• 1373 Citations
  • 20 h-Index
1993 …2022
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Research Output 1993 2019

  • 1373 Citations
  • 20 h-Index
  • 54 Article
  • 4 Patent
  • 3 Chapter
  • 1 Editorial
2019
1 Citation (Scopus)

Improved Electro- and Photocatalytic Water Reduction by Confined Cobalt Catalysts in Streptavidin

Call, A., Casadevall, C., Romero-Rivera, A., Martin-Diaconescu, V., Sommer, D. J., Osuna, S., Ghirlanda, G. & Lloret-Fillol, J., Jan 1 2019, In : ACS Catalysis. p. 5837-5846 10 p.

Research output: Contribution to journalArticle

Streptavidin
Cobalt
Hydrogen
Catalysts
Water

Repeat proteins as versatile scaffolds for arrays of redox-active FeS clusters

Mejias, S. H., Bahrami-Dizicheh, Z., Liutkus, M., Sommer, D. J., Astashkin, A., Kodis, G., Ghirlanda, G. & Cortajarena, A. L., Jan 1 2019, In : Chemical Communications. 55, 23, p. 3319-3322 4 p.

Research output: Contribution to journalArticle

Open Access
Scaffolds (biology)
Scaffolds
Charge transfer
Stabilization
Proteins
2018

Editorial overview: The many facets of protein design: from self-assembled materials to vaccines

Korendovych, I. V. & Ghirlanda, G., Aug 1 2018, In : Current Opinion in Structural Biology. 51, p. iv-vi

Research output: Contribution to journalEditorial

Vaccines
Proteins
1 Citation (Scopus)

Rational design of a hexameric protein assembly stabilized by metal chelation

Alcala-Torano, R., Walther, M., Sommer, D. J., Park, C. K. & Ghirlanda, G., Jan 1 2018, (Accepted/In press) In : Biopolymers.

Research output: Contribution to journalArticle

Chelation
Metals
Proteins
Nanostructures
Circular Dichroism
2017
6 Citations (Scopus)

Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins

Olson, T. L., Espiritu, E., Edwardraja, S., Canarie, E., Flores, M., Williams, J., Ghirlanda, G. & Allen, J., Dec 1 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 12, p. 945-954 10 p.

Research output: Contribution to journalArticle

Proteins
Hydrogen Peroxide
Metals
Electrons
Oxygen
1 Citation (Scopus)

De Novo Design of Iron–Sulfur Proteins

Dizicheh, Z. B., Halloran, N., Asma, W. & Ghirlanda, G., 2017, Methods in Enzymology. Academic Press Inc., Vol. 595. p. 33-53 21 p. (Methods in Enzymology; vol. 595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidation-Reduction
Proteins
Electrons
Mutagenesis
Proxy
2016
2 Citations (Scopus)

A designed “Nested” dimer of cyanovirin-N increases antiviral activity

Woodrum, B. W., Maxwell, J., Allen, D. M., Wilson, J., Krumpe, L. R. H., Bobkov, A. A., Hill, R. B., Kibler, K., O’Keefe, B. R. & Ghirlanda, G., Jun 6 2016, In : Viruses. 8, 6, 158.

Research output: Contribution to journalArticle

Antiviral Agents
Polysaccharides
Binding Sites
HIV
Lectins
8 Citations (Scopus)

Design of dinuclear manganese cofactors for bacterial reaction centers

Olson, T. L., Espiritu, E., Edwardraja, S., Simmons, C. R., Williams, J., Ghirlanda, G. & Allen, J., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 539-547 9 p.

Research output: Contribution to journalArticle

Manganese
Proteins
Metals
Electrons
Cytochromes c2

Design of redox-active peptides: Towards functional materials

Sommer, D. J., Alcala-Torano, R., Dizicheh, Z. B. & Ghirlanda, G., Sep 1 2016, In : Advances in Experimental Medicine and Biology. 940, p. 215-243 29 p.

Research output: Contribution to journalArticle

Functional materials
Oxidation-Reduction
Electrons
Peptides
Protons

Design Strategies for Redox Active Metalloenzymes: Applications in Hydrogen Production

Alcala-Torano, R., Sommer, D. J., Bahrami Dizicheh, Z. & Ghirlanda, G., 2016, Methods in Enzymology. Academic Press Inc., Vol. 580. p. 389-416 28 p. (Methods in Enzymology; vol. 580).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hydrogen production
Oxidation-Reduction
Hydrogen
Organometallics
Peptides
14 Citations (Scopus)

Reengineering cyt b562 for hydrogen production: A facile route to artificial hydrogenases

Sommer, D. J., Vaughn, M. D., Clark, B. C., Tomlin, J., Roy, A. & Ghirlanda, G., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 598-603 6 p.

Research output: Contribution to journalArticle

Hydrogenase
Reengineering
Hydrogen production
Hydrogen
Protons
2015
4 Citations (Scopus)

A Rigid Hinge Region Is Necessary for High-Affinity Binding of Dimannose to Cyanovirin and Associated Constructs

Li, Z., Bolia, A., Maxwell, J. D., Bobkov, A. A., Ghirlanda, G., Ozkan, S. & Margulis, C. J., Oct 28 2015, In : Biochemistry. 54, 46, p. 6951-6960 10 p.

Research output: Contribution to journalArticle

Hinges
Mutation
Binding Sites
Oligomerization
Calorimetry
7 Citations (Scopus)

Copper Environment in Artificial Metalloproteins Probed by Electron Paramagnetic Resonance Spectroscopy

Flores, M., Olson, T. L., Wang, D., Edwardraja, S., Shinde, S., Williams, J., Ghirlanda, G. & Allen, J., Oct 29 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13825-13833 9 p.

Research output: Contribution to journalArticle

Metalloproteins
Paramagnetic resonance
Copper
electron paramagnetic resonance
Metals
11 Citations (Scopus)

Modulation of cluster incorporation specificity in a de novo iron-sulfur cluster binding peptide

Sommer, D. J. O., Roy, A., Astashkin, A. & Ghirlanda, G., Jul 1 2015, In : Biopolymers. 104, 4, p. 412-418 7 p.

Research output: Contribution to journalArticle

Sulfur
Peptides
Oxidation-Reduction
Iron
Modulation
9 Citations (Scopus)

Slow Internal Dynamics and Charge Expansion in the Disordered Protein CGRP: A Comparison with Amylin

Sizemore, S. M., Cope, S. M., Roy, A., Ghirlanda, G. & Vaiana, S., Sep 2 2015, In : Biophysical Journal. 109, 5, p. 1038-1048 11 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Calcitonin Gene-Related Peptide
Peptides
Calcitonin
Proteins
2014
32 Citations (Scopus)

A de novo designed 2[4Fe-4S] ferredoxin mimic mediates electron transfer

Roy, A., Sommer, D. J., Schmitz, R. A., Brown, C. L., Gust, D., Astashkin, A. & Ghirlanda, G., Dec 10 2014, In : Journal of the American Chemical Society. 136, 49, p. 17343-17349 7 p.

Research output: Contribution to journalArticle

Ferredoxins
Electrons
Proteins
Carrier Proteins
Biomimetics

A designed buried salt bridge modulates heterodimerization of a membrane peptide

Shinde, S., Binder, J. K., Goyal, B., Woodrum, B., De Munari, S., Levitus, M. & Ghirlanda, G., Nov 1 2014, In : Biopolymers - Peptide Science Section. 102, 6, p. 437-443 7 p.

Research output: Contribution to journalArticle

Peptides
Salts
Carboxylic Acids
Proteins
Membranes
6 Citations (Scopus)

A flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding

Bolia, A., Woodrum, B. W., Cereda, A., Ruben, M. A., Wang, X., Ozkan, S. & Ghirlanda, G., Mar 4 2014, In : Biophysical Journal. 106, 5, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

Polysaccharides
Mutation
cyanovirin N
Lectins
Computer Simulation
20 Citations (Scopus)

Low temperature assembly of functional 3D DNA-PNA-protein complexes

Flory, J. D., Simmons, C. R., Lin, S., Johnson, T., Andreoni, A., Zook, J., Ghirlanda, G., Liu, Y., Yan, H. & Fromme, P., Jun 11 2014, In : Journal of the American Chemical Society. 136, 23, p. 8283-8295 13 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
DNA
Proteins
Temperature
Azurin
38 Citations (Scopus)

Protein secondary-shell interactions enhance the photoinduced hydrogen production of cobalt protoporphyrin IX

Sommer, D. J., Vaughn, M. D. & Ghirlanda, G., Dec 28 2014, In : Chemical Communications. 50, 100, p. 15852-15855 4 p.

Research output: Contribution to journalArticle

Hydrogen production
Cobalt
Proteins
Myoglobin
Scaffolds

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. D., Lin, S., Ghirlanda, G. & Fromme, P., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e992181

Research output: Contribution to journalArticle

Purification
DNA
Coloring Agents
Electrophoresis
Peptides
2 Citations (Scopus)

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. R., Lin, S., Ghirlanda, G. & Fromme, P., 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. 1-8 8 p.

Research output: Contribution to journalArticle

Purification
DNA
Coloring Agents
Electrophoresis
Peptides
55 Citations (Scopus)

Water oxidation by a nickel-glycine catalyst

Wang, D., Ghirlanda, G. & Allen, J., Jul 23 2014, In : Journal of the American Chemical Society. 136, 29, p. 10198-10201 4 p.

Research output: Contribution to journalArticle

Molecular oxygen
Nickel
Glycine
Amino acids
Current density
2013
1 Citation (Scopus)

Computational biology: A recipe for ligand-binding proteins

Ghirlanda, G., 2013, In : Nature. 501, 7466, p. 177-178 2 p.

Research output: Contribution to journalArticle

biological analysis
Digoxigenin
Drug Design
Computational Biology
Computer Simulation
6 Citations (Scopus)

Cyclic N-terminal loop of amylin forms non amyloid fibers

Cope, S. M., Shinde, S., Best, R. B., Ghirlanda, G. & Vaiana, S., Oct 1 2013, In : Biophysical Journal. 105, 7, p. 1661-1669 9 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Amyloid
Peptides
Calcitonin
30 Citations (Scopus)

De novo design of an artificial bis[4fe-4s] binding protein

Roy, A., Sarrou, I., Vaughn, M. D., Astashkin, A. V. & Ghirlanda, G., Oct 29 2013, In : Biochemistry. 52, 43, p. 7586-7594 9 p.

Research output: Contribution to journalArticle

Carrier Proteins
Sulfur
Oxidation-Reduction
Iron
Electrons
17 Citations (Scopus)

De novo design of functional proteins: Toward artificial hydrogenases

Faiella, M., Roy, A., Sommer, D. & Ghirlanda, G., Nov 2013, In : Biopolymers. 100, 6, p. 558-571 14 p.

Research output: Contribution to journalArticle

Hydrogenase
Proteins
Peptides
Catalysts
24 Citations (Scopus)

PNA-peptide assembly in a 3D DNA nanocage at room temperature

Flory, J. D., Shinde, S., Lin, S., Liu, Y., Yan, H., Ghirlanda, G. & Fromme, P., May 8 2013, In : Journal of the American Chemical Society. 135, 18, p. 6985-6993 9 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Peptides
DNA
Temperature
Polypeptides

Preface

Ghirlanda, G. & Senes, A., 2013, In : Methods in molecular biology (Clifton, N.J.). 1063

Research output: Contribution to journalArticle

8 Citations (Scopus)

The antiviral lectin cyanovirin-N: Probing multivalency and glycan recognition through experimental and computational approaches

Woodrum, B. W., Maxwell, J. D., Bolia, A., Ozkan, S. & Ghirlanda, G., Oct 2013, In : Biochemical Society Transactions. 41, 5, p. 1170-1176 7 p.

Research output: Contribution to journalArticle

Lectins
Antiviral Agents
Polysaccharides
Anti-HIV Agents
Mutagenesis
2012
6 Citations (Scopus)

A multivalent HIV-1 fusion inhibitor based on small helical foldamers

Guarise, C., Shinde, S., Kibler, K., Ghirlanda, G., Prins, L. J. & Scrimin, P., Jun 10 2012, In : Tetrahedron. 68, 23, p. 4346-4352 7 p.

Research output: Contribution to journalArticle

HIV Fusion Inhibitors
Aminoisobutyric Acids
HIV-1
Assays
Fusion reactions
21 Citations (Scopus)

Modulation of function in a minimalist heme-binding membrane protein

Shinde, S., Cordova, J. M., Woodrum, B. W. & Ghirlanda, G., Apr 2012, In : Journal of Biological Inorganic Chemistry. 17, 4, p. 557-564 8 p.

Research output: Contribution to journalArticle

Heme
Oxidation-Reduction
Membrane Proteins
Modulation
Membranes
61 Citations (Scopus)

Photo-induced hydrogen production in a helical peptide incorporating a [FeFe] hydrogenase active site mimic

Roy, A., Madden, C. & Ghirlanda, G., Oct 11 2012, In : Chemical Communications. 48, 79, p. 9816-9818 3 p.

Research output: Contribution to journalArticle

Hydrogenase
Hydrogen production
Peptides
Amino acids
Hydrogen
2011
AIDS Vaccines
Vaccines
HIV
DNA
HIV Infections
15 Citations (Scopus)

Simultaneous observation of peptide backbone lipid solvation and α-helical structure by deep-UV resonance Raman spectroscopy

Halsey, C. M., Xiong, J., Oshokoya, O. O., Johnson, J. A., Shinde, S., Beatty, J. T., Ghirlanda, G., Jiji, R. D. & Cooley, J. W., Sep 19 2011, In : ChemBioChem. 12, 14, p. 2125-2128 4 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Molecular Models
Raman Spectrum Analysis
Solvation
Ultraviolet Rays
2010

Catalysis by Peptide-Based Enzyme Models

Ghirlanda, G., Prins, L. J. & Scrimin, P., Dec 28 2010, Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH, Vol. 2. p. 433-471 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Redox reactions
Catalysis
Hydrolysis
Peptides
Enzymes
2009
23 Citations (Scopus)

Design of membrane proteins: toward functional systems

Ghirlanda, G., Dec 2009, In : Current Opinion in Chemical Biology. 13, 5-6, p. 643-651 9 p.

Research output: Contribution to journalArticle

Membrane Proteins
Artificial Membranes
Computational methods
Modulators
Oxidation-Reduction
19 Citations (Scopus)

Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin

Liu, Y., Carroll, J. R., Holt, L. A., McMahon, J., Giomarelli, B. & Ghirlanda, G., 2009, In : Biopolymers. 92, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

Dimers
HIV
Binding sites
Carbohydrates
Mutation
2008
3 Citations (Scopus)

Computational biochemistry: Old enzymes, new tricks

Ghirlanda, G., May 8 2008, In : Nature. 453, 7192, p. 164-166 3 p.

Research output: Contribution to journalArticle

bioengineering
computer aided design
biochemistry
catalysis
crystal structure
19 Citations (Scopus)
Antiviral Agents
Crystal structure
Binding Sites
Mannose
Conformations
15 Citations (Scopus)

Modulation of protein stability by O-glycosylation in a designed Gc-MAF analog

Spiriti, J., Bogani, F., van der Vaart, A. & Ghirlanda, G., May 2008, In : Biophysical Chemistry. 134, 3, p. 157-167 11 p.

Research output: Contribution to journalArticle

Glycosylation
Protein Stability
Modulation
analogs
proteins
2007
31 Citations (Scopus)

A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity

Fromme, R., Katiliene, Z., Giomarelli, B., Bogani, F., Mc Mahon, J., Mori, T., Fromme, P. & Ghirlanda, G., Aug 14 2007, In : Biochemistry. 46, 32, p. 9199-9207 9 p.

Research output: Contribution to journalArticle

Dimers
Antiviral Agents
Binding Sites
Carbohydrates
HIV
34 Citations (Scopus)

Design of a functional membrane protein by engineering a heme-binding site in glycophorin A

Cordova, J. M., Noack, P. L., Hilcove, S. A., Lear, J. D. & Ghirlanda, G., Jan 24 2007, In : Journal of the American Chemical Society. 129, 3, p. 512-518 7 p.

Research output: Contribution to journalArticle

Glycophorin
Protein Engineering
Binding sites
Heme
Membrane Proteins
2006
7 Citations (Scopus)

A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity

Bogani, F., McConnell, E., Joshi, L., Chang, Y. & Ghirlanda, G., Jun 7 2006, In : Journal of the American Chemical Society. 128, 22, p. 7142-7143 2 p.

Research output: Contribution to journalArticle

Glycoproteins
Proteins
Macrophages
Vitamin D-Binding Protein
Protein Engineering
Lectins
Glycosylation
Carbohydrates
Cell signaling
Oligosaccharides
2005
Glycosylation
Proteins
Glycoproteins
Carbohydrates
HIV
2004
54 Citations (Scopus)

De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1

Ghirlanda, G., Osyczka, A., Liu, W., Antolovich, M., Smith, K. M., Dutton, P. L., Wand, A. J. & DeGrado, W. F., Jul 7 2004, In : Journal of the American Chemical Society. 126, 26, p. 8141-8147 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Heme
Proteins
Ligands
Cytochrome b Group
11 Citations (Scopus)

Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide

Ghirlanda, G., Hilcove, S. A., Pidikiti, R., Johansson, J. S., Lear, J. D., DeGrado, W. F. & Eckenhoff, R. G., Dec 3 2004, In : FEBS Letters. 578, 1-2, p. 140-144 5 p.

Research output: Contribution to journalArticle

Oligomerization
Anesthetics
Modulation
Halothane
Oligomers
2003
Protein Engineering
Immunomodulation
Peptides
2002
30 Citations (Scopus)

A hierarchic approach to the design of hexameric helical barrels

Ghirlanda, G., Lear, J. D., Ogihara, N. L., Eisenberg, D. & DeGrado, W. F., 2002, In : Journal of Molecular Biology. 319, 1, p. 243-253 11 p.

Research output: Contribution to journalArticle

Protein Engineering
Nanotechnology
Molecular Models
Ultracentrifugation
Fluorescence Spectrometry