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19972020
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Research Output 1997 2018

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Article
2018
5 Citations (Scopus)

A single nucleotide incorporation step limits human telomerase repeat addition activity

Chen, Y., Podlevsky, J. D., Logeswaran, D. & Chen, J., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Telomerase
Nucleotides
DNA
Diphosphates
DNA-Directed DNA Polymerase
2017
2 Citations (Scopus)

Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma

Donaires, F. S., Scatena, N. F., Alves-Paiva, R. M., Podlevsky, J. D., Logeswaran, D., Santana, B. A., Teixeira, A. C., Chen, J., Calado, R. T. & Martinelli, A. L. C., Aug 1 2017, In : PLoS One. 12, 8, e0183287.

Research output: Contribution to journalArticle

telomerase
Telomerase
telomeres
Telomere
hepatoma
2016
5 Citations (Scopus)

Structure and function of echinoderm telomerase RNA

Podlevsky, J. D., Li, Y. & Chen, J., Feb 1 2016, In : RNA. 22, 2, p. 204-215 12 p.

Research output: Contribution to journalArticle

Telomerase
Vertebrates
Ribonucleoproteins
Insulator Elements
telomerase RNA
5 Citations (Scopus)

The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes

Podlevsky, J. D., Li, Y. & Chen, J., 2016, In : Nucleic Acids Research. 44, 20, p. 9891-9901 11 p.

Research output: Contribution to journalArticle

Telomerase
Eukaryota
Trypanosomiasis
Trypanosoma brucei brucei
telomerase RNA
2015
12 Citations (Scopus)

Prevalent and distinct spliceosomal 3′-end processing mechanisms for fungal telomerase RNA

Qi, X., Rand, D. P., Podlevsky, J. D., Li, Y., Mosig, A., Stadler, P. F. & Chen, J., 2015, In : Nature Communications. 6, 6105.

Research output: Contribution to journalArticle

Fungal RNA
cleavage
Neurospora crassa
RNA Splice Sites
Schizosaccharomyces
77 Citations (Scopus)

Telomerase mutations in smokers with severe emphysema

Stanley, S. E., Chen, J., Podlevsky, J. D., Alder, J. K., Hansel, N. N., Mathias, R. A., Qi, X., Rafaels, N. M., Wise, R. A., Silverman, E. K., Barnes, K. C. & Armanios, M., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 563-570 8 p.

Research output: Contribution to journalArticle

Telomerase
Emphysema
Telomere
Mutation
Pulmonary Fibrosis
2014
19 Citations (Scopus)

A self-regulating template in human telomerase

Brown, A. F., Podlevsky, J. D., Qi, X., Chen, Y., Xie, M. & Chen, J., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11311-11316 6 p.

Research output: Contribution to journalArticle

Telomerase
DNA
Nucleotides
DNA Primers
Terminal Repeat Sequences
38 Citations (Scopus)

Structural basis for protein-RNA recognition in telomerase

Huang, J., Brown, A. F., Wu, J., Xue, J., Bley, C. J., Rand, D. P., Wu, L., Zhang, R., Chen, J. & Lei, M., 2014, In : Nature Structural and Molecular Biology. 21, 6, p. 507-512 6 p.

Research output: Contribution to journalArticle

Telomerase
RNA
Proteins
Oryzias
Tetrahymena
2013
17 Citations (Scopus)

A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome

Gramatges, M. M., Qi, X., Sasa, G. S., Chen, J. & Bertuch, A. A., May 2 2013, In : Blood. 121, 18, p. 3586-3593 8 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Dyskeratosis Congenita
Siblings
Mutation
9 Citations (Scopus)

Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach

Li, Y., Podlevsky, J. D., Marz, M., Qi, X., Hoffmann, S., Stadler, P. F. & Chen, J., Jun 2013, In : RNA. 19, 6, p. 852-860 9 p.

Research output: Contribution to journalArticle

Strongylocentrotus purpuratus
Telomerase
Vertebrates
Ribonucleoproteins
Sea Urchins
40 Citations (Scopus)

The common ancestral core of vertebrate and fungal telomerase RNAs

Qi, X., Li, Y., Honda, S., Hoffmann, S., Marz, M., Mosig, A., Podlevsky, J. D., Stadler, P. F., Selker, E. U. & Chen, J., Jan 2013, In : Nucleic Acids Research. 41, 1, p. 450-462 13 p.

Research output: Contribution to journalArticle

Fungal RNA
Telomerase
Vertebrates
Neurospora crassa
Fungal Genome
2012
79 Citations (Scopus)

It all comes together at the ends: Telomerase structure, function, and biogenesis

Podlevsky, J. D. & Chen, J., Feb 1 2012, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 730, 1-2, p. 3-11 9 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Chromosomes
Ribonucleoproteins
RNA-Directed DNA Polymerase
40 Citations (Scopus)

RNA/DNA hybrid binding affinity determines telomerase template- translocation efficiency

Qi, X., Xie, M., Brown, A. F., Bley, C. J., Podlevsky, J. D. & Chen, J., Jan 4 2012, In : EMBO Journal. 31, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

Telomerase
RNA
Catalytic Domain
DNA
DNA Primers
2011
60 Citations (Scopus)

Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis

Alder, J. K., Cogan, J. D., Brown, A. F., Anderson, C. J., Lawson, W. E., Lansdorp, P. M., Phillips, J. A., Loyd, J. E., Chen, J. & Armanios, M., Mar 2011, In : PLoS Genetics. 7, 3, e1001352.

Research output: Contribution to journalArticle

telomerase
Pulmonary Fibrosis
Telomerase
telomeres
Telomere
3 Citations (Scopus)

Recombinant production and purification of the subunit c of chloroplast ATP synthase

Lawrence, R. M., Varco-Merth, B., Bley, C. J., Chen, J. & Fromme, P., Mar 2011, In : Protein Expression and Purification. 76, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Chloroplasts
Adenosine Triphosphate
Maltose-Binding Proteins
Spinacia oleracea
Protons
36 Citations (Scopus)

RNA-protein binding interface in the telomerase ribonucleoprotein

Bley, C. J., Qi, X., Rand, D. P., Borges, C., Nelson, R. W. & Chen, J., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20333-20338 6 p.

Research output: Contribution to journalArticle

Ribonucleoproteins
RNA-Binding Proteins
Telomerase
RNA
Oryzias
90 Citations (Scopus)

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

Parry, E. M., Alder, J. K., Qi, X., Chen, J. & Armanios, M., May 26 2011, In : Blood. 117, 21, p. 5607-5611 5 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Pulmonary Fibrosis
Telomerase
Bone
Defects
2009
45 Citations (Scopus)

A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity

Xie, M., Podlevsky, J. D., Qi, X., Bley, C. J. & Chen, J., Dec 30 2009, In : Nucleic Acids Research. 38, 6, p. 1982-1996 15 p., gkp1198.

Research output: Contribution to journalArticle

Telomerase
Telomere
DNA
RNA
Mutation
77 Citations (Scopus)

Evolution of vault RNAs

Stadler, P. F., Chen, J., Hackermüller, J., Hoffmann, S., Horn, F., Khaitovich, P., Kretzschmar, A. K., Mosig, A., Prohaska, S. J., Qi, X., Schutt, K. & Ullmann, K., Sep 2009, In : Molecular Biology and Evolution. 26, 9, p. 1975-1991 17 p.

Research output: Contribution to journalArticle

RNA
Multigene Family
loci
cadherins
gene
2008
10 Citations (Scopus)

Direct electrochemical monitoring of RNase activity

Ye, Y., Wen, W., Xiang, Y., Qi, X., LaBelle, J., Chen, J. & Wang, J., Apr 2008, In : Electroanalysis. 20, 8, p. 919-922 4 p.

Research output: Contribution to journalArticle

Ribonucleases
Assays
Magnetic separation
Molecular biology
Monitoring
414 Citations (Scopus)

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

Alder, J. K., Chen, J., Lancaster, L., Danoff, S., Su, S. C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., Phillips, J. A., Lansdorp, P. M., Loyd, J. E. & Armanios, M. Y., Sep 2 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 13051-13056 6 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Idiopathic Interstitial Pneumonias
Telomere
Alveolar Epithelial Cells
Telomerase
61 Citations (Scopus)

Structure and function of the smallest vertebrate telomerase RNA from teleost fish

Xie, M., Mosig, A., Qi, X., Li, Y., Stadler, P. F. & Chen, J., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 2049-2059 11 p.

Research output: Contribution to journalArticle

Fish
Vertebrates
Fishes
Telomerase
Nucleotides
116 Citations (Scopus)

The Telomerase Database

Podlevsky, J. D., Bley, C. J., Omana, R. V., Qi, X. & Chen, J., Jan 2008, In : Nucleic Acids Research. 36, SUPPL. 1

Research output: Contribution to journalArticle

Telomerase
Databases
Research Personnel
Chromosomal Instability
Ribonucleoproteins
2007
11 Citations (Scopus)

Identification and characterization of sea squirt telomerase reverse transcriptase

Li, Y., Yates, J. A. & Chen, J., Oct 1 2007, In : Gene. 400, 1-2, p. 16-24 9 p.

Research output: Contribution to journalArticle

Telomerase
Oceans and Seas
Vertebrates
Proteins
Ciona intestinalis
752 Citations (Scopus)

Telomerase mutations in families with idiopathic pulmonary fibrosis

Armanios, M. Y., Chen, J., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., Lansdorp, P. M., Greider, C. W. & Loyd, J. E., Mar 29 2007, In : New England Journal of Medicine. 356, 13, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Telomerase
Telomere
Mutation
Pulmonary Fibrosis
46 Citations (Scopus)

Ultrasensitive label-free aptamer-based electronic detection

Xiang, Y., Xie, M., Bash, R., Chen, J. & Wang, J., 2007, In : Angewandte Chemie - International Edition. 46, 47, p. 9054-9056 3 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Thrombin
Amplification
Labels
Assays
2006
40 Citations (Scopus)

Rolling-circle amplification of a DNA nanojunction

Lin, C., Xie, M., Chen, J., Liu, Y. & Yan, H., Nov 20 2006, In : Angewandte Chemie - International Edition. 45, 45, p. 7537-7539 3 p.

Research output: Contribution to journalArticle

Amplification
DNA
Nanostructures
38 Citations (Scopus)

Structure and Function of Eukaryotic Ribonuclease P RNA

Marquez, S. M., Chen, J., Evans, D. & Pace, N. R., Nov 3 2006, In : Molecular Cell. 24, 3, p. 445-456 12 p.

Research output: Contribution to journalArticle

Bacterial RNA
Ribonucleases
RNA
Ribonuclease P
Proteins
2005
86 Citations (Scopus)

Functional analysis of the pseudoknot structure in human telomerase RNA

Chen, J. & Greider, C. W., Jun 7 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 23, p. 8080-8085 6 p.

Research output: Contribution to journalArticle

Telomerase
Base Pairing
Mutation
RNA
Chromosomal Instability
310 Citations (Scopus)

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

Armanios, M., Chen, J., Chang, Y. P. C., Brodsky, R. A., Hawkins, A., Griffin, C. A., Eshleman, J. R., Cohen, A. R., Chakravarti, A., Hamosh, A. & Greider, C. W., Nov 1 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 44, p. 15960-15964 5 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Telomerase
Telomere Shortening
Mutation
Dyskeratosis Congenita
2004
68 Citations (Scopus)

An emerging consensus for telomerase RNA structure

Chen, J. & Greider, C. W., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14683-14684 2 p.

Research output: Contribution to journalArticle

Fungal RNA
Nucleic Acid Sequence Homology
Conserved Sequence
Sequence Alignment
Telomerase
120 Citations (Scopus)

Telomerase RNA structure and function: Implications for dyskeratosis congenita

Chen, J. & Greider, C. W., Apr 2004, In : Trends in Biochemical Sciences. 29, 4, p. 183-192 10 p.

Research output: Contribution to journalArticle

Dyskeratosis Congenita
Telomerase
Telomere
Chromosomes
Catalysis
2003
106 Citations (Scopus)

Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility

Chen, J. & Greider, C. W., Jan 15 2003, In : EMBO Journal. 22, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

Telomerase
Enzymes
Nucleotides
telomerase RNA
RNA
108 Citations (Scopus)

Template boundary definition in mammalian telomerase

Chen, J. & Greider, C. W., Nov 15 2003, In : Genes and Development. 17, 22, p. 2747-2752 6 p.

Research output: Contribution to journalArticle

Telomerase
Insulator Elements
Telomere
Mammals
Yeasts
2002
110 Citations (Scopus)

A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA

Chen, J., Opperman, K. K. & Greider, C. W., Jan 15 2002, In : Nucleic Acids Research. 30, 2, p. 592-597 6 p.

Research output: Contribution to journalArticle

Telomerase
Base Pairing
RNA
Mutation
Proteins
2000
8 Citations (Scopus)

[10] Photoaffinity cross-linking and RNA structure analysis

Thomas, B. C., Kazantsev, A. V., Chen, J. & Pace, N. R., 2000, In : Methods in Enzymology. 318, p. 136-147 12 p.

Research output: Contribution to journalArticle

Endoribonucleases
Genetic Transcription
Ribonuclease P
Cross-Linking Reagents
Chemical Models
453 Citations (Scopus)

Secondary structure of vertebrate telomerase RNA

Chen, J., Blasco, M. A. & Greider, C. W., Mar 3 2000, In : Cell. 100, 5, p. 503-514 12 p.

Research output: Contribution to journalArticle

Vertebrates
Ribonucleoproteins
Mammals
Reptiles
Telomerase
1998
112 Citations (Scopus)

Comparative photocross-linking analysis of the tertiary structures of escherichia coli and bacillus subtilis RNase P RNAs

Chen, J., Nolan, J. M., Harris, M. E. & Pace, N. R., Mar 2 1998, In : EMBO Journal. 17, 5, p. 1515-1525 11 p.

Research output: Contribution to journalArticle

Ribonuclease P
Bacilli
Bacillus subtilis
Escherichia coli
RNA
1997
78 Citations (Scopus)

Analysis of the tertiary structure of the ribonuclease P ribozyme- substrate complex by site-specific photoaffinity crosslinking

Harris, M. E., Kazantsev, A. V., Chen, J. & Pace, N. R., 1997, In : RNA. 3, 6, p. 561-576 16 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
RNA
RNA Precursors
Ribonucleoproteins
104 Citations (Scopus)

Identification of the universally conserved core of ribonuclease P RNA.

Chen, J. & Pace, N. R., Jun 1997, In : RNA (New York, N.Y.). 3, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
Endoribonucleases
Ribonuclease P
Nucleic Acid Conformation