Mehdi Nikkhah

Asst Professor

  • 4129 Citations
  • 31 h-Index
20052022

Research output per year

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Research Output

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2020

Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes

Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., Davies, H. A., Veldhuizen, J., Nikkhah, M., Hansen, M., Zhang, W., D'Souza, K., Franco, D. A. & Migrino, R. Q., Jan 21 2020, In : Journal of the American Heart Association. 9, 2, e014810.

Research output: Contribution to journalArticle

Open Access

Poly(N-isopropylacrylamide)-based dual-crosslinking biohybrid injectable hydrogels for vascularization

Pal, A., Smith, C. I., Palade, J., Nagaraju, S., Alarcon-Benedetto, B. A., Kilbourne, J., Rawls, A., Wilson-Rawls, J., Vernon, B. L. & Nikkhah, M., Apr 15 2020, In : Acta Biomaterialia. 107, p. 138-151 14 p.

Research output: Contribution to journalArticle

The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform

Saini, H., Rahmani Eliato, K., Veldhuizen, J., Zare, A., Allam, M., Silva, C., Kratz, A., Truong, D., Mouneimne, G., LaBaer, J., Ros, R. & Nikkhah, M., Jul 2020, In : Biomaterials. 247, 119975.

Research output: Contribution to journalArticle

2019

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

Truong, D. D., Kratz, A., Park, J. G., Barrientos, E. S., Saini, H., Nguyen, T., Pockaj, B., Mouneimne, G., LaBaer, J. & Nikkhah, M., Jun 15 2019, In : Cancer Research. 79, 12, p. 3139-3151 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells – Vascular interactions

Truong, D., Fiorelli, R., Barrientos, E. S., Melendez, E. L., Sanai, N., Mehta, S. & Nikkhah, M., Apr 2019, In : Biomaterials. 198, p. 63-77 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

Navaei, A., Rahmani Eliato, K., Ros, R., Migrino, R. Q., Willis, B. C. & Nikkhah, M., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 585-595 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Microfluidic Tumor–Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

Nagaraju, S., Truong, D., Mouneimne, G. & Nikkhah, M., May 9 2018, In : Advanced Healthcare Materials. 7, 9, 1701257.

Research output: Contribution to journalArticle

24 Scopus citations

Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells

Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F., Alexander, C. & Ghaemmaghami, A. M., Sep 19 2018, In : Frontiers in Bioengineering and Biotechnology. 6, SEP, 116.

Research output: Contribution to journalArticle

7 Scopus citations

The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model

Saini, H., Rahmani Eliato, K., Silva, C., Allam, M., Mouneimne, G., Ros, R. & Nikkhah, M., Oct 1 2018, In : Cellular and Molecular Bioengineering. 11, 5, p. 419-433 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts

Migrino, R. Q., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., Serrano, G. E., Truong, D., Nikkhah, M. & Madine, J., Sep 1 2017, In : Cardiovascular Research. 113, 11, p. 1389-1402 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Bioprinting technologies for disease modeling

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M. & Nikkhah, M., May 26 2017, (Accepted/In press) In : Biotechnology Letters. p. 1-12 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model

Peela, N., Barrientos, E. S., Truong, D., Mouneimne, G. & Nikkhah, M., Dec 1 2017, In : Integrative Biology (United Kingdom). 9, 12, p. 988-999 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Navaei, A., Moore, N., Sullivan, R. T., Truong, D., Migrino, R. Q. & Nikkhah, M., 2017, In : RSC Advances. 7, 6, p. 3302-3312 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues

Mehrali, M., Thakur, A., Pennisi, C. P., Talebian, S., Arpanaei, A., Nikkhah, M. & Dolatshahi-Pirouz, A., Feb 24 2017, In : Advanced Materials. 29, 8, 1603612.

Research output: Contribution to journalArticle

90 Scopus citations

Wireless passive stimulation of engineered cardiac tissues

Liu, S., Navaei, A., Meng, X., Nikkhah, M. & Chae, J., Jul 28 2017, In : ACS Sensors. 2, 7, p. 1006-1012 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

A three dimensional micropatterned tumor model for breast cancer cell migration studies

Peela, N., Sam, F. S., Christenson, W., Truong, D., Watson, A. W., Mouneimne, G., Ros, R. & Nikkhah, M., Mar 1 2016, In : Biomaterials. 81, p. 72-83 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Breast cancer cell invasion into a three dimensional tumor-stroma microenvironment

Truong, D., Puleo, J., Llave, A., Mouneimne, G., Kamm, R. D. & Nikkhah, M., Sep 28 2016, In : Scientific Reports. 6, 34094.

Research output: Contribution to journalArticle

52 Scopus citations

Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1533-1553 21 p.

Research output: Contribution to journalArticle

26 Scopus citations

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

Navaei, A., Truong, D., Heffernan, J., Cutts, J., Brafman, D., Sirianni, R. W., Vernon, B. & Nikkhah, M., Mar 1 2016, In : Acta Biomaterialia. 32, p. 10-23 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Reduced graphene oxide-GelMA hybrid hydrogels as scaffolds for cardiac tissue engineering

Shin, S. R., Zihlmann, C., Akbari, M., Assawes, P., Cheung, L., Zhang, K., Manoharan, V., Zhang, Y. S., Yüksekkaya, M., Wan, K. T., Nikkhah, M., Dokmeci, M. R., Tang, X. S. & Khademhosseini, A., Jan 1 2016, In : Small. 12, 27, p. 3677-3689 13 p.

Research output: Contribution to journalArticle

134 Scopus citations
2015

3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

Saini, H., Navaei, A., Van Putten, A. & Nikkhah, M., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1961-1971 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Dolatshahi-Pirouz, A., Nikkhah, M., Gaharwar, A. K., Hashmi, B., Guermani, E., Aliabadi, H., Camci-Unal, G., Ferrante, T., Foss, M., Ingber, D. E. & Khademhosseini, A., Apr 1 2015, In : Scientific reports. 4, 3896.

Research output: Contribution to journalArticle

84 Scopus citations

Anisotropic poly (glycerol sebacate)-poly (-caprolactone) electrospun fibers promote endothelial cell guidance

Gaharwar, A. K., Nikkhah, M., Sant, S. & Khademhosseini, A., Mar 1 2015, In : Biofabrication. 7, 1, 015001.

Research output: Contribution to journalArticle

57 Scopus citations

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gold nanorod-incorporated gelatin-based conductive hydrogels for engineering cardiac tissue constructs

Navaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R. & Nikkhah, M., Dec 15 2015, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

90 Scopus citations

Introductory editorial: Stem cell biology

Brafman, D., Campbell, S., Lam, A. Q., Kim, J. J., Nikkhah, M. & Stabenfeldt, S., 2015, In : Biomarker Insights. 10, p. 133-137 5 p., 013.

Research output: Contribution to journalArticle

2014

Biodegradable nanofibrous polymeric substrates for generating elastic and flexible electronics

Najafabadi, A. H., Tamayol, A., Annabi, N., Ochoa, M., Mostafalu, P., Akbari, M., Nikkhah, M., Rahimi, R., Dokmeci, M. R., Sonkusale, S., Ziaie, B. & Khademhosseini, A., Sep 3 2014, In : Advanced Materials. 26, 33, p. 5823-5830 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y. & Khademhosseini, A., Jul 7 2014, In : Lab on a Chip. 14, 13, p. 2202-2211 10 p.

Research output: Contribution to journalArticle

395 Scopus citations

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair

Paul, A., Hasan, A., Kindi, H. A., Gaharwar, A. K., Rao, V. T. S., Nikkhah, M., Shin, S. R., Krafft, D., Dokmeci, M. R., Shum-Tim, D. & Khademhosseini, A., Jan 1 2014, In : ACS nano. 8, 8, p. 8050-8062 13 p.

Research output: Contribution to journalArticle

224 Scopus citations

Layer-by-layer assembly of 3D tissue constructs with functionalized graphene

Shin, S. R., Aghaei-Ghareh-Bolagh, B., Gao, X., Nikkhah, M., Jung, S. M., Dolatshahi-Pirouz, A., Kim, S. B., Kim, S. M., Dokmeci, M. R., Tang, X. & Khademhosseini, A., Oct 22 2014, In : Advanced Functional Materials. 24, 39, p. 6136-6144 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Structural reinforcement of cell-laden hydrogels with microfabricated three dimensional scaffolds

Cha, C., Soman, P., Zhu, W., Nikkhah, M., Camci-Unal, G., Chen, S. & Khademhosseini, A., May 2014, In : Biomaterials Science. 2, 5, p. 703-709 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs

Kharaziha, M., Shin, S. R., Nikkhah, M., Topkaya, S. N., Masoumi, N., Annabi, N., Dokmeci, M. R. & Khademhosseini, A., Aug 2014, In : Biomaterials. 35, 26, p. 7346-7354 9 p.

Research output: Contribution to journalArticle

129 Scopus citations
2013

Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators

Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., Wan, K. T., Palacios, T., Dokmeci, M. R., Bae, H., Tang, X. & Khademhosseini, A., Mar 26 2013, In : ACS nano. 7, 3, p. 2369-2380 12 p.

Research output: Contribution to journalArticle

428 Scopus citations

Chitin nanofiber micropatterned flexible substrates for tissue engineering

Hassanzadeh, P., Kharaziha, M., Nikkhah, M., Shin, S. R., Jin, J., He, S., Sun, W., Zhong, C., Dokmeci, M. R., Khademhosseini, A. & Rolandi, M., Sep 14 2013, In : Journal of Materials Chemistry B. 1, 34, p. 4217-4224 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Highly elastic micropatterned hydrogel for engineering functional cardiac tissue

Annabi, N., Tsang, K., Mithieux, S. M., Nikkhah, M., Ameri, A., Khademhosseini, A. & Weiss, A. S., Oct 18 2013, In : Advanced Functional Materials. 23, 39, p. 4950-4959 10 p.

Research output: Contribution to journalArticle

150 Scopus citations

Isotropically etched silicon microarrays for rapid breast cancer cell capture

Nikkhah, M., Strobl, J. S., Srinivasaraghavan, V. & Agah, M., Feb 11 2013, In : IEEE Sensors Journal. 13, 3, p. 1125-1132 8 p., 6359735.

Research output: Contribution to journalArticle

5 Scopus citations

PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues

Kharaziha, M., Nikkhah, M., Shin, S. R., Annabi, N., Masoumi, N., Gaharwar, A. K., Camci-Unal, G. & Khademhosseini, A., Sep 1 2013, In : Biomaterials. 34, 27, p. 6355-6366 12 p.

Research output: Contribution to journalArticle

174 Scopus citations

Research highlights

Nikkhah, M., Arcibal, I. G., Dokmeci, M. R. & Khademhosseini, A., Dec 7 2013, In : Lab on a Chip. 13, 23, p. 4499-4502 4 p.

Research output: Contribution to journalArticle

2012

Directed endothelial cell morphogenesis in micropatterned gelatin methacrylate hydrogels

Nikkhah, M., Eshak, N., Zorlutuna, P., Annabi, N., Castello, M., Kim, K., Dolatshahi-Pirouz, A., Edalat, F., Bae, H., Yang, Y. & Khademhosseini, A., Dec 1 2012, In : Biomaterials. 33, 35, p. 9009-9018 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

Optimal sliding mode cascade control for stabilization of underactuated nonlinear systems

Muske, K. R., Ashrafiuon, H., Nersesov, S. & Nikkhah, M., Jan 23 2012, In : Journal of Dynamic Systems, Measurement and Control, Transactions of the ASME. 134, 2, 021020.

Research output: Contribution to journalArticle

23 Scopus citations

Vascularized bone tissue engineering: Approaches for potential improvement

Nguyen, L. H., Annabi, N., Nikkhah, M., Bae, H., Binan, L., Park, S., Kang, Y., Yang, Y. & Khademhosseini, A., Jan 10 2012, In : Tissue Engineering - Part B: Reviews. 18, 5, p. 363-382 20 p.

Research output: Contribution to journalArticle

174 Scopus citations
2011

Evaluation of the influence of growth medium composition on cell elasticity

Nikkhah, M., Strobl, J. S., Schmelz, E. M. & Agah, M., Feb 24 2011, In : Journal of Biomechanics. 44, 4, p. 762-766 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

MCF10A and MDA-MB-231 human breast basal epithelial cell co-culture in silicon micro-arrays

Nikkhah, M., Strobl, J. S., Schmelz, E. M., Roberts, P. C., Zhou, H. & Agah s, M., Oct 1 2011, In : Biomaterials. 32, 30, p. 7625-7632 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
2010

Actions of the anti-cancer drug suberoylanilide hydroxamic acid (SAHA) on human breast cancer cytoarchitecture in silicon microstructures

Strobl, J. S., Nikkhah, M. & Agah, M., Sep 1 2010, In : Biomaterials. 31, 27, p. 7043-7050 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Analysis of the passivation layer by testing and modeling a cell impedance micro-sensor

Narayanan, S., Nikkhah, M., Strob, J. S. & Agah, M., May 2010, In : Sensors and Actuators, A: Physical. 159, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

The cytoskeletal organization of breast carcinoma and fibroblast cells inside three dimensional (3-D) isotropic silicon microstructures

Nikkhah, M., Strobl, J. S., De Vita, R. & Agah, M., Jun 1 2010, In : Biomaterials. 31, 16, p. 4552-4561 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
2009

Attachment and response of human fibroblast and breast cancer cells to three dimensional silicon microstructures of different geometries

Nikkhah, M., Strobl, J. S. & Agah, M., Jan 1 2009, In : Biomedical Microdevices. 11, 2, p. 429-441 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cytoskeletal role in differential adhesion patterns of normal fibroblasts and breast cancer cells inside silicon microenvironments

Nikkhah, M., Strobl, J. S., Peddi, B. & Agah, M., Jan 1 2009, In : Biomedical Microdevices. 11, 3, p. 585-595 11 p.

Research output: Contribution to journalArticle

34 Scopus citations