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Research Output 1989 2019

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Article
2019
1 Citation (Scopus)

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants

Hurtado, J., Acharya, D., Lai, H., Sun, H., Kallolimath, S., Steinkellner, H., Bai, F. & Chen, Q., Jan 1 2019, In : Plant Biotechnology Journal.

Research output: Contribution to journalArticle

Open Access
Chikungunya virus
Nicotiana benthamiana
Tobacco
monoclonal antibodies
Monoclonal Antibodies
2018
5 Citations (Scopus)

A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

Lai, H., Paul, A. M., Sun, H., He, J., Yang, M., Bai, F. & Chen, Q., Jan 1 2018, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Zika virus
West Nile virus
Dengue virus
Dengue Virus
Virus Diseases
15 Citations (Scopus)

Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice

Yang, M., Sun, H., Lai, H., Hurtado, J. & Chen, Q., Feb 1 2018, In : Plant Biotechnology Journal. 16, 2, p. 572-580 9 p.

Research output: Contribution to journalArticle

Zika virus
Viral Envelope Proteins
neutralization
Immunity
immunity
2017
25 Citations (Scopus)

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Yang, M., Dent, M., Lai, H., Sun, H. & Chen, Q., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Zika virus
Viral Envelope Proteins
neutralization
Immunization
immunization
39 Citations (Scopus)

Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

Yang, M., Lai, H., Sun, H. & Chen, Q., Dec 1 2017, In : Scientific Reports. 7, 1, 7679.

Research output: Contribution to journalArticle

Viral Envelope Proteins
Virion
Hepatitis B Core Antigens
Dengue Virus
Vaccines
2016

A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

Powell, J. D., Chen, Q. & Mason, H., Aug 1 2016, In : Journal of Microbiological Methods. 127, p. 230-235 6 p.

Research output: Contribution to journalArticle

Agrobacterium
MicroRNAs
Tobacco
Antibodies
Agrobacterium tumefaciens
12 Citations (Scopus)

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

Dent, M., Hurtado, J., Paul, A. M., Sun, H., Lai, H., Yang, M., Esqueda, A., Bai, F., Steinkellner, H. & Chen, Q., Dec 1 2016, In : Journal of General Virology. 97, 12, p. 3280-3290 11 p., 000635.

Research output: Contribution to journalArticle

Antibody-Dependent Enhancement
Dengue Virus
Monoclonal Antibodies
Glycosylation
Infection
2015
21 Citations (Scopus)

Gene delivery into plant cells for recombinant protein production

Chen, Q. & Lai, H., 2015, In : BioMed Research International. 2015, 932161.

Research output: Contribution to journalArticle

Plant Cells
Recombinant Proteins
Genes
Scalability
Transgenes
9 Citations (Scopus)

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

Chen, Q., May 1 2015, In : Biotechnology Journal. 10, 5, p. 671-680 10 p.

Research output: Contribution to journalArticle

West Nile Virus Vaccines
Vaccines
West Nile virus
Costs and Cost Analysis
Economics
16 Citations (Scopus)

Purification of monoclonal antibody against Ebola GP1 protein expressed in Nicotiana benthamiana

Fulton, A., Lai, H., Chen, Q. & Zhang, C., Apr 10 2015, In : Journal of Chromatography A. 1389, p. 128-132 5 p.

Research output: Contribution to journalArticle

Plant Proteins
Chromatography
Polyelectrolytes
Tobacco
Purification
2014
21 Citations (Scopus)

A plant-produced antigen elicits potent immune responses against west nile virus in mice

He, J., Peng, L., Lai, H., Hurtado, J., Stahnke, J. & Chen, Q., 2014, In : BioMed Research International. 2014, 952865.

Research output: Contribution to journalArticle

Plant Antigens
West Nile virus
Viruses
Vaccines
Immunization
30 Citations (Scopus)

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus

He, J., Lai, H., Engle, M., Gorlatov, S., Gruber, C., Steinkellner, H., Diamond, M. S. & Chen, Q., Mar 27 2014, In : PLoS One. 9, 3, e93541.

Research output: Contribution to journalArticle

Plantibodies
West Nile virus
Antibody-Dependent Enhancement
Viruses
Monoclonal Antibodies
7 Citations (Scopus)

Plant-made biologics

Chen, Q., Santi, L. & Zhang, C., 2014, In : BioMed Research International. 2014, 418064.

Research output: Contribution to journalArticle

Plant Extracts
Biological Products
31 Citations (Scopus)

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Loos, A., Diamond, M. S. & Chen, Q., 2014, In : Plant Biotechnology Journal. 12, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

West Nile virus
monoclonal antibodies
Monoclonal Antibodies
glycosylation
Glycosylation
2013
77 Citations (Scopus)

Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins

Leuzinger, K., Dent, M., Hurtado, J., Stahnke, J., Lai, H., Zhou, X. & Chen, Q., 2013, In : Journal of visualized experiments : JoVE. 77

Research output: Contribution to journalArticle

Recombinant proteins
Syringes
Recombinant Proteins
Proteins
Infiltration
59 Citations (Scopus)

Plant-derived virus-like particles as vaccines

Chen, Q. & Lai, H., Jan 2013, In : Human Vaccines and Immunotherapeutics. 9, 1, p. 26-49 24 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Plant Viruses
Virion
Vaccines
Safety
2012
25 Citations (Scopus)
West Nile virus
Viruses
Costs and Cost Analysis
Costs
Scalability
73 Citations (Scopus)
Norwalk virus
bioprocessing
virus-like particles
coat proteins
manufacturing
62 Citations (Scopus)

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Lai, H., He, J., Engle, M., Diamond, M. S. & Chen, Q., Jan 2012, In : Plant Biotechnology Journal. 10, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

biopharmaceuticals
replicon
Lettuce
Replicon
virus-like particles
2011
50 Citations (Scopus)

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. & Herbst-Kralovetz, M. M., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Contribution to journalArticle

Ebolavirus
Subunit Vaccines
Antigen-Antibody Complex
Ebola Hemorrhagic Fever
Ebola Vaccines
71 Citations (Scopus)

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Phoolcharoen, W., Bhoo, S. H., Lai, H., Ma, J., Arntzen, C. J., Chen, Q. & Mason, H., Sep 2011, In : Plant Biotechnology Journal. 9, 7, p. 807-816 10 p.

Research output: Contribution to journalArticle

antigen-antibody complex
Ebolavirus
Nicotiana benthamiana
Antigen-Antibody Complex
Tobacco
69 Citations (Scopus)

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

Chen, Q., He, J., Phoolcharoen, W. & Mason, H., Mar 2011, In : Human Vaccines. 7, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle

Vaccines
Monoclonal Antibodies
Viruses
Antigens
Replicon
12 Citations (Scopus)

Turning a new leaf

Chen, Q., Jun 2011, In : EBR - European Biopharmaceutical Review. SUMMER 2011

Research output: Contribution to journalArticle

2010
122 Citations (Scopus)

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K. J., Arntzen, C. J., Mason, H. & Chen, Q., May 1 2010, In : Biotechnology and Bioengineering. 106, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Replicon
Monoclonal antibodies
Viruses
DNA
Monoclonal Antibodies
74 Citations (Scopus)

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

Laia, H., Engleb, M., Fuchsb, A., Kellera, T., Johnsonc, S., Gorlatovc, S., Diamond, M. S. & Chen, Q., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2419-2424 6 p.

Research output: Contribution to journalArticle

West Nile virus
Virus Diseases
Monoclonal Antibodies
Emerging Communicable Diseases
Viral Fusion Proteins
87 Citations (Scopus)

Norwalk virus-like particles as vaccines

Herbst-Kralovetz, M., Mason, H. & Chen, Q., 2010, In : Expert Review of Vaccines. 9, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Norwalk virus
Virion
Norovirus
Plant Cells
2009
110 Citations (Scopus)

A DNA replicon system for rapid high-level production of virus-like particles in plants

Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. & Mason, H., Jul 1 2009, In : Biotechnology and Bioengineering. 103, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

Replicon
Viruses
Virion
DNA
Virus-Like Particle Vaccines
150 Citations (Scopus)

Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria

Slater, S. C., Goldman, B. S., Goodner, B., Setubal, J. C., Farrand, S. K., Nester, E. W., Burr, T. J., Banta, L., Dickerman, A. W., Paulsen, I., Otten, L., Suen, G., Welch, R., Almeida, N. F., Arnold, F., Burton, O. T., Du, Z., Ewing, A., Godsy, E., Heisel, S. & 16 others, Houmiel, K. L., Jhaveri, J., Lu, J., Miller, N. M., Norton, S., Chen, Q., Phoolcharoen, W., Ohlin, V., Ondrusek, D., Pride, N., Stricklin, S. L., Sun, J., Wheeler, C., Wilson, L., Zhu, H. & Wood, D. W., Apr 2009, In : Journal of Bacteriology. 191, 8, p. 2501-2511 11 p.

Research output: Contribution to journalArticle

Agrobacterium
Chromosomes
Genome
Bacteria
Rhizobiaceae
2008
131 Citations (Scopus)

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C. J., Chen, Q. & Mason, H., Mar 28 2008, In : Vaccine. 26, 15, p. 1846-1854 9 p.

Research output: Contribution to journalArticle

Norwalk virus
virus-like particles
Virion
oral vaccination
Immunization
149 Citations (Scopus)

Viral vectors for production of recombinant proteins in plants

Lico, C., Chen, Q. & Santi, L., Aug 2008, In : Journal of Cellular Physiology. 216, 2, p. 366-377 12 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Plant Pathology
Genetic engineering
Molecular biology
Genetic Engineering
2005
5 Citations (Scopus)

Expression of porcine prorelaxin in transgenic tobacco

Buswell, S., Medina-Bolivar, F., Chen, Q., Van Cott, K. & Zhang, C., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 77-81 5 p.

Research output: Contribution to journalArticle

Relaxin
Tobacco
Swine
Genetically Modified Plants
Polymerase chain reaction
1996
66 Citations (Scopus)

Isolation and characterization of glutamine synthetase genes in Chlamydomonas reinhardtii

Chen, Q. & Silflow, C. D., Nov 1996, In : Plant Physiology. 112, 3, p. 987-996 10 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Glutamate-Ammonia Ligase
glutamate-ammonia ligase
assimilation (physiology)
Complementary DNA
1994
44 Citations (Scopus)

A 21-kDa chloroplast heat shock protein assembles into high molecular weight complexes in vivo and in organelle

Chen, Q., Osteryoung, K. & Vierling, E., May 6 1994, In : Journal of Biological Chemistry. 269, 18, p. 13216-13223 8 p.

Research output: Contribution to journalArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Organelles
Molecular Weight
1991
80 Citations (Scopus)

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein

Chen, Q. & Vierling, E., May 1991, In : MGG Molecular & General Genetics. 226, 3, p. 425-431 7 p.

Research output: Contribution to journalArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Methionine
Petunia
5 Citations (Scopus)

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein.

Chen, Q. & Vierling, E., Aug 1991, In : Molecular and General Genetics. 228, 1-2, p. 328 1 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
Chloroplast Proteins
Brassica
Chloroplasts

Erratum

Chen, Q. & Vierling, E., Aug 1991, In : MGG Molecular & General Genetics. 228, 1-2, p. 328 1 p.

Research output: Contribution to journalArticle

1990
76 Citations (Scopus)

Accumulation, stability, and localization of a major chloroplast heat-shock protein

Chen, Q., Lauzon, L. M., DeRocher, A. E. & Vierling, E., Jun 1990, In : Journal of Cell Biology. 110, 6, p. 1873-1883 11 p.

Research output: Contribution to journalArticle

Chloroplast Proteins
Heat-Shock Proteins
Chloroplasts
Molecular Weight
Peas
1989
39 Citations (Scopus)

The major low-molecular-weight heat shock protein in chloroplasts shows antigenic conservation among diverse higher plant species.

Vierling, E., Harris, L. M. & Chen, Q., Feb 1989, In : Molecular and Cellular Biology. 9, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

Chloroplasts
Heat-Shock Proteins
Molecular Weight
Chloroplast Proteins
Peas