., He, J., Phoolcharoen, W. & Mason, H. S. Mar 2011 In : Human Vaccines. 7, 3, p. 331-338 8 p.

Research output: Research - peer-reviewArticle

Vaccines
Monoclonal Antibodies
Viruses
Antigens
Proteins
10 Citations

Turning a new leaf

Chen, Q. S. Jun 2011 In : EBR - European Biopharmaceutical Review. SUMMER 2011

Research output: Research - peer-reviewArticle

2010
90 Citations

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K. J., Arntzen, C. J., Mason, H. S. & Chen, Q. May 1 2010 In : Biotechnology and Bioengineering. 106, 1, p. 9-17 9 p.

Research output: Research - peer-reviewArticle

Replicon
Monoclonal Antibodies
DNA
Monoclonal antibodies
Viruses
60 Citations

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

Laia, H., Engleb, M., Fuchsb, A., Kellera, T., Johnsonc, S., Gorlatovc, S., Diamond, M. S. & Chena, Q. Feb 9 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2419-2424 6 p.

Research output: Research - peer-reviewArticle

West Nile virus
Virus Diseases
Monoclonal Antibodies
Therapeutics
Emerging Communicable Diseases
83 Citations

Norwalk virus-like particles as vaccines

Herbst-Kralovetz, M., Mason, H. S. & Chen, Q. 2010 In : Expert Review of Vaccines. 9, 3, p. 299-307 9 p.

Research output: Research - peer-reviewArticle

Virus-Like Particle Vaccines
Norwalk virus
Virion
Norovirus
Antibodies
2009
90 Citations

A DNA replicon system for rapid high-level production of virus-like particles in plants

Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. & Mason, H. Jul 1 2009 In : Biotechnology and Bioengineering. 103, 4, p. 706-714 9 p.

Research output: Research - peer-reviewArticle

Replicon
Virion
DNA
Viruses
Proteins
117 Citations

Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria

Slater, S. C. , Goldman, B. S. , Goodner, B. , Setubal, J. C. , Farrand, S. K. , Nester, E. W. , Burr, T. J. , Banta, L. , Dickerman, A. W. , Paulsen, I. , Otten, L. , Suen, G. , Welch, R. , Almeida, N. F. , Arnold, F. , Burton, O. T. , Du, Z. , Ewing, A. , Godsy, E. , Heisel, S. & 16 others Houmiel, K. L., Jhaveri, J., Lu, J., Miller, N. M., Norton, S., Chen, Q., Phoolcharoen, W., Ohlin, V., Ondrusek, D., Pride, N., Stricklin, S. L., Sun, J., Wheeler, C., Wilson, L., Zhu, H. & Wood, D. W. Apr 2009 In : Journal of Bacteriology. 191, 8, p. 2501-2511 11 p.

Research output: Research - peer-reviewArticle

Agrobacterium
Chromosomes
Genome
Bacteria
Rhizobiaceae
2008
109 Citations

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C. J., Chen, Q. & Mason, H. S. Mar 28 2008 In : Vaccine. 26, 15, p. 1846-1854 9 p.

Research output: Research - peer-reviewArticle

Norwalk virus
virus-like particles
Virion
oral vaccination
mice
123 Citations

Viral vectors for production of recombinant proteins in plants

Lico, C., Chen, Q. & Santi, L. Aug 2008 In : Journal of Cellular Physiology. 216, 2, p. 366-377 12 p.

Research output: Research - peer-reviewArticle

Recombinant Proteins
Genetic engineering
Molecular biology
Cell culture
Gene expression
2005
5 Citations

Expression of porcine prorelaxin in transgenic tobacco

Buswell, S., Medina-Bolivar, F., Chen, Q., Van Cott, K. & Zhang, C. 2005 In : Annals of the New York Academy of Sciences. 1041, p. 77-81 5 p.

Research output: Research - peer-reviewArticle

Relaxin
Tobacco
Swine
prorelaxin
Genetically Modified Plants
1996
61 Citations

Isolation and characterization of glutamine synthetase genes in Chlamydomonas reinhardtii

Chen, Q. & Silflow, C. D. Nov 1996 In : Plant Physiology. 112, 3, p. 987-996 10 p.

Research output: Research - peer-reviewArticle

Chlamydomonas reinhardtii
glutamate-ammonia ligase
assimilation (physiology)
nitrates
genes
1994
42 Citations

A 21-kDa chloroplast heat shock protein assembles into high molecular weight complexes in vivo and in organelle

Chen, Q., Osteryoung, K. & Vierling, E. May 6 1994 In : Journal of Biological Chemistry. 269, 18, p. 13216-13223 8 p.

Research output: Research - peer-reviewArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Organelles
Molecular Weight
1991
75 Citations

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein

Chen, Q. & Vierling, E. May 1991 In : MGG Molecular & General Genetics. 226, 3, p. 425-431 7 p.

Research output: Research - peer-reviewArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Methionine
Petunia
3 Citations

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein.

Chen, Q. & Vierling, E. Aug 1991 In : Molecular and General Genetics. 228, 1-2, p. 328 1 p.

Research output: Research - peer-reviewArticle

Erratum

Chen, Q. & Vierling, E. Aug 1991 In : MGG Molecular & General Genetics. 228, 1-2, p. 328 1 p.

Research output: Research - peer-reviewArticle

1990
67 Citations

Accumulation, stability, and localization of a major chloroplast heat-shock protein

Chen, Q., Lauzon, L. M., DeRocher, A. E. & Vierling, E. Jun 1990 In : Journal of Cell Biology. 110, 6, p. 1873-1883 11 p.

Research output: Research - peer-reviewArticle

Chloroplast Proteins
Heat-Shock Proteins
Chloroplasts
Proteins
Molecular Weight
1989
30 Citations

The major low-molecular-weight heat shock protein in chloroplasts shows antigenic conservation among diverse higher plant species.

Vierling, E., Harris, L. M. & Chen, Q. Feb 1989 In : Molecular and Cellular Biology. 9, 2, p. 461-468 8 p.

Research output: Research - peer-reviewArticle

Chloroplasts
Heat-Shock Proteins
Molecular Weight
Peas
Chloroplast Proteins