Larisa Dedkova

Associate Research Professor

  • 476 Citations
  • 12 h-Index
20032021
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2003 2019

  • 476 Citations
  • 12 h-Index
  • 23 Article
2019
2 Citations (Scopus)

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

Ribosomes
Peptides
Proteins
RNA
Amino acids
3 Citations (Scopus)

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

Oxazoles
Amino acids
Proteins
Amino Acids
Escherichia coli
2017
10 Citations (Scopus)

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

Nucleotide Motifs
Amino acids
DNA
Proteins
Amino Acids
6 Citations (Scopus)

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

Tyrosine
Proteins
Puromycin
Phosphotyrosine
Ribosomes
2 Citations (Scopus)

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues

Daskalova, S. M., Bhattacharya, C., Dedkova, L. & Hecht, S., Jan 24 2017, In : Biochemistry. 56, 3, p. 500-513 14 p.

Research output: Contribution to journalArticle

Nucleophiles
Lyases
Schiff Bases
DNA-Directed DNA Polymerase
Lysine
2016
6 Citations (Scopus)

Synthesis and evaluation of a library of fluorescent dipeptidomimetic analogues as substrates for modified bacterial ribosomes

Chowdhury, S. R., Chauhan, P. S., Dedkova, L., Bai, X., Chen, S., Talukder, P. & Hecht, S., May 3 2016, In : Biochemistry. 55, 17, p. 2427-2440 14 p.

Research output: Contribution to journalArticle

Ribosomes
Fluorophores
Libraries
Green Fluorescent Proteins
Oxazoles
3 Citations (Scopus)

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

Talukder, P., Dedkova, L., Ellington, A. D., Yakovchuk, P., Lim, J., Anslyn, E. V. & Hecht, S., Sep 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 18, p. 4177-4187 11 p.

Research output: Contribution to journalArticle

Amino Acids
Nucleic Acids
DNA Polymerase I
Proteins
Tetrahydrofolate Dehydrogenase
2015
10 Citations (Scopus)

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ribosomal RNA
Mutation
Cell Culture Techniques
Molecular Cloning
25 Citations (Scopus)

Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids

Maini, R., Chowdhury, S. R., Dedkova, L., Roy, B., Daskalova, S. M., Paul, R., Chen, S. & Hecht, S., Jun 16 2015, In : Biochemistry. 54, 23, p. 3694-3706 13 p.

Research output: Contribution to journalArticle

Puromycin
Ribosomes
Alanine
Tetrahydrofolate Dehydrogenase
Amino Acids
23 Citations (Scopus)

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro

Maini, R., Dedkova, L., Paul, R., Madathil, M. M., Chowdhury, S. R., Chen, S. & Hecht, S., Sep 9 2015, In : Journal of the American Chemical Society. 137, 35, p. 11206-11209 4 p.

Research output: Contribution to journalArticle

Dipeptides
Ribosomes
Proteins
Puromycin
Clone Cells
9 Citations (Scopus)

Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein

Roy Chowdhury, S., Maini, R., Dedkova, L. & Hecht, S., May 8 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4715-4718 4 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Oxazoles
Thiazoles
Fluorophores
2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
2014
19 Citations (Scopus)

Design and expression of a short peptide as an HIV detection probe

Lines, J. A., Yu, Z., Dedkova, L. & Chen, S., Jan 3 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 308-312 5 p.

Research output: Contribution to journalArticle

HIV
Peptides
Proteins
Escherichia coli
HIV Infections
6 Citations (Scopus)

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues

Yu, X., Talukder, P., Bhattacharya, C., Fahmi, N. E., Lines, J. A., Dedkova, L., LaBaer, J., Hecht, S. & Chen, S., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5699-5703 5 p.

Research output: Contribution to journalArticle

Phenylalanine
HIV-1
Glycoproteins
HIV
Conformations
2013
38 Citations (Scopus)

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Tetrahydrofolate Dehydrogenase
Ribosomes
Amino Acids
Alanine
2012
34 Citations (Scopus)

β-puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids

Dedkova, L., Fahmi, N. E., Paul, R., Del Rosario, M., Zhang, L., Chen, S., Feder, G. & Hecht, S., Jan 10 2012, In : Biochemistry. 51, 1, p. 401-415 15 p.

Research output: Contribution to journalArticle

Puromycin
Ribosomes
Peptidyl Transferases
Amino Acids
Transfer RNA
2011
2 Citations (Scopus)

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

Transfer RNA
amino acids
protein synthesis
synthesis
condensation
2008
48 Citations (Scopus)

Inhibitors of DNA polymerase β: Activity and mechanism

Gao, Z., Maloney, D. J., Dedkova, L. & Hecht, S., Apr 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 8, p. 4331-4340 10 p.

Research output: Contribution to journalArticle

Nucleic Acid Synthesis Inhibitors
Lyases
Stigmasterol
DNA-Directed DNA Polymerase
Oleanolic Acid
2007
27 Citations (Scopus)

Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins

Fahmi, N. E., Dedkova, L., Wang, B., Golovine, S. & Hecht, S., Mar 28 2007, In : Journal of the American Chemical Society. 129, 12, p. 3586-3597 12 p.

Research output: Contribution to journalArticle

Firefly Luciferases
Serine
Tyrosine
Derivatives
Proteins
16 Citations (Scopus)

Synthesis of proteins containing modified arginine residues

Choudhury, A. K., Golovine, S. Y., Dedkova, L. & Hecht, S., Apr 3 2007, In : Biochemistry. 46, 13, p. 4066-4076 11 p.

Research output: Contribution to journalArticle

Luciferases
Arginine
Light
Amino Acids
Wavelength
2006
49 Citations (Scopus)

Construction of modified ribosomes for incorporation of D-amino acids into proteins

Dedkova, L., Fahmi, N. E., Golovine, S. Y. & Hecht, S., Dec 26 2006, In : Biochemistry. 45, 51, p. 15541-15551 11 p.

Research output: Contribution to journalArticle

Ribosomes
Amino Acids
Proteins
Peptidyl Transferases
Tetrahydrofolate Dehydrogenase
12 Citations (Scopus)

Effects of modification of the active site tyrosine of human DNA topoisomerase I

Gao, R., Zhang, Y., Dedkova, L., Choudhury, A. K., Rahier, N. J. & Hecht, S., Jul 11 2006, In : Biochemistry. 45, 27, p. 8402-8410 9 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Tyrosine
Catalytic Domain
DNA
Transfer RNA
2005
20 Citations (Scopus)

Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine

Gao, R., Zhang, Y., Choudhury, A. K., Dedkova, L. & Hecht, S., Mar 16 2005, In : Journal of the American Chemical Society. 127, 10, p. 3321-3331 11 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Vaccinia virus
Viruses
Tyrosine
Catalytic Domain
2003
106 Citations (Scopus)

Enhanced D-amino acid incorporation into protein by modified ribosomes

Dedkova, L., Fahmi, N. E., Golovine, S. Y. & Hecht, S., Jun 4 2003, In : Journal of the American Chemical Society. 125, 22, p. 6616-6617 2 p.

Research output: Contribution to journalArticle

Ribosomes
Amino acids
Proteins
Amino Acids
Mutation