• 2098 Citations
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1989 …2024

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2020

Codelivery of improved immune complex and virus-like particle vaccines containing Zika virus envelope domain III synergistically enhances immunogenicity

Diamos, A. G., Pardhe, M. D., Sun, H., Hunter, J. G. L., Mor, T., Meador, L., Kilbourne, J., Chen, Q. & Mason, H. S., Apr 16 2020, In : Vaccine. 38, 18, p. 3455-3463 9 p.

Research output: Contribution to journalArticle

Open Access

High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System

Diamos, A. G., Hunter, J. G. L., Pardhe, M. D., Rosenthal, S. H., Sun, H., Foster, B. C., DiPalma, M. P., Chen, Q. & Mason, H. S., Jan 17 2020, In : Frontiers in Bioengineering and Biotechnology. 7, 472.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2019

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants

Hurtado, J., Acharya, D., Lai, H., Sun, H., Kallolimath, S., Steinkellner, H., Bai, F. & Chen, Q., Jan 1 2019, In : Plant Biotechnology Journal.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

Lai, H., Paul, A. M., Sun, H., He, J., Yang, M., Bai, F. & Chen, Q., Mar 27 2018, In : Vaccine. 36, 14, p. 1846-1852 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice

Yang, M., Sun, H., Lai, H., Hurtado, J. & Chen, Q., Feb 1 2018, In : Plant Biotechnology Journal. 16, 2, p. 572-580 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2017

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Yang, M., Dent, M., Lai, H., Sun, H. & Chen, Q., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

32 Scopus citations

Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

Yang, M., Lai, H., Sun, H. & Chen, Q., Dec 1 2017, In : Scientific Reports. 7, 1, 7679.

Research output: Contribution to journalArticle

45 Scopus citations
2016

A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

Powell, J. D., Chen, Q. & Mason, H., Aug 1 2016, In : Journal of Microbiological Methods. 127, p. 230-235 6 p.

Research output: Contribution to journalArticle

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

Dent, M., Hurtado, J., Paul, A. M., Sun, H., Lai, H., Yang, M., Esqueda, A., Bai, F., Steinkellner, H. & Chen, Q., Dec 1 2016, In : Journal of General Virology. 97, 12, p. 3280-3290 11 p., 000635.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Gene delivery into plant cells for recombinant protein production

Chen, Q. & Lai, H., 2015, In : BioMed Research International. 2015, 932161.

Research output: Contribution to journalArticle

27 Scopus citations

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

Chen, Q., May 1 2015, In : Biotechnology Journal. 10, 5, p. 671-680 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Purification of monoclonal antibody against Ebola GP1 protein expressed in Nicotiana benthamiana

Fulton, A., Lai, H., Chen, Q. & Zhang, C., Apr 10 2015, In : Journal of Chromatography A. 1389, p. 128-132 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

A plant-produced antigen elicits potent immune responses against west nile virus in mice

He, J., Peng, L., Lai, H., Hurtado, J., Stahnke, J. & Chen, Q., 2014, In : BioMed Research International. 2014, 952865.

Research output: Contribution to journalArticle

24 Scopus citations

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus

He, J., Lai, H., Engle, M., Gorlatov, S., Gruber, C., Steinkellner, H., Diamond, M. S. & Chen, Q., Mar 27 2014, In : PloS one. 9, 3, e93541.

Research output: Contribution to journalArticle

33 Scopus citations

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Loos, A., Diamond, M. S. & Chen, Q., Jan 1 2014, In : Plant Biotechnology Journal. 12, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins

Leuzinger, K., Dent, M., Hurtado, J., Stahnke, J., Lai, H., Zhou, X. & Chen, Q., Jul 23 2013, In : Journal of Visualized Experiments. 77, p. e50521

Research output: Contribution to journalArticle

80 Scopus citations
2012

A novel system for rapid and cost-effective production of detection and diagnostic reagents of West Nile virus in plants

He, J., Lai, H., Brock, C. & Chen, Q., Jan 12 2012, In : Journal of Biomedicine and Biotechnology. 2012, 106783.

Research output: Contribution to journalArticle

27 Scopus citations
76 Scopus citations

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Lai, H., He, J., Engle, M., Diamond, M. S. & Chen, Q., Jan 1 2012, In : Plant Biotechnology Journal. 10, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. & Herbst-Kralovetz, M. M., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Phoolcharoen, W., Bhoo, S. H., Lai, H., Ma, J., Arntzen, C. J., Chen, Q. & Mason, H., Sep 1 2011, In : Plant Biotechnology Journal. 9, 7, p. 807-816 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
2010

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K. J., Arntzen, C. J., Mason, H. & Chen, Q., May 1 2010, In : Biotechnology and bioengineering. 106, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

Laia, H., Engleb, M., Fuchsb, A., Kellera, T., Johnsonc, S., Gorlatovc, S., Diamond, M. S. & Chen, Q., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2419-2424 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2009

A DNA replicon system for rapid high-level production of virus-like particles in plants

Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. & Mason, H., Jul 1 2009, In : Biotechnology and bioengineering. 103, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria

Slater, S. C., Goldman, B. S., Goodner, B., Setubal, J. C., Farrand, S. K., Nester, E. W., Burr, T. J., Banta, L., Dickerman, A. W., Paulsen, I., Otten, L., Suen, G., Welch, R., Almeida, N. F., Arnold, F., Burton, O. T., Du, Z., Ewing, A., Godsy, E., Heisel, S. & 16 others, Houmiel, K. L., Jhaveri, J., Lu, J., Miller, N. M., Norton, S., Chen, Q., Phoolcharoen, W., Ohlin, V., Ondrusek, D., Pride, N., Stricklin, S. L., Sun, J., Wheeler, C., Wilson, L., Zhu, H. & Wood, D. W., Apr 1 2009, In : Journal of bacteriology. 191, 8, p. 2501-2511 11 p.

Research output: Contribution to journalArticle

154 Scopus citations
2008

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C. J., Chen, Q. & Mason, H., Mar 28 2008, In : Vaccine. 26, 15, p. 1846-1854 9 p.

Research output: Contribution to journalArticle

136 Scopus citations
2005

Expression of porcine prorelaxin in transgenic tobacco

Buswell, S., Medina-Bolivar, F., Chen, Q., Van Cott, K. & Zhang, C., Jan 1 2005, In : Annals of the New York Academy of Sciences. 1041, p. 77-81 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
1996

Isolation and characterization of glutamine synthetase genes in Chlamydomonas reinhardtii

Chen, Q. & Silflow, C. D., Nov 1996, In : Plant Physiology. 112, 3, p. 987-996 10 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations
1994

A 21-kDa chloroplast heat shock protein assembles into high molecular weight complexes in vivo and in organelle

Chen, Q., Osteryoung, K. & Vierling, E., May 6 1994, In : Journal of Biological Chemistry. 269, 18, p. 13216-13223 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
1991

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein

Chen, Q. & Vierling, E., May 1 1991, In : MGG Molecular & General Genetics. 226, 3, p. 425-431 7 p.

Research output: Contribution to journalArticle

81 Scopus citations
1990

Accumulation, stability, and localization of a major chloroplast heat-shock protein

Chen, Q., Lauzon, L. M., DeRocher, A. E. & Vierling, E., Jun 1990, In : Journal of Cell Biology. 110, 6, p. 1873-1883 11 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations
1989

The major low-molecular-weight heat shock protein in chloroplasts shows antigenic conservation among diverse higher plant species.

Vierling, E., Harris, L. M. & Chen, Q., Feb 1989, In : Molecular and cellular biology. 9, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations