Jennifer Barrila

Assistant Research Professor

  • 604 Citations
  • 12 h-Index
20042021
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Research Output 2004 2018

  • 604 Citations
  • 12 h-Index
  • 16 Article
  • 4 Chapter
  • 1 Review article
2018

Microbiology of the Built Environment in Spacecraft Used for Human Flight

Yang, J., Thornhill, S. G., Barrila, J., Nickerson, C., Ott, C. M. & McLean, R. J. C., Jan 1 2018, (Accepted/In press) In : Methods in Microbiology.

Research output: Contribution to journalArticle

Spacecraft
Weightlessness
Microbiology
Space Flight
Hypogravity
8 Citations (Scopus)

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age

Barrila, J., Crabbé, A., Yang, J., Franco, K., Nydam, S. D., Forsyth, R. J., Davis, R. R., Gangaraju, S., Ott, C. M., Coyne, C. B., Bissell, M. J. & Nickerson, C., Nov 1 2018, In : Infection and Immunity. 86, 11

Research output: Contribution to journalReview article

Host-Pathogen Interactions
Communicable Diseases
Cell Culture Techniques
Microbiota
Organoids
2017
5 Citations (Scopus)

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns

Barrila, J., Yang, J., Crabbé, A., Sarker, S. F., Liu, Y., Ott, C. M., Nelman-Gonzalez, M. A., Clemett, S. J., Nydam, S. D., Forsyth, R. J., Davis, R. R., Crucian, B. E., Quiriarte, H., Roland, K. L., Brenneman, K., Sams, C., Loscher, C. & Nickerson, C., Dec 1 2017, In : npj Microgravity. 3, 1, 10.

Research output: Contribution to journalArticle

salmonella
Salmonella
macrophages
Salmonella enterica
Macrophages
2016

Outpacing infectious disease: Mimicking the host-pathogen microenvironment in three-dimensions

Crabbé, A., Barrila, J., Ott, C. M. & Nickerson, C., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 93-119 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

pathogens
infectious diseases
Communicable Diseases
Somatostatin-Secreting Cells
Cell Culture Techniques
5 Citations (Scopus)

Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella typhimurium D23580

Yang, J., Barrila, J., Roland, K. L., Ott, C. M. & Nickerson, C., Jan 7 2016, In : npj Microgravity. 2, 16021.

Research output: Contribution to journalArticle

virulence
salmonella
Salmonella
Salmonella typhimurium
Salmonella Typhimurium
1 Citation (Scopus)

Spaceflight and spaceflight analogue induced responses in gram positive bacteria

Castro, S. L., Niesel, D. W., Barrila, J. & Ott, C. M., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 283-296 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Space Flight
Gram-Positive Bacteria
organisms
Spacecraft
bacteria
10 Citations (Scopus)

Spaceflight modulates gene expression in the whole blood of astronauts

Barrila, J., Ott, C. M., Leblanc, C., Mehta, S. K., Crabbé, A., Stafford, P., Pierson, D. L. & Nickerson, C., Jan 7 2016, In : npj Microgravity. 2, 16039.

Research output: Contribution to journalArticle

Astronauts
space flight
Space Flight
astronauts
gene expression
1 Citation (Scopus)

Using spaceflight and spaceflight analogue culture for novel mechanistic insight into Salmonella pathogenesis

Barrila, J., Wilson, J. W., Soni, A., Yang, J., Ott, C. M. & Nickerson, C., Jan 1 2016, Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, p. 209-235 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

salmonella
Space Flight
pathogenesis
pathogens
Salmonella
2015
16 Citations (Scopus)

Characterization of the invasive, multidrug resistant non-typhoidal Salmonella strain D23580 in a murine model of infection

Yang, J., Barrila, J., Roland, K. L., Kilbourne, J., Ott, C. M., Forsyth, R. J. & Nickerson, C., Jun 19 2015, In : PLoS Neglected Tropical Diseases. 9, 6, e0003839.

Research output: Contribution to journalArticle

Salmonella
Infection
Tissue Distribution
A-130A
Melibiose
28 Citations (Scopus)

Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture

Crabbé, A., Liu, Y., Sarker, S. F., Bonenfant, N. R., Barrila, J., Borg, Z. D., Lee, J. J., Weiss, D. J. & Nickerson, C., May 11 2015, In : PLoS One. 10, 5, e0126846.

Research output: Contribution to journalArticle

Bioreactors
Scaffolds
Suspensions
lungs
Lung
2013
5 Citations (Scopus)

Microbial stress: Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew

Ott, C. M., Crabbé, A., Wilson, J. W., Barrila, J., Castro, S. L. & Nickerson, C., Nov 1 2013, Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies. Springer-Verlag Berlin Heidelberg, p. 203-225 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Space Flight
Communicable Diseases
Virulence
Pseudomonas aeruginosa
Molecular Biology
29 Citations (Scopus)

Spaceflight enhances cell aggregation and random budding in Candida albicans

Crabbé, A., Nielsen-Preiss, S. M., Woolley, C. M., Barrila, J., Buchanan, K., McCracken, J., Inglis, D. O., Searles, S. C., Nelman-Gonzalez, M. A., Ott, C. M., Wilson, J. W., Pierson, D. L., Stefanyshyn-Piper, H. M., Hyman, L. E. & Nickerson, C., Dec 4 2013, In : PLoS One. 8, 12, e80677.

Research output: Contribution to journalArticle

space flight
Space Flight
Cell Aggregation
Candida
Candida albicans
2011
14 Citations (Scopus)

Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders

Nickerson, C., Ott, C. M., Castro, S. L., Garcia, V. M., Molina, T. C., Briggler, J. T., Pitt, A. L., Tavano, J. J., Byram, J. K., Barrila, J. & Nickerson, M. A., Dec 19 2011, In : PLoS One. 6, 12, e28906.

Research output: Contribution to journalArticle

Urodela
Ozarks
Tissue regeneration
Amphibians
Pathogens
2010
12 Citations (Scopus)

Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CLpro

Barrila, J., Gabelli, S. B., Bacha, U., Amzel, L. M. & Freire, E., May 25 2010, In : Biochemistry. 49, 20, p. 4308-4317 10 p.

Research output: Contribution to journalArticle

Dimerization
Coronavirus
Mutation
Respiratory Tract Infections
Coronavirus Infections
146 Citations (Scopus)

Organotypic 3D cell culture models: Using the rotating wall vessel to study hostĝ€"pathogen interactions

Barrila, J., Radtke, A. L., Crabbé, A., Sarker, S. F., Herbst-Kralovetz, M. M., Ott, C. M. & Nickerson, C., Nov 2010, In : Nature Reviews Microbiology. 8, 11, p. 791-801 11 p.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Cell Culture Techniques
Bioreactors
Coculture Techniques
Communicable Diseases
2008
25 Citations (Scopus)

Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

Bacha, U., Barrila, J., Gabelli, S. B., Kiso, Y., Mario Amzel, L. & Freire, E., Jul 2008, In : Chemical Biology and Drug Design. 72, 1, p. 34-49 16 p.

Research output: Contribution to journalArticle

Lead compounds
Coronavirus
Sulfides
Ketones
Viruses
81 Citations (Scopus)

Media ion composition controls regulatory and virulence response of Salmonella in spaceflight

Wilson, J. W., Ott, C. M., Quick, L., Davis, R., zu Bentrup, K. H., Crabbé, A., Richter, E., Sarker, S., Barrila, J., Porwollik, S., Cheng, P., McClelland, M., Tsaprailis, G., Radabaugh, T., Hunt, A., Shah, M., Nelman-Gonzalez, M., Hing, S., Parra, M., Dumars, P. & 22 others, Norwood, K., Bober, R., Devich, J., Ruggles, A., CdeBaca, A., Narayan, S., Benjamin, J., Goulart, C., Rupert, M., Catella, L., Schurr, M. J., Buchanan, K., Morici, L., McCracken, J., Porter, M. D., Pierson, D. L., Smith, S. M., Mergeay, M., Leys, N., Stefanyshyn-Piper, H. M., Gorie, D. & Nickerson, C., Dec 12 2008, In : PLoS One. 3, 12, e3923.

Research output: Contribution to journalArticle

space flight
Space Flight
Salmonella
Virulence
virulence
2006
28 Citations (Scopus)

Long-range cooperative interactions modulate dimerization in SARS 3CL pro

Barrila, J., Bacha, U. & Freire, E., Dec 19 2006, In : Biochemistry. 45, 50, p. 14908-14916 9 p.

Research output: Contribution to journalArticle

Severe Acute Respiratory Syndrome
Dimerization
Dimers
Serine
Catalytic Domain
27 Citations (Scopus)

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

Sydnes, M. O., Hayashi, Y., Sharma, V. K., Hamada, T., Bacha, U., Barrila, J., Freire, E. & Kiso, Y., Sep 4 2006, In : Tetrahedron. 62, 36, p. 8601-8609 9 p.

Research output: Contribution to journalArticle

SARS Virus
Amino Alcohols
Oxazolidinones
Severe Acute Respiratory Syndrome
Coronavirus
2005
54 Citations (Scopus)

Structure and activity of the axon guidance protein MICAL

Nadella, M., Bianchet, M. A., Gabelli, S. B., Barrila, J. & Amzel, L. M., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16830-16835 6 p.

Research output: Contribution to journalArticle

Semaphorins
Flavin-Adenine Dinucleotide
Mixed Function Oxygenases
NADP
Amines
2004
109 Citations (Scopus)

Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

Bacha, U., Barrila, J., Velazquez-Campoy, A., Leavitt, S. A. & Freire, E., May 4 2004, In : Biochemistry. 43, 17, p. 4906-4912 7 p.

Research output: Contribution to journalArticle

Severe Acute Respiratory Syndrome
Coronavirus
Catalytic Domain
Peptide Hydrolases
Boronic Acids