• 2098 Citations
  • 26 h-Index
1989 …2024

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Codelivery of improved immune complex and virus-like particle vaccines containing Zika virus envelope domain III synergistically enhances immunogenicity

Diamos, A. G., Pardhe, M. D., Sun, H., Hunter, J. G. L., Mor, T., Meador, L., Kilbourne, J., Chen, Q. & Mason, H. S., Apr 16 2020, In : Vaccine. 38, 18, p. 3455-3463 9 p.

Research output: Contribution to journalArticle

Open Access

High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System

Diamos, A. G., Hunter, J. G. L., Pardhe, M. D., Rosenthal, S. H., Sun, H., Foster, B. C., DiPalma, M. P., Chen, Q. & Mason, H. S., Jan 17 2020, In : Frontiers in Bioengineering and Biotechnology. 7, 472.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2019

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants

Hurtado, J., Acharya, D., Lai, H., Sun, H., Kallolimath, S., Steinkellner, H., Bai, F. & Chen, Q., Jan 1 2019, In : Plant Biotechnology Journal.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

Lai, H., Paul, A. M., Sun, H., He, J., Yang, M., Bai, F. & Chen, Q., Mar 27 2018, In : Vaccine. 36, 14, p. 1846-1852 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development of antibody therapeutics against flaviviruses

Sun, H., Chen, Q. & Lai, H., Jan 1 2018, In : International Journal of Molecular Sciences. 19, 1, 54.

Research output: Contribution to journalReview article

14 Scopus citations

Molecular Pharming: Plant-Made Vaccines

Chen, Q., Dent, M. & Mason, H., Sep 12 2018, Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-Blackwell, p. 231-273 43 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice

Yang, M., Sun, H., Lai, H., Hurtado, J. & Chen, Q., Feb 1 2018, In : Plant Biotechnology Journal. 16, 2, p. 572-580 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Recombinant Therapeutic Molecules Produced in Plants

Chen, Q., Jan 1 2018, Transgenic Plants. Academic Press Inc, p. 207-244 38 p. (Advances in Botanical Research; vol. 86).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Vaccines against west nile virus

Sun, H. & Chen, Q., Jul 3 2018, Prospects of Plant-Based Vaccines in Veterinary Medicine. Springer International Publishing, p. 121-146 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Yang, M., Dent, M., Lai, H., Sun, H. & Chen, Q., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

32 Scopus citations

Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

Yang, M., Lai, H., Sun, H. & Chen, Q., Dec 1 2017, In : Scientific Reports. 7, 1, 7679.

Research output: Contribution to journalArticle

45 Scopus citations
2016

A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

Powell, J. D., Chen, Q. & Mason, H., Aug 1 2016, In : Journal of Microbiological Methods. 127, p. 230-235 6 p.

Research output: Contribution to journalArticle

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

Dent, M., Hurtado, J., Paul, A. M., Sun, H., Lai, H., Yang, M., Esqueda, A., Bai, F., Steinkellner, H. & Chen, Q., Dec 1 2016, In : Journal of General Virology. 97, 12, p. 3280-3290 11 p., 000635.

Research output: Contribution to journalArticle

17 Scopus citations
27 Scopus citations

Transient protein expression by agroinfiltration in lettuce

Chen, Q., Dent, M., Hurtado, J., Stahnke, J., McNulty, A., Leuzinger, K. & Lai, H., May 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1385. p. 55-67 13 p. (Methods in Molecular Biology; vol. 1385).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations
2015

Gene delivery into plant cells for recombinant protein production

Chen, Q. & Lai, H., 2015, In : BioMed Research International. 2015, 932161.

Research output: Contribution to journalArticle

27 Scopus citations

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

Chen, Q., May 1 2015, In : Biotechnology Journal. 10, 5, p. 671-680 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Purification of monoclonal antibody against Ebola GP1 protein expressed in Nicotiana benthamiana

Fulton, A., Lai, H., Chen, Q. & Zhang, C., Apr 10 2015, In : Journal of Chromatography A. 1389, p. 128-132 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

A plant-produced antigen elicits potent immune responses against west nile virus in mice

He, J., Peng, L., Lai, H., Hurtado, J., Stahnke, J. & Chen, Q., 2014, In : BioMed Research International. 2014, 952865.

Research output: Contribution to journalArticle

24 Scopus citations

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus

He, J., Lai, H., Engle, M., Gorlatov, S., Gruber, C., Steinkellner, H., Diamond, M. S. & Chen, Q., Mar 27 2014, In : PloS one. 9, 3, e93541.

Research output: Contribution to journalArticle

33 Scopus citations

Plant-derived monoclonal antibodies as human biologics for infectious disease and cancer

Chen, Q. & Lai, H., Oct 29 2014, Plant-derived Pharmaceuticals: Principles and Applications for Developing Countries. CABI International, p. 42-75 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Plant-made biologics

Chen, Q., Santi, L. & Zhang, C., 2014, In : BioMed Research International. 2014, 418064.

Research output: Contribution to journalReview article

7 Scopus citations

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Loos, A., Diamond, M. S. & Chen, Q., Jan 1 2014, In : Plant Biotechnology Journal. 12, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins

Leuzinger, K., Dent, M., Hurtado, J., Stahnke, J., Lai, H., Zhou, X. & Chen, Q., Jul 23 2013, In : Journal of Visualized Experiments. 77, p. e50521

Research output: Contribution to journalArticle

80 Scopus citations

Plant-derived virus-like particles as vaccines

Chen, Q. & Lai, H., Jan 1 2013, In : Human Vaccines and Immunotherapeutics. 9, 1, p. 26-49 24 p.

Research output: Contribution to journalReview article

68 Scopus citations

Virus-like particle vaccines for norovirus gastroenteritis

Chen, Q., Oct 1 2013, From Prophylaxis to Therapy. Springer-Verlag Wien, Vol. 1. p. 153-181 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations
2012

A novel system for rapid and cost-effective production of detection and diagnostic reagents of West Nile virus in plants

He, J., Lai, H., Brock, C. & Chen, Q., Jan 12 2012, In : Journal of Biomedicine and Biotechnology. 2012, 106783.

Research output: Contribution to journalArticle

27 Scopus citations
76 Scopus citations

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Lai, H., He, J., Engle, M., Diamond, M. S. & Chen, Q., Jan 1 2012, In : Plant Biotechnology Journal. 10, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. & Herbst-Kralovetz, M. M., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Expression and manufacture of pharmaceutical proteins in genetically engineered horticultural plants

Chen, Q., Jan 1 2011, Transgenic Horticultural Crops: Challenges and Opportunities. CRC Press, p. 83-124 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Phoolcharoen, W., Bhoo, S. H., Lai, H., Ma, J., Arntzen, C. J., Chen, Q. & Mason, H., Sep 1 2011, In : Plant Biotechnology Journal. 9, 7, p. 807-816 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

Chen, Q., He, J., Phoolcharoen, W. & Mason, H., Mar 1 2011, In : Human Vaccines. 7, 3, p. 331-338 8 p.

Research output: Contribution to journalReview article

72 Scopus citations

Turning a new leaf

Chen, Q., Jun 1 2011, In : EBR - European Biopharmaceutical Review. SUMMER 2011

Research output: Contribution to journalShort survey

13 Scopus citations
2010

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K. J., Arntzen, C. J., Mason, H. & Chen, Q., May 1 2010, In : Biotechnology and bioengineering. 106, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

Laia, H., Engleb, M., Fuchsb, A., Kellera, T., Johnsonc, S., Gorlatovc, S., Diamond, M. S. & Chen, Q., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2419-2424 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Norwalk virus-like particles as vaccines

Herbst-Kralovetz, M., Mason, H. & Chen, Q., Mar 22 2010, In : Expert review of vaccines. 9, 3, p. 299-307 9 p.

Research output: Contribution to journalReview article

87 Scopus citations
2009

A DNA replicon system for rapid high-level production of virus-like particles in plants

Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. & Mason, H., Jul 1 2009, In : Biotechnology and bioengineering. 103, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

cGMP processing of a plant-produced human vaccine candidate for sexually transmitted infections

Chen, Q., Morris, G. & Lai, H., Dec 1 2009, American Society of Agricultural and Biological Engineers Annual International Meeting 2009, ASABE 2009. p. 468-473 6 p. (American Society of Agricultural and Biological Engineers Annual International Meeting 2009, ASABE 2009; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria

Slater, S. C., Goldman, B. S., Goodner, B., Setubal, J. C., Farrand, S. K., Nester, E. W., Burr, T. J., Banta, L., Dickerman, A. W., Paulsen, I., Otten, L., Suen, G., Welch, R., Almeida, N. F., Arnold, F., Burton, O. T., Du, Z., Ewing, A., Godsy, E., Heisel, S. & 16 others, Houmiel, K. L., Jhaveri, J., Lu, J., Miller, N. M., Norton, S., Chen, Q., Phoolcharoen, W., Ohlin, V., Ondrusek, D., Pride, N., Stricklin, S. L., Sun, J., Wheeler, C., Wilson, L., Zhu, H. & Wood, D. W., Apr 1 2009, In : Journal of bacteriology. 191, 8, p. 2501-2511 11 p.

Research output: Contribution to journalArticle

154 Scopus citations
2008

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C. J., Chen, Q. & Mason, H., Mar 28 2008, In : Vaccine. 26, 15, p. 1846-1854 9 p.

Research output: Contribution to journalArticle

136 Scopus citations

Viral vectors for production of recombinant proteins in plants

Lico, C., Chen, Q. & Santi, L., Aug 1 2008, In : Journal of Cellular Physiology. 216, 2, p. 366-377 12 p.

Research output: Contribution to journalReview article

151 Scopus citations