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Mehdi Nikkhah

Asst Professor

  • 3658 Citations
  • 30 h-Index
20052022
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Research Output 2005 2019

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Article
2019
1 Citation (Scopus)

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

Truong, D. D., Kratz, A., Park, J., Barrientos, E. S., Saini, H., Nguyen, T., Pockaj, B., Mouneimne, G., LaBaer, J. & Nikkhah, M., Jun 15 2019, In : Cancer Research. 79, 12, p. 3139-3151 13 p.

Research output: Contribution to journal › Article

Microfluidics
Fibroblasts
Breast Neoplasms
Neoplasms
Glycoproteins
4 Citations (Scopus)

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells – Vascular interactions

Truong, D., Fiorelli, R., Barrientos, E. S., Melendez, E. L., Sanai, N., Mehta, S. & Nikkhah, M., Apr 1 2019, In : Biomaterials. 198, p. 63-77 15 p.

Research output: Contribution to journal › Article

Microfluidics
Stem cells
Glioma
Cell Communication
Blood Vessels
1 Citation (Scopus)

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

Navaei, A., Rahmani Eliato, K., Ros, R., Migrino, R. Q., Willis, B. C. & Nikkhah, M., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 585-595 11 p.

Research output: Contribution to journal › Article

Nanostructured materials
Scaffolds
Nanocomposites
Tissue
Stiffness matrix
2018
15 Citations (Scopus)

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

Nagaraju, S., Truong, D., Mouneimne, G. & Nikkhah, M., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journal › Article

Microfluidics
Blood Vessels
Tumors
Cells
Breast Neoplasms
4 Citations (Scopus)

Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells

Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F., Alexander, C. & Ghaemmaghami, A. M., Sep 19 2018, In : Frontiers in Bioengineering and Biotechnology. 6, SEP, 116.

Research output: Contribution to journal › Article

Hydrogels
Gelatin
Biomaterials
Biocompatible Materials
Cytokines
2 Citations (Scopus)

The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model

Saini, H., Rahmani Eliato, K., Silva, C., Allam, M., Mouneimne, G., Ros, R. & Nikkhah, M., Jan 1 2018, (Accepted/In press) In : Cellular and Molecular Bioengineering.

Research output: Contribution to journal › Article

Drug Resistance
Fibroblasts
Tumors
Tumor
Cancer
2017
5 Citations (Scopus)

Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts

Migrino, R. Q., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., Serrano, G. E., Truong, D., Nikkhah, M. & Madine, J., Sep 1 2017, In : Cardiovascular Research. 113, 11, p. 1389-1402 14 p.

Research output: Contribution to journal › Article

Arterioles
Blood Vessels
Inflammation
Oxidative Stress
Endothelial Cells
14 Citations (Scopus)

Bioprinting technologies for disease modeling

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M. & Nikkhah, M., May 26 2017, (Accepted/In press) In : Biotechnology Letters. p. 1-12 12 p.

Research output: Contribution to journal › Article

Bioprinting
Technology
Tissue
Assays
Biomimetics
5 Citations (Scopus)

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model

Peela, N., Barrientos, E. S., Truong, D., Mouneimne, G. & Nikkhah, M., Dec 1 2017, In : Integrative Biology (United Kingdom). 9, 12, p. 988-999 12 p.

Research output: Contribution to journal › Article

Microfluidics
Tumors
Cells
Breast Neoplasms
Neoplasms
18 Citations (Scopus)

Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Navaei, A., Moore, N., Sullivan, R. T., Truong, D., Migrino, R. Q. & Nikkhah, M., 2017, In : RSC Advances. 7, 6, p. 3302-3312 11 p.

Research output: Contribution to journal › Article

Methacrylates
Hydrogel
Gelatin
Hydrogels
Topography
72 Citations (Scopus)

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues

Mehrali, M., Thakur, A., Pennisi, C. P., Talebian, S., Arpanaei, A., Nikkhah, M. & Dolatshahi-Pirouz, A., Feb 24 2017, In : Advanced Materials. 29, 8, 1603612.

Research output: Contribution to journal › Article

Bearings (structural)
Hydrogels
Biocompatible Materials
Tissue engineering
Biomaterials
2 Citations (Scopus)

Wireless passive stimulation of engineered cardiac tissues

Liu, S., Navaei, A., Meng, X., Nikkhah, M. & Chae, J., Jul 28 2017, In : ACS Sensors. 2, 7, p. 1006-1012 7 p.

Research output: Contribution to journal › Article

stimulation
contraction
Tissue
antennas
microwaves
2016
37 Citations (Scopus)

A three dimensional micropatterned tumor model for breast cancer cell migration studies

Peela, N., Sam, F. S., Christenson, W., Truong, D., Watson, A. W., Mouneimne, G., Ros, R. & Nikkhah, M., Mar 1 2016, In : Biomaterials. 81, p. 72-83 12 p.

Research output: Contribution to journal › Article

Cell Movement
Tumors
Cells
Breast Neoplasms
Neoplasms
45 Citations (Scopus)

Breast cancer cell invasion into a three dimensional tumor-stroma microenvironment

Truong, D., Puleo, J., Llave, A., Mouneimne, G., Kamm, R. D. & Nikkhah, M., Sep 28 2016, In : Scientific Reports. 6, 34094.

Research output: Contribution to journal › Article

Tumor Microenvironment
Breast Neoplasms
Neoplasms
Microfluidics
Hydrogel
23 Citations (Scopus)

Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1533-1553 21 p.

Research output: Contribution to journal › Article

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Biomaterials
37 Citations (Scopus)

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

Navaei, A., Truong, D., Heffernan, J., Cutts, J., Brafman, D., Sirianni, R. W., Vernon, B. & Nikkhah, M., Mar 1 2016, In : Acta Biomaterialia. 32, p. 10-23 14 p.

Research output: Contribution to journal › Article

Hydrogel
Tissue Engineering
Tissue engineering
Hydrogels
Coculture Techniques
106 Citations (Scopus)

Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering

Shin, S. R., Zihlmann, C., Akbari, M., Assawes, P., Cheung, L., Zhang, K., Manoharan, V., Zhang, Y. S., Yüksekkaya, M., Wan, K. T., Nikkhah, M., Dokmeci, M. R., Tang, X. S. & Khademhosseini, A., Jul 20 2016, In : Small. p. 3677-3689 13 p.

Research output: Contribution to journal › Article

Hydrogels
Graphite
Gelatin
Tissue Engineering
Scaffolds (biology)
2015
38 Citations (Scopus)

3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

Saini, H., Navaei, A., Van Putten, A. & Nikkhah, M., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1961-1971 11 p.

Research output: Contribution to journal › Article

Fibroblasts
Coculture Techniques
Cell culture
Cardiac Myocytes
Tissue
76 Citations (Scopus)

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Dolatshahi-Pirouz, A., Nikkhah, M., Gaharwar, A. K., Hashmi, B., Guermani, E., Aliabadi, H., Camci-Unal, G., Ferrante, T., Foss, M., Ingber, D. E. & Khademhosseini, A., Apr 1 2015, In : Scientific Reports. 4, 3896.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells
Gels
Stem Cells
Miniaturization
Hydrogels
50 Citations (Scopus)

Anisotropic poly (glycerol sebacate)-poly (-caprolactone) electrospun fibers promote endothelial cell guidance

Gaharwar, A. K., Nikkhah, M., Sant, S. & Khademhosseini, A., Mar 1 2015, In : Biofabrication. 7, 1, 015001.

Research output: Contribution to journal › Article

Endothelial cells
Glycerol
Scaffolds
Endothelial Cells
Fibers
13 Citations (Scopus)

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journal › Article

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
5 Citations (Scopus)

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journal › Article

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
70 Citations (Scopus)

Gold nanorod-incorporated gelatin-based conductive hydrogels for engineering cardiac tissue constructs

Navaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R. & Nikkhah, M., Dec 15 2015, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journal › Article

Nanotubes
Hydrogels
Gelatin
Tissue Engineering
Nanorods

Introductory editorial: Stem cell biology

Brafman, D., Campbell, S., Lam, A. Q., Kim, J. J., Nikkhah, M. & Stabenfeldt, S., 2015, In : Biomarker Insights. 10, p. 133-137 5 p., 013.

Research output: Contribution to journal › Article

Cell Biology
Stem Cells
2014
68 Citations (Scopus)

Biodegradable nanofibrous polymeric substrates for generating elastic and flexible electronics

Najafabadi, A. H., Tamayol, A., Annabi, N., Ochoa, M., Mostafalu, P., Akbari, M., Nikkhah, M., Rahimi, R., Dokmeci, M. R., Sonkusale, S., Ziaie, B. & Khademhosseini, A., Sep 3 2014, In : Advanced Materials. 26, 33, p. 5823-5830 8 p.

Research output: Contribution to journal › Article

Flexible electronics
Substrates
Sensors
Electronic equipment
Gases
350 Citations (Scopus)

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y. & Khademhosseini, A., Jul 7 2014, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 13, p. 2202-2211 10 p.

Research output: Contribution to journal › Article

Hydrogel
Tissue Engineering
Microchannels
Tissue engineering
Hydrogels
203 Citations (Scopus)

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair

Paul, A., Hasan, A., Kindi, H. A., Gaharwar, A. K., Rao, V. T. S., Nikkhah, M., Shin, S. R., Krafft, D., Dokmeci, M. R., Shum-Tim, D. & Khademhosseini, A., 2014, In : ACS Nano. 8, 8, p. 8050-8062 13 p.

Research output: Contribution to journal › Article

Graphite
Hydrogel
Hydrogels
genes
Oxides
84 Citations (Scopus)

Layer-by-layer assembly of 3D tissue constructs with functionalized graphene

Shin, S. R., Aghaei-Ghareh-Bolagh, B., Gao, X., Nikkhah, M., Jung, S. M., Dolatshahi-Pirouz, A., Kim, S. B., Kim, S. M., Dokmeci, M. R., Tang, X. & Khademhosseini, A., Oct 22 2014, In : Advanced Functional Materials. 24, 39, p. 6136-6144 9 p.

Research output: Contribution to journal › Article

Graphite
Graphene
graphene
assembly
Tissue
45 Citations (Scopus)

Structural reinforcement of cell-laden hydrogels with microfabricated three dimensional scaffolds

Cha, C., Soman, P., Zhu, W., Nikkhah, M., Camci-Unal, G., Chen, S. & Khademhosseini, A., 2014, In : Biomaterials Science. 2, 5, p. 703-709 7 p.

Research output: Contribution to journal › Article

Hydrogels
Scaffolds (biology)
Reinforcement
Scaffolds
Hydrogel
116 Citations (Scopus)

Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs

Kharaziha, M., Shin, S. R., Nikkhah, M., Topkaya, S. N., Masoumi, N., Annabi, N., Dokmeci, M. R. & Khademhosseini, A., 2014, In : Biomaterials. 35, 26, p. 7346-7354 9 p.

Research output: Contribution to journal › Article

Carbon Nanotubes
Scaffolds
Carbon nanotubes
Cardiac Myocytes
Nanofibers
2013
384 Citations (Scopus)

Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators

Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., Wan, K. T., Palacios, T., Dokmeci, M. R., Bae, H., Tang, X. & Khademhosseini, A., Mar 26 2013, In : ACS Nano. 7, 3, p. 2369-2380 12 p.

Research output: Contribution to journal › Article

Carbon Nanotubes
Hydrogel
gelatins
Gelatin
Hydrogels
29 Citations (Scopus)

Chitin nanofiber micropatterned flexible substrates for tissue engineering

Hassanzadeh, P., Kharaziha, M., Nikkhah, M., Shin, S. R., Jin, J., He, S., Sun, W., Zhong, C., Dokmeci, M. R., Khademhosseini, A. & Rolandi, M., Sep 14 2013, In : Journal of Materials Chemistry B. 1, 34, p. 4217-4224 8 p.

Research output: Contribution to journal › Article

Nanofibers
Chitin
Tissue Engineering
Tissue engineering
Substrates
135 Citations (Scopus)

Highly elastic micropatterned hydrogel for engineering functional cardiac tissue

Annabi, N., Tsang, K., Mithieux, S. M., Nikkhah, M., Ameri, A., Khademhosseini, A. & Weiss, A. S., Oct 18 2013, In : Advanced Functional Materials. 23, 39, p. 4950-4959 10 p.

Research output: Contribution to journal › Article

Hydrogel
Hydrogels
Tropoelastin
engineering
Tissue
5 Citations (Scopus)

Isotropically etched silicon microarrays for rapid breast cancer cell capture

Nikkhah, M., Strobl, J. S., Srinivasaraghavan, V. & Agah, M., 2013, In : IEEE Sensors Journal. 13, 3, p. 1125-1132 8 p., 6359735.

Research output: Contribution to journal › Article

Microarrays
breast
cancer
Cells
Silicon
146 Citations (Scopus)

PGS: Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues

Kharaziha, M., Nikkhah, M., Shin, S. R., Annabi, N., Masoumi, N., Gaharwar, A. K., Camci-Unal, G. & Khademhosseini, A., Sep 2013, In : Biomaterials. 34, 27, p. 6355-6366 12 p.

Research output: Contribution to journal › Article

Gelatin
Tissue Engineering
Scaffolds
Structural properties
Anisotropy

Research highlights

Nikkhah, M., Arcibal, I. G., Dokmeci, M. R. & Khademhosseini, A., Dec 7 2013, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 13, 23, p. 4499-4502 4 p.

Research output: Contribution to journal › Article

2012
148 Citations (Scopus)

Directed endothelial cell morphogenesis in micropatterned gelatin methacrylate hydrogels

Nikkhah, M., Eshak, N., Zorlutuna, P., Annabi, N., Castello, M., Kim, K., Dolatshahi-Pirouz, A., Edalat, F., Bae, H., Yang, Y. & Khademhosseini, A., Dec 2012, In : Biomaterials. 33, 35, p. 9009-9018 10 p.

Research output: Contribution to journal › Article

Hydrogels
Methacrylates
Hydrogel
Endothelial cells
Gelatin
384 Citations (Scopus)

Engineering microscale topographies to control the cell-substrate interface

Nikkhah, M., Edalat, F., Manoucheri, S. & Khademhosseini, A., Jul 2012, In : Biomaterials. 33, 21, p. 5230-5246 17 p.

Research output: Contribution to journal › Article

Topography
Substrates
Cues
Microtechnology
Microfabrication
258 Citations (Scopus)

Microfabricated biomaterials for engineering 3D tissues

Zorlutuna, P., Annabi, N., Camci-Unal, G., Nikkhah, M., Cha, J. M., Nichol, J. W., Manbachi, A., Bae, H., Chen, S. & Khademhosseini, A., Apr 10 2012, In : Advanced Materials. 24, 14, p. 1782-1804 23 p.

Research output: Contribution to journal › Article

Biocompatible Materials
Biomaterials
Tissue
Tissue engineering
Biomimetics
21 Citations (Scopus)

Optimal sliding mode cascade control for stabilization of underactuated nonlinear systems

Muske, K. R., Ashrafiuon, H., Nersesov, S. & Nikkhah, M., 2012, In : Journal of Dynamic Systems, Measurement and Control, Transactions of the ASME. 134, 2, 021020.

Research output: Contribution to journal › Article

cascade control
Sliding mode control
nonlinear systems
sliding
Nonlinear systems
163 Citations (Scopus)

Vascularized bone tissue engineering: Approaches for potential improvement

Nguyen, L. H., Annabi, N., Nikkhah, M., Bae, H., Binan, L., Park, S., Kang, Y., Yang, Y. & Khademhosseini, A., Jan 10 2012, In : Tissue Engineering - Part B: Reviews. 18, 5, p. 363-382 20 p.

Research output: Contribution to journal › Article

Bioelectric potentials
Tissue Engineering
Tissue engineering
Bone
Bone and Bones
2011
53 Citations (Scopus)

Evaluation of the influence of growth medium composition on cell elasticity

Nikkhah, M., Strobl, J. S., Schmelz, E. M. & Agah, M., Feb 24 2011, In : Journal of Biomechanics. 44, 4, p. 762-766 5 p.

Research output: Contribution to journal › Article

Elasticity
Elastic moduli
Growth
Chemical analysis
Elastic Modulus
30 Citations (Scopus)

MCF10A and MDA-MB-231 human breast basal epithelial cell co-culture in silicon micro-arrays

Nikkhah, M., Strobl, J. S., Schmelz, E. M., Roberts, P. C., Zhou, H. & Agah s, M., Oct 2011, In : Biomaterials. 32, 30, p. 7625-7632 8 p.

Research output: Contribution to journal › Article

Histone Deacetylase Inhibitors
Silicon
Coculture Techniques
Breast
Cell Culture Techniques
2010
34 Citations (Scopus)

Actions of the anti-cancer drug suberoylanilide hydroxamic acid (SAHA) on human breast cancer cytoarchitecture in silicon microstructures

Strobl, J. S., Nikkhah, M. & Agah, M., Sep 2010, In : Biomaterials. 31, 27, p. 7043-7050 8 p.

Research output: Contribution to journal › Article

Silicon
Breast Neoplasms
Microstructure
Acids
Pharmaceutical Preparations
11 Citations (Scopus)

Analysis of the passivation layer by testing and modeling a cell impedance micro-sensor

Narayanan, S., Nikkhah, M., Strob, J. S. & Agah, M., May 2010, In : Sensors and Actuators, A: Physical. 159, 2, p. 241-247 7 p.

Research output: Contribution to journal › Article

Passivation
passivity
impedance
sensors
Sensors
60 Citations (Scopus)

The cytoskeletal organization of breast carcinoma and fibroblast cells inside three dimensional (3-D) isotropic silicon microstructures

Nikkhah, M., Strobl, J. S., De Vita, R. & Agah, M., Jun 2010, In : Biomaterials. 31, 16, p. 4552-4561 10 p.

Research output: Contribution to journal › Article

Silicon
Fibroblasts
Vinculin
Adhesion
Cells
2009
26 Citations (Scopus)

Attachment and response of human fibroblast and breast cancer cells to three dimensional silicon microstructures of different geometries

Nikkhah, M., Strobl, J. S. & Agah, M., 2009, In : Biomedical Microdevices. 11, 2, p. 429-441 13 p.

Research output: Contribution to journal › Article

Silicon
Fibroblasts
Cells
Breast Neoplasms
Microstructure
32 Citations (Scopus)

Cytoskeletal role in differential adhesion patterns of normal fibroblasts and breast cancer cells inside silicon microenvironments

Nikkhah, M., Strobl, J. S., Peddi, B. & Agah, M., 2009, In : Biomedical Microdevices. 11, 3, p. 585-595 11 p.

Research output: Contribution to journal › Article

Silicon
Fibroblasts
Adhesion
Cells
Breast Neoplasms
2007
1 Citation (Scopus)

Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures.

Nikkhah, M., Strobl, J. S. & Agah, M., 2007, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. p. 6078-6081 4 p.

Research output: Contribution to journal › Article

Silicon
Fibroblasts
Cells
Cytology
Microstructure
39 Citations (Scopus)

Robust control of underactuated bipeds using sliding modes

Nikkhah, M., Ashrafiuon, H. & Fahimi, F., May 2007, In : Robotica. 25, 3, p. 367-374 8 p.

Research output: Contribution to journal › Article

Robust control
Sliding Mode
Robust Control
Disturbance
Trajectories