• 3927 Citations
  • 36 h-Index
1982 …2021
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Research Output 1982 2019

2019
1 Citation (Scopus)
Bispecific Antibodies
Amyloid Precursor Protein Secretases
Immunoglobulin Fragments
Amyloid beta-Protein Precursor
Health
2018

CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury

Williams, S. M., Peltz, C., Yaffe, K., Schulz, P. & Sierks, M., Oct 9 2018, In : Neurology. 91, 15, p. 702-709 8 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Biomarkers
Proteins
Neurodegenerative Diseases
Traumatic Brain Injury
2017
19 Citations (Scopus)

APP/Aβ structural diversity and Alzheimer's disease pathogenesis

Roher, A. E., Kokjohn, T. A., Clarke, S. G., Sierks, M., Maarouf, C. L., Serrano, G. E., Sabbagh, M. S. & Beach, T. G., Nov 1 2017, In : Neurochemistry International. 110, p. 1-13 13 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Amyloid
Post Translational Protein Processing
Dementia
Peptides
9 Citations (Scopus)

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease

Williams, S. M., Schulz, P., Rosenberry, T. L., Caselli, R. J. & Sierks, M., 2017, In : Journal of Alzheimer's Disease. 58, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Proteins
Single-Chain Antibodies
Immunoglobulin Fragments
12 Citations (Scopus)

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

Williams, S. M., Khan, G., Harris, B. T., Ravits, J. & Sierks, M., Jan 25 2017, In : BMC Neuroscience. 18, 1, 20.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Biomarkers
Proteins
Immunoglobulin Fragments
Brain
2016
19 Citations (Scopus)

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

Williams, S. M., Schulz, P. & Sierks, M., Jan 1 2016, In : European Journal of Neuroscience. 43, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

Synucleins
Amyloid
Parkinson Disease
Alzheimer Disease
Biomarkers
17 Citations (Scopus)

α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

Spencer, B., Williams, S., Rockenstein, E., Valera, E., Xin, W., Mante, M., Florio, J., Adame, A., Masliah, E. & Sierks, M., Aug 1 2016, In : Annals of Clinical and Translational Neurology. 3, 8, p. 588-606 19 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Immunotherapy
Antibodies
Cell-Penetrating Peptides
2015
22 Citations (Scopus)

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Liu, Q., Xie, X., Emadi, S., Sierks, M. & Wu, J., Oct 1 2015, In : Neuropharmacology. 97, p. 457-463 7 p., 5834.

Research output: Contribution to journalArticle

Amyloid
L-Lactate Dehydrogenase
Neurons
Mecamylamine
Cholinergic Neurons
10 Citations (Scopus)

A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

Williams, S., Schulz, P. & Sierks, M., Jan 1 2015, In : Biotechnology Progress. 31, 1, p. 289-298 10 p.

Research output: Contribution to journalArticle

Bacteriophages
Enzyme-Linked Immunosorbent Assay
Proteins
Epitopes
Capsid Proteins
13 Citations (Scopus)

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

Tian, H., Davidowitz, E., Lopez, P., He, P., Schulz, P., Moe, J. & Sierks, M., Mar 1 2015, In : Neurobiology of Aging. 36, 3, p. 1342-1355 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Poisons
Alzheimer Disease
Brain
Single-Chain Antibodies
8 Citations (Scopus)

Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis

Williams, S. M., Venkataraman, L., Tian, H., Khan, G., Harris, B. T. & Sierks, M., 2015, In : Journal of visualized experiments : JoVE. 96

Research output: Contribution to journalArticle

Atomic Force Microscopy
Amyotrophic Lateral Sclerosis
Atomic force microscopy
Bacteriophages
Proteins
Neurodegenerative Diseases
Alzheimer Disease
Biomarkers
Single-Domain Antibodies
Proteins
19 Citations (Scopus)

Toxic oligomeric alpha-synuclein variants present in human Parkinson’s disease brains are differentially generated in mammalian cell models

Xin, W., Emadi, S., Williams, S., Liu, Q., Schulz, P., He, P., Alam, N. B., Wu, J. & Sierks, M., Jul 22 2015, In : Biomolecules. 5, 3, p. 1634-1651 18 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Poisons
Parkinson Disease
Brain
2014
Immunoglobulin Fragments
DNA-Binding Proteins
Neurodegenerative Diseases
Single-Domain Antibodies
Proteins
51 Citations (Scopus)

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

Spencer, B., Emadi, S., Desplats, P., Eleuteri, S., Michael, S., Kosberg, K., Shen, J., Rockenstein, E., Patrick, C., Adame, A., Gonzalez, T., Sierks, M. & Masliah, E., Jan 1 2014, In : Molecular Therapy. 22, 10, p. 1753-1767 15 p.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
Synucleins
Single-Chain Antibodies
Apolipoproteins B
Parkinson Disease

Probing antibody-antigen interactions

Yang, G., Velgos, S. N., Boddapati, S. P. & Sierks, M., 2014, In : Microbiology spectrum. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

antigen
antibody
Antigens
Antibody Specificity
Antibodies
6 Citations (Scopus)

Protein misfolding and neurodegenerative diseases

Cardinale, A., Chiesa, R. & Sierks, M., 2014, In : International Journal of Cell Biology. 217371.

Research output: Contribution to journalArticle

Proteostasis Deficiencies
Neurodegenerative Diseases
Biomarkers
Single-Domain Antibodies
Neurodegenerative Diseases
Proteins
Parkinson Disease
2013
10 Citations (Scopus)

Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein

Liu, Q., Emadi, S., Shen, J. X., Sierks, M. & Wu, J., Feb 20 2013, In : PLoS One. 8, 2, e55886.

Research output: Contribution to journalArticle

Synucleins
cholinergic receptors
Parkinson disease
Nicotinic Receptors
cholinergic agents
14 Citations (Scopus)

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

Kasturirangan, S., Reasoner, T., Schulz, P., Boddapati, S., Emadi, S., Valla, J. & Sierks, M., Apr 2013, In : Biotechnology Progress. 29, 2, p. 463-471 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Alzheimer Disease
Antigens
Single-Chain Antibodies
Antibodies
Immunoglobulin Fragments
Neurodegenerative Diseases
Single-Domain Antibodies
Proteins
Parkinson Disease
Blood-Brain Barrier
Carrier Proteins
Peptides
Brain
Brain Diseases
31 Citations (Scopus)

Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations

Tian, H., Davidowitz, E., Lopez, P., Emadi, S., Moe, J. & Sierks, M., 2013, In : International Journal of Cell Biology. 260787.

Research output: Contribution to journalArticle

Poisons
Alzheimer Disease
Tauopathies
Neurofibrillary Tangles
Cholinergic Neurons
2012
10 Citations (Scopus)

Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP

Boddapati, S., Levites, Y., Suryadi, V., Kasturirangan, S. & Sierks, M., 2012, In : Journal of Alzheimer's Disease. 28, 4, p. 961-969 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Proteolysis
Peptide Hydrolases
18 Citations (Scopus)

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Kasturirangan, S., Li, L., Emadi, S., Boddapati, S., Schulz, P. & Sierks, M., Jul 2012, In : Neurobiology of Aging. 33, 7, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Amyloid
Alzheimer Disease
Cell Surface Display Techniques
Atomic Force Microscopy

Nanotextured material for applications in CSF sample screening and characterization

Vattipalli, K., Brandigampala, S., McGraw, C., Chatterjee, G., Kasturirangan, S., Schulz, P., Sierks, M. & Prasad, S., 2012, Materials Research Society Symposium Proceedings. Vol. 1466. p. 26-31 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

cerebrospinal fluid
Cerebrospinal fluid
Screening
screening
proteins

Probing protein nanoassemblies in neurodegenerative disease

Wang, M. S. & Sierks, M., Jan 1 2012, Nanomedicine and the Nervous System. CRC Press, p. 75-96 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurodegenerative diseases
Atomic Force Microscopy
Neurodegenerative Diseases
Atomic force microscopy
Proteins
Immunoglobulin Fragments
Alzheimer Disease
Single-Domain Antibodies
Poisons
Frontotemporal Dementia
2011
54 Citations (Scopus)

CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

Sierks, M., Chatterjee, G., McGraw, C., Kasturirangan, S., Schulz, P. & Prasad, S., Dec 2011, In : Integrative Biology. 3, 12, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
alpha-Synuclein
Biomarkers
Amyloid
Neurodegenerative Diseases
32 Citations (Scopus)

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP

Boddapati, S., Levites, Y. & Sierks, M., Jan 14 2011, In : Journal of Molecular Biology. 405, 2, p. 436-447 12 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid
Proteins
Viruses
Bacteria
Protein Isoforms
Inventors
Bispecific Antibodies
Immunoglobulin Fragments
Amyloid
Alzheimer Disease
Inventors
2010
Poisons
Amyloid
Immunization
Antibodies
Neurodegenerative Diseases
2 Citations (Scopus)

Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta-amyloid

Wang, M. S., Boddapati, S. & Sierks, M., Jul 2010, In : Biotechnology Progress. 26, 4, p. 1172-1179 8 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Poisons
Raffinose
Mannose
111 Citations (Scopus)

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

Wang, M. S., Boddapati, S., Emadi, S. & Sierks, M., Apr 30 2010, In : BMC Neuroscience. 11, 57.

Research output: Contribution to journalArticle

Synucleins
Curcumin
Parkinson Disease
Reactive Oxygen Species
Apoptosis
13 Citations (Scopus)

Engineered proteolytic nanobodies reduce Aβ burden and ameliorate Aβ-induced cytotoxicity

Kasturirangan, S., Boddapati, S. & Sierks, M., Jun 1 2010, In : Biochemistry. 49, 21, p. 4501-4508 8 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Cytotoxicity
Serum Amyloid A Protein
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor

Immunization with abeta oligomers

Sierks, M., Jun 7 2010

Research output: Patent

Immunization
Alzheimer Disease
Vaccination
Therapeutics
Brain
Neurodegenerative diseases
Poisons
Immunization
Proteins
Biosensors
37 Citations (Scopus)

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Kvam, E., Sierks, M., Shoemaker, C. B. & Messer, A., Jun 2010, In : Protein Engineering, Design and Selection. 23, 6, p. 489-498 10 p.

Research output: Contribution to journalArticle

Antibodies
Immunoglobulin Fragments
Cytoplasm
Agglomeration
Cells
9 Citations (Scopus)

Targeted hydrolysis of beta-amyloid with engineered antibody fragments

Kasturirangan, S. & Sierks, M., May 2010, In : Current Alzheimer Research. 7, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Amyloid
Alzheimer Disease
Hydrolysis
Amyloid Precursor Protein Secretases
2009
129 Citations (Scopus)

A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

Liu, Q., Huang, Y., Xue, F., Simard, A., DeChon, J., Li, G., Zhang, J., Lucero, L., Wang, M., Sierks, M., Hu, G., Chang, Y., Lukas, R. J. & Wu, J., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 918-929 12 p.

Research output: Contribution to journalArticle

Cholinergic Neurons
Nicotinic Receptors
Amyloid
Peptides
Alzheimer Disease
Single-Domain Antibodies
Amyloid Precursor Protein Secretases
Alzheimer Disease
Immunoglobulin Fragments
Amyloid beta-Protein Precursor
17 Citations (Scopus)

Characterizing antibody specificity to different protein morphologies by AFM

Wang, M. S., Zameer, A., Emadi, S. & Sierks, M., Jan 20 2009, In : Langmuir. 25, 2, p. 912-918 7 p.

Research output: Contribution to journalArticle

antibodies
Antibodies
Atomic force microscopy
atomic force microscopy
proteins
47 Citations (Scopus)

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

Kvam, E., Nannenga, B., Wang, M. S., Jia, Z., Sierks, M. & Messer, A., May 28 2009, In : PLoS One. 4, 5, e5727.

Research output: Contribution to journalArticle

Cell Aggregation
Cytotoxicity
Conformations
cytotoxicity
amyloid
25 Citations (Scopus)

Cyclodextrins promote protein aggregation posing risks for therapeutic applications

Wang, M. S., Boddapati, S. & Sierks, M., Aug 28 2009, In : Biochemical and Biophysical Research Communications. 386, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

Cyclodextrins
Agglomeration
Type C Niemann-Pick Disease
Proteins
Neurofibrillary Tangles
62 Citations (Scopus)

Detecting morphologically distinct oligomeric forms of α-synuclein

Emadi, S., Kasturirangan, S., Wang, M. S., Schulz, P. & Sierks, M., Apr 24 2009, In : Journal of Biological Chemistry. 284, 17, p. 11048-11058 11 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Agglomeration
Single-Chain Antibodies
Immunoglobulin Fragments
23 Citations (Scopus)

Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells

Yuan, B. & Sierks, M., Jul 31 2009, In : Neuroscience Letters. 459, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Immunoglobulin Fragments
Proteostasis Deficiencies
Single-Chain Antibodies
Poisons
11 Citations (Scopus)

Promoting α-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments

Kasturirangan, S., Brune, D. & Sierks, M., Jul 2009, In : Biotechnology Progress. 25, 4, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Immunoglobulin Fragments
Amyloid
Alzheimer Disease
Cats

Response letter to comments on "Cyclodextrins promote protein aggregation posing risks for therapeutic applications"

Wang, M., Boddapati, S. & Sierks, M., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1426-1427 2 p.

Research output: Contribution to journalArticle

beta-Cyclodextrins
Cyclodextrins
Agglomeration
Proteins
2008
59 Citations (Scopus)

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

Zameer, A., Kasturirangan, S., Emadi, S., Nimmagadda, S. V. & Sierks, M., Dec 26 2008, In : Journal of Molecular Biology. 384, 4, p. 917-928 12 p.

Research output: Contribution to journalArticle

Neuroblastoma
Alzheimer Disease
Poisons
Bacteriophages
Antibodies