• 9481 Citations
  • 47 h-Index
1955 …2020

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2019

Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood

Lardenoije, R., Roubroeks, J. A. Y., Pishva, E., Leber, M., Wagner, H., Iatrou, A., Smith, A. R., Smith, R. G., Eijssen, L. M. T., Kleineidam, L., Kawalia, A., Hoffmann, P., Luck, T., Riedel-Heller, S., Jessen, F., Maier, W., Wagner, M., Hurlemann, R., Kenis, G., Ali, M. & 9 others, Del Sol, A., Mastroeni, D., Delvaux, E., Coleman, P. D., Mill, J., Rutten, B. P. F., Lunnon, K., Ramirez, A. & Van Den Hove, D. L. A., Nov 27 2019, In : Clinical Epigenetics. 11, 1, 164.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: Comparison of single cell versus neuron pools

Deng, W., Xing, C., David, R., Mastroeni, D., Ning, M. M., Lo, E. H. & Coleman, P. D., Jan 1 2019, In : Aging and Disease. 10, 6, p. 1146-1158 13 p.

Research output: Contribution to journalArticle

Open Access

Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., De Both, M. D., Mastroeni, D., Serrano, G. E., Sue, L. I., Beach, T. G., Coleman, P. & Huentelman, M. J., Sep 15 2019, In : Brain Research. 1719, p. 217-224 8 p.

Research output: Contribution to journalArticle

Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning

Willeman, M. N., Chawla, M. K., Zempare, M. A., Biwer, L. A., Hoang, L. T., Uprety, A. R., Fitzhugh, M. C., De Both, M., Coleman, P., Trouard, T. P., Alexander, G. E., Mitchell, K. D., Barnes, C. A., Hale, T. M. & Huentelman, M., Mar 2019, In : Physiological reports. 7, 6, e14010.

Research output: Contribution to journalArticle

Open Access

Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., Mastroeni, D. F., Persico, A. M., Jepsen, W. M., Beach, T. G., Huentelman, M. J., Coleman, P. D. & Combs, C., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 3, p. 691-713 23 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J. & Coleman, P., Mar 1 2018, In : Neurobiology of Aging. 63, p. 12-21 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease

Tan, Y., Delvaux, E., Nolz, J., Coleman, P., Chen, S. & Mastroeni, D., Aug 1 2018, In : Neurobiology of Aging. 68, p. 134-141 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

Mastroeni, D., Sekar, S., Nolz, J., Delvaux, E., Lunnon, K., Mill, J., Liang, W. S. & Coleman, P., Jul 2017, In : PloS one. 12, 7, e0177814.

Research output: Contribution to journalArticle

15 Scopus citations

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's

Delvaux, E., Mastroeni, D., Nolz, J., Chow, N., Sabbagh, M., Caselli, R. J., Reiman, E. M., Marshall, F. J. & Coleman, P., Oct 1 2017, In : Neurobiology of Aging. 58, p. 225-237 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

Mastroeni, D., Chouliaras, L., Van den Hove, D. L., Nolz, J., Rutten, B. P. F., Delvaux, E. & Coleman, P., Jun 1 2016, In : Neuroepigenetics. 6, p. 26-31 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

Mastroeni, D., Delvaux, E., Nolz, J., Tan, Y., Grover, A., Oddo, S. & Coleman, P., Dec 1 2015, In : Neurobiology of Aging. 36, 12, p. 3121-3129 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epigenetics of cognition and neurodegenerative disorders

Coleman, P., Huentelman, M. & Dunckley, T., Jan 1 2015, In : Neuromethods. 94, p. 285-298 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P. D., Rutten, B. P. F. & van den Hove, D. L. A., Sep 1 2013, In : Neurobiology of Aging. 34, 9, p. 2091-2099 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes

Delvaux, E., Bentley, K., Stubbs, V., Sabbagh, M. & Coleman, P. D., Jun 1 2013, In : Neurobiology of Aging. 34, 6, p. 1680-1686 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology

Mastroeni, D., Chouliaras, L., Grover, A., Liang, W. S., Hauns, K., Rogers, J. & Coleman, P. D., Jan 8 2013, In : PloS one. 8, 1, e53349.

Research output: Contribution to journalArticle

32 Scopus citations

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Berchtold, N. C., Coleman, P. D., Cribbs, D. H., Rogers, J., Gillen, D. L. & Cotman, C. W., Jun 1 2013, In : Neurobiology of Aging. 34, 6, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

98 Scopus citations
2012

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J. & Cotman, C. W., Jul 23 2012, In : Journal of Neuroinflammation. 9, 179.

Research output: Contribution to journalArticle

213 Scopus citations
2010

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. D. & Rogers, J., Dec 1 2010, In : Neurobiology of Aging. 31, 12, p. 2025-2037 13 p.

Research output: Contribution to journalArticle

216 Scopus citations
2009

Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

Mastroeni, D., McKee, A., Grover, A., Rogers, J. & Coleman, P. D., Aug 12 2009, In : PloS one. 4, 8, e6617.

Research output: Contribution to journalArticle

196 Scopus citations

Microglial responses to dopamine in a cell culture model of Parkinson's disease

Mastroeni, D., Grover, A., Leonard, B., Joyce, J. N., Coleman, P. D., Kozik, B., Bellinger, D. L. & Rogers, J., Nov 1 2009, In : Neurobiology of Aging. 30, 11, p. 1805-1817 13 p.

Research output: Contribution to journalArticle

62 Scopus citations
2008

Aging elevates metabolic gene expression in brain cholinergic neurons

Baskerville, K. A., Kent, C., Personett, D., Lai, W. R., Park, P. J., Coleman, P. & McKinney, M., Dec 1 2008, In : Neurobiology of Aging. 29, 12, p. 1874-1893 20 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., Zielke, H. R. & Cotman, C. W., Oct 7 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15605-15610 6 p.

Research output: Contribution to journalArticle

293 Scopus citations

Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium

Mhyre, T. R., Loy, R., Tariot, P. N., Profenno, L. A., Maguire-Zeiss, K. A., Zhang, D., Coleman, P. D. & Federoff, H. J., Nov 1 2008, In : Neurobiology of Aging. 29, 11, p. 1631-1643 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
2004

A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5

Coleman, P., Kurlan, R., Crook, R., Werner, J. & Hardy, J., Jul 8 2004, In : Neuroscience Letters. 364, 3, p. 139-140 2 p.

Research output: Contribution to journalArticle

14 Scopus citations
4 Scopus citations
2003

Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease

Yao, P. J., Zhu, M., Pyun, E. I., Brooks, A. I., Therianos, S., Meyers, V. E. & Coleman, P. D., Mar 2003, In : Neurobiology of Disease. 12, 2, p. 97-109 13 p.

Research output: Contribution to journalArticle

176 Scopus citations

Facial nerve axotomy in aged and young adult rats: Analysis of the glial response

Hurley, S. D. & Coleman, P. D., May 1 2003, In : Neurobiology of Aging. 24, 3, p. 511-518 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain

Yao, P. J., O'Herron, T. M. & Coleman, P. D., Jan 1 2003, In : Neurobiology of Aging. 24, 1, p. 173-178 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Synapses sizzle

Coleman, P., Dec 2003, In : Neurobiology of Aging. 24, 8, 1 p.

Research output: Contribution to journalArticle

Synaptic slaughter in Alzheimer's disease

Coleman, P. D. & Yao, P. J., Dec 2003, In : Neurobiology of Aging. 24, 8, p. 1023-1027 5 p.

Research output: Contribution to journalArticle

290 Scopus citations
2002

High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons

Yao, P. J., Coleman, P. D. & Calkins, D. J., May 27 2002, In : Journal of Comparative Neurology. 447, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Progressive reduction of synaptophysin message in single neurons in Alzheimer disease

Callahan, L. M., Vaules, W. A. & Coleman, P. D., Jan 1 2002, In : Journal of Neuropathology and Experimental Neurology. 61, 5, p. 384-395 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2001

Two-dimensional gel analysis of secreted proteins induced by interleukin-1β in rat astrocytes

Chang, J. W., Young, D. A., Coleman, P. D. & O'Banion, M. K., Oct 9 2001, In : Neurochemistry International. 39, 5-6, p. 349-359 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2000

Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

Yao, P. J., Weimer, J. M., O’Herron, T. M. & Coleman, P. D., Jan 1 2000, In : Neurobiology of Aging. 21, 6, p. 921-929 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
1999

Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry

Yao, P. J., Morsch, R., Callahan, L. M. & Coleman, P. D., Sep 1 1999, In : Neuroscience. 94, 2, p. 389-394 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Neurons may live for decades with neurofibrillary tangles

Morsch, R., Simon, W. & Coleman, P. D., Feb 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 2, p. 188-197 10 p.

Research output: Contribution to journalArticle

288 Scopus citations
4 Scopus citations
104 Scopus citations
1998

Analysis of message expression in single neurons of Alzheimer's disease brain

Callahan, L. M., Chow, N., Cheetham, J. E., Cox, C. & Coleman, P. D., Jan 1 1998, In : Neurobiology of Aging. 19, SUPPL. 1, p. S99-S105

Research output: Contribution to journalArticle

16 Scopus citations

Dendritic changes in Alzheimer's disease and factors that may underlie these changes

Anderton, B. H., Callahan, L., Coleman, P., Davies, P., Flood, D., Jicha, G. A., Ohm, T. & Weaver, C., Aug 1 1998, In : Progress in Neurobiology. 55, 6, p. 595-609 15 p.

Research output: Contribution to journalArticle

83 Scopus citations

Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons

Combs, C. K., Coleman, P. D. & O'Banion, M. K., Apr 17 1998, In : Developmental Brain Research. 107, 1, p. 143-158 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Expression profiles of multiple genes in single neurons of Alzheimer's disease

Chow, N., Cox, C., Callahan, L. M., Weimer, J. M., Guo, L. & Coleman, P. D., Aug 4 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 16, p. 9620-9625 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Identification of a neuronal calmodulin-binding peptide, CAP-19, containing an IQ motif

Smith, M. L., Johanson, R. A., Rogers, K. E., Coleman, P. D. & Slemmon, J. R., Nov 12 1998, In : Molecular Brain Research. 62, 1, p. 12-24 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Interleukin-1β stimulates mitogen-activated protein kinase in U373 astrocytoma cells without the production of lipid second messengers

Utal, A. K., Stopka, A. L. & Coleman, P. D., Apr 2 1998, In : Neurochemical Research. 23, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease

Utal, A. K., Stopka, A. L., Roy, M. & Coleman, P. D., Jun 18 1998, In : Neuroscience. 86, 4, p. 1055-1063 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
50 Scopus citations