• 6659 Citations
  • 41 h-Index
1986 …2024

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2019

16α-Hydroxytrametenolic Acid from Poria cocos Improves Intestinal Barrier Function through the Glucocorticoid Receptor-Mediated PI3K/Akt/NF-κB Pathway

Xu, H., Wang, Y., Jurutka, P. W., Wu, S., Chen, Y., Cao, C., Chen, G., Tian, B., Wang, S. & Cheng, S., Oct 2 2019, In : Journal of Agricultural and Food Chemistry. 67, 39, p. 10871-10879 9 p.

Research output: Contribution to journalArticle

Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention

Zhang, D., Leal, A. S., Carapellucci, S., Shahani, P. H., Bhogal, J. S., Ibrahim, S., Raban, S., Jurutka, P., Marshall, P., Sporn, M. B., Wagner, C. & Liby, K. T., Apr 1 2019, In : Cancer Prevention Research. 12, 4, p. 211-224 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Hanish, B. J., Hackney Price, J., Kaneko, I., Ma, N., van der Vaart, A., Wagner, C., Jurutka, P. & Marshall, P., Jul 1 2018, In : Steroids. 135, p. 36-49 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with risk for psoriasis

Karrys, A., Rady, I., Chamcheu, R. C. N., Sabir, M. S., Mallick, S., Chamcheu, J. C., Jurutka, P., Haussler, M. R. & Whitfield, G. K., Feb 4 2018, In : Nutrients. 10, 2, 174.

Research output: Contribution to journalArticle

3 Scopus citations

Dataset on the response of Hut78 cells to novel rexinoids

Hackney Price, J., Hanish, B. J., Wagner, C., Kaneko, I., Jurutka, P. & Marshall, P., Oct 1 2018, In : Data in Brief. 20, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

Gene expression profiling and assessment of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome

Dussik, C. M., Hockley, M., Grozic, A., Kaneko, I., Zhang, L., Sabir, M. S., Park, J., Wang, J., Nickerson, C., Yale, S. H., Rall, C. J., Foxx-Orenstein, A. E., Borror, C. M., Sandrin, T. & Jurutka, P., Jan 1 2018, In : Journal of Neurogastroenterology and Motility. 24, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling

Chamcheu, J. C., Rady, I., Chamcheu, R. C. N., Siddique, A. B., Bloch, M. B., Mbeumi, S. B., Babatunde, A. S., Uddin, M. B., Noubissi, F. K., Jurutka, P., Liu, Y. Y., Spiegelman, V. S., Whitfield, G. K. & El Sayed, K. A., Jun 16 2018, In : International Journal of Molecular Sciences. 19, 6, 1791.

Research output: Contribution to journalArticle

3 Scopus citations

Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines

Sabir, M. S., Haussler, M. R., Mallick, S., Kaneko, I., Lucas, D. A., Haussler, C. A., Whitfield, G. K. & Jurutka, P., Jul 11 2018, In : Genes and Nutrition. 13, 1, 19.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials

Kohler, L. N., Hibler, E. A., Harris, R. B., Oren, E., Roe, D. J., Jurutka, P. & Jacobs, E. T., Mar 1 2017, In : The Journal of nutrition. 147, 3, p. 421-429 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation

Sabir, M. S., Khan, Z., Hu, C., Galligan, M. A., Dussik, C. M., Mallick, S., Stone, A. D., Batie, S. F., Jacobs, E. T., Whitfield, G. K., Haussler, M. R., Heck, M. C. & Jurutka, P., 2017, (Accepted/In press) In : Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journalArticle

7 Scopus citations

Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans

Andersen, S. W., Shu, X. O., Cai, Q., Khankari, N. K., Steinwande, M. D., Jurutka, P., Blot, W. J. & Zheng, W., Aug 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 8, p. 1242-1247 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age

Haussler, M. R., Kerr Whitfield, G., Haussler, C. A., Sabir, M. S., Khan, Z., Sandoval, R. & Jurutka, P., 2016, (Accepted/In press) In : Vitamins and Hormones.

Research output: Contribution to journalArticle

16 Scopus citations

Association between circulating Vitamin D metabolites and fecal bile acid concentrations

Jacobs, E. T., Haussler, M. R., Alberts, D. S., Kohler, L. N., Lance, P., Martínez, M. E., Roe, D. J. & Jurutka, P., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 589-597 9 p.

Research output: Contribution to journalArticle

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Heck, M. C., Wagner, C., Shahani, P. H., Macneill, M., Grozic, A., Darwaiz, T., Shimabuku, M., Deans, D. G., Robinson, N. M., Salama, S. H., Ziller, J. W., Ma, N., Van Der Vaart, A., Marshall, P. & Jurutka, P., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8924-8940 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Physical activity, sedentary behavior, and vitamin D metabolites

Hibler, E. A., Sardo Molmenti, C. L., Dai, Q., Kohler, L. N., Warren Anderson, S., Jurutka, P. & Jacobs, E. T., Feb 1 2016, In : Bone. 83, p. 248-255 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D

Kaneko, I., Sabir, M. S., Dussik, C. M., Whitfield, G. K., Karrys, A., Hsieh, J. C., Haussler, M. R., Meyer, M. B., Pike, J. W. & Jurutka, P., Sep 1 2015, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 9, p. 4023-4035 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles

Marshall, P., Jurutka, P., Wagner, C., van der Vaart, A., Kaneko, I., Chavez, P. I., Ma, N., Bhogal, J. S., Shahani, P., Swierski, J. C. & Macneill, M., Mar 1 2015, In : Pharmacology Research and Perspectives. 3, 2, p. 1-19 19 p.

Research output: Contribution to journalArticle

13 Scopus citations

Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components

Bea, J. W., Jurutka, P., Hibler, E. A., Lance, P., Martínez, M. E., Roe, D. J., Sardo Molmenti, C. L., Thompson, P. A. & Jacobs, E. T., Mar 1 2015, In : Metabolism: Clinical and Experimental. 64, 3, p. 447-459 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Hibler, E. A., Klimentidis, Y. C., Jurutka, P., Kohler, L. N., Lance, P., Roe, D. J., Thompson, P. A. & Jacobs, E. T., Oct 3 2015, In : Nutrition and Cancer. 67, 7, p. 1131-1141 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distinct functional modes of SUMOylation for retinoid X receptor alpha

Lee, W. P., Jena, S., Rodriguez, E. P., O'Donovan, S. P., Wagner, C., Jurutka, P. & Thompson, P. D., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

FGF23 gene regulation by 1,25-dihyoxyvitamin D: Opposing effects in adipocytes and osteocytes

Kaneko, I., Saini, R. K., Griffin, K. P., Whitfield, G. K., Haussler, M. R. & Jurutka, P., 2015, In : Journal of Endocrinology. 226, 3, p. 155-166 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Resveratrol potentiates vitamin D and nuclear receptor signaling

Dampf Stone, A., Batie, S. F., Sabir, M. S., Jacobs, E. T., Lee, J. H., Whitfield, G. K., Haussler, M. R. & Jurutka, P., Jun 1 2015, In : Journal of Cellular Biochemistry. 116, 6, p. 1130-1143 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma

Hibler, E. A., Sardo Molmenti, C. L., Lance, P., Jurutka, P. & Jacobs, E. T., 2014, In : Cancer Causes and Control. 25, 7, p. 809-817 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells

Hibler, E. A., Jacobs, E. T., Stone, A. D., Sardo, C. L., Galligan, M. A. & Jurutka, P., 2014, In : Cancer Prevention Research. 7, 4, p. 426-434 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin

Austin, H. R., Hoss, E., Batie, S. F., Moffet, E. W., Jurutka, P., Haussler, M. R. & Whitfield, G. K., Jan 24 2014, In : Biochemical and Biophysical Research Communications. 443, 4, p. 1275-1279 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling

Lee, W. P., Jena, S., Doherty, D., Ventakesh, J., Schimdt, J., Furmick, J., Widener, T., Lemau, J., Jurutka, P. & Thompson, P. D., Feb 20 2014, In : PLoS One. 9, 2, e89506.

Research output: Contribution to journalArticle

7 Scopus citations

Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes

Hsieh, J. C., Estess, R. C., Kaneko, I., Kerr Whitfield, G., Jurutka, P. & Haussler, M. R., Feb 2014, In : Journal of Endocrinology. 220, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

1,25-Dihydroxyvitamin D3 regulation of fibroblast growth factor-23 expression in bone cells: Evidence for primary and secondary mechanisms modulated by leptin and interleukin-6

Saini, R. K., Kaneko, I., Jurutka, P., Forster, R., Hsieh, A., Hsieh, J. C., Haussler, M. R. & Whitfield, G. K., Apr 2013, In : Calcified Tissue International. 92, 4, p. 339-353 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis

Jacobs, E. T., Hibler, E. A., Lance, P., Sardo, C. L. & Jurutka, P., Dec 15 2013, In : International Journal of Cancer. 133, 12, p. 2980-2988 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Control of late cornified envelope genes relevant to psoriasis risk: Upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin

Hoss, E., Austin, H. R., Batie, S. F., Jurutka, P., Haussler, M. R. & Whitfield, G. K., 2013, In : Archives of Dermatological Research. 305, 10, p. 867-878 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells

Jacobs, E. T., Van Pelt, C., Forster, R. E., Zaidi, W., Hibler, E. A., Galligan, M. A., Haussler, M. R. & Jurutka, P., Apr 15 2013, In : Cancer Research. 73, 8, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl) -4-hydroxyphenyl)acrylic acid (CD3254)

Jurutka, P., Kaneko, I., Yang, J., Bhogal, J. S., Swierski, J. C., Tabacaru, C. R., Montano, L. A., Huynh, C. C., Jama, R. A., Mahelona, R. D., Sarnowski, J. T., Marcus, L. M., Quezada, A., Lemming, B., Tedesco, M. A., Fischer, A. J., Mohamed, S. A., Ziller, J. W., Ma, N., Gray, G. M. & 3 others, Van Der Vaart, A., Marshall, P. & Wagner, C., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8432-8454 23 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular mechanisms of vitamin D action

Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J. C. & Jurutka, P., 2013, In : Calcified Tissue International. 92, 2, p. 77-98 22 p.

Research output: Contribution to journalArticle

318 Scopus citations

Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S., Lee, J. H., Jama, R. A., Browder, D. O., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Mohammed, Z., Trang, V., Marshall, P., Jurutka, P. & Wagner, C., Feb 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 3, p. 693-702 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling

Marshall, P., Hernandez, Z., Kaneko, I., Widener, T., Tabacaru, C., Aguayo, I. & Jurutka, P., Oct 2012, In : Journal of Steroid Biochemistry and Molecular Biology. 132, 1-2, p. 147-159 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modeling, Synthesis and Biological Evaluation of Potential RetinoidX Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)

Furmick, J. K., Kaneko, I., Walsh, A. N., Yang, J., Bhogal, J. S., Gray, G. M., Baso, J. C., Browder, D. O., Prentice, J. L. S., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Kwon, J. S., Quezada, A., Reyes, N. M., Lemming, B., Saini, P., vanderVaart, A., Groy, T. L. & 3 others, Marshall, P., Jurutka, P. & Wagner, C., Sep 2012, In : ChemMedChem. 7, 9, p. 1551-1566 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia

Hibler, E. A., Hu, C., Jurutka, P., Martinez, M. E. & Jacobs, E. T., Feb 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis

Haussler, M. R., Whitfield, G. K., Kaneko, I., Forster, R., Saini, R., Hsieh, J. C., Haussler, C. A. & Jurutka, P., Mar 2012, In : Reviews in Endocrine and Metabolic Disorders. 13, 1, p. 57-69 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
2011

Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma

Jacobs, E., Martinez, M. E., Buckmeier, J., Lance, P., May, M. & Jurutka, P., 2011, In : Journal of Carcinogenesis. 10, 3.

Research output: Contribution to journalArticle

15 Scopus citations

Vitamin D: Marker or mechanism of action?

Jacobs, E. T., Martínez, M. E. & Jurutka, P., Apr 2011, In : Cancer Epidemiology Biomarkers and Prevention. 20, 4, p. 585-590 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Vitamin D receptor (VDR)-mediated actions of 1α,25(OH) 2vitamin D 3: Genomic and non-genomic mechanisms

Haussler, M. R., Jurutka, P., Mizwicki, M. & Norman, A. W., Aug 2011, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 25, 4, p. 543-559 17 p.

Research output: Contribution to journalArticle

331 Scopus citations

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

Forster, R. E., Jurutka, P., Hsieh, J. C., Haussler, C. A., Lowmiller, C. L., Kaneko, I., Haussler, M. R. & Kerr Whitfield, G., Oct 28 2011, In : Biochemical and Biophysical Research Communications. 414, 3, p. 557-562 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
2010

Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites

Hibler, E. A., Jurutka, P., Egan, J. B., Hu, C., LeRoy, E. C., Martinez, M. E., Thompson, P. A. & Jacobs, E. T., Jul 2010, In : Journal of Steroid Biochemistry and Molecular Biology. 121, 1-2, p. 438-441 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase

Deutch, C. E., Krumbholz, R., Schmid, S. M., Bonate, P. L. & Jurutka, P., Mar 5 2010, In : Enzyme and Microbial Technology. 46, 3-4, p. 246-251 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

Bartik, L., Whitfield, G. K., Kaczmarska, M., Lowmiller, C. L., Moffet, E. W., Furmick, J. K., Hernandez, Z., Haussler, C. A., Haussler, M. R. & Jurutka, P., Dec 2010, In : Journal of Nutritional Biochemistry. 21, 12, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence

Egan, J. B., Thompson, P. A., Ashbeck, E. L., Conti, D. V., Duggan, D., Hibler, E., Jurutka, P., LeRoy, E. C., Martínez, M. E., Mount, D. & Jacobs, E. T., Feb 15 2010, In : Cancer Research. 70, 4, p. 1496-1504 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the " Fountain of Youth" to mediate healthful aging

Haussler, M. R., Haussler, C. A., Whitfield, G. K., Hsieh, J. C., Thompson, P. D., Barthel, T. K., Bartik, L., Egan, J. B., Wu, Y., Kubicek, J. L., Lowmiller, C. L., Moffet, E. W., Forster, R. E. & Jurutka, P., Jul 2010, In : Journal of Steroid Biochemistry and Molecular Biology. 121, 1-2, p. 88-97 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β-catenin activity in colon cancer cells

Egan, J. B., Thompson, P. A., Vitanov, M. V., Bartik, L., Jacobs, E. T., Haussler, M. R., Gerner, E. W. & Jurutka, P., Apr 2010, In : Molecular Carcinogenesis. 49, 4, p. 337-352 16 p.

Research output: Contribution to journalArticle

51 Scopus citations
2009

Modeling, synthesis and biological evaluation of potential Retinoid X Receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)

Wagner, C., Jurutka, P., Marshall, P., Groy, T. L., Van Der Vaart, A., Ziller, J. W., Furmick, J. K., Graeber, M. E., Matro, E., Miguel, B. V., Tran, I. T., Kwon, J., Tedeschi, J. N., Moosavi, S., Danishyar, A., Philp, J. S., Khamees, R. O., Jackson, J. N., Grupe, D. K., Badshah, S. L. & 1 others, Hart, J. W., Oct 8 2009, In : Journal of Medicinal Chemistry. 52, 19, p. 5950-5966 17 p.

Research output: Contribution to journalArticle

45 Scopus citations

Vitamin D, calcium, and colorectal neoplasia: New insights on mechanisms of action

Jacobs, E. T., Jurutka, P., Martínez, M. E. & Alberts, D. S., Mar 2009, In : Cancer Prevention Research. 2, 3, p. 197-199 3 p.

Research output: Contribution to journalArticle

10 Scopus citations