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Research Output 1989 2019

2019

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants

Hurtado, J., Acharya, D., Lai, H., Sun, H., Kallolimath, S., Steinkellner, H., Bai, F. & Chen, Q., Jan 1 2019, In : Plant Biotechnology Journal.

Research output: Contribution to journalArticle

Open Access
Chikungunya virus
Nicotiana benthamiana
Tobacco
monoclonal antibodies
Monoclonal Antibodies
2018
3 Citations (Scopus)

A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

Lai, H., Paul, A. M., Sun, H., He, J., Yang, M., Bai, F. & Chen, Q., Jan 1 2018, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Zika virus
West Nile virus
Dengue virus
Dengue Virus
Virus Diseases
8 Citations (Scopus)

Development of antibody therapeutics against flaviviruses

Sun, H., Chen, Q. & Lai, H., Jan 1 2018, In : International Journal of Molecular Sciences. 19, 1, 54.

Research output: Contribution to journalReview article

Flavivirus
Monoclonal antibodies
antibodies
Antibodies
Monoclonal Antibodies

Molecular Pharming: Plant-Made Vaccines

Chen, Q., Dent, M. & Mason, H., Sep 12 2018, Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-Blackwell, p. 231-273 43 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vaccines
Viral Vaccines
Antigens
Genetically Modified Plants
Zea mays
11 Citations (Scopus)

Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice

Yang, M., Sun, H., Lai, H., Hurtado, J. & Chen, Q., Feb 1 2018, In : Plant Biotechnology Journal. 16, 2, p. 572-580 9 p.

Research output: Contribution to journalArticle

Zika virus
Viral Envelope Proteins
neutralization
Immunity
immunity
1 Citation (Scopus)

Recombinant Therapeutic Molecules Produced in Plants

Chen, Q., Jan 1 2018, Transgenic Plants. Academic Press Inc, p. 207-244 38 p. (Advances in Botanical Research; vol. 86).

Research output: Chapter in Book/Report/Conference proceedingChapter

therapeutics
prions
clinical trials
polysaccharides
vaccines
2017
20 Citations (Scopus)

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Yang, M., Dent, M., Lai, H., Sun, H. & Chen, Q., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Zika virus
Viral Envelope Proteins
neutralization
Immunization
immunization
30 Citations (Scopus)

Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

Yang, M., Lai, H., Sun, H. & Chen, Q., Dec 1 2017, In : Scientific Reports. 7, 1, 7679.

Research output: Contribution to journalArticle

Viral Envelope Proteins
Virion
Hepatitis B Core Antigens
Dengue Virus
Vaccines
2016

A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

Powell, J. D., Chen, Q. & Mason, H., Aug 1 2016, In : Journal of Microbiological Methods. 127, p. 230-235 6 p.

Research output: Contribution to journalArticle

Agrobacterium
MicroRNAs
Tobacco
Antibodies
Agrobacterium tumefaciens
11 Citations (Scopus)

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

Dent, M., Hurtado, J., Paul, A. M., Sun, H., Lai, H., Yang, M., Esqueda, A., Bai, F., Steinkellner, H. & Chen, Q., Dec 1 2016, In : Journal of General Virology. 97, 12, p. 3280-3290 11 p., 000635.

Research output: Contribution to journalArticle

Antibody-Dependent Enhancement
Dengue Virus
Monoclonal Antibodies
Glycosylation
Infection
18 Citations (Scopus)
Human Development
Biological Products
Plant Proteins
Bioterrorism
Drug Approval
11 Citations (Scopus)

Transient protein expression by agroinfiltration in lettuce

Chen, Q., Dent, M., Hurtado, J., Stahnke, J., McNulty, A., Leuzinger, K. & Lai, H., May 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1385. p. 55-67 13 p. (Methods in Molecular Biology; vol. 1385).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lettuce
Recombinant Proteins
Proteins
Agrobacterium tumefaciens
Agriculture
2015
20 Citations (Scopus)

Gene delivery into plant cells for recombinant protein production

Chen, Q. & Lai, H., 2015, In : BioMed Research International. 2015, 932161.

Research output: Contribution to journalArticle

Plant Cells
Recombinant Proteins
Genes
Scalability
Transgenes
9 Citations (Scopus)

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

Chen, Q., May 1 2015, In : Biotechnology Journal. 10, 5, p. 671-680 10 p.

Research output: Contribution to journalArticle

West Nile Virus Vaccines
Vaccines
West Nile virus
Costs and Cost Analysis
Economics
14 Citations (Scopus)

Purification of monoclonal antibody against Ebola GP1 protein expressed in Nicotiana benthamiana

Fulton, A., Lai, H., Chen, Q. & Zhang, C., Apr 10 2015, In : Journal of Chromatography A. 1389, p. 128-132 5 p.

Research output: Contribution to journalArticle

Plant Proteins
Chromatography
Polyelectrolytes
Tobacco
Purification
2014
20 Citations (Scopus)

A plant-produced antigen elicits potent immune responses against west nile virus in mice

He, J., Peng, L., Lai, H., Hurtado, J., Stahnke, J. & Chen, Q., 2014, In : BioMed Research International. 2014, 952865.

Research output: Contribution to journalArticle

Plant Antigens
West Nile virus
Viruses
Vaccines
Immunization
29 Citations (Scopus)

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus

He, J., Lai, H., Engle, M., Gorlatov, S., Gruber, C., Steinkellner, H., Diamond, M. S. & Chen, Q., Mar 27 2014, In : PLoS One. 9, 3, e93541.

Research output: Contribution to journalArticle

Plantibodies
West Nile virus
Antibody-Dependent Enhancement
Viruses
Monoclonal Antibodies
7 Citations (Scopus)

Plant-derived monoclonal antibodies as human biologics for infectious disease and cancer

Chen, Q. & Lai, H., Oct 29 2014, Plant-derived Pharmaceuticals: Principles and Applications for Developing Countries. CABI International, p. 42-75 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Plantibodies
Biological Products
Communicable Diseases
Monoclonal Antibodies
Neoplasms
6 Citations (Scopus)

Plant-made biologics

Chen, Q., Santi, L. & Zhang, C., 2014, In : BioMed Research International. 2014, 418064.

Research output: Contribution to journalArticle

Plant Extracts
Biological Products
30 Citations (Scopus)

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Loos, A., Diamond, M. S. & Chen, Q., 2014, In : Plant Biotechnology Journal. 12, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

West Nile virus
monoclonal antibodies
Monoclonal Antibodies
glycosylation
Glycosylation
2013
75 Citations (Scopus)

Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins

Leuzinger, K., Dent, M., Hurtado, J., Stahnke, J., Lai, H., Zhou, X. & Chen, Q., 2013, In : Journal of visualized experiments : JoVE. 77

Research output: Contribution to journalArticle

Recombinant proteins
Syringes
Recombinant Proteins
Proteins
Infiltration
54 Citations (Scopus)

Plant-derived virus-like particles as vaccines

Chen, Q. & Lai, H., Jan 2013, In : Human Vaccines and Immunotherapeutics. 9, 1, p. 26-49 24 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Plant Viruses
Virion
Vaccines
Safety
10 Citations (Scopus)

Virus-like particle vaccines for norovirus gastroenteritis

Chen, Q., Jan 1 2013, Molecular Vaccines: From Prophylaxis to Therapy-Volume 1. Springer-Verlag Vienna, p. 153-181 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Virus-Like Particle Vaccines
Norovirus
Gastroenteritis
Virion
Vaccines
2012
25 Citations (Scopus)
West Nile virus
Viruses
Costs and Cost Analysis
Costs
Scalability
70 Citations (Scopus)
Norwalk virus
bioprocessing
virus-like particles
coat proteins
manufacturing
60 Citations (Scopus)

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Lai, H., He, J., Engle, M., Diamond, M. S. & Chen, Q., Jan 2012, In : Plant Biotechnology Journal. 10, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

biopharmaceuticals
replicon
Lettuce
Replicon
virus-like particles
2011
48 Citations (Scopus)

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. & Herbst-Kralovetz, M. M., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Contribution to journalArticle

Ebolavirus
Subunit Vaccines
Antigen-Antibody Complex
Ebola Hemorrhagic Fever
Ebola Vaccines
21 Citations (Scopus)

Expression and manufacture of pharmaceutical proteins in genetically engineered horticultural plants

Chen, Q., Jan 1 2011, Transgenic Horticultural Crops: Challenges and Opportunities. CRC Press, p. 83-124 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

biopharmaceuticals
Genetically Modified Plants
horticultural crops
Drug products
manufacturing
71 Citations (Scopus)

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Phoolcharoen, W., Bhoo, S. H., Lai, H., Ma, J., Arntzen, C. J., Chen, Q. & Mason, H., Sep 2011, In : Plant Biotechnology Journal. 9, 7, p. 807-816 10 p.

Research output: Contribution to journalArticle

antigen-antibody complex
Ebolavirus
Nicotiana benthamiana
Antigen-Antibody Complex
Tobacco
68 Citations (Scopus)

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

Chen, Q., He, J., Phoolcharoen, W. & Mason, H., Mar 2011, In : Human Vaccines. 7, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle

Vaccines
Monoclonal Antibodies
Viruses
Antigens
Replicon
West Nile virus
Blood-Brain Barrier
Directories
Virus Diseases
Plantibodies
12 Citations (Scopus)

Turning a new leaf

Chen, Q., Jun 2011, In : EBR - European Biopharmaceutical Review. SUMMER 2011

Research output: Contribution to journalArticle

2010
119 Citations (Scopus)

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K. J., Arntzen, C. J., Mason, H. & Chen, Q., May 1 2010, In : Biotechnology and Bioengineering. 106, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Replicon
Monoclonal antibodies
Viruses
DNA
Monoclonal Antibodies
72 Citations (Scopus)

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

Laia, H., Engleb, M., Fuchsb, A., Kellera, T., Johnsonc, S., Gorlatovc, S., Diamond, M. S. & Chen, Q., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2419-2424 6 p.

Research output: Contribution to journalArticle

West Nile virus
Virus Diseases
Monoclonal Antibodies
Emerging Communicable Diseases
Viral Fusion Proteins
87 Citations (Scopus)

Norwalk virus-like particles as vaccines

Herbst-Kralovetz, M., Mason, H. & Chen, Q., 2010, In : Expert Review of Vaccines. 9, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Norwalk virus
Virion
Norovirus
Plant Cells
2009
108 Citations (Scopus)

A DNA replicon system for rapid high-level production of virus-like particles in plants

Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. & Mason, H., Jul 1 2009, In : Biotechnology and Bioengineering. 103, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

Replicon
Viruses
Virion
DNA
Virus-Like Particle Vaccines
1 Citation (Scopus)

cGMP processing of a plant-produced human vaccine candidate for sexually transmitted infections

Chen, Q., Morris, G. & Lai, H., 2009, American Society of Agricultural and Biological Engineers Annual International Meeting 2009, ASABE 2009. Vol. 1. p. 468-473 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

sexually transmitted diseases
good manufacturing practices
Sexually Transmitted Diseases
Vaccines
vaccines
147 Citations (Scopus)

Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria

Slater, S. C., Goldman, B. S., Goodner, B., Setubal, J. C., Farrand, S. K., Nester, E. W., Burr, T. J., Banta, L., Dickerman, A. W., Paulsen, I., Otten, L., Suen, G., Welch, R., Almeida, N. F., Arnold, F., Burton, O. T., Du, Z., Ewing, A., Godsy, E., Heisel, S. & 16 others, Houmiel, K. L., Jhaveri, J., Lu, J., Miller, N. M., Norton, S., Chen, Q., Phoolcharoen, W., Ohlin, V., Ondrusek, D., Pride, N., Stricklin, S. L., Sun, J., Wheeler, C., Wilson, L., Zhu, H. & Wood, D. W., Apr 2009, In : Journal of Bacteriology. 191, 8, p. 2501-2511 11 p.

Research output: Contribution to journalArticle

Agrobacterium
Chromosomes
Genome
Bacteria
Rhizobiaceae
West Nile virus
Monoclonal Antibodies
Infection
Antibodies
Virus Diseases
2008
129 Citations (Scopus)

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C. J., Chen, Q. & Mason, H., Mar 28 2008, In : Vaccine. 26, 15, p. 1846-1854 9 p.

Research output: Contribution to journalArticle

Norwalk virus
virus-like particles
Virion
oral vaccination
Immunization
Geminiviridae
replicon
plant proteins
monoclonal antibodies
biopharmaceuticals
145 Citations (Scopus)

Viral vectors for production of recombinant proteins in plants

Lico, C., Chen, Q. & Santi, L., Aug 2008, In : Journal of Cellular Physiology. 216, 2, p. 366-377 12 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Plant Pathology
Genetic engineering
Molecular biology
Genetic Engineering
2005
5 Citations (Scopus)

Expression of porcine prorelaxin in transgenic tobacco

Buswell, S., Medina-Bolivar, F., Chen, Q., Van Cott, K. & Zhang, C., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 77-81 5 p.

Research output: Contribution to journalArticle

Relaxin
Tobacco
Swine
Genetically Modified Plants
Polymerase chain reaction
1996
66 Citations (Scopus)

Isolation and characterization of glutamine synthetase genes in Chlamydomonas reinhardtii

Chen, Q. & Silflow, C. D., Nov 1996, In : Plant Physiology. 112, 3, p. 987-996 10 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Glutamate-Ammonia Ligase
glutamate-ammonia ligase
assimilation (physiology)
Complementary DNA
1994
44 Citations (Scopus)

A 21-kDa chloroplast heat shock protein assembles into high molecular weight complexes in vivo and in organelle

Chen, Q., Osteryoung, K. & Vierling, E., May 6 1994, In : Journal of Biological Chemistry. 269, 18, p. 13216-13223 8 p.

Research output: Contribution to journalArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Organelles
Molecular Weight
1991
79 Citations (Scopus)

Analysis of conserved domains identifies a unique structural feature of a chloroplast heat shock protein

Chen, Q. & Vierling, E., May 1991, In : MGG Molecular & General Genetics. 226, 3, p. 425-431 7 p.

Research output: Contribution to journalArticle

Chloroplast Proteins
Chloroplasts
Heat-Shock Proteins
Methionine
Petunia