Peter Jurutka

Professor

  • 6309 Citations
  • 39 h-Index
1986 …2020
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Research Output 1986 2019

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Article
2019

Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention

Zhang, D., Leal, A. S., Carapellucci, S., Shahani, P. H., Bhogal, J. S., Ibrahim, S., Raban, S., Jurutka, P., Marshall, P., Sporn, M. B., Wagner, C. & Liby, K. T., Apr 1 2019, In : Cancer Prevention Research. 12, 4, p. 211-224 14 p.

Research output: Contribution to journalArticle

Neoplasms
Sterol Regulatory Element Binding Proteins
Retinoid X Receptors
Lung
Hepatomegaly
2018
1 Citation (Scopus)

A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Hanish, B. J., Hackney Price, J., Kaneko, I., Ma, N., van der Vaart, A., Wagner, C., Jurutka, P. & Marshall, P., Jul 1 2018, In : Steroids. 135, p. 36-49 14 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Neoplasms
Cutaneous T-Cell Lymphoma
T-cells
1 Citation (Scopus)

Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with risk for psoriasis

Karrys, A., Rady, I., Chamcheu, R. C. N., Sabir, M. S., Mallick, S., Chamcheu, J. C., Jurutka, P., Haussler, M. R. & Whitfield, G. K., Feb 4 2018, In : Nutrients. 10, 2, 174.

Research output: Contribution to journalArticle

psoriasis
Calcitriol Receptors
Curcumin
Docosahexaenoic Acids
vitamin D

Dataset on the response of Hut78 cells to novel rexinoids

Hackney Price, J., Hanish, B. J., Wagner, C., Kaneko, I., Jurutka, P. & Marshall, P., Oct 1 2018, In : Data in Brief. 20, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

Gene Expression
Cutaneous T-Cell Lymphoma
Retinoids
Response Elements
Genetic Promoter Regions
2 Citations (Scopus)

Gene expression profiling and assessment of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome

Dussik, C. M., Hockley, M., Grozic, A., Kaneko, I., Zhang, L., Sabir, M. S., Park, J., Wang, J., Nickerson, C., Yale, S. H., Rall, C. J., Foxx-Orenstein, A. E., Borror, C. M., Sandrin, T. & Jurutka, P., Jan 1 2018, In : Journal of Neurogastroenterology and Motility. 24, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gene Expression Profiling
Vitamin D
Serotonin
Tryptophan Hydroxylase
2 Citations (Scopus)

Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling

Chamcheu, J. C., Rady, I., Chamcheu, R. C. N., Siddique, A. B., Bloch, M. B., Mbeumi, S. B., Babatunde, A. S., Uddin, M. B., Noubissi, F. K., Jurutka, P., Liu, Y. Y., Spiegelman, V. S., Whitfield, G. K. & El Sayed, K. A., Jun 16 2018, In : International Journal of Molecular Sciences. 19, 6, 1791.

Research output: Contribution to journalArticle

Annona
Hedgehogs
Skin Neoplasms
Skin
cancer
1 Citation (Scopus)

Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines

Sabir, M. S., Haussler, M. R., Mallick, S., Kaneko, I., Lucas, D. A., Haussler, C. A., Whitfield, G. K. & Jurutka, P., Jul 11 2018, In : Genes and Nutrition. 13, 1, 19.

Research output: Contribution to journalArticle

Monoamine Oxidase
Vitamin D
Serotonin
Gene Expression
Cell Line
2017
2 Citations (Scopus)

Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials

Kohler, L. N., Hibler, E. A., Harris, R. B., Oren, E., Roe, D. J., Jurutka, P. & Jacobs, E. T., Mar 1 2017, In : The Journal of nutrition. 147, 3, p. 421-429 9 p.

Research output: Contribution to journalArticle

Chemoprevention
Vitamin D
Cross-Sectional Studies
Guidelines
Neoplasms
6 Citations (Scopus)

SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation

Sabir, M. S., Khan, Z., Hu, C., Galligan, M. A., Dussik, C. M., Mallick, S., Stone, A. D., Batie, S. F., Jacobs, E. T., Whitfield, G. K., Haussler, M. R., Heck, M. C. & Jurutka, P., 2017, (Accepted/In press) In : Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journalArticle

Sirtuin 1
Calcitriol Receptors
Calcitriol
Acetylation
Transcription
3 Citations (Scopus)

Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans

Andersen, S. W., Shu, X. O., Cai, Q., Khankari, N. K., Steinwande, M. D., Jurutka, P., Blot, W. J. & Zheng, W., Aug 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 8, p. 1242-1247 6 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Vitamin D
African Americans
Colorectal Neoplasms
Prospective Studies
2016
11 Citations (Scopus)

1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age

Haussler, M. R., Kerr Whitfield, G., Haussler, C. A., Sabir, M. S., Khan, Z., Sandoval, R. & Jurutka, P., 2016, (Accepted/In press) In : Vitamins and Hormones.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Hormones
Kidney
Vitamin D

Association between circulating Vitamin D metabolites and fecal bile acid concentrations

Jacobs, E. T., Haussler, M. R., Alberts, D. S., Kohler, L. N., Lance, P., Martínez, M. E., Roe, D. J. & Jurutka, P., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 589-597 9 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Vitamin D
Ursodeoxycholic Acid
Adenoma
Confidence Intervals
2 Citations (Scopus)

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Heck, M. C., Wagner, C., Shahani, P. H., Macneill, M., Grozic, A., Darwaiz, T., Shimabuku, M., Deans, D. G., Robinson, N. M., Salama, S. H., Ziller, J. W., Ma, N., Van Der Vaart, A., Marshall, P. & Jurutka, P., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8924-8940 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Niacin
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
8 Citations (Scopus)

Physical activity, sedentary behavior, and vitamin D metabolites

Hibler, E. A., Sardo Molmenti, C. L., Dai, Q., Kohler, L. N., Warren Anderson, S., Jurutka, P. & Jacobs, E. T., Feb 1 2016, In : Bone. 83, p. 248-255 8 p.

Research output: Contribution to journalArticle

Vitamin D
Exercise
Linear Models
Chronic Disease
Logistic Models
2015
43 Citations (Scopus)

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D

Kaneko, I., Sabir, M. S., Dussik, C. M., Whitfield, G. K., Karrys, A., Hsieh, J. C., Haussler, M. R., Meyer, M. B., Pike, J. W. & Jurutka, P., Sep 1 2015, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 9, p. 4023-4035 13 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Calcitriol
Leptin
Vitamin D
Genes
9 Citations (Scopus)

Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles

Marshall, P., Jurutka, P., Wagner, C., van der Vaart, A., Kaneko, I., Chavez, P. I., Ma, N., Bhogal, J. S., Shahani, P., Swierski, J. C. & Macneill, M., Mar 1 2015, In : Pharmacology Research and Perspectives. 3, 2, p. 1-19 19 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Ligands
RNA Sequence Analysis
Lipids
Thyrotropin
20 Citations (Scopus)

Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components

Bea, J. W., Jurutka, P., Hibler, E. A., Lance, P., Martínez, M. E., Roe, D. J., Sardo Molmenti, C. L., Thompson, P. A. & Jacobs, E. T., Mar 1 2015, In : Metabolism: Clinical and Experimental. 64, 3, p. 447-459 13 p.

Research output: Contribution to journalArticle

Vitamin D
HDL Lipoproteins
Triglycerides
Waist Circumference
LDL Lipoproteins
6 Citations (Scopus)

CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Hibler, E. A., Klimentidis, Y. C., Jurutka, P., Kohler, L. N., Lance, P., Roe, D. J., Thompson, P. A. & Jacobs, E. T., Oct 3 2015, In : Nutrition and Cancer. 67, 7, p. 1131-1141 11 p.

Research output: Contribution to journalArticle

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Vitamin D
Adenoma
Recurrence
Alleles
1 Citation (Scopus)

Distinct functional modes of SUMOylation for retinoid X receptor alpha

Lee, W. P., Jena, S., Rodriguez, E. P., O'Donovan, S. P., Wagner, C., Jurutka, P. & Thompson, P. D., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Retinoid X Receptor alpha
Sumoylation
Lysine
Protein Inhibitors of Activated STAT
Ubiquitin
20 Citations (Scopus)

FGF23 gene regulation by 1,25-dihyoxyvitamin D: Opposing effects in adipocytes and osteocytes

Kaneko, I., Saini, R. K., Griffin, K. P., Whitfield, G. K., Haussler, M. R. & Jurutka, P., 2015, In : Journal of Endocrinology. 226, 3, p. 155-166 12 p.

Research output: Contribution to journalArticle

Osteocytes
Calcitriol
Adipocytes
Genes
Calcitriol Receptors
14 Citations (Scopus)

Resveratrol potentiates vitamin D and nuclear receptor signaling

Dampf Stone, A., Batie, S. F., Sabir, M. S., Jacobs, E. T., Lee, J. H., Whitfield, G. K., Haussler, M. R. & Jurutka, P., Jun 1 2015, In : Journal of Cellular Biochemistry. 116, 6, p. 1130-1143 14 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Cytoplasmic and Nuclear Receptors
Calcitriol
Retinoid X Receptors
Vitamin D
2014
11 Citations (Scopus)

Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma

Hibler, E. A., Sardo Molmenti, C. L., Lance, P., Jurutka, P. & Jacobs, E. T., 2014, In : Cancer Causes and Control. 25, 7, p. 809-817 9 p.

Research output: Contribution to journalArticle

Adenoma
Secosteroids
Ursodeoxycholic Acid
Vitamin D
Colon
11 Citations (Scopus)

Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells

Hibler, E. A., Jacobs, E. T., Stone, A. D., Sardo, C. L., Galligan, M. A. & Jurutka, P., 2014, In : Cancer Prevention Research. 7, 4, p. 426-434 9 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Vitamin D
Colonic Neoplasms
Clinical Trials
HCT116 Cells
7 Citations (Scopus)

Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin

Austin, H. R., Hoss, E., Batie, S. F., Moffet, E. W., Jurutka, P., Haussler, M. R. & Whitfield, G. K., Jan 24 2014, In : Biochemical and Biophysical Research Communications. 443, 4, p. 1275-1279 5 p.

Research output: Contribution to journalArticle

Psoriasis
Genes
Keratinocytes
Calcitriol Receptors
Calcitriol
7 Citations (Scopus)

Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling

Lee, W. P., Jena, S., Doherty, D., Ventakesh, J., Schimdt, J., Furmick, J., Widener, T., Lemau, J., Jurutka, P. & Thompson, P. D., Feb 20 2014, In : PLoS One. 9, 2, e89506.

Research output: Contribution to journalArticle

SUMO-1 Protein
Calcitriol Receptors
modifiers (genes)
ubiquitin
Ubiquitin
7 Citations (Scopus)

Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes

Hsieh, J. C., Estess, R. C., Kaneko, I., Kerr Whitfield, G., Jurutka, P. & Haussler, M. R., Feb 2014, In : Journal of Endocrinology. 220, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Keratinocytes
Gene Expression
Vitamin D
2013
42 Citations (Scopus)

1,25-Dihydroxyvitamin D3 regulation of fibroblast growth factor-23 expression in bone cells: Evidence for primary and secondary mechanisms modulated by leptin and interleukin-6

Saini, R. K., Kaneko, I., Jurutka, P., Forster, R., Hsieh, A., Hsieh, J. C., Haussler, M. R. & Whitfield, G. K., Apr 2013, In : Calcified Tissue International. 92, 4, p. 339-353 15 p.

Research output: Contribution to journalArticle

Calcitriol
Leptin
Interleukin-6
Bone and Bones
Calcitriol Receptors
18 Citations (Scopus)

Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis

Jacobs, E. T., Hibler, E. A., Lance, P., Sardo, C. L. & Jurutka, P., Dec 15 2013, In : International Journal of Cancer. 133, 12, p. 2980-2988 9 p.

Research output: Contribution to journalArticle

Adenoma
Vitamin D
Odds Ratio
Recurrence
Neoplasms
14 Citations (Scopus)

Control of late cornified envelope genes relevant to psoriasis risk: Upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin

Hoss, E., Austin, H. R., Batie, S. F., Jurutka, P., Haussler, M. R. & Whitfield, G. K., 2013, In : Archives of Dermatological Research. 305, 10, p. 867-878 12 p.

Research output: Contribution to journalArticle

delphinidin
Calcitriol
Psoriasis
Up-Regulation
Keratinocytes
36 Citations (Scopus)

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells

Jacobs, E. T., Van Pelt, C., Forster, R. E., Zaidi, W., Hibler, E. A., Galligan, M. A., Haussler, M. R. & Jurutka, P., Apr 15 2013, In : Cancer Research. 73, 8, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Vitamin D
Colonic Neoplasms
Single Nucleotide Polymorphism
Calcitriol Receptors
12 Citations (Scopus)

Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl) -4-hydroxyphenyl)acrylic acid (CD3254)

Jurutka, P., Kaneko, I., Yang, J., Bhogal, J. S., Swierski, J. C., Tabacaru, C. R., Montano, L. A., Huynh, C. C., Jama, R. A., Mahelona, R. D., Sarnowski, J. T., Marcus, L. M., Quezada, A., Lemming, B., Tedesco, M. A., Fischer, A. J., Mohamed, S. A., Ziller, J. W., Ma, N., Gray, G. M. & 3 othersVan Der Vaart, A., Marshall, P. & Wagner, C., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8432-8454 23 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
Drug Design
278 Citations (Scopus)

Molecular mechanisms of vitamin D action

Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J. C. & Jurutka, P., 2013, In : Calcified Tissue International. 92, 2, p. 77-98 22 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Vitamin D
Retinoid X Receptors
Ligands
Claudin-2
11 Citations (Scopus)

Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S., Lee, J. H., Jama, R. A., Browder, D. O., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Mohammed, Z., Trang, V., Marshall, P., Jurutka, P. & Wagner, C., Feb 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 3, p. 693-702 10 p.

Research output: Contribution to journalArticle

Curcumin
Cytoplasmic and Nuclear Receptors
Calcitriol Receptors
Retinoid X Receptors
Assays
2012
9 Citations (Scopus)

Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling

Marshall, P., Hernandez, Z., Kaneko, I., Widener, T., Tabacaru, C., Aguayo, I. & Jurutka, P., Oct 2012, In : Journal of Steroid Biochemistry and Molecular Biology. 132, 1-2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Two-Hybrid System Techniques
Assays
Transcription
17 Citations (Scopus)

Modeling, Synthesis and Biological Evaluation of Potential RetinoidX Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)

Furmick, J. K., Kaneko, I., Walsh, A. N., Yang, J., Bhogal, J. S., Gray, G. M., Baso, J. C., Browder, D. O., Prentice, J. L. S., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Kwon, J. S., Quezada, A., Reyes, N. M., Lemming, B., Saini, P., vanderVaart, A., Groy, T. L. & 3 othersMarshall, P., Jurutka, P. & Wagner, C., Sep 2012, In : ChemMedChem. 7, 9, p. 1551-1566 16 p.

Research output: Contribution to journalArticle

Benzoic Acid
Assays
Cutaneous T-Cell Lymphoma
Halogens
T-cells
22 Citations (Scopus)

Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia

Hibler, E. A., Hu, C., Jurutka, P., Martinez, M. E. & Jacobs, E. T., Feb 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Vitamin D
Single Nucleotide Polymorphism
Genes
Ursodeoxycholic Acid
64 Citations (Scopus)

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis

Haussler, M. R., Whitfield, G. K., Kaneko, I., Forster, R., Saini, R., Hsieh, J. C., Haussler, C. A. & Jurutka, P., Mar 2012, In : Reviews in Endocrine and Metabolic Disorders. 13, 1, p. 57-69 13 p.

Research output: Contribution to journalArticle

Vitamin D
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Phosphates
Kidney
Bone and Bones
2011
15 Citations (Scopus)

Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma

Jacobs, E., Martinez, M. E., Buckmeier, J., Lance, P., May, M. & Jurutka, P., 2011, In : Journal of Carcinogenesis. 10, 3.

Research output: Contribution to journalArticle

Adenoma
Vitamin D
Linear Models
fibroblast growth factor 23
Fibroblast Growth Factor 1
16 Citations (Scopus)

Vitamin D: Marker or mechanism of action?

Jacobs, E. T., Martínez, M. E. & Jurutka, P., Apr 2011, In : Cancer Epidemiology Biomarkers and Prevention. 20, 4, p. 585-590 6 p.

Research output: Contribution to journalArticle

Vitamin D
Molecular Biology
Neoplasms
Carcinogenesis
Epidemiology
294 Citations (Scopus)

Vitamin D receptor (VDR)-mediated actions of 1α,25(OH) 2vitamin D 3: Genomic and non-genomic mechanisms

Haussler, M. R., Jurutka, P., Mizwicki, M. & Norman, A. W., Aug 2011, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 25, 4, p. 543-559 17 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Ligands
Vitamin D
Secosteroids
Retinoid X Receptors
79 Citations (Scopus)

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

Forster, R. E., Jurutka, P., Hsieh, J. C., Haussler, C. A., Lowmiller, C. L., Kaneko, I., Haussler, M. R. & Kerr Whitfield, G., Oct 28 2011, In : Biochemical and Biophysical Research Communications. 414, 3, p. 557-562 6 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Vitamin D
Genes
Aging of materials
Kidney
2010
21 Citations (Scopus)

Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites

Hibler, E. A., Jurutka, P., Egan, J. B., Hu, C., LeRoy, E. C., Martinez, M. E., Thompson, P. A. & Jacobs, E. T., Jul 2010, In : Journal of Steroid Biochemistry and Molecular Biology. 121, 1-2, p. 438-441 4 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Metabolites
Vitamin D
Single Nucleotide Polymorphism
Polymorphism
1 Citation (Scopus)

Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase

Deutch, C. E., Krumbholz, R., Schmid, S. M., Bonate, P. L. & Jurutka, P., Mar 5 2010, In : Enzyme and Microbial Technology. 46, 3-4, p. 246-251 6 p.

Research output: Contribution to journalArticle

prolyl oligopeptidase
Metabolites
Metabolism
Peptides
Tumors
79 Citations (Scopus)

Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

Bartik, L., Whitfield, G. K., Kaczmarska, M., Lowmiller, C. L., Moffet, E. W., Furmick, J. K., Hernandez, Z., Haussler, C. A., Haussler, M. R. & Jurutka, P., Dec 2010, In : Journal of Nutritional Biochemistry. 21, 12, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Curcumin
Chemoprevention
Colonic Neoplasms
Ligands
40 Citations (Scopus)

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence

Egan, J. B., Thompson, P. A., Ashbeck, E. L., Conti, D. V., Duggan, D., Hibler, E., Jurutka, P., LeRoy, E. C., Martínez, M. E., Mount, D. & Jacobs, E. T., Feb 15 2010, In : Cancer Research. 70, 4, p. 1496-1504 9 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Genetic Polymorphisms
Adenoma
Colon
Single Nucleotide Polymorphism
111 Citations (Scopus)

The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the " Fountain of Youth" to mediate healthful aging

Haussler, M. R., Haussler, C. A., Whitfield, G. K., Hsieh, J. C., Thompson, P. D., Barthel, T. K., Bartik, L., Egan, J. B., Wu, Y., Kubicek, J. L., Lowmiller, C. L., Moffet, E. W., Forster, R. E. & Jurutka, P., Jul 2010, In : Journal of Steroid Biochemistry and Molecular Biology. 121, 1-2, p. 88-97 10 p.

Research output: Contribution to journalArticle

Fountains
Calcitriol Receptors
Gene encoding
Aging of materials
Gene Expression
49 Citations (Scopus)

Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β-catenin activity in colon cancer cells

Egan, J. B., Thompson, P. A., Vitanov, M. V., Bartik, L., Jacobs, E. T., Haussler, M. R., Gerner, E. W. & Jurutka, P., Apr 2010, In : Molecular Carcinogenesis. 49, 4, p. 337-352 16 p.

Research output: Contribution to journalArticle

Catenins
Calcitriol Receptors
Adenomatous Polyposis Coli
Colonic Neoplasms
Calcitriol
2009
37 Citations (Scopus)

Modeling, synthesis and biological evaluation of potential Retinoid X Receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)

Wagner, C., Jurutka, P., Marshall, P., Groy, T. L., Van Der Vaart, A., Ziller, J. W., Furmick, J. K., Graeber, M. E., Matro, E., Miguel, B. V., Tran, I. T., Kwon, J., Tedeschi, J. N., Moosavi, S., Danishyar, A., Philp, J. S., Khamees, R. O., Jackson, J. N., Grupe, D. K., Badshah, S. L. & 1 othersHart, J. W., Oct 8 2009, In : Journal of Medicinal Chemistry. 52, 19, p. 5950-5966 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Apoptosis
Cutaneous T-Cell Lymphoma
Drug Design
10 Citations (Scopus)

Vitamin D, calcium, and colorectal neoplasia: New insights on mechanisms of action

Jacobs, E. T., Jurutka, P., Martínez, M. E. & Alberts, D. S., Mar 2009, In : Cancer Prevention Research. 2, 3, p. 197-199 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein
Biological Models
Vitamin D
Colorectal Neoplasms
2008
4 Citations (Scopus)

Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma

Egan, J. B., Jacobs, E. T., Martínez, M. E., Gerner, E. W., Jurutka, P. & Thompson, P. A., Jul 15 2008, In : Cancer Research. 68, 14, p. 6006-6013 8 p.

Research output: Contribution to journalArticle

APC Genes
Adenoma
Haplotypes
Codon
Single Nucleotide Polymorphism