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Giovanna Ghirlanda

Assoc Professor

  • 1440 Citations
  • 21 h-Index
1993 …2020

Research output per year

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Research Output

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Article
2020

Enhanced Photocatalytic Hydrogen Production by Hybrid Streptavidin-Diiron Catalysts

Roy, A., Vaughn, M. D., Tomlin, J., Booher, G. J., Kodis, G., Simmons, C. R., Allen, J. P. & Ghirlanda, G., May 15 2020, In : Chemistry - A European Journal. 26, 28, p. 6240-6246 7 p.

Research output: Contribution to journal › Article

Rational development of a high-affinity secretin receptor antagonist

Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In : Biochemical Pharmacology. 177, 113929.

Research output: Contribution to journal › Article

2019

Improved Electro- and Photocatalytic Water Reduction by Confined Cobalt Catalysts in Streptavidin

Call, A., Casadevall, C., Romero-Rivera, A., Martin-Diaconescu, V., Sommer, D. J., Osuna, S., Ghirlanda, G. & Lloret-Fillol, J., Jan 1 2019, In : ACS Catalysis. p. 5837-5846 10 p.

Research output: Contribution to journal › Article

7 Scopus citations

Repeat proteins as versatile scaffolds for arrays of redox-active FeS clusters

Mejias, S. H., Bahrami-Dizicheh, Z., Liutkus, M., Sommer, D. J., Astashkin, A., Kodis, G., Ghirlanda, G. & Cortajarena, A. L., Jan 1 2019, In : Chemical Communications. 55, 23, p. 3319-3322 4 p.

Research output: Contribution to journal › Article

Open Access
3 Scopus citations
2018

Rational design of a hexameric protein assembly stabilized by metal chelation

Alcala-Torano, R., Walther, M., Sommer, D. J., Park, C. K. & Ghirlanda, G., Aug 2018, In : Biopolymers. 109, 10, e23233.

Research output: Contribution to journal › Article

1 Scopus citations
2017

Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins

Olson, T. L., Espiritu, E., Edwardraja, S., Canarie, E., Flores, M., Williams, J., Ghirlanda, G. & Allen, J., Dec 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 12, p. 945-954 10 p.

Research output: Contribution to journal › Article

7 Scopus citations
2016

A designed “Nested” dimer of cyanovirin-N increases antiviral activity

Woodrum, B. W., Maxwell, J., Allen, D. M., Wilson, J., Krumpe, L. R. H., Bobkov, A. A., Hill, R. B., Kibler, K., O’Keefe, B. R. & Ghirlanda, G., Jun 6 2016, In : Viruses. 8, 6, 158.

Research output: Contribution to journal › Article

2 Scopus citations

Design of dinuclear manganese cofactors for bacterial reaction centers

Olson, T. L., Espiritu, E., Edwardraja, S., Simmons, C. R., Williams, J., Ghirlanda, G. & Allen, J., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 539-547 9 p.

Research output: Contribution to journal › Article

8 Scopus citations

Design of redox-active peptides: Towards functional materials

Sommer, D. J., Alcala-Torano, R., Dizicheh, Z. B. & Ghirlanda, G., Sep 1 2016, In : Advances in Experimental Medicine and Biology. 940, p. 215-243 29 p.

Research output: Contribution to journal › Article

Reengineering cyt b562 for hydrogen production: A facile route to artificial hydrogenases

Sommer, D. J., Vaughn, M. D., Clark, B. C., Tomlin, J., Roy, A. & Ghirlanda, G., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 598-603 6 p.

Research output: Contribution to journal › Article

16 Scopus citations
2015

A Rigid Hinge Region Is Necessary for High-Affinity Binding of Dimannose to Cyanovirin and Associated Constructs

Li, Z., Bolia, A., Maxwell, J. D., Bobkov, A. A., Ghirlanda, G., Ozkan, S. & Margulis, C. J., Oct 28 2015, In : Biochemistry. 54, 46, p. 6951-6960 10 p.

Research output: Contribution to journal › Article

6 Scopus citations

Copper Environment in Artificial Metalloproteins Probed by Electron Paramagnetic Resonance Spectroscopy

Flores, M., Olson, T. L., Wang, D., Edwardraja, S., Shinde, S., Williams, J., Ghirlanda, G. & Allen, J., Oct 29 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13825-13833 9 p.

Research output: Contribution to journal › Article

7 Scopus citations

Modulation of cluster incorporation specificity in a de novo iron-sulfur cluster binding peptide

Sommer, D. J. O., Roy, A., Astashkin, A. & Ghirlanda, G., Jul 1 2015, In : Biopolymers. 104, 4, p. 412-418 7 p.

Research output: Contribution to journal › Article

11 Scopus citations

Slow Internal Dynamics and Charge Expansion in the Disordered Protein CGRP: A Comparison with Amylin

Sizemore, S. M., Cope, S. M., Roy, A., Ghirlanda, G. & Vaiana, S., Sep 2 2015, In : Biophysical Journal. 109, 5, p. 1038-1048 11 p.

Research output: Contribution to journal › Article

11 Scopus citations
2014

A de novo designed 2[4Fe-4S] ferredoxin mimic mediates electron transfer

Roy, A., Sommer, D. J., Schmitz, R. A., Brown, C. L., Gust, D., Astashkin, A. & Ghirlanda, G., Dec 10 2014, In : Journal of the American Chemical Society. 136, 49, p. 17343-17349 7 p.

Research output: Contribution to journal › Article

32 Scopus citations

A designed buried salt bridge modulates heterodimerization of a membrane peptide

Shinde, S., Binder, J. K., Goyal, B., Woodrum, B., De Munari, S., Levitus, M. & Ghirlanda, G., Nov 1 2014, In : Biopolymers - Peptide Science Section. 102, 6, p. 437-443 7 p.

Research output: Contribution to journal › Article

A flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding

Bolia, A., Woodrum, B. W., Cereda, A., Ruben, M. A., Wang, X., Ozkan, S. & Ghirlanda, G., Mar 4 2014, In : Biophysical journal. 106, 5, p. 1142-1151 10 p.

Research output: Contribution to journal › Article

7 Scopus citations

Low temperature assembly of functional 3D DNA-PNA-protein complexes

Flory, J. D., Simmons, C. R., Lin, S., Johnson, T., Andreoni, A., Zook, J., Ghirlanda, G., Liu, Y., Yan, H. & Fromme, P., Jun 11 2014, In : Journal of the American Chemical Society. 136, 23, p. 8283-8295 13 p.

Research output: Contribution to journal › Article

22 Scopus citations

Protein secondary-shell interactions enhance the photoinduced hydrogen production of cobalt protoporphyrin IX

Sommer, D. J., Vaughn, M. D. & Ghirlanda, G., Nov 20 2014, In : Chemical Communications. 50, 100, p. 15852-15855 4 p.

Research output: Contribution to journal › Article

46 Scopus citations

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. R., Lin, S., Ghirlanda, G. & Fromme, P., 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. 1-8 8 p.

Research output: Contribution to journal › Article

3 Scopus citations

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. D., Lin, S., Ghirlanda, G. & Fromme, P., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e992181

Research output: Contribution to journal › Article

Water oxidation by a nickel-glycine catalyst

Wang, D., Ghirlanda, G. & Allen, J., Jul 23 2014, In : Journal of the American Chemical Society. 136, 29, p. 10198-10201 4 p.

Research output: Contribution to journal › Article

65 Scopus citations
2013

Computational biology: A recipe for ligand-binding proteins

Ghirlanda, G., Sep 5 2013, In : Nature. 501, 7466, p. 177-178 2 p.

Research output: Contribution to journal › Article

1 Scopus citations

Cyclic N-terminal loop of amylin forms non amyloid fibers

Cope, S. M., Shinde, S., Best, R. B., Ghirlanda, G. & Vaiana, S., Oct 1 2013, In : Biophysical journal. 105, 7, p. 1661-1669 9 p.

Research output: Contribution to journal › Article

6 Scopus citations

De novo design of an artificial bis[4fe-4s] binding protein

Roy, A., Sarrou, I., Vaughn, M. D., Astashkin, A. V. & Ghirlanda, G., Oct 29 2013, In : Biochemistry. 52, 43, p. 7586-7594 9 p.

Research output: Contribution to journal › Article

31 Scopus citations

PNA-peptide assembly in a 3D DNA nanocage at room temperature

Flory, J. D., Shinde, S., Lin, S., Liu, Y., Yan, H., Ghirlanda, G. & Fromme, P., May 8 2013, In : Journal of the American Chemical Society. 135, 18, p. 6985-6993 9 p.

Research output: Contribution to journal › Article

24 Scopus citations

Preface

Ghirlanda, G. & Senes, A., 2013, In : Methods in molecular biology (Clifton, N.J.). 1063

Research output: Contribution to journal › Article

The antiviral lectin cyanovirin-N: Probing multivalency and glycan recognition through experimental and computational approaches

Woodrum, B. W., Maxwell, J. D., Bolia, A., Ozkan, S. & Ghirlanda, G., Oct 1 2013, In : Biochemical Society Transactions. 41, 5, p. 1170-1176 7 p.

Research output: Contribution to journal › Article

8 Scopus citations
2012

A multivalent HIV-1 fusion inhibitor based on small helical foldamers

Guarise, C., Shinde, S., Kibler, K., Ghirlanda, G., Prins, L. J. & Scrimin, P., Jun 10 2012, In : Tetrahedron. 68, 23, p. 4346-4352 7 p.

Research output: Contribution to journal › Article

6 Scopus citations

Modulation of function in a minimalist heme-binding membrane protein

Shinde, S., Cordova, J. M., Woodrum, B. W. & Ghirlanda, G., Apr 1 2012, In : Journal of Biological Inorganic Chemistry. 17, 4, p. 557-564 8 p.

Research output: Contribution to journal › Article

22 Scopus citations

Photo-induced hydrogen production in a helical peptide incorporating a [FeFe] hydrogenase active site mimic

Roy, A., Madden, C. & Ghirlanda, G., Sep 10 2012, In : Chemical Communications. 48, 79, p. 9816-9818 3 p.

Research output: Contribution to journal › Article

65 Scopus citations
2011

Simultaneous observation of peptide backbone lipid solvation and α-helical structure by deep-UV resonance Raman spectroscopy

Halsey, C. M., Xiong, J., Oshokoya, O. O., Johnson, J. A., Shinde, S., Beatty, J. T., Ghirlanda, G., Jiji, R. D. & Cooley, J. W., Sep 19 2011, In : ChemBioChem. 12, 14, p. 2125-2128 4 p.

Research output: Contribution to journal › Article

15 Scopus citations
2009

Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin

Liu, Y., Carroll, J. R., Holt, L. A., McMahon, J., Giomarelli, B. & Ghirlanda, G., Aug 3 2009, In : Biopolymers. 92, 3, p. 194-200 7 p.

Research output: Contribution to journal › Article

21 Scopus citations
2008

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 Å resolution

Fromme, R., Katiliene, Z., Fromme, P. & Ghirlanda, G., May 1 2008, In : Protein Science. 17, 5, p. 939-944 6 p.

Research output: Contribution to journal › Article

19 Scopus citations

Modulation of protein stability by O-glycosylation in a designed Gc-MAF analog

Spiriti, J., Bogani, F., van der Vaart, A. & Ghirlanda, G., May 1 2008, In : Biophysical Chemistry. 134, 3, p. 157-167 11 p.

Research output: Contribution to journal › Article

15 Scopus citations
2007

A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity

Fromme, R., Katiliene, Z., Giomarelli, B., Bogani, F., Mc Mahon, J., Mori, T., Fromme, P. & Ghirlanda, G., Aug 14 2007, In : Biochemistry. 46, 32, p. 9199-9207 9 p.

Research output: Contribution to journal › Article

32 Scopus citations

Design of a functional membrane protein by engineering a heme-binding site in glycophorin A

Cordova, J. M., Noack, P. L., Hilcove, S. A., Lear, J. D. & Ghirlanda, G., Jan 24 2007, In : Journal of the American Chemical Society. 129, 3, p. 512-518 7 p.

Research output: Contribution to journal › Article

35 Scopus citations
2006

A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity

Bogani, F., McConnell, E., Joshi, L., Chang, Y. & Ghirlanda, G., Jun 7 2006, In : Journal of the American Chemical Society. 128, 22, p. 7142-7143 2 p.

Research output: Contribution to journal › Article

7 Scopus citations
2004

De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1

Ghirlanda, G., Osyczka, A., Liu, W., Antolovich, M., Smith, K. M., Dutton, P. L., Wand, A. J. & DeGrado, W. F., Jul 7 2004, In : Journal of the American Chemical Society. 126, 26, p. 8141-8147 7 p.

Research output: Contribution to journal › Article

55 Scopus citations

Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide

Ghirlanda, G., Hilcove, S. A., Pidikiti, R., Johansson, J. S., Lear, J. D., DeGrado, W. F. & Eckenhoff, R. G., Dec 3 2004, In : FEBS Letters. 578, 1-2, p. 140-144 5 p.

Research output: Contribution to journal › Article

11 Scopus citations
2002

A hierarchic approach to the design of hexameric helical barrels

Ghirlanda, G., Lear, J. D., Ogihara, N. L., Eisenberg, D. & DeGrado, W. F., Jan 1 2002, In : Journal of molecular biology. 319, 1, p. 243-253 11 p.

Research output: Contribution to journal › Article

31 Scopus citations
2001

Design of three-dimensional domain-swapped dimers and fibrous oligomers

Ogihara, N. L., Ghirlanda, G., Bryson, J. W., Gingery, M., DeGrado, W. F. & Eisenberg, D., Feb 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 4, p. 1404-1409 6 p.

Research output: Contribution to journal › Article

136 Scopus citations

Dn-symmetrical tertiary templates for the design of tubular proteins

North, B., Summa, C. M., Ghirlanda, G. & DeGrado, W. F., Aug 31 2001, In : Journal of molecular biology. 311, 5, p. 1081-1090 10 p.

Research output: Contribution to journal › Article

44 Scopus citations

Fluorinated coiled-coil proteins prepared in vivo display enhanced thermal and chemical stability

Tang, Y., Ghirlanda, G., Petka, W. A., Nakajima, T., DeGrado, W. F. & Tirrell, D. A., Apr 17 2001, In : Angewandte Chemie - International Edition. 40, 8, p. 1494-1496 3 p.

Research output: Contribution to journal › Article

171 Scopus citations

Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine

Tang, Y., Ghirlanda, G., Vaidehi, N., Kua, J., Mainz, D. T., Goddard, W. A., DeGrado, W. F. & Tirrell, D. A., Mar 6 2001, In : Biochemistry. 40, 9, p. 2790-2796 7 p.

Research output: Contribution to journal › Article

163 Scopus citations
1998

Amphiphilic copper(II) complexes modeled after the metal-complexation subunit of bleomycin antibiotics

Ghirlanda, G., Scrimin, P., Tecilla, P. & Toffoletti, A., Mar 31 1998, In : Langmuir. 14, 7, p. 1646-1655 10 p.

Research output: Contribution to journal › Article

41 Scopus citations

From synthetic coiled coils to functional proteins: Automated design of a receptor for the calmodulin-binding domain of calcineurin

Ghirlanda, G., Lear, J. D., Lombardi, A. & Degrado, W. F., Aug 14 1998, In : Journal of molecular biology. 281, 2, p. 379-391 13 p.

Research output: Contribution to journal › Article

37 Scopus citations
1997

Design of a synthetic receptor for the calmodulin-binding domain of calcineurin

Lombardi, A., Bryson, J. W., Ghirlanda, G. & DeGrado, W. F., 1997, In : Journal of the American Chemical Society. 119, p. 12378-12379 2 p.

Research output: Contribution to journal › Article

18 Scopus citations
1996

Influence of aggregation on redox potentials of amphiphilic Cu(II) complexes modeled after bleomycin antibiotics

Ghirlanda, G., Scrimin, P. & Echegoyen, L. A., Oct 16 1996, In : Langmuir. 12, 21, p. 5188-5194 7 p.

Research output: Contribution to journal › Article

10 Scopus citations

Self-assembled monolayers of Cu(II) metallosurfactants on GC and HOPG

Ghirlanda, G., Scrimin, P., Kaifer, A. E. & Echegoyen, L. A., Jul 24 1996, In : Langmuir. 12, 15, p. 3695-3701 7 p.

Research output: Contribution to journal › Article

13 Scopus citations