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1986 …2024
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Research Output 1986 2019

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Article
118 Citations (Scopus)

1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism

Barthel, T. K., Mathern, D. R., Whitfield, G. K., Haussler, C. A., Hopper IV, H. A., Hsieh, J. C., Slater, S. A., Hsieh, G., Kaczmarska, M., Jurutka, P., Kolek, O. I., Ghishan, F. K. & Haussler, M. R., Mar 2007, In : Journal of Steroid Biochemistry and Molecular Biology. 103, 3-5, p. 381-388 8 p.

Research output: Contribution to journalArticle

Calcitriol
Metabolism
Minerals
Bone
Genes
30 Citations (Scopus)

1,25-Dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter

Hines, E. R., Kolek, O. I., Jones, M. D., Serey, S. H., Sirjani, N. B., Kiela, P. R., Jurutka, P., Haussler, M. R., Collins, J. F. & Ghishan, F. K., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46406-46414 9 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Gene Expression Regulation
Gene expression
Down-Regulation
46 Citations (Scopus)

1,25-Dihydroxyvitamin D3 regulation of fibroblast growth factor-23 expression in bone cells: Evidence for primary and secondary mechanisms modulated by leptin and interleukin-6

Saini, R. K., Kaneko, I., Jurutka, P., Forster, R., Hsieh, A., Hsieh, J. C., Haussler, M. R. & Whitfield, G. K., Apr 2013, In : Calcified Tissue International. 92, 4, p. 339-353 15 p.

Research output: Contribution to journalArticle

Calcitriol
Leptin
Interleukin-6
Bone and Bones
Calcitriol Receptors
16 Citations (Scopus)

1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age

Haussler, M. R., Kerr Whitfield, G., Haussler, C. A., Sabir, M. S., Khan, Z., Sandoval, R. & Jurutka, P., 2016, (Accepted/In press) In : Vitamins and Hormones.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Hormones
Kidney
Vitamin D
48 Citations (Scopus)

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D

Kaneko, I., Sabir, M. S., Dussik, C. M., Whitfield, G. K., Karrys, A., Hsieh, J. C., Haussler, M. R., Meyer, M. B., Pike, J. W. & Jurutka, P., Sep 1 2015, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 9, p. 4023-4035 13 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Calcitriol
Leptin
Vitamin D
Genes

16α-Hydroxytrametenolic Acid from Poria cocos Improves Intestinal Barrier Function through the Glucocorticoid Receptor-Mediated PI3K/Akt/NF-κB Pathway

Xu, H., Wang, Y., Jurutka, P. W., Wu, S., Chen, Y., Cao, C., Chen, G., Tian, B., Wang, S. & Cheng, S., Oct 2 2019, In : Journal of Agricultural and Food Chemistry. 67, 39, p. 10871-10879 9 p.

Research output: Contribution to journalArticle

Wolfiporia cocos
Phosphatidylinositol 3-Kinase
NF-kappa B
Glucocorticoid Receptors
phosphatidylinositol 3-kinase
65 Citations (Scopus)
CCAAT-Binding Factor
Vitamin D Response Element
Retinoid X Receptors
Dilatation and Curettage
Calcitriol Receptors
84 Citations (Scopus)

A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation

Whitfield, G. K., Hsieh, J. C., Nakajima, S., MacDonald, P. N., Thompson, P. D., Jurutka, P., Haussler, C. A. & Haussler, M. R., 1995, In : Molecular Endocrinology. 9, 9, p. 1166-1179 14 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Calcitriol Receptors
Vitamin D
Transcriptional Activation
Hormones
13 Citations (Scopus)

Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles

Marshall, P., Jurutka, P., Wagner, C., van der Vaart, A., Kaneko, I., Chavez, P. I., Ma, N., Bhogal, J. S., Shahani, P., Swierski, J. C. & Macneill, M., Mar 1 2015, In : Pharmacology Research and Perspectives. 3, 2, p. 1-19 19 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Ligands
RNA Sequence Analysis
Lipids
Thyrotropin
1 Citation (Scopus)

A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Hanish, B. J., Hackney Price, J., Kaneko, I., Ma, N., van der Vaart, A., Wagner, C., Jurutka, P. & Marshall, P., Jul 1 2018, In : Steroids. 135, p. 36-49 14 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Neoplasms
Cutaneous T-Cell Lymphoma
T-cells
21 Citations (Scopus)

Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis

Jacobs, E. T., Hibler, E. A., Lance, P., Sardo, C. L. & Jurutka, P., Dec 15 2013, In : International Journal of Cancer. 133, 12, p. 2980-2988 9 p.

Research output: Contribution to journalArticle

Adenoma
Vitamin D
Odds Ratio
Recurrence
Neoplasms

Association between circulating Vitamin D metabolites and fecal bile acid concentrations

Jacobs, E. T., Haussler, M. R., Alberts, D. S., Kohler, L. N., Lance, P., Martínez, M. E., Roe, D. J. & Jurutka, P., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 589-597 9 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Vitamin D
Ursodeoxycholic Acid
Adenoma
Confidence Intervals
24 Citations (Scopus)

Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites

Hibler, E. A., Jurutka, P., Egan, J. B., Hu, C., LeRoy, E. C., Martinez, M. E., Thompson, P. A. & Jacobs, E. T., Jul 2010, In : Journal of Steroid Biochemistry and Molecular Biology. 121, 1-2, p. 438-441 4 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Metabolites
Vitamin D
Single Nucleotide Polymorphism
Polymorphism
12 Citations (Scopus)

Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma

Hibler, E. A., Sardo Molmenti, C. L., Lance, P., Jurutka, P. & Jacobs, E. T., 2014, In : Cancer Causes and Control. 25, 7, p. 809-817 9 p.

Research output: Contribution to journalArticle

Adenoma
Secosteroids
Ursodeoxycholic Acid
Vitamin D
Colon
11 Citations (Scopus)

Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells

Hibler, E. A., Jacobs, E. T., Stone, A. D., Sardo, C. L., Galligan, M. A. & Jurutka, P., 2014, In : Cancer Prevention Research. 7, 4, p. 426-434 9 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Vitamin D
Colonic Neoplasms
Clinical Trials
HCT116 Cells
3 Citations (Scopus)

Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with risk for psoriasis

Karrys, A., Rady, I., Chamcheu, R. C. N., Sabir, M. S., Mallick, S., Chamcheu, J. C., Jurutka, P., Haussler, M. R. & Whitfield, G. K., Feb 4 2018, In : Nutrients. 10, 2, 174.

Research output: Contribution to journalArticle

psoriasis
Calcitriol Receptors
Curcumin
Docosahexaenoic Acids
vitamin D
7 Citations (Scopus)

Biochemical evidence for a 170-kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts

Jurutka, P., Remus, L. S., Whitfield, G. K., Galligan, M. A., Haussler, C. A. & Haussler, M. R., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 813-819 7 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Calcitriol Receptors
Osteoblasts
Chemical activation
Transcriptional Activation
32 Citations (Scopus)

Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor

Hsieh, J. C., Whitfield, G. K., Oza, A. K., Dang, H. T. L., Price, J. N., Galligan, M. A., Jurutka, P., Thompson, P. D., Haussler, C. A. & Haussler, M. R., Dec 7 1999, In : Biochemistry. 38, 49, p. 16347-16358 12 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Zinc Fingers
Transcriptional Activation
Zinc
Chemical activation
15 Citations (Scopus)

Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma

Jacobs, E., Martinez, M. E., Buckmeier, J., Lance, P., May, M. & Jurutka, P., 2011, In : Journal of Carcinogenesis. 10, 3.

Research output: Contribution to journalArticle

Adenoma
Vitamin D
Linear Models
fibroblast growth factor 23
Fibroblast Growth Factor 1
1 Citation (Scopus)

Computer simulated metabolism: A student-interactive program

Tirri, L. J. & Jurutka, P., 1986, In : Journal of Chemical Education. 63, 12, p. 1071-1072 2 p.

Research output: Contribution to journalArticle

Metabolism
Students
student
22 Citations (Scopus)

Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components

Bea, J. W., Jurutka, P., Hibler, E. A., Lance, P., Martínez, M. E., Roe, D. J., Sardo Molmenti, C. L., Thompson, P. A. & Jacobs, E. T., Mar 1 2015, In : Metabolism: Clinical and Experimental. 64, 3, p. 447-459 13 p.

Research output: Contribution to journalArticle

Vitamin D
HDL Lipoproteins
Triglycerides
Waist Circumference
LDL Lipoproteins
14 Citations (Scopus)

Control of late cornified envelope genes relevant to psoriasis risk: Upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin

Hoss, E., Austin, H. R., Batie, S. F., Jurutka, P., Haussler, M. R. & Whitfield, G. K., 2013, In : Archives of Dermatological Research. 305, 10, p. 867-878 12 p.

Research output: Contribution to journalArticle

delphinidin
Calcitriol
Psoriasis
Up-Regulation
Keratinocytes
1 Citation (Scopus)

Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase

Deutch, C. E., Krumbholz, R., Schmid, S. M., Bonate, P. L. & Jurutka, P., Mar 5 2010, In : Enzyme and Microbial Technology. 46, 3-4, p. 246-251 6 p.

Research output: Contribution to journalArticle

prolyl oligopeptidase
Metabolites
Metabolism
Peptides
Tumors
84 Citations (Scopus)

Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

Bartik, L., Whitfield, G. K., Kaczmarska, M., Lowmiller, C. L., Moffet, E. W., Furmick, J. K., Hernandez, Z., Haussler, C. A., Haussler, M. R. & Jurutka, P., Dec 2010, In : Journal of Nutritional Biochemistry. 21, 12, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Curcumin
Chemoprevention
Colonic Neoplasms
Ligands
11 Citations (Scopus)

CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Hibler, E. A., Klimentidis, Y. C., Jurutka, P., Kohler, L. N., Lance, P., Roe, D. J., Thompson, P. A. & Jacobs, E. T., Oct 3 2015, In : Nutrition and Cancer. 67, 7, p. 1131-1141 11 p.

Research output: Contribution to journalArticle

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Vitamin D
Adenoma
Recurrence
Alleles
43 Citations (Scopus)

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells

Jacobs, E. T., Van Pelt, C., Forster, R. E., Zaidi, W., Hibler, E. A., Galligan, M. A., Haussler, M. R. & Jurutka, P., Apr 15 2013, In : Cancer Research. 73, 8, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Vitamin D
Colonic Neoplasms
Single Nucleotide Polymorphism
Calcitriol Receptors

Dataset on the response of Hut78 cells to novel rexinoids

Hackney Price, J., Hanish, B. J., Wagner, C., Kaneko, I., Jurutka, P. & Marshall, P., Oct 1 2018, In : Data in Brief. 20, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

Gene Expression
Cutaneous T-Cell Lymphoma
Retinoids
Response Elements
Genetic Promoter Regions
10 Citations (Scopus)

Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling

Marshall, P., Hernandez, Z., Kaneko, I., Widener, T., Tabacaru, C., Aguayo, I. & Jurutka, P., Oct 2012, In : Journal of Steroid Biochemistry and Molecular Biology. 132, 1-2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Two-Hybrid System Techniques
Assays
Transcription
1 Citation (Scopus)

Distinct functional modes of SUMOylation for retinoid X receptor alpha

Lee, W. P., Jena, S., Rodriguez, E. P., O'Donovan, S. P., Wagner, C., Jurutka, P. & Thompson, P. D., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Retinoid X Receptor alpha
Sumoylation
Lysine
Protein Inhibitors of Activated STAT
Ubiquitin
53 Citations (Scopus)

Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts

Thompson, P. D., Remus, L. S., Hsieh, J. C., Jurutka, P., Whitfield, G. K., Galligan, M. A., Encinas Dominguez, C., Haussler, C. A. & Haussler, M. R., 2001, In : Journal of Molecular Endocrinology. 27, 2, p. 211-227 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Calcitriol Receptors
Transcriptional Activation
Aminoacylation
Gene Expression
26 Citations (Scopus)

Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor

Nakajima, S., Hsieh, J. C., Jurutka, P., Galligan, M. A., Haussler, C. A., Whitfield, G. K. & Haussler, M. R., Mar 1 1996, In : Journal of Biological Chemistry. 271, 9, p. 5143-5149 7 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Cysteine
Hormones
Ligands
Vitamin D
21 Citations (Scopus)

FGF23 gene regulation by 1,25-dihyoxyvitamin D: Opposing effects in adipocytes and osteocytes

Kaneko, I., Saini, R. K., Griffin, K. P., Whitfield, G. K., Haussler, M. R. & Jurutka, P., 2015, In : Journal of Endocrinology. 226, 3, p. 155-166 12 p.

Research output: Contribution to journalArticle

Osteocytes
Calcitriol
Adipocytes
Genes
Calcitriol Receptors
297 Citations (Scopus)

Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene

Kerr Whitfield, G., Remus, L. S., Jurutka, P., Zitzer, H., Oza, A. K., Dang, H. T. L., Haussler, C. A., Galligan, M. A., Thatcher, M. L., Dominguez, C. E. & Haussler, M. R., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 145-159 15 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Polymorphism
Genes
Genotype
Exons
4 Citations (Scopus)

Gene expression profiling and assessment of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome

Dussik, C. M., Hockley, M., Grozic, A., Kaneko, I., Zhang, L., Sabir, M. S., Park, J., Wang, J., Nickerson, C., Yale, S. H., Rall, C. J., Foxx-Orenstein, A. E., Borror, C. M., Sandrin, T. & Jurutka, P., Jan 1 2018, In : Journal of Neurogastroenterology and Motility. 24, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gene Expression Profiling
Vitamin D
Serotonin
Tryptophan Hydroxylase
43 Citations (Scopus)

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence

Egan, J. B., Thompson, P. A., Ashbeck, E. L., Conti, D. V., Duggan, D., Hibler, E., Jurutka, P., LeRoy, E. C., Martínez, M. E., Mount, D. & Jacobs, E. T., Feb 15 2010, In : Cancer Research. 70, 4, p. 1496-1504 9 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Genetic Polymorphisms
Adenoma
Colon
Single Nucleotide Polymorphism
64 Citations (Scopus)

Genomic actions of 1,25-dihydroxyvitamin D3

Whitfield, G. K., Hsieh, J. C., Jurutka, P., Selznick, S. H., Haussler, C. A., MacDonald, P. N. & Haussler, M. R., 1995, In : Journal of Nutrition. 125, 6 SUPPL.

Research output: Contribution to journalArticle

calcitriol
Calcitriol Receptors
Calcitriol
vitamin D
Retinoid X Receptors
3 Citations (Scopus)

Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling

Chamcheu, J. C., Rady, I., Chamcheu, R. C. N., Siddique, A. B., Bloch, M. B., Mbeumi, S. B., Babatunde, A. S., Uddin, M. B., Noubissi, F. K., Jurutka, P., Liu, Y. Y., Spiegelman, V. S., Whitfield, G. K. & El Sayed, K. A., Jun 16 2018, In : International Journal of Molecular Sciences. 19, 6, 1791.

Research output: Contribution to journalArticle

Annona
Hedgehogs
Skin Neoplasms
Skin
cancer
4 Citations (Scopus)

Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials

Kohler, L. N., Hibler, E. A., Harris, R. B., Oren, E., Roe, D. J., Jurutka, P. & Jacobs, E. T., Mar 1 2017, In : The Journal of nutrition. 147, 3, p. 421-429 9 p.

Research output: Contribution to journalArticle

Chemoprevention
Vitamin D
Cross-Sectional Studies
Guidelines
Neoplasms
93 Citations (Scopus)

Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis- retinoic acid. Evidence for allosteric receptor interactions

Thompson, P. D., Jurutka, P., Haussler, C. A., Whitfield, G. K. & Haussler, M. R., Apr 3 1998, In : Journal of Biological Chemistry. 273, 14, p. 8483-8491 9 p.

Research output: Contribution to journalArticle

Vitamin D Response Element
Retinoid X Receptors
Calcitriol Receptors
Calcitriol
DNA
180 Citations (Scopus)

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function

Hsieh, J. C., Jurutka, P., Galligan, M. A., Terpening, C. M., Haussler, C. A., Samuels, D. S., Shimizu, Y., Shimizu, N. & Haussler, M. R., Oct 15 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 20, p. 9315-9319 5 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Serine
Protein Kinase C
Phosphorylation
Vitamin D
76 Citations (Scopus)

Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation

Jurutka, P., Hsieh, J. C., Nakajima, S., Haussler, C. A., Whitfield, G. K. & Haussler, M. R., Apr 16 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 8, p. 3519-3524 6 p.

Research output: Contribution to journalArticle

Casein Kinase II
Calcitriol Receptors
Transcriptional Activation
Phosphorylation
Vitamin D
21 Citations (Scopus)

Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR

Blanco, J. C. G., Dey, A., Leid, M., Minucci, S., Park, B. K., Jurutka, P., Haussler, M. R. & Ozato, K., 1996, In : Genes to Cells. 1, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Ligands
Retinoic Acid Receptors
Clone Cells
Embryonal Carcinoma Stem Cells
34 Citations (Scopus)

Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor

Jurutka, P., MacDonald, P. N., Nakajima, S., Hsieh, J. C., Thompson, P. D., Kerr Whitfield, G., Galligan, M. A., Haussler, C. A. & Haussler, M. R., 2002, In : Journal of Cellular Biochemistry. 85, 2, p. 435-457 23 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Phosphorylation
Baculoviridae
Retinoid X Receptors
Vitamin D
110 Citations (Scopus)

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements

Thompson, P. D., Jurutka, P., Whitfield, G. K., Myskowski, S. M., Eichhorst, K. R., Encinas Dominguez, C., Haussler, C. A. & Haussler, M. R., 2002, In : Biochemical and Biophysical Research Communications. 299, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Cytochrome P-450 CYP3A
Calcitriol Receptors
Vitamin D
Colonic Neoplasms
17 Citations (Scopus)

Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl) -4-hydroxyphenyl)acrylic acid (CD3254)

Jurutka, P., Kaneko, I., Yang, J., Bhogal, J. S., Swierski, J. C., Tabacaru, C. R., Montano, L. A., Huynh, C. C., Jama, R. A., Mahelona, R. D., Sarnowski, J. T., Marcus, L. M., Quezada, A., Lemming, B., Tedesco, M. A., Fischer, A. J., Mohamed, S. A., Ziller, J. W., Ma, N., Gray, G. M. & 3 others, Van Der Vaart, A., Marshall, P. & Wagner, C., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8432-8454 23 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
Drug Design
7 Citations (Scopus)

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Heck, M. C., Wagner, C., Shahani, P. H., Macneill, M., Grozic, A., Darwaiz, T., Shimabuku, M., Deans, D. G., Robinson, N. M., Salama, S. H., Ziller, J. W., Ma, N., Van Der Vaart, A., Marshall, P. & Jurutka, P., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8924-8940 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Niacin
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
44 Citations (Scopus)

Modeling, synthesis and biological evaluation of potential Retinoid X Receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)

Wagner, C., Jurutka, P., Marshall, P., Groy, T. L., Van Der Vaart, A., Ziller, J. W., Furmick, J. K., Graeber, M. E., Matro, E., Miguel, B. V., Tran, I. T., Kwon, J., Tedeschi, J. N., Moosavi, S., Danishyar, A., Philp, J. S., Khamees, R. O., Jackson, J. N., Grupe, D. K., Badshah, S. L. & 1 others, Hart, J. W., Oct 8 2009, In : Journal of Medicinal Chemistry. 52, 19, p. 5950-5966 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Apoptosis
Cutaneous T-Cell Lymphoma
Drug Design
21 Citations (Scopus)

Modeling, Synthesis and Biological Evaluation of Potential RetinoidX Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)

Furmick, J. K., Kaneko, I., Walsh, A. N., Yang, J., Bhogal, J. S., Gray, G. M., Baso, J. C., Browder, D. O., Prentice, J. L. S., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Kwon, J. S., Quezada, A., Reyes, N. M., Lemming, B., Saini, P., vanderVaart, A., Groy, T. L. & 3 others, Marshall, P., Jurutka, P. & Wagner, C., Sep 2012, In : ChemMedChem. 7, 9, p. 1551-1566 16 p.

Research output: Contribution to journalArticle

Benzoic Acid
Assays
Cutaneous T-Cell Lymphoma
Halogens
T-cells
69 Citations (Scopus)

Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4

Jurutka, P., Thompson, P. D., Whitfield, G. K., Eichhorst, K. R., Hall, N., Dominguez, C. E., Hsieh, J. C., Haussler, C. A. & Haussler, M. R., Apr 1 2005, In : Journal of Cellular Biochemistry. 94, 5, p. 917-943 27 p.

Research output: Contribution to journalArticle

Lithocholic Acid
Cytochrome P-450 CYP3A
Calcitriol Receptors
Calcitriol
Transcription
309 Citations (Scopus)

Molecular mechanisms of vitamin D action

Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J. C. & Jurutka, P., 2013, In : Calcified Tissue International. 92, 2, p. 77-98 22 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Vitamin D
Retinoid X Receptors
Ligands
Claudin-2