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Research Output 1900 2019

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Article
2019
1 Citation (Scopus)

Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase

Ishigami, I., Lewis-Ballester, A., Echelmeier, A., Brehm, G., Zatsepin, N., Grant, T. D., Coe, J. D., Lisova, S., Nelson, G., Zhang, S., Dobson, Z. F., Boutet, S., Sierra, R. G., Batyuk, A., Fromme, P., Fromme, R., Spence, J., Ros, A., Yeh, S. R. & Rousseau, D. L., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3572-3577 6 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Oxygen
Protons
Protein Conformation
Crystallography

SPIND: A reference-based auto-indexing algorithm for sparse serial crystallography data

Li, C., Li, X., Kirian, R., Spence, J., Liu, H. & Zatsepin, N., Jan 1 2019, In : IUCrJ. 6, p. 72-84 13 p.

Research output: Contribution to journalArticle

Crystallography
Diffraction patterns
crystallography
Boidae
Proteins
2018
2 Citations (Scopus)
X ray absorption spectroscopy
Cobalt
Ground state
absorption spectroscopy
cobalt
14 Citations (Scopus)

Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography

Olmos, J. L., Pandey, S., Martin-Garcia, J. M., Calvey, G., Katz, A., Knoska, J., Kupitz, C., Hunter, M. S., Liang, M., Oberthuer, D., Yefanov, O., Wiedorn, M., Heyman, M., Holl, M., Pande, K., Barty, A., Miller, M. D., Stern, S., Roy-Chowdhury, S., Coe, J. & 30 othersNagaratnam, N., Zook, J., Verburgt, J., Norwood, T., Poudyal, I., Xu, D., Koglin, J., Seaberg, M. H., Zhao, Y., Bajt, S., Grant, T., Mariani, V., Nelson, G., Subramanian, G., Bae, E., Fromme, R., Fung, R., Schwander, P., Frank, M., White, T. A., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Chapman, H. N., Pollack, L., Tremblay, L., Ourmazd, A., Phillips, G. N. & Schmidt, M., May 31 2018, In : BMC Biology. 16, 1, 59.

Research output: Contribution to journalArticle

crystallography
Crystallography
Diptera
X-radiation
X-Rays
2 Citations (Scopus)

Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

Woitowich, N. C., Halavaty, A. S., Waltz, P., Kupitz, C., Valera, J., Tracy, G., Gallagher, K. D., Claesson, E., Nakane, T., Pandey, S., Nelson, G., Tanaka, R., Nango, E., Mizohata, E., Owada, S., Tono, K., Joti, Y., Nugent, A. C., Patel, H., Mapara, A. & 21 othersHopkins, J., Duong, P., Bizhga, D., Kovaleva, S. E., Peter, R. S., Hernandez, C. N., Ozarowski, W. B., Roy-Chowdhuri, S., Yang, J. H., Edlund, P., Takala, H., Ihalainen, J., Brayshaw, J., Norwood, T., Poudyal, I., Fromme, P., Spence, J., Moffat, K., Westenhoff, S., Schmidt, M. & Stojković, E. A., Jan 1 2018, In : IUCrJ. 5, p. 619-634 16 p.

Research output: Contribution to journalArticle

phytochrome
Phytochrome
Threonine
Chromophores
Myxococcales

Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

Lee, D. B., Kim, J. M., Seok, J. H., Lee, J. H., Jo, J. D., Mun, J. Y., Conrad, C., Coe, J., Nelson, G., Hogue, B., White, T. A., Zatsepin, N., Weierstall, U., Barty, A., Chapman, H., Fromme, P., Spence, J., Chung, M. S., Oh, C. H. & Kim, K. H., Dec 1 2018, In : Scientific Reports. 8, 1, 2541.

Research output: Contribution to journalArticle

supersaturation
crystallography
microcrystals
free electron lasers
evaporation
1 Citation (Scopus)

The phase problem for two-dimensional crystals.II. Simulations

Arnal, R. D., Zhao, Y., Mitra, A. K., Spence, J. & Millane, R. P., Sep 1 2018, In : Acta Crystallographica Section A: Foundations and Advances. 74, 5, p. 537-544 8 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
free electron lasers
Lasers
envelopes
2017
25 Citations (Scopus)

Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

Gati, C., Oberthuer, D., Yefanov, O., Bunker, R. D., Stellato, F., Chiu, E., Yeh, S. M., Aquila, A., Basu, S., Bean, R., Beyerlein, K. R., Botha, S., Boutet, S., DePonte, D. P., Doak, R. B., Fromme, R., Galli, L., Grotjohann, I., James, D. R., Kupitz, C. & 17 othersLomb, L., Messerschmidt, M., Nass, K., Rendek, K., Shoeman, R. L., Wang, D., Weierstall, U., White, T. A., Williams, G. J., Zatsepin, N., Fromme, P., Spence, J., Goldie, K. N., Jehle, J. A., Metcalf, P., Barty, A. & Chapman, H. N., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2247-2252 6 p.

Research output: Contribution to journalArticle

Granulovirus
Lasers
X-Rays
Electrons
Radiation
14 Citations (Scopus)

Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source

Reddy, H. K. N., Yoon, C. H., Aquila, A., Awel, S., Ayyer, K., Barty, A., Berntsen, P., Bielecki, J., Bobkov, S., Bucher, M., Carini, G. A., Carron, S., Chapman, H., Daurer, B., Demirci, H., Ekeberg, T., Fromme, P., Hajdu, J., Hanke, M. F., Hart, P. & 25 othersHogue, B., Hosseinizadeh, A., Kim, Y., Kirian, R., Kurta, R. P., Larsson, D. S. D., Duane Loh, N., Maia, F. R. N. C., Mancuso, A. P., Mühlig, K., Munke, A., Nam, D., Nettelblad, C., Ourmazd, A., Rose, M., Schwander, P., Seibert, M., Sellberg, J. A., Song, C., Spence, J., Svenda, M., Van Der Schot, G., Vartanyants, I. A., Williams, G. J. & Lourdu Xavier, P., Jun 27 2017, In : Scientific data. 4, 170079.

Research output: Contribution to journalArticle

X ray lasers
Molecular imaging
Soft X-ray
Free electron lasers
Viruses
2 Citations (Scopus)

Diffraction data of core-shell nanoparticles from an X-ray free electron laser

Li, X., Chiu, C. Y., Wang, H. J., Kassemeyer, S., Botha, S., Shoeman, R. L., Lawrence, R. M., Kupitz, C., Kirian, R., James, D., Wang, DI., Nelson, G., Messerschmidt, M., Boutet, S., Williams, G. J., Hartmann, E., Jafarpour, A., Foucar, L. M., Barty, A., Chapman, H. & 13 othersLiang, M., Menzel, A., Wang, F., Basu, S., Fromme, R., Doak, R. B., Fromme, P., Weierstall, U., Huang, M. H., Spence, J., Schlichting, I., Hogue, B. & Liu, H., Apr 11 2017, In : Scientific data. 4, 170048.

Research output: Contribution to journalArticle

X ray lasers
X-ray Laser
Free Electron Laser
Free electron lasers
Nanoparticles
28 Citations (Scopus)

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 othersWang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific Reports. 7, 44628.

Research output: Contribution to journalArticle

liquid flow
injectors
nozzles
crystallography
room temperature

Local electric field direct writing – Electron-beam lithography and mechanism

Jiang, N., Su, D. & Spence, J., Oct 5 2017, In : Microelectronic Engineering. 182, p. 8-14 7 p.

Research output: Contribution to journalArticle

Electron beam lithography
electron probes
lithography
Electric fields
electron beams
1 Citation (Scopus)

Merging single-shot XFEL diffraction data from inorganic nanoparticles: A new approach to size and orientation determination

Li, X., Spence, J., Hogue, B. & Liu, H., 2017, In : IUCrJ. 4, p. 741-750 10 p.

Research output: Contribution to journalArticle

size determination
X ray lasers
Free electron lasers
Merging
free electron lasers
7 Citations (Scopus)

Outrunning damage: Electrons vs X-rays-timescales and mechanisms

Spence, J., Jul 1 2017, In : Structural Dynamics. 4, 4, 044027.

Research output: Contribution to journalArticle

X ray lasers
damage
X rays
Elastic scattering
Electrons
20 Citations (Scopus)

Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

Martin-Garcia, J. M., Conrad, C. E., Nelson, G., Stander, N., Zatsepin, N., Zook, J., Zhu, L., Geiger, J., Chun, E., Kissick, D., Hilgart, M. C., Ogata, C., Ishchenko, A., Nagaratnam, N., Roy-Chowdhury, S., Coe, J., Subramanian, G., Schaffer, A., James, D., Ketwala, G. & 10 othersVenugopalan, N., Xu, S., Corcoran, S., Ferguson, D., Weierstall, U., Spence, J., Cherezov, V., Fromme, P., Fischetti, R. F. & Liu, W., 2017, In : IUCrJ. 4, p. 439-454 16 p.

Research output: Contribution to journalArticle

Crystallography
Microcrystals
Synchrotrons
microcrystals
Phycocyanin
1 Citation (Scopus)

Split-Second Reactions

Fromme, P. & Spence, J., Apr 18 2017, In : Scientific American. 316, 5, p. 62-67 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Structural enzymology using X-ray free electron lasers

Kupitz, C., Olmos, J. L., Holl, M., Tremblay, L., Pande, K., Pandey, S., Oberthür, D., Hunter, M., Liang, M., Aquila, A., Tenboer, J., Calvey, G., Katz, A., Chen, Y., Wiedorn, M. O., Knoska, J., Meents, A., Majriani, V., Norwood, T., Poudyal, I. & 30 othersGrant, T., Miller, M. D., Xu, W., Tolstikova, A., Morgan, A., Metz, M., Martin-Gracia, J., Zook, J. D., Roy-Chowdhury, S., Coe, J., Nagaratnam, N., Meza, D., Fromme, R., Basu, S., Frank, M., White, T., Barty, A., Bajt, S., Yefanov, O., Chapman, H. N., Zatsepin, N., Nelson, G., Weierstall, U., Spence, J., Schwander, P., Pollack, L., Fromme, P., Ourmazd, A., Phillips, G. N. & Schmidt, M., Jul 1 2017, In : Structural Dynamics. 4, 4, 044003.

Research output: Contribution to journalArticle

enzymology
X ray lasers
Crystallography
Ceftriaxone
Free electron lasers
61 Citations (Scopus)

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Stagno, J. R., Liu, Y., Bhandari, Y. R., Conrad, C. E., Panja, S., Swain, M., Fan, L., Nelson, G., Li, C., Wendel, D. R., White, T. A., Coe, J. D., Wiedorn, M. O., Knoska, J., Oberthuer, D., Tuckey, R. A., Yu, P., Dyba, M., Tarasov, S. G., Weierstall, U. & 18 othersGrant, T. D., Schwieters, C. D., Zhang, J., Ferré-D'Amaré, A. R., Fromme, P., Draper, D. E., Liang, M., Hunter, M. S., Boutet, S., Tan, K., Zuo, X., Ji, X., Barty, A., Zatsepin, N., Chapman, H. N., Spence, J., Woodson, S. A. & Wang, Y. X., Jan 12 2017, In : Nature. 541, 7636, p. 242-246 5 p.

Research output: Contribution to journalArticle

Riboswitch
Crystallography
Lasers
X-Rays
RNA
30 Citations (Scopus)

XFELs for structure and dynamics in biology

Spence, J., 2017, In : IUCrJ. 4, p. 322-339 18 p.

Research output: Contribution to journalArticle

Radiation damage
biology
Diffraction
X-Rays
Scattering
2016
133 Citations (Scopus)

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

Pande, K., Hutchison, C. D. M., Groenhof, G., Aquila, A., Robinson, J. S., Tenboer, J., Basu, S., Boutet, S., DePonte, D. P., Liang, M., White, T. A., Zatsepin, N., Yefanov, O., Morozov, D., Oberthuer, D., Gati, C., Subramanian, G., James, D., Zhao, Y., Koralek, J. & 24 othersBrayshaw, J., Kupitz, C., Conrad, C., Roy-Chowdhury, S., Coe, J. D., Metz, M., Xavier, P. L., Grant, T. D., Koglin, J. E., Ketawala, G., Fromme, R., Srajer, V., Henning, R., Spence, J., Ourmazd, A., Schwander, P., Weierstall, U., Frank, M., Fromme, P., Barty, A., Chapman, H. N., Moffat, K., Van Thor, J. J. & Schmidt, M., May 6 2016, In : Science. 352, 6286, p. 725-729 5 p.

Research output: Contribution to journalArticle

Light
Crystallography
Proteins
Photons
X-Rays
28 Citations (Scopus)

Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography

Nogly, P., Panneels, V., Nelson, G., Gati, C., Kimura, T., Milne, C., Milathianaki, D., Kubo, M., Wu, W., Conrad, C., Coe, J., Bean, R., Zhao, Y., Båth, P., Dods, R., Harimoorthy, R., Beyerlein, K. R., Rheinberger, J., James, D., DePonte, D. & 20 othersLi, C., Sala, L., Williams, G. J., Hunter, M. S., Koglin, J. E., Berntsen, P., Nango, E., Iwata, S., Chapman, H. N., Fromme, P., Frank, M., Abela, R., Boutet, S., Barty, A., White, T. A., Weierstall, U., Spence, J., Neutze, R., Schertler, G. & Standfuss, J., Aug 22 2016, In : Nature Communications. 7, 12314.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Crystallography
injectors
crystallography
delivery
65 Citations (Scopus)

Macromolecular diffractive imaging using imperfect crystals

Ayyer, K., Yefanov, O. M., Oberthür, D., Roy-Chowdhury, S., Galli, L., Mariani, V., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Schaffer, A., Dörner, K., James, D., Kupitz, C., Metz, M., Nelson, G., Xavier, P. L., Beyerlein, K. R., Schmidt, M., Sarrou, I. & 14 othersSpence, J., Weierstall, U., White, T. A., Yang, J. H., Zhao, Y., Liang, M., Aquila, A., Hunter, M. S., Robinson, J. S., Koglin, J. E., Boutet, S., Fromme, P., Barty, A. & Chapman, H. N., Feb 10 2016, In : Nature. 530, 7589, p. 202-206 5 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
Crystallography
X Ray Crystallography
Cell Size
X-Ray Diffraction
35 Citations (Scopus)

Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

Batyuk, A., Galli, L., Ishchenko, A., Han, G. W., Gati, C., Popov, P. A., Lee, M. Y., Stauch, B., White, T. A., Barty, A., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Pu, M., Liu, Z. J., Nelson, G., James, D., Li, C., Zhao, Y. & 7 othersSpence, J., Liu, W., Fromme, P., Katritch, V., Weierstall, U., Stevens, R. C. & Cherezov, V., Sep 1 2016, In : Science advances. 2, 9, e1600292.

Research output: Contribution to journalArticle

Lasers
X-Rays
Electrons
Adenosine A2A Receptors
Crystallography

Ondrej Krivanek's early scientific research

Spence, J., Oct 2 2016, (Accepted/In press) In : Ultramicroscopy.

Research output: Contribution to journalArticle

Electron energy loss spectroscopy
X ray lasers
Multiple scattering
Free electron lasers
Radiation damage
13 Citations (Scopus)

The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography

Edlund, P., Takala, H., Claesson, E., Henry, L., Dods, R., Lehtivuori, H., Panman, M., Pande, K., White, T., Nakane, T., Berntsson, O., Gustavsson, E., Båth, P., Modi, V., Roy-Chowdhury, S., Zook, J., Berntsen, P., Pandey, S., Poudyal, I., Tenboer, J. & 16 othersKupitz, C., Barty, A., Fromme, P., Koralek, J. D., Tanaka, T., Spence, J., Liang, M., Hunter, M. S., Boutet, S., Nango, E., Moffat, K., Groenhof, G., Ihalainen, J., Stojkovi, E. A., Schmidt, M. & Westenhoff, S., Oct 19 2016, In : Scientific Reports. 6, 35279.

Research output: Contribution to journalArticle

Phytochrome
Bacterial Structures
Crystallography
Temperature
Deinococcus
22 Citations (Scopus)

Three-dimensional-printed gas dynamic virtual nozzles for x-ray laser sample delivery

Nelson, G., Kirian, R., Weierstall, U., Zatsepin, N., Faragó, T., Baumbach, T., Wilde, F., Niesler, F. B. P., Zimmer, B., Ishigami, I., Hikita, M., Bajt, S., Yeh, S. R., Rousseau, D. L., Chapman, H. N., Spence, J. & Heymann, M., May 30 2016, In : Optics Express. 24, 11, p. 11515-11530 16 p.

Research output: Contribution to journalArticle

x ray lasers
gas dynamics
nozzles
delivery
free electron lasers
19 Citations (Scopus)

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

Zhou, X. E., Gao, X., Barty, A., Kang, Y., He, Y., Liu, W., Ishchenko, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Suino-Powell, K. M., Boutet, S., Williams, G. J., Wang, M., Li, D., Caffrey, M., Chapman, H. N., Spence, J. & 6 othersFromme, P., Weierstall, U., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Apr 12 2016, In : Scientific data. 3, 201621.

Research output: Contribution to journalArticle

X ray lasers
X-ray Laser
Free Electron Laser
Free electron lasers
Femtosecond
2015
58 Citations (Scopus)

A novel inert crystal delivery medium for serial femtosecond crystallography

Conrad, C. E., Basu, S., James, D., Wang, D., Schaffer, A., Roy-Chowdhury, S., Zatsepin, N., Aquila, A., Coe, J., Gati, C., Hunter, M. S., Koglin, J. E., Kupitz, C., Nelson, G., Subramanian, G., White, T. A., Zhao, Y., Zook, J., Boutet, S., Cherezov, V. & 4 othersSpence, J., Fromme, R., Weierstall, U. & Fromme, P., Jul 1 2015, In : IUCrJ. 2, p. 421-430 10 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
delivery
Sepharose
proteins
334 Citations (Scopus)

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Ke, J., Tan, M. H. E., Zhang, C., Moeller, A., West, G. M., Pascal, B. D., Van Eps, N., Caro, L. N. & 52 othersVishnivetskiy, S. A., Lee, R. J., Suino-Powell, K. M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G. J., Messerschmidt, M., Gati, C., Zatsepin, N., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C. E., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C. S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H. N., Spence, J., Fromme, P., Weierstall, U., Ernst, O. P., Katritch, V., Gurevich, V. V., Griffin, P. R., Hubbell, W. L., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Jul 30 2015, In : Nature. 523, 7562, p. 561-567 7 p.

Research output: Contribution to journalArticle

Arrestin
Rhodopsin
Lasers
X-Rays
G-Protein-Coupled Receptors
5 Citations (Scopus)

Data collection strategies for time-resolved X-ray free-electron laser diffraction, and 2-color methods

Li, C., Schmidt, K. & Spence, J., Jul 1 2015, In : Structural Dynamics. 2, 4, 041714.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
free electron lasers
Diffraction
shot
9 Citations (Scopus)

Electronic damage in S atoms in a native protein crystal induced by an intense X-ray free-electron laser pulse

Galli, L., Son, S. K., Klinge, M., Bajt, S., Barty, A., Bean, R., Betzel, C., Beyerlein, K. R., Caleman, C., Doak, R. B., Duszenko, M., Fleckenstein, H., Gati, C., Hunt, B., Kirian, R., Liang, M., Nanao, M. H., Nass, K., Oberthür, D., Redecke, L. & 7 othersShoeman, R., Stellato, F., Yoon, C. H., White, T. A., Yefanov, O., Spence, J. & Chapman, H. N., Jul 1 2015, In : Structural Dynamics. 2, 4, 041703.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
Radiation damage
radiation damage
free electron lasers
7 Citations (Scopus)

Hollow cone illumination for fast TEM, and outrunning damage with electrons

Spence, J., Subramanian, G. & Musumeci, P., Sep 23 2015, In : Journal of Physics B: Atomic, Molecular and Optical Physics. 48, 21, 214003.

Research output: Contribution to journalArticle

hollow
cones
illumination
damage
transmission electron microscopy
86 Citations (Scopus)

Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

Nogly, P., James, D., Wang, D., White, T. A., Zatsepin, N., Shilova, A., Nelson, G., Liu, H., Johansson, L., Heymann, M., Jaeger, K., Metz, M., Wickstrand, C., Wu, W., Båth, P., Berntsen, P., Oberthuer, D., Panneels, V., Cherezov, V., Chapman, H. & 7 othersSchertler, G., Neutze, R., Spence, J., Moraes, I., Burghammer, M., Standfuss, J. & Weierstall, U., Feb 26 2015, In : IUCrJ. 2, p. 168-176 9 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Crystallography
Synchrotrons
Synchrotron radiation
crystallography
7 Citations (Scopus)

Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction

Abdallah, B. G., Zatsepin, N., Roy-Chowdhury, S., Coe, J., Conrad, C. E., Dörner, K., Sierra, R. G., Stevenson, H. P., Camacho-Alanis, F., Grant, T. D., Nelson, G., James, D., Calero, G., Wachter, R., Spence, J., Weierstall, U., Fromme, P. & Ros, A., Jul 1 2015, In : Structural Dynamics. 2, 4, 041719.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
classifying
Sorting
Microfluidics
29 Citations (Scopus)

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

Fromme, R., Ishchenko, A., Metz, M., Chowdhury, S. R., Basu, S., Boutet, S., Fromme, P., White, T. A., Barty, A., Spence, J., Weierstall, U., Liu, W. & Cherezov, V., Sep 1 2015, In : IUCrJ. 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
Microcrystals
proteins
Proteins
7 Citations (Scopus)

Serial femtosecond X-ray diffraction of enveloped virus microcrystals

Lawrence, R. M., Conrad, C. E., Zatsepin, N., Grant, T. D., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Coe, J., Spence, J., Weierstall, U., Liu, W., Fromme, P., Cherezov, V. & Hogue, B., Jul 1 2015, In : Structural Dynamics. 2, 4, 041720.

Research output: Contribution to journalArticle

Microcrystals
microcrystals
viruses
Viruses
X ray diffraction
15 Citations (Scopus)

Solving protein nanocrystals by cryo-EM diffraction: Multiple scattering artifacts

Subramanian, G., Basu, S., Liu, H., Zuo, J. M. & Spence, J., Jan 1 2015, In : Ultramicroscopy. 148, p. 87-93 7 p.

Research output: Contribution to journalArticle

Multiple scattering
Nanocrystals
artifacts
nanocrystals
Diffraction
81 Citations (Scopus)

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J., Boutet, S., Messerschmidt, M., Williams, G. J., Gati, C., Yefanov, O. M., White, T. A., Oberthuer, D. & 16 othersMetz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptides
Analgesics
Opiate Alkaloids
phenylalanylphenylalanine
73 Citations (Scopus)

The linac coherent light source single particle imaging road map

Aquila, A., Barty, A., Bostedt, C., Boutet, S., Carini, G., DePonte, D., Drell, P., Doniach, S., Downing, K. H., Earnest, T., Elmlund, H., Elser, V., Gühr, M., Hajdu, J., Hastings, J., Hau-Riege, S. P., Huang, Z., Lattman, E. E., Maia, F. R. N. C., Marchesini, S. & 10 othersOurmazd, A., Pellegrini, C., Santra, R., Schlichting, I., Schroer, C., Spence, J., Vartanyants, I. A., Wakatsuki, S., Weis, W. I. & Williams, G. J., Jul 1 2015, In : Structural Dynamics. 2, 4, 041701.

Research output: Contribution to journalArticle

coherent light
Light sources
light sources
Free electron lasers
Imaging techniques
5 Citations (Scopus)

X-ray lasers and serial crystallography

Spence, J., Apr 30 2015, In : IUCrJ. 2, p. 305-306 2 p.

Research output: Contribution to journalArticle

X ray lasers
Crystallography
crystallography
Lasers
X-Rays
2014
25 Citations (Scopus)

7 Å resolution in protein twodimensional-crystal X-ray diffraction at Linac Coherent Light Source

Pedrini, B., Tsai, C. J., Capitani, G., Padeste, C., Hunter, M. S., Zatsepin, N., Barty, A., Henry Benner, W., Boutet, S., Feld, G. K., Hau-Riege, S. P., Kirian, R., Kupitz, C., Messerschmitt, M., Ogren, J. I., Pardini, T., Segelke, B., Williams, G. J., Spence, J., Abela, R. & 5 othersColeman, M., Evans, J. E., Schertler, G. F. X., Frank, M. & Li, X. D., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130500.

Research output: Contribution to journalArticle

crystal proteins
X ray lasers
X-ray diffraction
X-Ray Diffraction
crystals
14 Citations (Scopus)

Ab-initio phasing using nanocrystal shape transforms with incomplete unit cells

Liu, H., Zatsepin, N. & Spence, J., Jan 1 2014, In : IUCrJ. 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Nanoparticles
Nanocrystals
nanocrystals
Crystals
cells
14 Citations (Scopus)

Approaches to time-resolved diffraction using an XFEL

Spence, J., Dec 1 2014, In : Faraday Discussions. 171, p. 429-438 10 p.

Research output: Contribution to journalArticle

Diffraction
delivery
recording
diffraction
Crystallography
9 Citations (Scopus)

Coherent convergent-beam time-resolved X-ray diffraction

Spence, J., Zatsepin, N. & Li, C., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130325.

Research output: Contribution to journalArticle

X ray lasers
nanocrystals
X-ray diffraction
X-Ray Diffraction
Nanocrystals
12 Citations (Scopus)

Direct phasing in femtosecond nanocrystallography. I. Diffraction characteristics

Chen, J. P. J., Spence, J. & Millane, R. P., 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Noise
Diffraction
X-Rays
Crystallography
10 Citations (Scopus)

Direct phasing in femtosecond nanocrystallography. II. Phase retrieval

Chen, J. P. J., Spence, J. & Millane, R. P., 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
Nanocrystals
Diffraction patterns
retrieval
33 Citations (Scopus)

Double-focusing mixing jet for XFEL study of chemical kinetics

Wang, D., Weierstall, U., Pollack, L. & Spence, J., Nov 1 2014, In : Journal of Synchrotron Radiation. 21, p. 1364-1366 3 p.

Research output: Contribution to journalArticle

Reaction kinetics
reaction kinetics
X-Rays
Equipment and Supplies
Motion Pictures
5 Citations (Scopus)

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 othersLiu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

vaccines
human immunodeficiency virus
Vaccines
Crystallization
Viruses
47 Citations (Scopus)

Femtosecond X-ray diffraction from two-dimensional protein crystals

Frank, M., Carlson, D. B., Hunter, M. S., Williams, G. J., Messerschmidt, M., Zatsepin, N., Barty, A., Benner, W. H., Chu, K., Graf, A. T., Hau-Riege, S. P., Kirian, R., Padeste, C., Pardini, T., Pedrini, B., Segelke, B., Seibert, M. M., Spence, J., Tsai, C. J., Lane, S. M. & 5 othersLi, X. D., Schertler, G., Boutet, S., Coleman, M. & Evans, J. E., Feb 28 2014, In : IUCrJ. 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

X-Ray Diffraction
X-Rays
proteins
Proteins
X ray diffraction
1 Citation (Scopus)

Instrumentation and methods: General discussion

Küpper, J., Williams, G., Chapman, H., Reid, K., Christensen, J., Wörner, H. J., Seddon, E., Dixit, G., Campbell, E., Underwood, J., Woerner, M., Spence, J., Van Thor, J., Wolf, M., Vendrell, O., De Ninno, G., Bressler, C. & Berrah, N., Dec 1 2014, In : Faraday Discussions. 171, p. 505-523 19 p.

Research output: Contribution to journalArticle