Mehdi Nikkhah

Asst Professor

  • 4129 Citations
  • 31 h-Index
20052022

Research output per year

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Research Output

2020

Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes

Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., Davies, H. A., Veldhuizen, J., Nikkhah, M., Hansen, M., Zhang, W., D'Souza, K., Franco, D. A. & Migrino, R. Q., Jan 21 2020, In : Journal of the American Heart Association. 9, 2, e014810.

Research output: Contribution to journalArticle

Open Access

Poly(N-isopropylacrylamide)-based dual-crosslinking biohybrid injectable hydrogels for vascularization

Pal, A., Smith, C. I., Palade, J., Nagaraju, S., Alarcon-Benedetto, B. A., Kilbourne, J., Rawls, A., Wilson-Rawls, J., Vernon, B. L. & Nikkhah, M., Apr 15 2020, In : Acta Biomaterialia. 107, p. 138-151 14 p.

Research output: Contribution to journalArticle

The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform

Saini, H., Rahmani Eliato, K., Veldhuizen, J., Zare, A., Allam, M., Silva, C., Kratz, A., Truong, D., Mouneimne, G., LaBaer, J., Ros, R. & Nikkhah, M., Jul 2020, In : Biomaterials. 247, 119975.

Research output: Contribution to journalArticle

2019

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

Truong, D. D., Kratz, A., Park, J. G., Barrientos, E. S., Saini, H., Nguyen, T., Pockaj, B., Mouneimne, G., LaBaer, J. & Nikkhah, M., Jun 15 2019, In : Cancer Research. 79, 12, p. 3139-3151 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells – Vascular interactions

Truong, D., Fiorelli, R., Barrientos, E. S., Melendez, E. L., Sanai, N., Mehta, S. & Nikkhah, M., Apr 2019, In : Biomaterials. 198, p. 63-77 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Biomaterials, Cells, and Patho-physiology: Building Better Organoids and On-Chip Technologies

Singh, A., Nikkhah, M. & Annabi, N., Apr 2019, In : Biomaterials. 198, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

Talebian, S., Mehrali, M., Taebnia, N., Pennisi, C. P., Kadumudi, F. B., Foroughi, J., Hasany, M., Nikkhah, M., Akbari, M., Orive, G. & Dolatshahi-Pirouz, A., Jan 1 2019, In : Advanced Science. 6, 16, 1801664.

Research output: Contribution to journalReview article

Open Access
11 Scopus citations

The impact of electrically conductive and non-conductive nanocomposite hydrogels on functionalities of engineered cardiac tissues

Navaei, A. & Nikkhah, M., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

Navaei, A., Rahmani Eliato, K., Ros, R., Migrino, R. Q., Willis, B. C. & Nikkhah, M., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 585-595 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Three-dimensional microengineered models of human cardiac diseases

Veldhuizen, J., Migrino, R. Q. & Nikkhah, M., Apr 3 2019, In : Journal of Biological Engineering. 13, 1, 29.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2018

Microfluidic Tumor–Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

Nagaraju, S., Truong, D., Mouneimne, G. & Nikkhah, M., May 9 2018, In : Advanced Healthcare Materials. 7, 9, 1701257.

Research output: Contribution to journalArticle

24 Scopus citations

Nanoengineered biomaterials for cardiac regeneration

Karperien, L., Navaei, A., Godau, B., Dolatshahi-Pirouz, A., Akbari, M. & Nikkhah, M., Jan 1 2018, Nanoengineered Biomaterials for Regenerative Medicine. Elsevier, p. 95-124 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells

Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F., Alexander, C. & Ghaemmaghami, A. M., Sep 19 2018, In : Frontiers in Bioengineering and Biotechnology. 6, SEP, 116.

Research output: Contribution to journalArticle

7 Scopus citations

Therapeutic neovascularization promoted by injectable hydrogels

Pal, A., Vernon, B. & Nikkhah, M., Dec 1 2018, In : Bioactive Materials. 3, 4, p. 389-400 12 p.

Research output: Contribution to journalReview article

8 Scopus citations

The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model

Saini, H., Rahmani Eliato, K., Silva, C., Allam, M., Mouneimne, G., Ros, R. & Nikkhah, M., Oct 1 2018, In : Cellular and Molecular Bioengineering. 11, 5, p. 419-433 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis

Peela, N., Truong, D., Saini, H., Chu, H., Mashaghi, S., Ham, S. L., Singh, S., Tavana, H., Mosadegh, B. & Nikkhah, M., Jul 1 2017, In : Biomaterials. 133, p. 176-207 32 p.

Research output: Contribution to journalReview article

37 Scopus citations

Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts

Migrino, R. Q., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., Serrano, G. E., Truong, D., Nikkhah, M. & Madine, J., Sep 1 2017, In : Cardiovascular Research. 113, 11, p. 1389-1402 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Bioprinting technologies for disease modeling

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M. & Nikkhah, M., May 26 2017, (Accepted/In press) In : Biotechnology Letters. p. 1-12 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model

Peela, N., Barrientos, E. S., Truong, D., Mouneimne, G. & Nikkhah, M., Dec 1 2017, In : Integrative Biology (United Kingdom). 9, 12, p. 988-999 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Navaei, A., Moore, N., Sullivan, R. T., Truong, D., Migrino, R. Q. & Nikkhah, M., 2017, In : RSC Advances. 7, 6, p. 3302-3312 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs

Pedde, R. D., Mirani, B., Navaei, A., Styan, T., Wong, S., Mehrali, M., Thakur, A., Mohtaram, N. K., Bayati, A., Dolatshahi-Pirouz, A., Nikkhah, M., Willerth, S. M. & Akbari, M., May 17 2017, In : Advanced Materials. 29, 19, 1606061.

Research output: Contribution to journalReview article

98 Scopus citations

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues

Mehrali, M., Thakur, A., Pennisi, C. P., Talebian, S., Arpanaei, A., Nikkhah, M. & Dolatshahi-Pirouz, A., Feb 24 2017, In : Advanced Materials. 29, 8, 1603612.

Research output: Contribution to journalArticle

90 Scopus citations

Wireless passive stimulation of engineered cardiac tissues

Liu, S., Navaei, A., Meng, X., Nikkhah, M. & Chae, J., Jul 28 2017, In : ACS Sensors. 2, 7, p. 1006-1012 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

A three dimensional micropatterned tumor model for breast cancer cell migration studies

Peela, N., Sam, F. S., Christenson, W., Truong, D., Watson, A. W., Mouneimne, G., Ros, R. & Nikkhah, M., Mar 1 2016, In : Biomaterials. 81, p. 72-83 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

A wireless passive stimulator of cardiomyocytes

Liu, S., Navaei, A., Nikkhah, M. & Chae, J., Jan 1 2016, 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016. Allen, M. G. & Lamers, T. (eds.). Transducer Research Foundation, p. 298-301 4 p. (2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access

Breast cancer cell invasion into a three dimensional tumor-stroma microenvironment

Truong, D., Puleo, J., Llave, A., Mouneimne, G., Kamm, R. D. & Nikkhah, M., Sep 28 2016, In : Scientific Reports. 6, 34094.

Research output: Contribution to journalArticle

52 Scopus citations

Evaluation of anti-cancer drug Suberoylanilide Hydroxamic Acid (SAHA) on cancer cell phenotype in a three-dimensional (3D) breast tumor-stroma platform

Peela, N., Truong, D., Barrientos, E. S., Mouneimne, G. & Nikkhah, M., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 565-566 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Gelatin-Based Biomaterials For Tissue Engineering And Stem Cell Bioengineering

Nikkhah, M., Akbari, M., Paul, A., Memic, A., Dolatshahi-Pirouz, A. & Khademhosseini, A., Jan 1 2016, Biomaterials from Nature for Advanced Devices and Therapies. Wiley-Blackwell, p. 37-62 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1533-1553 21 p.

Research output: Contribution to journalArticle

26 Scopus citations

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

Navaei, A., Truong, D., Heffernan, J., Cutts, J., Brafman, D., Sirianni, R. W., Vernon, B. & Nikkhah, M., Mar 1 2016, In : Acta Biomaterialia. 32, p. 10-23 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Reduced graphene oxide-GelMA hybrid hydrogels as scaffolds for cardiac tissue engineering

Shin, S. R., Zihlmann, C., Akbari, M., Assawes, P., Cheung, L., Zhang, K., Manoharan, V., Zhang, Y. S., Yüksekkaya, M., Wan, K. T., Nikkhah, M., Dokmeci, M. R., Tang, X. S. & Khademhosseini, A., Jan 1 2016, In : Small. 12, 27, p. 3677-3689 13 p.

Research output: Contribution to journalArticle

134 Scopus citations

Tissue Engineering: Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering(Adv. Healthcare Mater. 13/2016)

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1532 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2015

3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

Saini, H., Navaei, A., Van Putten, A. & Nikkhah, M., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1961-1971 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Dolatshahi-Pirouz, A., Nikkhah, M., Gaharwar, A. K., Hashmi, B., Guermani, E., Aliabadi, H., Camci-Unal, G., Ferrante, T., Foss, M., Ingber, D. E. & Khademhosseini, A., Apr 1 2015, In : Scientific reports. 4, 3896.

Research output: Contribution to journalArticle

84 Scopus citations

Anisotropic poly (glycerol sebacate)-poly (-caprolactone) electrospun fibers promote endothelial cell guidance

Gaharwar, A. K., Nikkhah, M., Sant, S. & Khademhosseini, A., Mar 1 2015, In : Biofabrication. 7, 1, 015001.

Research output: Contribution to journalArticle

57 Scopus citations

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gold nanorod-incorporated gelatin-based conductive hydrogels for engineering cardiac tissue constructs

Navaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R. & Nikkhah, M., Dec 15 2015, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

90 Scopus citations

Introductory editorial: Stem cell biology

Brafman, D., Campbell, S., Lam, A. Q., Kim, J. J., Nikkhah, M. & Stabenfeldt, S., 2015, In : Biomarker Insights. 10, p. 133-137 5 p., 013.

Research output: Contribution to journalArticle

Microfabrication of cell-laden hydrogels for engineering mineralized and load bearing tissues

Li, C. C., Kharaziha, M., Min, C., Maas, R. & Nikkhah, M., 2015, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 881. p. 15-31 17 p. (Advances in Experimental Medicine and Biology; vol. 881).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Spatial patterning of stem cells to engineer microvascular networks

Kharaziha, M. & Nikkhah, M., Aug 19 2015, Microscale Technologies for Cell Engineering. Springer International Publishing, p. 143-166 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Biodegradable nanofibrous polymeric substrates for generating elastic and flexible electronics

Najafabadi, A. H., Tamayol, A., Annabi, N., Ochoa, M., Mostafalu, P., Akbari, M., Nikkhah, M., Rahimi, R., Dokmeci, M. R., Sonkusale, S., Ziaie, B. & Khademhosseini, A., Sep 3 2014, In : Advanced Materials. 26, 33, p. 5823-5830 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y. & Khademhosseini, A., Jul 7 2014, In : Lab on a Chip. 14, 13, p. 2202-2211 10 p.

Research output: Contribution to journalArticle

395 Scopus citations

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair

Paul, A., Hasan, A., Kindi, H. A., Gaharwar, A. K., Rao, V. T. S., Nikkhah, M., Shin, S. R., Krafft, D., Dokmeci, M. R., Shum-Tim, D. & Khademhosseini, A., Jan 1 2014, In : ACS nano. 8, 8, p. 8050-8062 13 p.

Research output: Contribution to journalArticle

224 Scopus citations

Layer-by-layer assembly of 3D tissue constructs with functionalized graphene

Shin, S. R., Aghaei-Ghareh-Bolagh, B., Gao, X., Nikkhah, M., Jung, S. M., Dolatshahi-Pirouz, A., Kim, S. B., Kim, S. M., Dokmeci, M. R., Tang, X. & Khademhosseini, A., Oct 22 2014, In : Advanced Functional Materials. 24, 39, p. 6136-6144 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Polymeric Biomaterials for Implantable Prostheses

Dang, T. T., Nikkhah, M., Memic, A. & Khademhosseini, A., Jan 2014, Natural and Synthetic Biomedical Polymers. Elsevier Inc., p. 309-331 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations