• 3978 Citations
  • 36 h-Index
1982 …2021

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Article
2019
1 Scopus citations
2018

CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury

Williams, S. M., Peltz, C., Yaffe, K., Schulz, P. & Sierks, M., Oct 9 2018, In : Neurology. 91, 15, p. 702-709 8 p.

Research output: Contribution to journalArticle

2017

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease

Williams, S. M., Schulz, P., Rosenberry, T. L., Caselli, R. J. & Sierks, M., 2017, In : Journal of Alzheimer's Disease. 58, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

Williams, S. M., Khan, G., Harris, B. T., Ravits, J. & Sierks, M., Jan 25 2017, In : BMC Neuroscience. 18, 1, 20.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

Williams, S. M., Schulz, P. & Sierks, M., Jan 1 2016, In : European Journal of Neuroscience. 43, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

Spencer, B., Williams, S., Rockenstein, E., Valera, E., Xin, W., Mante, M., Florio, J., Adame, A., Masliah, E. & Sierks, M., Aug 1 2016, In : Annals of Clinical and Translational Neurology. 3, 8, p. 588-606 19 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Liu, Q., Xie, X., Emadi, S., Sierks, M. & Wu, J., Oct 1 2015, In : Neuropharmacology. 97, p. 457-463 7 p., 5834.

Research output: Contribution to journalArticle

23 Scopus citations

A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

Williams, S., Schulz, P. & Sierks, M., Jan 1 2015, In : Biotechnology Progress. 31, 1, p. 289-298 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

Tian, H., Davidowitz, E., Lopez, P., He, P., Schulz, P., Moe, J. & Sierks, M., Mar 1 2015, In : Neurobiology of Aging. 36, 3, p. 1342-1355 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis

Williams, S. M., Venkataraman, L., Tian, H., Khan, G., Harris, B. T. & Sierks, M., 2015, In : Journal of visualized experiments : JoVE. 96

Research output: Contribution to journalArticle

8 Scopus citations

Toxic oligomeric alpha-synuclein variants present in human Parkinson’s disease brains are differentially generated in mammalian cell models

Xin, W., Emadi, S., Williams, S., Liu, Q., Schulz, P., He, P., Alam, N. B., Wu, J. & Sierks, M., Jul 22 2015, In : Biomolecules. 5, 3, p. 1634-1651 18 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

Spencer, B., Emadi, S., Desplats, P., Eleuteri, S., Michael, S., Kosberg, K., Shen, J., Rockenstein, E., Patrick, C., Adame, A., Gonzalez, T., Sierks, M. & Masliah, E., Jan 1 2014, In : Molecular Therapy. 22, 10, p. 1753-1767 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Probing antibody-antigen interactions

Yang, G., Velgos, S. N., Boddapati, S. P. & Sierks, M., 2014, In : Microbiology spectrum. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Protein misfolding and neurodegenerative diseases

Cardinale, A., Chiesa, R. & Sierks, M., 2014, In : International Journal of Cell Biology. 217371.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein

Liu, Q., Emadi, S., Shen, J. X., Sierks, M. & Wu, J., Feb 20 2013, In : PLoS One. 8, 2, e55886.

Research output: Contribution to journalArticle

10 Scopus citations

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

Kasturirangan, S., Reasoner, T., Schulz, P., Boddapati, S., Emadi, S., Valla, J. & Sierks, M., Apr 2013, In : Biotechnology Progress. 29, 2, p. 463-471 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations

Tian, H., Davidowitz, E., Lopez, P., Emadi, S., Moe, J. & Sierks, M., 2013, In : International Journal of Cell Biology. 260787.

Research output: Contribution to journalArticle

33 Scopus citations
2012

Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP

Boddapati, S., Levites, Y., Suryadi, V., Kasturirangan, S. & Sierks, M., 2012, In : Journal of Alzheimer's Disease. 28, 4, p. 961-969 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Kasturirangan, S., Li, L., Emadi, S., Boddapati, S., Schulz, P. & Sierks, M., Jul 2012, In : Neurobiology of Aging. 33, 7, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

Sierks, M., Chatterjee, G., McGraw, C., Kasturirangan, S., Schulz, P. & Prasad, S., Dec 2011, In : Integrative Biology. 3, 12, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP

Boddapati, S., Levites, Y. & Sierks, M., Jan 14 2011, In : Journal of Molecular Biology. 405, 2, p. 436-447 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta-amyloid

Wang, M. S., Boddapati, S. & Sierks, M., Jul 2010, In : Biotechnology Progress. 26, 4, p. 1172-1179 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

Wang, M. S., Boddapati, S., Emadi, S. & Sierks, M., Apr 30 2010, In : BMC Neuroscience. 11, 57.

Research output: Contribution to journalArticle

113 Scopus citations

Engineered proteolytic nanobodies reduce Aβ burden and ameliorate Aβ-induced cytotoxicity

Kasturirangan, S., Boddapati, S. & Sierks, M., Jun 1 2010, In : Biochemistry. 49, 21, p. 4501-4508 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Kvam, E., Sierks, M., Shoemaker, C. B. & Messer, A., Jun 2010, In : Protein Engineering, Design and Selection. 23, 6, p. 489-498 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Targeted hydrolysis of beta-amyloid with engineered antibody fragments

Kasturirangan, S. & Sierks, M., May 2010, In : Current Alzheimer Research. 7, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

Liu, Q., Huang, Y., Xue, F., Simard, A., DeChon, J., Li, G., Zhang, J., Lucero, L., Wang, M., Sierks, M., Hu, G., Chang, Y., Lukas, R. J. & Wu, J., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 918-929 12 p.

Research output: Contribution to journalArticle

129 Scopus citations

Characterizing antibody specificity to different protein morphologies by AFM

Wang, M. S., Zameer, A., Emadi, S. & Sierks, M., Jan 20 2009, In : Langmuir. 25, 2, p. 912-918 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

Kvam, E., Nannenga, B., Wang, M. S., Jia, Z., Sierks, M. & Messer, A., May 28 2009, In : PLoS One. 4, 5, e5727.

Research output: Contribution to journalArticle

48 Scopus citations

Cyclodextrins promote protein aggregation posing risks for therapeutic applications

Wang, M. S., Boddapati, S. & Sierks, M., Aug 28 2009, In : Biochemical and Biophysical Research Communications. 386, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Detecting morphologically distinct oligomeric forms of α-synuclein

Emadi, S., Kasturirangan, S., Wang, M. S., Schulz, P. & Sierks, M., Apr 24 2009, In : Journal of Biological Chemistry. 284, 17, p. 11048-11058 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells

Yuan, B. & Sierks, M., Jul 31 2009, In : Neuroscience Letters. 459, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Promoting α-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments

Kasturirangan, S., Brune, D. & Sierks, M., Jul 2009, In : Biotechnology Progress. 25, 4, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Response letter to comments on "Cyclodextrins promote protein aggregation posing risks for therapeutic applications"

Wang, M., Boddapati, S. & Sierks, M., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1426-1427 2 p.

Research output: Contribution to journalArticle

2008

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

Zameer, A., Kasturirangan, S., Emadi, S., Nimmagadda, S. V. & Sierks, M., Dec 26 2008, In : Journal of Molecular Biology. 384, 4, p. 917-928 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and α-synuclein aggregates

Nannenga, B., Zameer, A. & Sierks, M., Feb 20 2008, In : FEBS Letters. 582, 4, p. 517-522 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations
2007

Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity

Emadi, S., Barkhordarian, H., Wang, M. S., Schulz, P. & Sierks, M., May 11 2007, In : Journal of Molecular Biology. 368, 4, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

122 Scopus citations

Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy

Shlyakhtenko, L. S., Yuan, B., Emadi, S., Lyubchenko, Y. L. & Sierks, M., Sep 2007, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 3, 3, p. 192-197 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2006
8 Scopus citations

Improved affinity selection using phage display technology and off-rate based selection

Yuan, B., Schulz, P., Liu, R. & Sierks, M., Apr 15 2006, In : Electronic Journal of Biotechnology. 9, 2, p. 171-175 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Levites, Y., Smithson, L. A., Price, R. W., Dakin, R. S., Yuan, B., Sierks, M., Kim, J., McGowan, E., Dana, K. R., Rosenberry, T. L., Das, P. & Golde, T. E., Dec 2006, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20, 14, p. 2576-2578 3 p.

Research output: Contribution to journalArticle

89 Scopus citations

Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies

Barkhordarian, H., Emadi, S., Schulz, P. & Sierks, M., Nov 2006, In : Protein Engineering, Design and Selection. 19, 11, p. 497-502 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Isolation of an scFv targeting BRG1 using phage display with characterization by AFM

Marcus, W. D., Wang, H., Lohr, D., Sierks, M. & Lindsay, S., Apr 21 2006, In : Biochemical and Biophysical Research Communications. 342, 4, p. 1123-1129 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reduction of nonspecific protein binding on surface plasmon resonance biosensors

Masson, J. F., Battaglia, T. M., Cramer, J., Beaudoin, S., Sierks, M. & Booksh, K. S., Dec 2006, In : Analytical and Bioanalytical Chemistry. 386, 7-8, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Single chain Fv antibodies against the 25-35 Aβ fragment inhibit aggregation and toxicity of Aβ42

Zameer, A., Schulz, P., Wang, M. S. & Sierks, M., Sep 26 2006, In : Biochemistry. 45, 38, p. 11532-11539 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's β-amyloid

Kanapathipillai, M., Lentzen, G., Sierks, M. & Park, C. B., Aug 29 2005, In : FEBS Letters. 579, 21, p. 4775-4780 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Quantification of cytokines involved in wound healing using surface plasmon resonance

Battaglia, T. M., Masson, J. F., Sierks, M., Beaudoin, S. P., Rogers, J., Foster, K. N., Holloway, G. A. & Booksh, K. S., Nov 1 2005, In : Analytical Chemistry. 77, 21, p. 7016-7023 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

Liu, R., Barkhordarian, H., Emadi, S., Chan, B. P. & Sierks, M., Oct 2005, In : Neurobiology of Disease. 20, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

231 Scopus citations
2004

A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein

Zhou, C., Emadi, S., Sierks, M. & Messer, A., Dec 2004, In : Molecular Therapy. 10, 6, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

96 Scopus citations