Heather Bimonte-Nelson

Professor

  • 3397 Citations
  • 35 h-Index
1996 …2023
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Research Output 1996 2019

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Article
2019
2 Citations (Scopus)

Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes

Koebele, S. V., Palmer, J. M., Hadder, B., Melikian, R., Fox, C., Strouse, I. M., Denardo, D., George, C., Daunis, E., Nimer, A., Mayer, L. P., Dyer, C. A. & Bimonte-Nelson, H., Jan 1 2019, In : Endocrinology. 160, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

Hysterectomy
Uterus
Menopause
Ovary
Short-Term Memory
2 Citations (Scopus)

N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking

Goenaga, J., Powell, G. L., Leyrer-Jackson, J. M., Piña, J., Phan, S., Prakapenka, A. V., Koebele, S. V., Namba, M. D., McClure, E. A., Bimonte-Nelson, H. & Gipson-Reichardt, C., Jan 1 2019, In : Addiction Biology.

Research output: Contribution to journalArticle

Acetylcysteine
Nicotine
Cues
Estrous Cycle
Recurrence
Hysterectomy
Uterus
Spatial Memory

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning

Holter, M. C., Hewitt, L. T., Koebele, S. V., Judd, J. M., Xing, L., Bimonte-Nelson, H., Conrad, C., Araki, T., Neel, B. G., Snider, W. D. & Newbern, J., Apr 1 2019, In : PLoS genetics. 15, 4, p. e1008108

Research output: Contribution to journalArticle

Open Access
Noonan Syndrome
neuroglia
Neuroglia
mutation
cortex
2018
4 Citations (Scopus)

Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two

Prakapenka, A. V., Hiroi, R., Quihuis, A. M., Carson, C., Patel, S., Berns-Leone, C., Fox, C., Sirianni, R. W. & Bimonte-Nelson, H., Apr 1 2018, In : Neurobiology of Aging. 64, p. 1-14 14 p.

Research output: Contribution to journalArticle

Levonorgestrel
Progestins
Short-Term Memory
Estrogens
Extracellular Signal-Regulated MAP Kinases
3 Citations (Scopus)

Reversing interferon-alpha neurotoxicity in a HIV-associated neurocognitive disorder mouse model

Koneru, R., Bimonte-Nelson, H., Ciavatta, V., Haile, W., Elmore, K., Ward, J., Maroun, L. & Tyor, W. R., Jul 17 2018, In : AIDS. 32, 11, p. 1403-1411 9 p.

Research output: Contribution to journalArticle

Interferon-alpha
HIV
Dendritic Spines
AMPA Receptors
Therapeutics

The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats

Willeman, M. N., Mennenga, S. E., Siniard, A. L., Corneveaux, J. J., De Both, M., Hewitt, L. T., Tsang, C. W. S., Caselli, J., Braden, B., Bimonte-Nelson, H. & Huentelman, M. J., Jun 1 2018, In : PLoS One. 13, 6, e0198256.

Research output: Contribution to journalArticle

middle-aged adults
protein kinase C
Rats
Data storage equipment
Protein Kinase C
2017
4 Citations (Scopus)
HIV
Brain
Animal Models
AIDS Dementia Complex
Therapeutics
10 Citations (Scopus)

Cognitive changes across the menopause transition: A longitudinal evaluation of the impact of age and ovarian status on spatial memory

Koebele, S. V., Mennenga, S. E., Hiroi, R., Quihuis, A. M., Hewitt, L. T., Poisson, M. L., George, C., Mayer, L. P., Dyer, C. A., Aiken, L. S., Demers, L. M., Carson, C. & Bimonte-Nelson, H., Jan 1 2017, In : Hormones and Behavior. 87, p. 96-114 19 p.

Research output: Contribution to journalArticle

Menopause
Age of Onset
Ovarian Follicle
Ovary
Hormones
3 Citations (Scopus)

Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for Controlled Delivery of 17β-Estradiol

Prakapenka, A. V., Bimonte-Nelson, H. & Sirianni, R. W., Jun 20 2017, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

Neurology
Acids
Pharmacodynamics
Pharmacokinetics
Hormones
2016
8 Citations (Scopus)

A comparison of progestins within three classes: Differential effects on learning and memory in the aging surgically menopausal rat

Braden, B., Andrews, M. G., Acosta, J. I., Mennenga, S. E., Lavery, C. & Bimonte-Nelson, H., Apr 14 2016, (Accepted/In press) In : Behavioural Brain Research.

Research output: Contribution to journalArticle

Progestins
Learning
Medroxyprogesterone Acetate
Water
Levonorgestrel
10 Citations (Scopus)
Tryptophan Hydroxylase
Conjugated (USP) Estrogens
Estradiol
Estrogens
Anxiety
5 Citations (Scopus)

Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory

Braden, B., Dassel, K. B., Bimonte-Nelson, H., O'Rourke, H., Connor, D. J., Moorhous, S., Sabbagh, M. N., Caselli, R. J. & Baxter, L. C., Jun 5 2016, (Accepted/In press) In : Aging, Neuropsychology, and Cognition. p. 1-20 20 p.

Research output: Contribution to journalArticle

Postmenopause
Hormones
Verbal Learning
Therapeutics
Repression (Psychology)
24 Citations (Scopus)

Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood

Hiroi, R., Carbone, D. L., Zuloaga, D. G., Bimonte-Nelson, H. & Handa, R. J., Apr 21 2016, In : Neuroscience. 320, p. 43-56 14 p.

Research output: Contribution to journalArticle

Embryonic and Fetal Development
Glucocorticoids
Serotonin
Messenger RNA
Anxiety
10 Citations (Scopus)
Brain
Aging of materials
Learning
Hormones
Data storage equipment
2015

A primer of methods in biobehavioral research: Improving a study’s design, analysis, and write up

Talboom, J. S., West, S. & Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 323-374 52 p.

Research output: Contribution to journalArticle

Practice Guidelines
Research
Design of experiments
Animals
Research Design
7 Citations (Scopus)

Differential effects of duration of sleep fragmentation on spatial learning and synaptic plasticity in pubertal mice

Wallace, E., Kim, D. Y., Kim, K. M., Chen, S., Braden, B., Williams, J., Jasso, K., Garcia, A., Rho, J. M., Bimonte-Nelson, H. & Maganti, R., 2015, In : Brain Research. 1615, p. 116-128 13 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Sleep Deprivation
Long-Term Potentiation
Touch
Actigraphy

General water escape maze testing necessities and guidelines for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 407-410 4 p.

Research output: Contribution to journalArticle

Rodentia
Guidelines
Water
Testing
Cues
13 Citations (Scopus)
Harmine
Aptitude
Short-Term Memory
Cognition
Water
11 Citations (Scopus)

Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats

Mennenga, S. E., Koebele, S. V., Mousa, A. A., Alderete, T. J., Tsang, C. W. S., Acosta, J. I., Camp, B. W., Demers, L. M. & Bimonte-Nelson, H., Jul 1 2015, In : Steroids. 99, PA, p. 16-25 10 p.

Research output: Contribution to journalArticle

Aromatase
Androstenedione
Androgen Receptors
Rats
Pharmacology
2 Citations (Scopus)

Rodent mazes and memory: Continuing the search for the engram

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 3-36 34 p.

Research output: Contribution to journalArticle

Rodentia
Learning
Data storage equipment
Rats
Research

The delayed match to sample protocol for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 433-440 8 p.

Research output: Contribution to journalArticle

Rodentia
Data storage equipment
Testing
Cations
Exercise Test
5 Citations (Scopus)

The GABA<inf>A</inf> antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

Braden, B., Kingston, M. L., Whitton, E., Lavery, C., Tsang, C. W. S. & Bimonte-Nelson, H., 2015, In : Frontiers in Aging Neuroscience. 7, JUL, 149.

Research output: Contribution to journalArticle

GABA-A Receptor Antagonists
Bicuculline
Progesterone
Short-Term Memory
Cognition
3 Citations (Scopus)

The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays

Mennenga, S. E. & Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 299-321 23 p.

Research output: Contribution to journalArticle

Rodentia
Assays
Hormones
Drug therapy
Reproductive Behavior

The mazes

Bimonte-Nelson, H., Daniel, J. M. & Koebele, S. V., 2015, In : Neuromethods. 94, p. 37-71 35 p.

Research output: Contribution to journalArticle

Rodentia
Learning
Data storage equipment
Cognition
Behavioral research
1 Citation (Scopus)

The morris maze protocol for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 441-449 9 p.

Research output: Contribution to journalArticle

Rodentia
Data storage equipment
Exercise Test
Research
Spatial Memory
15 Citations (Scopus)

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H., McLaughlin, K. J., Talboom, J. S., Conrad, C., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., Jul 22 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticle

Prodrugs
Estradiol
Estrogens
Brain
Menopause
1 Citation (Scopus)

The visible platform task for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 451-454 4 p.

Research output: Contribution to journalArticle

Rodentia
Water
Exercise Test
Mental Competency
Research

The water radial-arm maze: Seven out of eight arms platformed protocol for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 421-427 7 p.

Research output: Contribution to journalArticle

Rodentia
Water
Testing
Cations
Exercise Test

The water radial-arm maze: Four out of eight arms platformed protocol for rodents

Bimonte-Nelson, H., 2015, In : Neuromethods. 94, p. 411-419 9 p.

Research output: Contribution to journalArticle

Rodentia
Water
Testing
Exercise Test
Short-Term Memory
16 Citations (Scopus)

Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?

Koebele, S. V. & Bimonte-Nelson, H., Aug 1 2015, In : Hormones and Behavior. 74, p. 86-104 19 p.

Research output: Contribution to journalArticle

Estrogens
Phenotype
Brain
Hormones
Menopause
14 Citations (Scopus)

Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: Tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity

Mennenga, S. E., Gerson, J. E., Koebele, S. V., Kingston, M. L., Tsang, C. W. S., Engler-Chiurazzi, E. B., Baxter, L. C. & Bimonte-Nelson, H., Apr 1 2015, In : Psychoneuroendocrinology. 54, p. 1-13 13 p.

Research output: Contribution to journalArticle

Ethinyl Estradiol
Contraceptive Agents
Cholinergic Agents
Estrogens
Oral Contraceptives
2014
6 Citations (Scopus)

Learning to remember: Cognitive training-induced attenuation of age-related memory decline depends on sex and cognitive demand, and can transfer to untrained cognitive domains

Talboom, J. S., West, S., Engler-Chiurazzi, E. B., Enders, C. K., Crain, I. & Bimonte-Nelson, H., Dec 1 2014, In : Neurobiology of Aging. 35, 12, p. 2791-2802 12 p.

Research output: Contribution to journalArticle

Learning
Nerve Growth Factors
Brain
Longitudinal Studies
Transfer (Psychology)
6 Citations (Scopus)

Navigating to new frontiers in behavioral neuroscience: Traditional neuropsychological tests predict human performance on a rodent-inspired radial-arm maze

Mennenga, S. E., Baxter, L. C., Grunfeld, I. S., Brewer, G., Aiken, L. S., Engler-Chiurazzi, E. B., Camp, B. W., Acosta, J. I., Braden, B., Schaefe, K. R., Gerson, J. E., Lavery, C. N., Tsang, C. W. S., Hewitt, L. T., Kingston, M. L., Koebele, S. V., Patten, K. J., Ball, B. H., McBeath, M. & Bimonte-Nelson, H., Sep 9 2014, In : Frontiers in Behavioral Neuroscience. 8, SEP, 294.

Research output: Contribution to journalArticle

Neuropsychological Tests
Neurosciences
Rodentia
Short-Term Memory
Aptitude
2013
18 Citations (Scopus)

An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms

Acosta, J. I., Hiroi, R., Camp, B. W., Talboom, J. S. & Bimonte-Nelson, H., Jun 13 2013, In : Brain Research. 1514, p. 18-39 22 p.

Research output: Contribution to journalArticle

Hormones
Therapeutics
Cognition
Progestins
Menopause
27 Citations (Scopus)

Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

Rao, V. R., Neogi, U., Talboom, J. S., Padilla, L., Rahman, M., Fritz-French, C., Gonzalez-Ramirez, S., Verma, A., Wood, C., Ruprecht, R. M., Ranga, U., Azim, T., Joska, J., Eugenin, E., Shet, A., Bimonte-Nelson, H., Tyor, W. R. & Prasad, V. R., Jun 8 2013, In : Retrovirology. 10, 1, 61.

Research output: Contribution to journalArticle

Southern Africa
Southeastern Asia
HIV-1
HIV
AIDS Dementia Complex
8 Citations (Scopus)

Translational cognitive endocrinology: Designing rodent experiments with the goal to ultimately enhance cognitive health in women

Mennenga, S. E. & Bimonte-Nelson, H., Jun 13 2013, In : Brain Research. 1514, p. 50-62 13 p.

Research output: Contribution to journalArticle

Endocrinology
Women's Health
Rodentia
Hormones
Neuroendocrinology
13 Citations (Scopus)

Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease

Singh, M., Simpkins, J. W., Bimonte-Nelson, H. & Brinton, R. D., Jun 13 2013, In : Brain Research. 1514, p. 1-2 2 p.

Research output: Contribution to journalArticle

Brain Diseases
Progestins
Alzheimer Disease
Estrogens
Brain
2012
8 Citations (Scopus)

Broad-Based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention

Wolf, A. B., Braden, B., Bimonte-Nelson, H., Kusne, Y., Young, N., Engler-Chiurazzi, E., Garcia, A. N., Walker, D. G., Moses, G. S. D., Tran, H., Laferla, F., Lue, L., Emerson Lombardo, N. & Valla, J., 2012, In : Journal of Alzheimer's Disease. 32, 1, p. 217-232 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Diet Therapy
Glucose
Brain
Electron Transport Complex IV
48 Citations (Scopus)

Chronic stress impairs prefrontal cortex-dependent response inhibition and spatial working memory

Mika, A., Mazur, G. J., Hoffman, A. N., Talboom, J. S., Bimonte-Nelson, H., Sanabria, F. & Conrad, C., Oct 2012, In : Behavioral Neuroscience. 126, 5, p. 605-619 15 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Short-Term Memory
Water
Reinforcement Schedule
Spatial Memory
26 Citations (Scopus)

Continuous estrone treatment impairs spatial memory and does not impact number of basal forebrain cholinergic neurons in the surgically menopausal middle-aged rat

Engler-Chiurazzi, E. B., Talboom, J. S., Braden, B., Tsang, C. W. S., Mennenga, S., Andrews, M., Demers, L. M. & Bimonte-Nelson, H., Jun 2012, In : Hormones and Behavior. 62, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Cholinergic Neurons
Choline O-Acetyltransferase
Estrone
Conjugated (USP) Estrogens
Estrogens
13 Citations (Scopus)

High serum androstenedione levels correlate with impaired memory in the surgically menopausal rat: A replication and new findings

Camp, B. W., Gerson, J. E., Tsang, C. W. S., Villa, S. R., Acosta, J. I., Braden, B., Hoffman, A. N., Conrad, C. & Bimonte-Nelson, H., Oct 2012, In : European Journal of Neuroscience. 36, 8, p. 3086-3095 10 p.

Research output: Contribution to journalArticle

Androstenedione
Serum
Short-Term Memory
Aptitude
Glutamate Decarboxylase
64 Citations (Scopus)

Novel allosteric agonists of M 1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models

Digby, G. J., Noetzel, M. J., Bubser, M., Utley, T. J., Walker, A. G., Byun, N. E., Lebois, E. P., Xiang, Z., Sheffler, D. J., Cho, H. P., Davis, A. A., Nemirovsky, N. E., Mennenga, S. E., Camp, B. W., Bimonte-Nelson, H., Bode, J., Italiano, K., Morrison, R., Scott Daniels, J., Niswender, C. M. & 4 others, Olive, M., Lindsley, C. W., Jones, C. K. & Jeffrey Conn, P., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8532-8544 13 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
Animal Models
Aptitude
Pyramidal Cells
Central Nervous System Diseases
2011
30 Citations (Scopus)

Cognitive-impairing effects of medroxyprogesterone acetate in the rat: Independent and interactive effects across time

Braden, B., Garcia, A. N., Mennenga, S. E., Prokai, L., Villa, S. R., Acosta, J. I., Lefort, N., Simard, A. R. & Bimonte-Nelson, H., Nov 2011, In : Psychopharmacology. 218, 2, p. 405-418 14 p.

Research output: Contribution to journalArticle

Medroxyprogesterone Acetate
Therapeutics
Short-Term Memory
Cognition
Rodentia
73 Citations (Scopus)

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

Lockrow, J., Boger, H., Bimonte-Nelson, H. & Granholm, A. C., Aug 10 2011, In : Behavioural Brain Research. 221, 2, p. 610-622 13 p.

Research output: Contribution to journalArticle

Memantine
Down Syndrome
Alzheimer Disease
Animal Models
Neuropathology
39 Citations (Scopus)

Recovery after chronic stress within spatial reference and working memory domains: Correspondence with hippocampal morphology

Hoffman, A. N., Krigbaum, A., Ortiz, J. B., Mika, A., Hutchinson, K. M., Bimonte-Nelson, H. & Conrad, C., Sep 2011, In : European Journal of Neuroscience. 34, 6, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

Short-Term Memory
Water
Memory Disorders
Dendrites
Sprague Dawley Rats
38 Citations (Scopus)

Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats

Engler-Chiurazzi, E., Tsang, C., Nonnenmacher, S., Liang, W. S., Corneveaux, J. J., Prokai, L., Huentelman, M. J. & Bimonte-Nelson, H., Apr 2011, In : Neurobiology of Aging. 32, 4, p. 680-697 18 p.

Research output: Contribution to journalArticle

Conjugated (USP) Estrogens
Nerve Growth Factors
Gene Expression
Proteins
Estrone
2010
13 Citations (Scopus)

A component of Premarin® enhances multiple cognitive functions and influences nicotinic receptor expression

Talboom, J. S., Engler-Chiurazzi, E. B., Whiteaker, P., Simard, A. R., Lukas, R., Acosta, J. I., Prokai, L. & Bimonte-Nelson, H., Nov 2010, In : Hormones and Behavior. 58, 5, p. 917-928 12 p.

Research output: Contribution to journalArticle

Conjugated (USP) Estrogens
Equilin
Nicotinic Receptors
Cognition
Estrogens
51 Citations (Scopus)
Aptitude
Hippocampus
Hormones
Genetic Predisposition to Disease
Life Expectancy
53 Citations (Scopus)

Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats

Braden, B., Talboom, J. S., Crain, I. D., Simard, A. R., Lukas, R. J., Prokai, L., Scheldrup, M. R., Bowman, B. L. & Bimonte-Nelson, H., Mar 2010, In : Neurobiology of Learning and Memory. 93, 3, p. 444-453 10 p.

Research output: Contribution to journalArticle

Medroxyprogesterone Acetate
Progestins
Progesterone
Nerve Growth Factors
Brain