Paul Coleman

2023

Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases

Huseby, C. J., Delvaux, E., Brokaw, D. L. & Coleman, P. D., Jun 2023, In: Alzheimer's and Dementia. 19, 6, p. 2618-2632 15 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Integrated DNA Methylation/RNA Profiling in Middle Temporal Gyrus of Alzheimer’s Disease

Piras, I. S., Brokaw, D., Kong, Y., Weisenberger, D. J., Krate, J., Delvaux, E., Mahurkar, S., Blattler, A., Siegmund, K. D., Sue, L., Serrano, G. E., Beach, T. G., Laird, P. W., Huentelman, M. J. & Coleman, P. D., Jul 2023, In: Cellular and Molecular Neurobiology. 43, 5, p. 2289-2307 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Intracellular Amyloid-β Detection from Human Brain Sections Using a Microfluidic Immunoassay in Tandem with MALDI-MS

Villarreal, J. C., Kow, K., Pham, B., Egatz-Gomez, A., Sandrin, T. R., Coleman, P. D. & Ros, A., Apr 4 2023, In: Analytical Chemistry. 95, 13, p. 5522-5531 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Blood Transcript Biomarkers Selected by Machine Learning Algorithm Classify Neurodegenerative Diseases including Alzheimer’s Disease

Huseby, C. J., Delvaux, E., Brokaw, D. L. & Coleman, P. D., Nov 2022, In: Biomolecules. 12, 11, 1592.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

Cruz Villarreal, J., Kruithoff, R., Egatz-Gomez, A., Coleman, P. D., Ros, R., Sandrin, T. R. & Ros, A., May 2022, In: Analytical and bioanalytical chemistry. 414, 13, p. 3945-3958 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach

Giovagnoni, C., Ali, M., Eijssen, L. M. T., Maes, R., Choe, K., Mulder, M., Kleinjans, J., del Sol, A., Glaab, E., Mastroeni, D., Delvaux, E., Coleman, P., Losen, M., Pishva, E., Martinez-Martinez, P. & van den Hove, D. L. A., Jun 2021, In: Neurobiology of Aging. 102, p. 178-187 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

Smith, R. G., Pishva, E., Shireby, G., Smith, A. R., Roubroeks, J. A. Y., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Riemenschneider, M., Giese, A., Sharp, A. J., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., van den Hove, D. L. A., Weedon, M., Brokaw, D., Francis, P. T., Thomas, A. J., & 8 othersLove, S., Morgan, K., Walter, J., Coleman, P. D., Bennett, D. A., De Jager, P. L., Mill, J. & Lunnon, K., Dec 1 2021, In: Nature communications. 12, 1, 3517.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity

Liao, R., Mondal, M., Nazaroff, C. D., Mastroeni, D., Coleman, P. D., Labaer, J. & Guo, J., Jan 8 2021, In: Frontiers in Cell and Developmental Biology. 8, 614624.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease

Paes, D., Lardenoije, R., Carollo, R. M., Roubroeks, J. A. Y., Schepers, M., Coleman, P., Mastroeni, D., Delvaux, E., Pishva, E., Lunnon, K., Vanmierlo, T., van den Hove, D. & Prickaerts, J., Jan 2021, In: Neurobiology of Aging. 97, p. 56-64 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2020

Alzheimer's disease specific markers detected with microfluidic MALDI mass spectrometry (MIMAS)

Villarreal, J. C., Williams, S., Egatz-Gomez, A., Coleman, P., Nedelkov, D., Sierks, M. R. & Ros, A., Jan 1 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 1287-1288 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Amyloid β analysis from microdissected brain cells using microfluidics and maldi mass spectrometry

Villarreal, J. C., Egatz-Gomez, A., Liu, J., Ros, R., Coleman, P. D. & Ros, A., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 711-712 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

Brokaw, D. L., Piras, I. S., Mastroeni, D., Weisenberger, D. J., Nolz, J., Delvaux, E., Serrano, G. E., Beach, T. G., Huentelman, M. J. & Coleman, P. D., Nov 2020, In: Neurobiology of Aging. 95, p. 15-25 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin

Liao, R., Pham, T., Mastroeni, D., Coleman, P. D., Labaer, J. & Guo, J., Apr 1 2020, In: Cells. 9, 4, 1786.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin

Liao, R., Pham, T., Mastroeni, D., Coleman, P., LaBaer, J. & Guo, J., 2020, In: Cells. 9, 4, p. 852

Research output: Contribution to journal › Article › peer-review

2019

Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood

Lardenoije, R., Roubroeks, J. A. Y., Pishva, E., Leber, M., Wagner, H., Iatrou, A., Smith, A. R., Smith, R. G., Eijssen, L. M. T., Kleineidam, L., Kawalia, A., Hoffmann, P., Luck, T., Riedel-Heller, S., Jessen, F., Maier, W., Wagner, M., Hurlemann, R., Kenis, G., Ali, M., & 9 othersDel Sol, A., Mastroeni, D., Delvaux, E., Coleman, P. D., Mill, J., Rutten, B. P. F., Lunnon, K., Ramirez, A. & Van Den Hove, D. L. A., Nov 27 2019, In: Clinical Epigenetics. 11, 1, 164.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: Comparison of single cell versus neuron pools

Deng, W., Xing, C., David, R., Mastroeni, D., Ning, M. M., Lo, E. H. & Coleman, P. D., 2019, In: Aging and Disease. 10, 6, p. 1146-1158 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., De Both, M. D., Mastroeni, D. F., Serrano, G. E., Sue, L. I., Beach, T. G., Coleman, P. D. & Huentelman, M. J., Sep 15 2019, In: Brain Research. 1719, p. 217-224 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning

Willeman, M. N., Chawla, M. K., Zempare, M. A., Biwer, L. A., Hoang, L. T., Uprety, A. R., Fitzhugh, M. C., De Both, M., Coleman, P., Trouard, T. P., Alexander, G. E., Mitchell, K. D., Barnes, C. A., Hale, T. M. & Huentelman, M., Mar 2019, In: Physiological reports. 7, 6, e14010.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., Mastroeni, D. F., Persico, A. M., Jepsen, W. M., Beach, T. G., Huentelman, M. J., Coleman, P. D. & Combs, C., 2019, In: Journal of Alzheimer's Disease. 70, 3, p. 691-713 23 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

2018

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J. & Coleman, P., Mar 2018, In: Neurobiology of Aging. 63, p. 12-21 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jun 2018, In: Alzheimer's and Dementia. 14, 6, p. 775-786 12 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease

Tan, Y., Delvaux, E., Nolz, J., Coleman, P., Chen, S. & Mastroeni, D., Aug 2018, In: Neurobiology of Aging. 68, p. 134-141 8 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2017

A call for new approaches to Alzheimer's disease research

Coleman, P. & Mastroeni, D., Sep 1 2017, In: Neurobiology of Aging. 57, p. iii-iv

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

Mastroeni, D., Sekar, S., Nolz, J., Delvaux, E., Lunnon, K., Mill, J., Liang, W. S. & Coleman, P., Jul 2017, In: PloS one. 12, 7, e0177814.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's

Delvaux, E., Mastroeni, D., Nolz, J., Chow, N., Sabbagh, M., Caselli, R. J., Reiman, E. M., Marshall, F. J. & Coleman, P., Oct 2017, In: Neurobiology of Aging. 58, p. 225-237 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., May 2017, In: Alzheimer's and Dementia. 13, 5, p. 510-519 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

2016

Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

Mastroeni, D., Chouliaras, L., Van den Hove, D. L., Nolz, J., Rutten, B. P. F., Delvaux, E. & Coleman, P., Jun 1 2016, In: Neuroepigenetics. 6, p. 26-31 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Novel method to ascertain chromatin accessibility at specific genomic loci from frozen brain homogenates and laser capture microdissected defined cells

Delvaux, E., Mastroeni, D., Nolz, J. & Coleman, P., Jun 1 2016, In: Neuroepigenetics. 6, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

Mastroeni, D., Delvaux, E., Nolz, J., Tan, Y., Grover, A., Oddo, S. & Coleman, P., Dec 2015, In: Neurobiology of Aging. 36, 12, p. 3121-3129 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Epigenetics of cognition and neurodegenerative disorders

Coleman, P., Huentelman, M. & Dunckley, T., Mar 10 2015, The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York, p. 285-298 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Epigenetics of cognition and neurodegenerative disorders

Coleman, P., Huentelman, M. & Dunckley, T., 2015, In: Neuromethods. 94, p. 285-298 14 p.

Research output: Contribution to journal › Article › peer-review

Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function

Mastroeni, D., Khdour, O., Arce, P. M., Hecht, S. & Coleman, P., Apr 15 2015, In: ACS chemical neuroscience. 6, 4, p. 588-598 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A. & Rutten, B. P. F., Aug 1 2015, In: Progress in Neurobiology. 131, p. 21-64 44 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

279 Scopus citations

Welcome to Neuroepigenetics

Petanceska, S. S. & Coleman, P. D., Jan 1 2015, In: Neuroepigenetics. 1, p. 1 1 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

2014

Editor's comment

Coleman, P. D., Nov 1 2014, In: Neurobiology of Aging. 35, 11, p. 2427 1 p.

Research output: Contribution to journal › Editorial › peer-review

Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease

Fitzsimons, C. P., Van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., Van Den Hurk, M., Boks, M. P., Biojone, C., Joca, S., Steinbusch, H. W. M., Lunnon, K., Mastroeni, D. F., Mill, J., Lucassen, P. J., Coleman, P. D., Van Den Hove, D. L. A. & Rutten, B. P. F., Jun 25 2014, In: Molecular Neurodegeneration. 9, 1, 25.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Scopus citations

2013

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P. D., Rutten, B. P. F. & van den Hove, D. L. A., Sep 2013, In: Neurobiology of Aging. 34, 9, p. 2091-2099 9 p.

Research output: Contribution to journal › Article › peer-review

345 Scopus citations

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes

Delvaux, E., Bentley, K., Stubbs, V., Sabbagh, M. & Coleman, P. D., Jun 2013, In: Neurobiology of Aging. 34, 6, p. 1680-1686 7 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology

Mastroeni, D., Chouliaras, L., Grover, A., Liang, W. S., Hauns, K., Rogers, J. & Coleman, P. D., Jan 8 2013, In: PloS one. 8, 1, e53349.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Berchtold, N. C., Coleman, P. D., Cribbs, D. H., Rogers, J., Gillen, D. L. & Cotman, C. W., Jun 2013, In: Neurobiology of Aging. 34, 6, p. 1653-1661 9 p.

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

2012

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J. & Cotman, C. W., Jul 23 2012, In: Journal of Neuroinflammation. 9, 643.

Research output: Contribution to journal › Article › peer-review

Open Access