Mehdi Nikkhah

Asst Professor

  • 3715 Citations
  • 30 h-Index
20052022
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Research Output 2005 2019

2019
1 Citation (Scopus)

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

Truong, D. D., Kratz, A., Park, J., Barrientos, E. S., Saini, H., Nguyen, T., Pockaj, B., Mouneimne, G., LaBaer, J. & Nikkhah, M., Jun 15 2019, In : Cancer Research. 79, 12, p. 3139-3151 13 p.

Research output: Contribution to journalArticle

Microfluidics
Fibroblasts
Breast Neoplasms
Neoplasms
Glycoproteins
4 Citations (Scopus)

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells – Vascular interactions

Truong, D., Fiorelli, R., Barrientos, E. S., Melendez, E. L., Sanai, N., Mehta, S. & Nikkhah, M., Apr 1 2019, In : Biomaterials. 198, p. 63-77 15 p.

Research output: Contribution to journalArticle

Microfluidics
Stem cells
Glioma
Cell Communication
Blood Vessels

Biomaterials, Cells, and Patho-physiology: Building Better Organoids and On-Chip Technologies

Singh, A., Nikkhah, M. & Annabi, N., Apr 1 2019, In : Biomaterials. 198, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Organoids
Cell Physiological Phenomena
Physiology
Biocompatible Materials
Biomaterials
2 Citations (Scopus)

Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

Talebian, S., Mehrali, M., Taebnia, N., Pennisi, C. P., Kadumudi, F. B., Foroughi, J., Hasany, M., Nikkhah, M., Akbari, M., Orive, G. & Dolatshahi-Pirouz, A., Jan 1 2019, In : Advanced Science. 1801664.

Research output: Contribution to journalReview article

Open Access
Hydrogels
tissue engineering
healing
Tissue Engineering
Tissue engineering

The impact of electrically conductive and non-conductive nanocomposite hydrogels on functionalities of engineered cardiac tissues

Navaei, A. & Nikkhah, M., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanocomposites
Electric Conductivity
Hydrogels
Nanostructures
Scaffolds
1 Citation (Scopus)

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

Navaei, A., Rahmani Eliato, K., Ros, R., Migrino, R. Q., Willis, B. C. & Nikkhah, M., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 585-595 11 p.

Research output: Contribution to journalArticle

Nanostructured materials
Scaffolds
Nanocomposites
Tissue
Stiffness matrix

Three-dimensional microengineered models of human cardiac diseases

Veldhuizen, J., Migrino, R. Q. & Nikkhah, M., Apr 3 2019, In : Journal of Biological Engineering. 13, 1, 29.

Research output: Contribution to journalReview article

Open Access
Heart Diseases
Tissue
Therapeutic Human Experimentation
Biomimetics
Disease Progression
2018
15 Citations (Scopus)

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

Nagaraju, S., Truong, D., Mouneimne, G. & Nikkhah, M., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

Microfluidics
Blood Vessels
Tumors
Cells
Breast Neoplasms
4 Citations (Scopus)

Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells

Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F., Alexander, C. & Ghaemmaghami, A. M., Sep 19 2018, In : Frontiers in Bioengineering and Biotechnology. 6, SEP, 116.

Research output: Contribution to journalArticle

Hydrogels
Gelatin
Biomaterials
Biocompatible Materials
Cytokines
5 Citations (Scopus)

Therapeutic neovascularization promoted by injectable hydrogels

Pal, A., Vernon, B. & Nikkhah, M., Dec 1 2018, In : Bioactive Materials. 3, 4, p. 389-400 12 p.

Research output: Contribution to journalReview article

Hydrogels
Repair
Tissue
Angiogenesis Inducing Agents
Injections
2 Citations (Scopus)

The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model

Saini, H., Rahmani Eliato, K., Silva, C., Allam, M., Mouneimne, G., Ros, R. & Nikkhah, M., Jan 1 2018, (Accepted/In press) In : Cellular and Molecular Bioengineering.

Research output: Contribution to journalArticle

Drug Resistance
Fibroblasts
Tumors
Tumor
Cancer
2017
29 Citations (Scopus)

Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis

Peela, N., Truong, D., Saini, H., Chu, H., Mashaghi, S., Ham, S. L., Singh, S., Tavana, H., Mosadegh, B. & Nikkhah, M., Jul 1 2017, In : Biomaterials. 133, p. 176-207 32 p.

Research output: Contribution to journalReview article

Biocompatible Materials
Biomaterials
Neoplasm Metastasis
Technology
Tumors
5 Citations (Scopus)

Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts

Migrino, R. Q., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., Serrano, G. E., Truong, D., Nikkhah, M. & Madine, J., Sep 1 2017, In : Cardiovascular Research. 113, 11, p. 1389-1402 14 p.

Research output: Contribution to journalArticle

Arterioles
Blood Vessels
Inflammation
Oxidative Stress
Endothelial Cells
14 Citations (Scopus)

Bioprinting technologies for disease modeling

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M. & Nikkhah, M., May 26 2017, (Accepted/In press) In : Biotechnology Letters. p. 1-12 12 p.

Research output: Contribution to journalArticle

Bioprinting
Technology
Tissue
Assays
Biomimetics
5 Citations (Scopus)

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model

Peela, N., Barrientos, E. S., Truong, D., Mouneimne, G. & Nikkhah, M., Dec 1 2017, In : Integrative Biology (United Kingdom). 9, 12, p. 988-999 12 p.

Research output: Contribution to journalArticle

Microfluidics
Tumors
Cells
Breast Neoplasms
Neoplasms
18 Citations (Scopus)

Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Navaei, A., Moore, N., Sullivan, R. T., Truong, D., Migrino, R. Q. & Nikkhah, M., 2017, In : RSC Advances. 7, 6, p. 3302-3312 11 p.

Research output: Contribution to journalArticle

Methacrylates
Hydrogel
Gelatin
Hydrogels
Topography
84 Citations (Scopus)

Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs

Pedde, R. D., Mirani, B., Navaei, A., Styan, T., Wong, S., Mehrali, M., Thakur, A., Mohtaram, N. K., Bayati, A., Dolatshahi-Pirouz, A., Nikkhah, M., Willerth, S. M. & Akbari, M., May 17 2017, In : Advanced Materials. 29, 19, 1606061.

Research output: Contribution to journalReview article

Biocompatible Materials
Tissue
Biomaterials
Scaffolds
Repair
73 Citations (Scopus)

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues

Mehrali, M., Thakur, A., Pennisi, C. P., Talebian, S., Arpanaei, A., Nikkhah, M. & Dolatshahi-Pirouz, A., Feb 24 2017, In : Advanced Materials. 29, 8, 1603612.

Research output: Contribution to journalArticle

Bearings (structural)
Hydrogels
Biocompatible Materials
Tissue engineering
Biomaterials
3 Citations (Scopus)

Wireless passive stimulation of engineered cardiac tissues

Liu, S., Navaei, A., Meng, X., Nikkhah, M. & Chae, J., Jul 28 2017, In : ACS Sensors. 2, 7, p. 1006-1012 7 p.

Research output: Contribution to journalArticle

stimulation
contraction
Tissue
antennas
microwaves
2016
37 Citations (Scopus)

A three dimensional micropatterned tumor model for breast cancer cell migration studies

Peela, N., Sam, F. S., Christenson, W., Truong, D., Watson, A. W., Mouneimne, G., Ros, R. & Nikkhah, M., Mar 1 2016, In : Biomaterials. 81, p. 72-83 12 p.

Research output: Contribution to journalArticle

Cell Movement
Tumors
Cells
Breast Neoplasms
Neoplasms

A wireless passive stimulator of cardiomyocytes

Liu, S., Navaei, A., Nikkhah, M. & Chae, J., Jan 1 2016, 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016. Allen, M. G. & Lamers, T. (eds.). Transducer Research Foundation, p. 298-301 4 p. (2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
Rats
Antennas
46 Citations (Scopus)

Breast cancer cell invasion into a three dimensional tumor-stroma microenvironment

Truong, D., Puleo, J., Llave, A., Mouneimne, G., Kamm, R. D. & Nikkhah, M., Sep 28 2016, In : Scientific Reports. 6, 34094.

Research output: Contribution to journalArticle

Tumor Microenvironment
Breast Neoplasms
Neoplasms
Microfluidics
Hydrogel
1 Citation (Scopus)

Evaluation of anti-cancer drug Suberoylanilide Hydroxamic Acid (SAHA) on cancer cell phenotype in a three-dimensional (3D) breast tumor-stroma platform

Peela, N., Truong, D., Barrientos, E. S., Mouneimne, G. & Nikkhah, M., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 565-566 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumors
Cells
Acids
Microfluidics
Drug interactions
5 Citations (Scopus)

Gelatin-Based Biomaterials For Tissue Engineering And Stem Cell Bioengineering

Nikkhah, M., Akbari, M., Paul, A., Memic, A., Dolatshahi-Pirouz, A. & Khademhosseini, A., Jan 1 2016, Biomaterials from Nature for Advanced Devices and Therapies. Wiley Blackwell, p. 37-62 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biocompatible Materials
Gelatin
Stem cells
Tissue engineering
Biomaterials
24 Citations (Scopus)

Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1533-1553 21 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Biomaterials
38 Citations (Scopus)

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

Navaei, A., Truong, D., Heffernan, J., Cutts, J., Brafman, D., Sirianni, R. W., Vernon, B. & Nikkhah, M., Mar 1 2016, In : Acta Biomaterialia. 32, p. 10-23 14 p.

Research output: Contribution to journalArticle

Hydrogel
Tissue Engineering
Tissue engineering
Hydrogels
Coculture Techniques
113 Citations (Scopus)

Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering

Shin, S. R., Zihlmann, C., Akbari, M., Assawes, P., Cheung, L., Zhang, K., Manoharan, V., Zhang, Y. S., Yüksekkaya, M., Wan, K. T., Nikkhah, M., Dokmeci, M. R., Tang, X. S. & Khademhosseini, A., Jul 20 2016, In : Small. p. 3677-3689 13 p.

Research output: Contribution to journalArticle

Hydrogels
Graphite
Gelatin
Tissue Engineering
Scaffolds (biology)
2 Citations (Scopus)

Tissue Engineering: Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering(Adv. Healthcare Mater. 13/2016)

Kharaziha, M., Memic, A., Akbari, M., Brafman, D. & Nikkhah, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1532 1 p.

Research output: Contribution to journalComment/debate

Nanostructures
Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
2015
38 Citations (Scopus)

3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

Saini, H., Navaei, A., Van Putten, A. & Nikkhah, M., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1961-1971 11 p.

Research output: Contribution to journalArticle

Fibroblasts
Coculture Techniques
Cell culture
Cardiac Myocytes
Tissue
76 Citations (Scopus)

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Dolatshahi-Pirouz, A., Nikkhah, M., Gaharwar, A. K., Hashmi, B., Guermani, E., Aliabadi, H., Camci-Unal, G., Ferrante, T., Foss, M., Ingber, D. E. & Khademhosseini, A., Apr 1 2015, In : Scientific Reports. 4, 3896.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Gels
Stem Cells
Miniaturization
Hydrogels
50 Citations (Scopus)

Anisotropic poly (glycerol sebacate)-poly (-caprolactone) electrospun fibers promote endothelial cell guidance

Gaharwar, A. K., Nikkhah, M., Sant, S. & Khademhosseini, A., Mar 1 2015, In : Biofabrication. 7, 1, 015001.

Research output: Contribution to journalArticle

Endothelial cells
Glycerol
Scaffolds
Endothelial Cells
Fibers
14 Citations (Scopus)

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
5 Citations (Scopus)

Biomaterial approaches for stem cell-based myocardial tissue engineering

Cutts, J., Nikkhah, M. & Brafman, D., Jun 1 2015, In : Biomarker Insights. 10, p. 77-90 14 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
74 Citations (Scopus)

Gold nanorod-incorporated gelatin-based conductive hydrogels for engineering cardiac tissue constructs

Navaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R. & Nikkhah, M., Dec 15 2015, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Nanotubes
Hydrogels
Gelatin
Tissue Engineering
Nanorods
Nanotubes
Hydrogels
Gelatin
Tissue Engineering
Gold
Regeneration
Myocardium
Biocompatible Materials
Stem Cell Transplantation
Tissue Engineering

Introductory editorial: Stem cell biology

Brafman, D., Campbell, S., Lam, A. Q., Kim, J. J., Nikkhah, M. & Stabenfeldt, S., 2015, In : Biomarker Insights. 10, p. 133-137 5 p., 013.

Research output: Contribution to journalArticle

Cell Biology
Stem Cells
3 Citations (Scopus)

Microfabrication of cell-laden hydrogels for engineering mineralized and load bearing tissues

Li, C. C., Kharaziha, M., Min, C., Maas, R. & Nikkhah, M., 2015, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 881. p. 15-31 17 p. (Advances in Experimental Medicine and Biology; vol. 881).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bearings (structural)
Microtechnology
Hydrogels
Microfabrication
Weight-Bearing

Spatial patterning of stem cells to engineer microvascular networks

Kharaziha, M. & Nikkhah, M., Aug 19 2015, Microscale Technologies for Cell Engineering. Springer International Publishing, p. 143-166 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microvessels
Stem cells
Blood Vessels
Stem Cells
Blood vessels
Cell Movement
Breast Neoplasms
Tumor Microenvironment
Neoplasms
Neoplasm Metastasis
2014
68 Citations (Scopus)

Biodegradable nanofibrous polymeric substrates for generating elastic and flexible electronics

Najafabadi, A. H., Tamayol, A., Annabi, N., Ochoa, M., Mostafalu, P., Akbari, M., Nikkhah, M., Rahimi, R., Dokmeci, M. R., Sonkusale, S., Ziaie, B. & Khademhosseini, A., Sep 3 2014, In : Advanced Materials. 26, 33, p. 5823-5830 8 p.

Research output: Contribution to journalArticle

Flexible electronics
Substrates
Sensors
Electronic equipment
Gases
Tumor Microenvironment
Microfluidics
Breast Neoplasms
Neoplasms
Neoplasm Metastasis
356 Citations (Scopus)

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y. & Khademhosseini, A., Jul 7 2014, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 13, p. 2202-2211 10 p.

Research output: Contribution to journalArticle

Hydrogel
Tissue Engineering
Microchannels
Tissue engineering
Hydrogels
207 Citations (Scopus)

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair

Paul, A., Hasan, A., Kindi, H. A., Gaharwar, A. K., Rao, V. T. S., Nikkhah, M., Shin, S. R., Krafft, D., Dokmeci, M. R., Shum-Tim, D. & Khademhosseini, A., 2014, In : ACS Nano. 8, 8, p. 8050-8062 13 p.

Research output: Contribution to journalArticle

Graphite
Hydrogel
Hydrogels
genes
Oxides
84 Citations (Scopus)

Layer-by-layer assembly of 3D tissue constructs with functionalized graphene

Shin, S. R., Aghaei-Ghareh-Bolagh, B., Gao, X., Nikkhah, M., Jung, S. M., Dolatshahi-Pirouz, A., Kim, S. B., Kim, S. M., Dokmeci, M. R., Tang, X. & Khademhosseini, A., Oct 22 2014, In : Advanced Functional Materials. 24, 39, p. 6136-6144 9 p.

Research output: Contribution to journalArticle

Graphite
Graphene
graphene
assembly
Tissue
8 Citations (Scopus)

Polymeric Biomaterials for Implantable Prostheses

Dang, T. T., Nikkhah, M., Memic, A. & Khademhosseini, A., Jan 2014, Natural and Synthetic Biomedical Polymers. Elsevier Inc., p. 309-331 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biocompatible Materials
Prosthetics
Prostheses and Implants
Polymers
Dental Prosthesis
46 Citations (Scopus)

Structural reinforcement of cell-laden hydrogels with microfabricated three dimensional scaffolds

Cha, C., Soman, P., Zhu, W., Nikkhah, M., Camci-Unal, G., Chen, S. & Khademhosseini, A., 2014, In : Biomaterials Science. 2, 5, p. 703-709 7 p.

Research output: Contribution to journalArticle

Hydrogels
Scaffolds (biology)
Reinforcement
Scaffolds
Hydrogel
117 Citations (Scopus)

Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs

Kharaziha, M., Shin, S. R., Nikkhah, M., Topkaya, S. N., Masoumi, N., Annabi, N., Dokmeci, M. R. & Khademhosseini, A., 2014, In : Biomaterials. 35, 26, p. 7346-7354 9 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Scaffolds
Carbon nanotubes
Cardiac Myocytes
Nanofibers
2013
389 Citations (Scopus)

Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators

Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., Wan, K. T., Palacios, T., Dokmeci, M. R., Bae, H., Tang, X. & Khademhosseini, A., Mar 26 2013, In : ACS Nano. 7, 3, p. 2369-2380 12 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Hydrogel
gelatins
Gelatin
Hydrogels
29 Citations (Scopus)

Chitin nanofiber micropatterned flexible substrates for tissue engineering

Hassanzadeh, P., Kharaziha, M., Nikkhah, M., Shin, S. R., Jin, J., He, S., Sun, W., Zhong, C., Dokmeci, M. R., Khademhosseini, A. & Rolandi, M., Sep 14 2013, In : Journal of Materials Chemistry B. 1, 34, p. 4217-4224 8 p.

Research output: Contribution to journalArticle

Nanofibers
Chitin
Tissue Engineering
Tissue engineering
Substrates