Haiwei Gu

Asst Professor

  • 2758 Citations
  • 29 h-Index
20072023

Research output per year

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Research Output

  • 2758 Citations
  • 29 h-Index
  • 93 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Chapter
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Article
2020

Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract

Gutierrez, D., Weinstock, A., Antharam, V. C., Gu, H., Jasbi, P., Shi, X., Dirks, B., Krajmalnik-Brown, R., Maldonado, J., Guinan, J. & Thangamani, S., Feb 1 2020, In : FEMS microbiology ecology. 96, 1, fiz187.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identifying Significant Metabolic Pathways Using Multi-Block Partial Least-Squares Analysis

Deng, L., Guo, F., Cheng, K. K., Zhu, J., Gu, H., Raftery, D. & Dong, J., May 1 2020, In : Journal of Proteome Research. 19, 5, p. 1965-1974 10 p.

Research output: Contribution to journalArticle

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L. & 22 others, Schön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In : EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Biodiversity and dynamics of cyanobacterial communities during blooms in temperate lake (Harsha Lake, Ohio, USA)

Zhu, B., Cao, H., Li, G., Du, W., Xu, G., Domingo, J. S., Gu, H., Xu, N., Duan, S. & Lu, J., Feb 1 2019, In : Harmful Algae. 82, p. 9-18 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Breast cancer detection using targeted plasma metabolomics

Jasbi, P., Wang, D., Cheng, S. L., Fei, Q., Cui, J. Y., Liu, L., Wei, Y., Raftery, D. & Gu, H., Jan 15 2019, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1105, p. 26-37 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Coccidioidomycosis Detection Using Targeted Plasma and Urine Metabolic Profiling

Jasbi, P., Mitchell, N. M., Shi, X., Grys, T. E., Wei, Y., Liu, L., Lake, D. & Gu, H., Jan 1 2019, In : Journal of Proteome Research.

Research output: Contribution to journalArticle

2 Scopus citations

Combining NMR and MS with chemical derivatization for absolute quantification with reduced matrix effects

Fei, Q., Wang, D., Jasbi, P., Zhang, P., Nagana Gowda, G. A., Raftery, D. & Gu, H., Mar 19 2019, In : Analytical chemistry. 91, 6, p. 4055-4062 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Daily red wine vinegar ingestion for eight weeks improves glucose homeostasis and affects the metabolome but does not reduce adiposity in adults

Jasbi, P., Baker, O., Shi, X., Gonzalez, L. A., Wang, S., Anderson, S., Xi, B., Gu, H. & Johnston, C. S., Nov 2019, In : Food and Function. 10, 11, p. 7343-7355 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Database-Assisted Globally Optimized Targeted Mass Spectrometry (dGOT-MS): Broad and Reliable Metabolomics Analysis with Enhanced Identification

Shi, X., Wang, S., Jasbi, P., Turner, C., Hrovat, J., Wei, Y., Liu, J. & Gu, H., Jan 1 2019, (Accepted/In press) In : Analytical chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

Zhang, X., Xie, X., Heckmann, B. L., Saarinen, A. M., Gu, H., Zechner, R. & Liu, J., May 1 2019, In : FASEB Journal. 33, 5, p. 6655-6666 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search

Kurgan, G., Kurgan, L., Schneider, A., Onyeabor, M., Rodriguez-Sanchez, Y., Taylor, E., Martinez, R., Carbonell, P., Shi, X., Gu, H. & Wang, X., Nov 1 2019, In : Applied Microbiology and Biotechnology. 103, 21-22, p. 9001-9011 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Influence of storage conditions and preservatives on metabolite fingerprints in urine

Wang, X., Gu, H., Palma-Duran, S. A., Fierro, A., Jasbi, P., Shi, X., Bresette, W. & Tasevska, N., Oct 2019, In : Metabolites. 9, 10, 203.

Research output: Contribution to journalArticle

Open Access

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mass spectral similarity networking and gas-phase fragmentation reactions in the structural analysis of flavonoid glycoconjugates

Pilon, A. C., Gu, H., Raftery, D., Bolzani, V. D. S., Lopes, N. P., Castro-Gamboa, I. & Carnevale Neto, F., Aug 20 2019, In : Analytical chemistry. 91, 16, p. 10458-10466 9 p.

Research output: Contribution to journalArticle

Open Access

Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia

Wang, D., Cheng, S. L., Fei, Q., Gu, H., Raftery, D., Cao, B., Sun, X., Yan, J., Zhang, C. & Wang, J., Feb 1 2019, In : Psychiatry Research. 272, p. 18-29 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Metabolomics test materials for quality control: A study of a urine materials suite

Bearden, D. W., Sheen, D. A., Simón-Manso, Y., Benner, B. A., Rocha, W. F. C., Blonder, N., Lippa, K. A., Beger, R. D., Schnackenberg, L. K., Sun, J., Mehta, K. Y., Cheema, A. K., Gu, H., Marupaka, R., Nagana Gowda, G. A. & Raftery, D., Nov 2019, In : Metabolites. 9, 11, 270.

Research output: Contribution to journalArticle

Open Access

Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis

Dempsey, J. L., Wang, D., Siginir, G., Fei, Q., Raftery, D., Gu, H. & Yue Cui, J., Mar 1 2019, In : Toxicological Sciences. 168, 1, p. 40-60 21 p.

Research output: Contribution to journalArticle

3 Scopus citations

Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism

Navarro, S. L., Tarkhan, A., Shojaie, A., Randolph, T. W., Gu, H., Djukovic, D., Osterbauer, K. J., Hullar, M. A., Kratz, M., Neuhouser, M. L., Lampe, P. D., Raftery, D. & Lampe, J. W., Oct 1 2019, In : American Journal of Clinical Nutrition. 110, 4, p. 984-992 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Polybrominated diphenyl ethers and gut microbiome modulate metabolic syndrome-related aqueous metabolites in mice

Scoville, D. K., Li, C. Y., Wang, D., Dempsey, J. L., Raftery, D., Mani, S., Gu, H. & Cui, J. Y., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 8, p. 928-940 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Quarles, E., Basisty, N., Chiao, Y. A., Merrihew, G., Gu, H., Sweetwyne, M. T., Fredrickson, J., Nguyen, N. H., Razumova, M., Kooiker, K., Moussavi-Harami, F., Regnier, M., Quarles, C., MacCoss, M. & Rabinovitch, P. S., Jan 1 2019, (Accepted/In press) In : Aging Cell. e13086.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Alterations of eicosanoids and related mediators in patients with schizophrenia

Wang, D., Sun, X., Yan, J., Ren, B., Cao, B., Lu, Q., Liu, Y., Zeng, J., Huang, N., Xie, Q., Gu, H. & Wang, J., Jul 1 2018, In : Journal of Psychiatric Research. 102, p. 168-178 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chronic kidney disease attenuates the plasma metabolome response to insulin

Roshanravan, B., Zelnick, L. R., Djucovic, D., Gu, H., Alvarez, J. A., Ziegler, T. R., Gamboa, J. L., Utzschneider, K., Kestenbaum, B., Himmelfarb, J., Kahn, S. E., Raftery, D. & de Boer, I. H., Aug 23 2018, In : JCI insight. 3, 16

Research output: Contribution to journalArticle

7 Scopus citations

Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study

Ginos, B. N. R., Navarro, S. L., Schwarz, Y., Gu, H., Wang, D., Randolph, T. W., Shojaie, A., Hullar, M. A. J., Lampe, P. D., Kratz, M., Neuhouser, M. L., Raftery, D. & Lampe, J. W., Jun 1 2018, In : Metabolism: Clinical and Experimental. 83, p. 197-204 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Glucose promotes cell growth by suppressing branched-chain amino acid degradation

Shao, D., Villet, O., Zhang, Z., Choi, S. W., Yan, J., Ritterhoff, J., Gu, H., Djukovic, D., Christodoulou, D., Kolwicz, S. C., Raftery, D. & Tian, R., Dec 1 2018, In : Nature Communications. 9, 1, 2935.

Research output: Contribution to journalArticle

14 Scopus citations

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation

Centini, R., Tsang, M., Iwata, T., Park, H., Delrow, J., Margineantu, D., Iritani, B. M., Gu, H., Liggitt, H. D., Kang, J., Kang, L., Hockenbery, D. M., Raftery, D. & Iritani, B. M., Jun 1 2018, In : PLoS One. 13, 6, 0197973.

Research output: Contribution to journalArticle

3 Scopus citations

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates

Pilon, A. C., Gu, H., Raftery, D., Bolzani, V. D. S., Lopes, N. P., Castro-Gamboa, I. & Carnevale Neto, F., Jan 1 2018, (Accepted/In press) In : Analytical chemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid

Du, D., Gu, H., Djukovic, D., Bettcher, L., Gong, M., Zheng, W., Hu, L., Zhang, X., Zhang, R., Wang, D. & Raftery, D., Jun 1 2018, In : Journal of Proteome Research. 17, 6, p. 2092-2101 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

NMR-Guided Mass Spectrometry for Absolute Quantitation of Human Blood Metabolites

Nagana Gowda, G. A., Djukovic, D., Bettcher, L. F., Gu, H. & Raftery, D., Feb 6 2018, In : Analytical Chemistry. 90, 3, p. 2001-2009 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism

Davis, R. J., Gönen, M., Margineantu, D. H., Handeli, S., Swanger, J., Hoellerbauer, P., Paddison, P. J., Gu, H., Raftery, D., Grim, J. E., Hockenbery, D. M., Margolin, A. A. & Clurman, B. E., May 22 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5462-5467 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

PBDEs altered gut microbiome and bile acid homeostasis in male C57BL/6 mice

Li, C. Y., Dempsey, J. L., Wang, D., Lee, S. W., Weigel, K. M., Fei, Q., Bhatt, D. K., Prasad, B., Raftery, D., Gu, H. & Cui, J. Y., Aug 1 2018, In : Drug Metabolism and Disposition. 46, 8, p. 1226-1240 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls

Lohavanichbutr, P., Zhang, Y., Wang, P., Gu, H., Nagana Gowda, G. A., Djukovic, D., Buas, M. F., Raftery, D. & Chen, C., Sep 1 2018, In : PLoS One. 13, 9, e0204249.

Research output: Contribution to journalArticle

11 Scopus citations

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Li, R., Grimm, S. A., Mav, D., Gu, H., Djukovic, D., Shah, R., Merrick, B. A., Raftery, D. & Wade, P. A., Jan 16 2018, In : Cell Reports. 22, 3, p. 624-637 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis

Chen, C., Nagana Gowda, G. A., Zhu, J., Deng, L., Gu, H., Chiorean, E. G., Abu Zaid, M., Harrison, M., Zhang, D., Zhang, M. & Raftery, D., Nov 1 2017, In : Metabolomics. 13, 11, 125.

Research output: Contribution to journalArticle

5 Scopus citations

Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma

Buas, M. F., Gu, H., Djukovic, D., Zhu, J., Onstad, L., Reid, B. J., Raftery, D. & Vaughan, T. L., Mar 1 2017, In : Metabolomics. 13, 3, 23.

Research output: Contribution to journalArticle

7 Scopus citations

Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury

Li, T., Zhang, Z., Kolwicz, S. C., Abell, L., Roe, N. D., Kim, M., Zhou, B., Cao, Y., Ritterhoff, J., Gu, H., Raftery, D., Sun, H. & Tian, R., Feb 7 2017, In : Cell Metabolism. 25, 2, p. 374-385 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Development of a High-Performance Imaging-Aided Extractive Electrospray Ionization Sprayer

Dong, X. F., Zhu, T. G., Zhou, P., Gu, H., Zhou, S. M. & Chen, H. W., Nov 1 2017, In : Journal of Chinese Mass Spectrometry Society. 38, 6, p. 671-677 7 p.

Research output: Contribution to journalArticle

Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side

Chao, J. R., Knight, K., Engel, A. L., Jankowski, C., Wang, Y., Manson, M. A., Gu, H., Djukovic, D., Raftery, D., Hurley, J. B. & Du, J., Aug 4 2017, In : Journal of Biological Chemistry. 292, 31, p. 12895-12905 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry

Lu, H., Zhang, H., Zhu, T., Xiao, Y., Xie, S., Gu, H., Cui, M. & Luo, L., Dec 1 2017, In : Scientific Reports. 7, 1, 5136.

Research output: Contribution to journalArticle

9 Scopus citations

Parenteral and enteral nutrition in surgical critical care: Plasma metabolomics demonstrates divergent effects on nitrogen, fatty-acid, ribonucleotide, and oxidative metabolism

Parent, B. A., Seaton, M., Djukovic, D., Gu, H., Wheelock, B., Navarro, S. L., Raftery, D. & O'Keefe, G. E., Apr 1 2017, In : Journal of Trauma and Acute Care Surgery. 82, 4, p. 704-713 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

Miles, F. L., Navarro, S. L., Schwarz, Y., Gu, H., Djukovic, D., Randolph, T. W., Shojaie, A., Kratz, M., Hullar, M. A. J., Lampe, P. D., Neuhouser, M. L., Raftery, D. & Lampe, J. W., Sep 1 2017, In : Food and Function. 8, 9, p. 3209-3218 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish

Rabinowitz, J. S., Robitaille, A. M., Wang, Y., Ray, C. A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J. D. & Moon, R. T., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. E717-E726

Research output: Contribution to journalArticle

31 Scopus citations
2016

Combining NMR and LC/MS using backward variable elimination: Metabolomics analysis of colorectal cancer, polyps, and healthy controls

Deng, L., Gu, H., Zhu, J., Nagana Gowda, G. A., Djukovic, D., Chiorean, E. G. & Raftery, D., Aug 16 2016, In : Analytical chemistry. 88, 16, p. 7975-7983 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dereplication of natural products using GC-TOF mass spectrometry: Improved metabolite identification by spectral deconvolution ratio analysis

Neto, F. C., Pilon, A. C., Selegato, D. M., Freire, R. T., Gu, H., Raftery, D., Lopes, N. P. & Castro-Gamboa, I., Sep 30 2016, In : Frontiers in Molecular Biosciences. 3, SEP, 59.

Research output: Contribution to journalArticle

5 Scopus citations

EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape

Lim, S. O., Li, C. W., Xia, W., Lee, H. H., Chang, S. S., Shen, J., Hsu, J. L., Raftery, D., Djukovic, D., Gu, H., Chang, W. C., Wang, H. L., Chen, M. L., Huo, L., Chen, C. H., Wu, Y., Sahin, A., Hanash, S. M., Hortobagyi, G. N. & Hung, M. C., Mar 1 2016, In : Cancer Research. 76, 5, p. 1284-1296 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors

Buas, M. F., Gu, H., Djukovic, D., Zhu, J., Drescher, C. W., Urban, N., Raftery, D. & Li, C. I., Jan 1 2016, In : Gynecologic Oncology. 140, 1, p. 138-144 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina

Du, J., Rountree, A., Cleghorn, W. M., Contreras, L., Lindsay, K. J., Sadilek, M., Gu, H., Djukovic, D., Raftery, D., Satrústegui, J., Kanow, M., Chan, L., Tsang, S. H., Sweet, I. R. & Hurley, J. B., Feb 26 2016, In : Journal of Biological Chemistry. 291, 9, p. 4698-4710 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine

Gu, H., Carroll, P. A., Du, J., Zhu, J., Neto, F. C., Eisenman, R. N. & Raftery, D., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 50, p. 15646-15650 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Chiao, Y. A., Kolwicz, S. C., Basisty, N., Gagnidze, A., Zhang, J., Gu, H., Djukovic, D., Beyer, R. P., Raftery, D., MacCoss, M., Tian, R. & Rabinovitch, P. S., Jan 1 2016, In : Aging. 8, 2, p. 314-327 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS)

Heitkemper, M. M., Han, C. J., Jarrett, M. E., Gu, H., Djukovic, D., Shulman, R. J., Raftery, D., Henderson, W. A. & Cain, K. C., Mar 1 2016, In : Biological Research for Nursing. 18, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Use of metabolomics to trend recovery and therapy after injury in critically ill trauma patients

Parent, B. A., Seaton, M., Sood, R. F., Gu, H., Djukovic, D., Raftery, D. & O'Keefe, G. E., Jul 1 2016, In : JAMA Surgery. 151, 7

Research output: Contribution to journalArticle

15 Scopus citations