Jennifer Barrila

Assistant Research Professor

  • 704 Citations
  • 14 h-Index
20042018

Research output per year

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Research Output

  • 704 Citations
  • 14 h-Index
  • 15 Article
  • 4 Chapter
  • 2 Review article
2018

Microbiology of the Built Environment in Spacecraft Used for Human Flight

Yang, J., Thornhill, S. G., Barrila, J., Nickerson, C., Ott, C. M. & McLean, R. J. C., Jan 1 2018, (Accepted/In press) In : Methods in Microbiology.

Research output: Contribution to journalArticle

2 Scopus citations

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age

Barrila, J., Crabbé, A., Yang, J., Franco, K., Nydam, S. D., Forsyth, R. J., Davis, R. R., Gangaraju, S., Ott, C. M., Coyne, C. B., Bissell, M. J. & Nickerson, C., Nov 1 2018, In : Infection and Immunity. 86, 11

Research output: Contribution to journalReview article

22 Scopus citations
2017

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns

Barrila, J., Yang, J., Crabbé, A., Sarker, S. F., Liu, Y., Ott, C. M., Nelman-Gonzalez, M. A., Clemett, S. J., Nydam, S. D., Forsyth, R. J., Davis, R. R., Crucian, B. E., Quiriarte, H., Roland, K. L., Brenneman, K., Sams, C., Loscher, C. & Nickerson, C., Dec 1 2017, In : npj Microgravity. 3, 1, 10.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Outpacing infectious disease: Mimicking the host-pathogen microenvironment in three-dimensions

Crabbé, A., Barrila, J., Ott, C. M. & Nickerson, C., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 93-119 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella typhimurium D23580

Yang, J., Barrila, J., Roland, K. L., Ott, C. M. & Nickerson, C., Jan 7 2016, In : npj Microgravity. 2, 16021.

Research output: Contribution to journalArticle

7 Scopus citations

Spaceflight and spaceflight analogue induced responses in gram positive bacteria

Castro, S. L., Niesel, D. W., Barrila, J. & Ott, C. M., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 283-296 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Spaceflight modulates gene expression in the whole blood of astronauts

Barrila, J., Ott, C. M., Leblanc, C., Mehta, S. K., Crabbé, A., Stafford, P., Pierson, D. L. & Nickerson, C., Jan 7 2016, In : npj Microgravity. 2, 16039.

Research output: Contribution to journalArticle

17 Scopus citations

Using spaceflight and spaceflight analogue culture for novel mechanistic insight into Salmonella pathogenesis

Barrila, J., Wilson, J. W., Soni, A., Yang, J., Ott, C. M. & Nickerson, C., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 209-235 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2015

Characterization of the invasive, multidrug resistant non-typhoidal Salmonella strain D23580 in a murine model of infection

Yang, J., Barrila, J., Roland, K. L., Kilbourne, J., Ott, C. M., Forsyth, R. J. & Nickerson, C., Jun 19 2015, In : PLoS Neglected Tropical Diseases. 9, 6, e0003839.

Research output: Contribution to journalArticle

18 Scopus citations

Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture

Crabbé, A., Liu, Y., Sarker, S. F., Bonenfant, N. R., Barrila, J., Borg, Z. D., Lee, J. J., Weiss, D. J. & Nickerson, C., May 11 2015, In : PloS one. 10, 5, e0126846.

Research output: Contribution to journalArticle

32 Scopus citations
2013

Spaceflight enhances cell aggregation and random budding in Candida albicans

Crabbé, A., Nielsen-Preiss, S. M., Woolley, C. M., Barrila, J., Buchanan, K., McCracken, J., Inglis, D. O., Searles, S. C., Nelman-Gonzalez, M. A., Ott, C. M., Wilson, J. W., Pierson, D. L., Stefanyshyn-Piper, H. M., Hyman, L. E. & Nickerson, C., Dec 4 2013, In : PloS one. 8, 12, e80677.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Microbial stress: Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew

Ott, C. M., Crabbé, A., Wilson, J. W., Barrila, J., Castro, S. L. & Nickerson, C., Nov 1 2012, Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies. Springer-Verlag Berlin Heidelberg, Vol. 9783642222726. p. 203-225 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
2011

Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders

Nickerson, C., Ott, C. M., Castro, S. L., Garcia, V. M., Molina, T. C., Briggler, J. T., Pitt, A. L., Tavano, J. J., Byram, J. K., Barrila, J. & Nickerson, M. A., Dec 19 2011, In : PloS one. 6, 12, e28906.

Research output: Contribution to journalArticle

15 Scopus citations
2010

Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CLpro

Barrila, J., Gabelli, S. B., Bacha, U., Amzel, L. M. & Freire, E., May 25 2010, In : Biochemistry. 49, 20, p. 4308-4317 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Organotypic 3D cell culture models: Using the rotating wall vessel to study hostĝ€"pathogen interactions

Barrila, J., Radtke, A. L., Crabbé, A., Sarker, S. F., Herbst-Kralovetz, M. M., Ott, C. M. & Nickerson, C., Nov 1 2010, In : Nature Reviews Microbiology. 8, 11, p. 791-801 11 p.

Research output: Contribution to journalReview article

159 Scopus citations
2008

Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

Bacha, U., Barrila, J., Gabelli, S. B., Kiso, Y., Mario Amzel, L. & Freire, E., Jul 1 2008, In : Chemical Biology and Drug Design. 72, 1, p. 34-49 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Media ion composition controls regulatory and virulence response of Salmonella in spaceflight

Wilson, J. W., Ott, C. M., Quick, L., Davis, R., zu Bentrup, K. H., Crabbé, A., Richter, E., Sarker, S., Barrila, J., Porwollik, S., Cheng, P., McClelland, M., Tsaprailis, G., Radabaugh, T., Hunt, A., Shah, M., Nelman-Gonzalez, M., Hing, S., Parra, M., Dumars, P. & 22 others, Norwood, K., Bober, R., Devich, J., Ruggles, A., CdeBaca, A., Narayan, S., Benjamin, J., Goulart, C., Rupert, M., Catella, L., Schurr, M. J., Buchanan, K., Morici, L., McCracken, J., Porter, M. D., Pierson, D. L., Smith, S. M., Mergeay, M., Leys, N., Stefanyshyn-Piper, H. M., Gorie, D. & Nickerson, C., Dec 12 2008, In : PloS one. 3, 12, e3923.

Research output: Contribution to journalArticle

93 Scopus citations
2006

Long-range cooperative interactions modulate dimerization in SARS 3CL pro

Barrila, J., Bacha, U. & Freire, E., Dec 19 2006, In : Biochemistry. 45, 50, p. 14908-14916 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

Sydnes, M. O., Hayashi, Y., Sharma, V. K., Hamada, T., Bacha, U., Barrila, J., Freire, E. & Kiso, Y., Sep 4 2006, In : Tetrahedron. 62, 36, p. 8601-8609 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2005

Structure and activity of the axon guidance protein MICAL

Nadella, M., Bianchet, M. A., Gabelli, S. B., Barrila, J. & Amzel, L. M., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16830-16835 6 p.

Research output: Contribution to journalArticle

57 Scopus citations
2004

Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

Bacha, U., Barrila, J., Velazquez-Campoy, A., Leavitt, S. A. & Freire, E., May 4 2004, In : Biochemistry. 43, 17, p. 4906-4912 7 p.

Research output: Contribution to journalArticle

120 Scopus citations