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1982 …2021
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Research Output 1982 2019

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Article
2019
1 Citation (Scopus)
Bispecific Antibodies
Amyloid Precursor Protein Secretases
Immunoglobulin Fragments
Amyloid beta-Protein Precursor
Health
2018

CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury

Williams, S. M., Peltz, C., Yaffe, K., Schulz, P. & Sierks, M., Oct 9 2018, In : Neurology. 91, 15, p. 702-709 8 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Biomarkers
Proteins
Neurodegenerative Diseases
Traumatic Brain Injury
2017
9 Citations (Scopus)

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease

Williams, S. M., Schulz, P., Rosenberry, T. L., Caselli, R. J. & Sierks, M., 2017, In : Journal of Alzheimer's Disease. 58, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Proteins
Single-Chain Antibodies
Immunoglobulin Fragments
12 Citations (Scopus)

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

Williams, S. M., Khan, G., Harris, B. T., Ravits, J. & Sierks, M., Jan 25 2017, In : BMC Neuroscience. 18, 1, 20.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Biomarkers
Proteins
Immunoglobulin Fragments
Brain
2016
19 Citations (Scopus)

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

Williams, S. M., Schulz, P. & Sierks, M., Jan 1 2016, In : European Journal of Neuroscience. 43, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

Synucleins
Amyloid
Parkinson Disease
Alzheimer Disease
Biomarkers
17 Citations (Scopus)

α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

Spencer, B., Williams, S., Rockenstein, E., Valera, E., Xin, W., Mante, M., Florio, J., Adame, A., Masliah, E. & Sierks, M., Aug 1 2016, In : Annals of Clinical and Translational Neurology. 3, 8, p. 588-606 19 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Immunotherapy
Antibodies
Cell-Penetrating Peptides
2015
22 Citations (Scopus)

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Liu, Q., Xie, X., Emadi, S., Sierks, M. & Wu, J., Oct 1 2015, In : Neuropharmacology. 97, p. 457-463 7 p., 5834.

Research output: Contribution to journalArticle

Amyloid
L-Lactate Dehydrogenase
Neurons
Mecamylamine
Cholinergic Neurons
10 Citations (Scopus)

A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

Williams, S., Schulz, P. & Sierks, M., Jan 1 2015, In : Biotechnology Progress. 31, 1, p. 289-298 10 p.

Research output: Contribution to journalArticle

Bacteriophages
Enzyme-Linked Immunosorbent Assay
Proteins
Epitopes
Capsid Proteins
13 Citations (Scopus)

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

Tian, H., Davidowitz, E., Lopez, P., He, P., Schulz, P., Moe, J. & Sierks, M., Mar 1 2015, In : Neurobiology of Aging. 36, 3, p. 1342-1355 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Poisons
Alzheimer Disease
Brain
Single-Chain Antibodies
8 Citations (Scopus)

Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis

Williams, S. M., Venkataraman, L., Tian, H., Khan, G., Harris, B. T. & Sierks, M., 2015, In : Journal of visualized experiments : JoVE. 96

Research output: Contribution to journalArticle

Atomic Force Microscopy
Amyotrophic Lateral Sclerosis
Atomic force microscopy
Bacteriophages
Proteins
19 Citations (Scopus)

Toxic oligomeric alpha-synuclein variants present in human Parkinson’s disease brains are differentially generated in mammalian cell models

Xin, W., Emadi, S., Williams, S., Liu, Q., Schulz, P., He, P., Alam, N. B., Wu, J. & Sierks, M., Jul 22 2015, In : Biomolecules. 5, 3, p. 1634-1651 18 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Poisons
Parkinson Disease
Brain
2014
51 Citations (Scopus)

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

Spencer, B., Emadi, S., Desplats, P., Eleuteri, S., Michael, S., Kosberg, K., Shen, J., Rockenstein, E., Patrick, C., Adame, A., Gonzalez, T., Sierks, M. & Masliah, E., Jan 1 2014, In : Molecular Therapy. 22, 10, p. 1753-1767 15 p.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
Synucleins
Single-Chain Antibodies
Apolipoproteins B
Parkinson Disease

Probing antibody-antigen interactions

Yang, G., Velgos, S. N., Boddapati, S. P. & Sierks, M., 2014, In : Microbiology spectrum. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

antigen
antibody
Antigens
Antibody Specificity
Antibodies
6 Citations (Scopus)

Protein misfolding and neurodegenerative diseases

Cardinale, A., Chiesa, R. & Sierks, M., 2014, In : International Journal of Cell Biology. 217371.

Research output: Contribution to journalArticle

Proteostasis Deficiencies
Neurodegenerative Diseases
2013
10 Citations (Scopus)

Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein

Liu, Q., Emadi, S., Shen, J. X., Sierks, M. & Wu, J., Feb 20 2013, In : PLoS One. 8, 2, e55886.

Research output: Contribution to journalArticle

Synucleins
cholinergic receptors
Parkinson disease
Nicotinic Receptors
cholinergic agents
14 Citations (Scopus)

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

Kasturirangan, S., Reasoner, T., Schulz, P., Boddapati, S., Emadi, S., Valla, J. & Sierks, M., Apr 2013, In : Biotechnology Progress. 29, 2, p. 463-471 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Alzheimer Disease
Antigens
Single-Chain Antibodies
Antibodies
31 Citations (Scopus)

Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations

Tian, H., Davidowitz, E., Lopez, P., Emadi, S., Moe, J. & Sierks, M., 2013, In : International Journal of Cell Biology. 260787.

Research output: Contribution to journalArticle

Poisons
Alzheimer Disease
Tauopathies
Neurofibrillary Tangles
Cholinergic Neurons
2012
10 Citations (Scopus)

Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP

Boddapati, S., Levites, Y., Suryadi, V., Kasturirangan, S. & Sierks, M., 2012, In : Journal of Alzheimer's Disease. 28, 4, p. 961-969 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Proteolysis
Peptide Hydrolases
18 Citations (Scopus)

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Kasturirangan, S., Li, L., Emadi, S., Boddapati, S., Schulz, P. & Sierks, M., Jul 2012, In : Neurobiology of Aging. 33, 7, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Amyloid
Alzheimer Disease
Cell Surface Display Techniques
Atomic Force Microscopy
2011
54 Citations (Scopus)

CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

Sierks, M., Chatterjee, G., McGraw, C., Kasturirangan, S., Schulz, P. & Prasad, S., Dec 2011, In : Integrative Biology. 3, 12, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
alpha-Synuclein
Biomarkers
Amyloid
Neurodegenerative Diseases
32 Citations (Scopus)

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP

Boddapati, S., Levites, Y. & Sierks, M., Jan 14 2011, In : Journal of Molecular Biology. 405, 2, p. 436-447 12 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid
2010
2 Citations (Scopus)

Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta-amyloid

Wang, M. S., Boddapati, S. & Sierks, M., Jul 2010, In : Biotechnology Progress. 26, 4, p. 1172-1179 8 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Poisons
Raffinose
Mannose
111 Citations (Scopus)

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

Wang, M. S., Boddapati, S., Emadi, S. & Sierks, M., Apr 30 2010, In : BMC Neuroscience. 11, 57.

Research output: Contribution to journalArticle

Synucleins
Curcumin
Parkinson Disease
Reactive Oxygen Species
Apoptosis
13 Citations (Scopus)

Engineered proteolytic nanobodies reduce Aβ burden and ameliorate Aβ-induced cytotoxicity

Kasturirangan, S., Boddapati, S. & Sierks, M., Jun 1 2010, In : Biochemistry. 49, 21, p. 4501-4508 8 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Cytotoxicity
Serum Amyloid A Protein
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
37 Citations (Scopus)

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Kvam, E., Sierks, M., Shoemaker, C. B. & Messer, A., Jun 2010, In : Protein Engineering, Design and Selection. 23, 6, p. 489-498 10 p.

Research output: Contribution to journalArticle

Antibodies
Immunoglobulin Fragments
Cytoplasm
Agglomeration
Cells
9 Citations (Scopus)

Targeted hydrolysis of beta-amyloid with engineered antibody fragments

Kasturirangan, S. & Sierks, M., May 2010, In : Current Alzheimer Research. 7, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Amyloid
Alzheimer Disease
Hydrolysis
Amyloid Precursor Protein Secretases
2009
129 Citations (Scopus)

A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

Liu, Q., Huang, Y., Xue, F., Simard, A., DeChon, J., Li, G., Zhang, J., Lucero, L., Wang, M., Sierks, M., Hu, G., Chang, Y., Lukas, R. J. & Wu, J., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 918-929 12 p.

Research output: Contribution to journalArticle

Cholinergic Neurons
Nicotinic Receptors
Amyloid
Peptides
Alzheimer Disease
17 Citations (Scopus)

Characterizing antibody specificity to different protein morphologies by AFM

Wang, M. S., Zameer, A., Emadi, S. & Sierks, M., Jan 20 2009, In : Langmuir. 25, 2, p. 912-918 7 p.

Research output: Contribution to journalArticle

antibodies
Antibodies
Atomic force microscopy
atomic force microscopy
proteins
47 Citations (Scopus)

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

Kvam, E., Nannenga, B., Wang, M. S., Jia, Z., Sierks, M. & Messer, A., May 28 2009, In : PLoS One. 4, 5, e5727.

Research output: Contribution to journalArticle

Cell Aggregation
Cytotoxicity
Conformations
cytotoxicity
amyloid
25 Citations (Scopus)

Cyclodextrins promote protein aggregation posing risks for therapeutic applications

Wang, M. S., Boddapati, S. & Sierks, M., Aug 28 2009, In : Biochemical and Biophysical Research Communications. 386, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

Cyclodextrins
Agglomeration
Type C Niemann-Pick Disease
Proteins
Neurofibrillary Tangles
62 Citations (Scopus)

Detecting morphologically distinct oligomeric forms of α-synuclein

Emadi, S., Kasturirangan, S., Wang, M. S., Schulz, P. & Sierks, M., Apr 24 2009, In : Journal of Biological Chemistry. 284, 17, p. 11048-11058 11 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Agglomeration
Single-Chain Antibodies
Immunoglobulin Fragments
23 Citations (Scopus)

Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells

Yuan, B. & Sierks, M., Jul 31 2009, In : Neuroscience Letters. 459, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Immunoglobulin Fragments
Proteostasis Deficiencies
Single-Chain Antibodies
Poisons
11 Citations (Scopus)

Promoting α-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments

Kasturirangan, S., Brune, D. & Sierks, M., Jul 2009, In : Biotechnology Progress. 25, 4, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Immunoglobulin Fragments
Amyloid
Alzheimer Disease
Cats

Response letter to comments on "Cyclodextrins promote protein aggregation posing risks for therapeutic applications"

Wang, M., Boddapati, S. & Sierks, M., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1426-1427 2 p.

Research output: Contribution to journalArticle

beta-Cyclodextrins
Cyclodextrins
Agglomeration
Proteins
2008
59 Citations (Scopus)

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

Zameer, A., Kasturirangan, S., Emadi, S., Nimmagadda, S. V. & Sierks, M., Dec 26 2008, In : Journal of Molecular Biology. 384, 4, p. 917-928 12 p.

Research output: Contribution to journalArticle

Neuroblastoma
Alzheimer Disease
Poisons
Bacteriophages
Antibodies
12 Citations (Scopus)

Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and α-synuclein aggregates

Nannenga, B., Zameer, A. & Sierks, M., Feb 20 2008, In : FEBS Letters. 582, 4, p. 517-522 6 p.

Research output: Contribution to journalArticle

Synucleins
Agglomeration
Antibodies
Poisons
Amyloidogenic Proteins
10 Citations (Scopus)
Single-Chain Antibodies
Atomic Force Microscopy
Insulin
Amyloid
Antibodies
2007
119 Citations (Scopus)

Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity

Emadi, S., Barkhordarian, H., Wang, M. S., Schulz, P. & Sierks, M., May 11 2007, In : Journal of Molecular Biology. 368, 4, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Synucleins
Single-Chain Antibodies
Immunoglobulin Fragments
Intrinsically Disordered Proteins
Lewy Bodies
15 Citations (Scopus)

Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy

Shlyakhtenko, L. S., Yuan, B., Emadi, S., Lyubchenko, Y. L. & Sierks, M., Sep 2007, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 3, 3, p. 192-197 6 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Antibodies
Atomic force microscopy
Proteins
Recovery
2006
8 Citations (Scopus)
Terminator Codon
stop codon
bacteriophages
Bacteriophages
Libraries
10 Citations (Scopus)

Improved affinity selection using phage display technology and off-rate based selection

Yuan, B., Schulz, P., Liu, R. & Sierks, M., Apr 15 2006, In : Electronic Journal of Biotechnology. 9, 2, p. 171-175 5 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Bacteriophages
Antibodies
Libraries
Display devices
89 Citations (Scopus)

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Levites, Y., Smithson, L. A., Price, R. W., Dakin, R. S., Yuan, B., Sierks, M., Kim, J., McGowan, E., Dana, K. R., Rosenberry, T. L., Das, P. & Golde, T. E., Dec 2006, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20, 14, p. 2576-2578 3 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Alzheimer Disease
Antibodies
Brain
Life Support Care
41 Citations (Scopus)

Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies

Barkhordarian, H., Emadi, S., Schulz, P. & Sierks, M., Nov 2006, In : Protein Engineering, Design and Selection. 19, 11, p. 497-502 6 p.

Research output: Contribution to journalArticle

Synucleins
Bacteriophages
Atomic Force Microscopy
Antibodies
Antigens
18 Citations (Scopus)

Isolation of an scFv targeting BRG1 using phage display with characterization by AFM

Marcus, W. D., Wang, H., Lohr, D., Sierks, M. & Lindsay, S., Apr 21 2006, In : Biochemical and Biophysical Research Communications. 342, 4, p. 1123-1129 7 p.

Research output: Contribution to journalArticle

Bacteriophages
Genes
Display devices
Chromatin Assembly and Disassembly
Antibodies
56 Citations (Scopus)

Reduction of nonspecific protein binding on surface plasmon resonance biosensors

Masson, J. F., Battaglia, T. M., Cramer, J., Beaudoin, S., Sierks, M. & Booksh, K. S., Dec 2006, In : Analytical and Bioanalytical Chemistry. 386, 7-8, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

Surface Plasmon Resonance
Surface plasmon resonance
Biosensing Techniques
Biomarkers
Protein Binding
42 Citations (Scopus)

Single chain Fv antibodies against the 25-35 Aβ fragment inhibit aggregation and toxicity of Aβ42

Zameer, A., Schulz, P., Wang, M. S. & Sierks, M., Sep 26 2006, In : Biochemistry. 45, 38, p. 11532-11539 8 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Toxicity
Agglomeration
Alzheimer Disease
Antibodies
2005
84 Citations (Scopus)

Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's β-amyloid

Kanapathipillai, M., Lentzen, G., Sierks, M. & Park, C. B., Aug 29 2005, In : FEBS Letters. 579, 21, p. 4775-4780 6 p.

Research output: Contribution to journalArticle

Amyloid
Agglomeration
Neurodegenerative diseases
Protein Denaturation
Denaturation
81 Citations (Scopus)

Quantification of cytokines involved in wound healing using surface plasmon resonance

Battaglia, T. M., Masson, J. F., Sierks, M., Beaudoin, S. P., Rogers, J., Foster, K. N., Holloway, G. A. & Booksh, K. S., Nov 1 2005, In : Analytical Chemistry. 77, 21, p. 7016-7023 8 p.

Research output: Contribution to journalArticle

Surface plasmon resonance
Cell culture
Culture Media
Palmitic Acid
Cytokines
225 Citations (Scopus)

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

Liu, R., Barkhordarian, H., Emadi, S., Chan, B. P. & Sierks, M., Oct 2005, In : Neurobiology of Disease. 20, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

Trehalose
Amyloid
Alzheimer Disease
Atomic Force Microscopy
Disaccharides
2004
94 Citations (Scopus)

A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein

Zhou, C., Emadi, S., Sierks, M. & Messer, A., Dec 2004, In : Molecular Therapy. 10, 6, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

Synucleins
Single-Chain Antibodies
Antibodies
Detergents
Pathology