George Poste

Chf Scientist & Regent's Prof

  • 13394 Citations
  • 61 h-Index
1970 …2019
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Research Output 1970 2019

  • 13394 Citations
  • 61 h-Index
  • 243 Article
  • 9 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2018
8 Citations (Scopus)

Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes

Domenyuk, V., Gatalica, Z., Santhanam, R., Wei, X., Stark, A., Kennedy, P., Toussaint, B., Levenberg, S., Wang, J., Xiao, N., Greil, R., Rinnerthaler, G., Gampenrieder, S. P., Heimberger, A. B., Berry, D. A., Barker, A., Quackenbush, J., Marshall, J. L., Poste, G., Vacirca, J. L. & 9 others, Vidal, G. A., Schwartzberg, L. S., Halbert, D. D., Voss, A., Magee, D., Miglarese, M. R., Famulok, M., Mayer, G. & Spetzler, D., Dec 1 2018, In : Nature Communications. 9, 1, 1219.

Research output: Contribution to journalArticle

breast
cancer
Breast Neoplasms
Ligands
ligands
2017
8 Citations (Scopus)

Converging and emerging threats to health security

Raina Macintyre, C., Engells, T. E., Scotch, M., Heslop, D. J., Gumel, A., Poste, G., Chen, X., Herche, W., Steinhöfel, K., Lim, S. & Broom, A., Nov 27 2017, (Accepted/In press) In : Environment Systems and Decisions. p. 1-10 10 p.

Research output: Contribution to journalArticle

biological weapon
regulatory framework
Cold War
medicine
health care
16 Citations (Scopus)

Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Domenyuk, V., Zhong, Z., Stark, A., Xiao, N., O'Neill, H. A., Wei, X., Wang, J., Tinder, T. T., Tonapi, S., Duncan, J., Hornung, T., Hunter, A., Miglarese, M. R., Schorr, J., Halbert, D. D., Quackenbush, J., Poste, G., Berry, D. A., Mayer, G., Famulok, M. & 1 others, Spetzler, D., Feb 20 2017, In : Scientific Reports. 7, 42741.

Research output: Contribution to journalArticle

Exosomes
Systems Biology
Oligodeoxyribonucleotides
Ligands
Neoplasms
2016
7 Citations (Scopus)

Prioritization schema for immunotherapy clinical trials in glioblastoma

Hodges, T. R., Ferguson, S. D., Caruso, H. G., Kohanbash, G., Zhou, S., Cloughesy, T. F., Berger, M. S., Poste, G., Khasraw, M., Ba, S., Jiang, T., Mikkelson, T., Yung, W. K. A., de Groot, J. F., Fine, H., Cantley, L. C., Mellinghoff, I. K., Mitchell, D. A., Okada, H. & Heimberger, A. B., May 16 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
Clinical Trials
Hope
Therapeutics
2015
15 Citations (Scopus)

Beyond Ebola: Lessons to mitigate future pandemics

Castillo-Chavez, C., Curtiss, R., Daszak, P., Levin, S. A., Patterson-Lomba, O., Perrings, C., Poste, G. & Towers, S., Jul 1 2015, In : The Lancet Global Health. 3, 7, p. e354-e355

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Ebolavirus
Communicable Disease Control
Pandemics
Global Health
1 Citation (Scopus)

Breaking down silos for improved biomarker development: An interview with George Poste

Poste, G., Nov 1 2015, In : Expert Review of Molecular Diagnostics. 15, 8, p. 975-978 4 p.

Research output: Contribution to journalArticle

Exosomes
Biomarkers
Interviews
14 Citations (Scopus)
Biomarkers
Research
Precision Medicine
Practice Guidelines
Private Sector
2014
12 Citations (Scopus)

The National Biomarker Development Alliance accelerating the translation of biomarkers to the clinic

Barker, A., Compton, C. & Poste, G., Jul 1 2014, In : Biomarkers in Medicine. 8, 6, p. 873-876 4 p.

Research output: Contribution to journalArticle

Precision Medicine
Translational Medical Research
Biomarkers
2013
2 Citations (Scopus)

Perspective from the founding editors

Juliano, R., Poste, G. & Tomlinson, E., Jan 2013, In : Advanced Drug Delivery Reviews. 65, 1, p. 3-4 2 p.

Research output: Contribution to journalArticle

Pharmaceutical Technology
Pharmaceutical Chemistry
Drug Delivery Systems
Cost-Benefit Analysis
Chronic Disease
5 Citations (Scopus)

Regulatory and reimbursement innovation

Lindor, R. A., Allocco, S. J., Cheatham, L., Cortese, D., Hall, R. F., Mangold, W. J., Pizziconi, V., Poste, G., Quinn, B., Roth, M., Saks, M., Wassman, E. R., Woosley, R. L. & Marchant, G., Mar 13 2013, In : Science Translational Medicine. 5, 176, 176cm3.

Research output: Contribution to journalArticle

Molecular Pathology
2012
33 Citations (Scopus)

Biospecimens, biomarkers, and burgeoning data: The imperative for more rigorous research standards

Poste, G., Dec 2012, In : Trends in Molecular Medicine. 18, 12, p. 717-722 6 p.

Research output: Contribution to journalArticle

Biomarkers
Research
Exome
Specimen Handling
Systems Analysis
35 Citations (Scopus)

Leveling the playing field: Bringing development of biomarkers and molecular diagnostics up to the standards for drug development

Poste, G., Carbone, D. P., Parkinson, D. R., Verweij, J., Hewitt, S. M. & Jessup, J. M., Mar 15 2012, In : Clinical Cancer Research. 18, 6, p. 1515-1523 9 p.

Research output: Contribution to journalArticle

Molecular Pathology
Biomarkers
Pharmaceutical Preparations
Technology
Drug Approval
1 Citation (Scopus)

The globalization of US medical countermeasure production and its implications for national security

Adalja, A. A., Wollner, S. B., Inglesby, T. V. & Poste, G., Sep 1 2012, In : Biosecurity and Bioterrorism. 10, 3, p. 255-257 3 p.

Research output: Contribution to journalArticle

Security Measures
national security
Internationality
National security
Illicium

Uncensored exchange of scientific results (Proceedings of the National Academy of Sciences (2003) 100, 4, (1464) DOI: 10.1073/pnas.0630491100)

Atlas, R., Campbell, P., Cozzarelli, N. R., Curfman, G., Enquist, L., Fink, G., Flanagin, A., Fletcher, J., George, E., Hammes, G., Heyman, D., Inglesby, T., Kaplan, S., Kennedy, D., Krug, J., Levinson, R. E., Marcus, E., Metzger, H., Morse, S. S., O'Brien, A. & 12 others, Onderdonk, A., Poste, G., Renault, B., Rich, R., Rosengard, A., Salzberg, S., Scanlan, M., Shenk, T., Tabor, H., Varmus, H., Wimmer, E. & Yamamoto, K., May 22 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 21, p. 8352 1 p.

Research output: Contribution to journalArticle

2011
336 Citations (Scopus)

Bring on the biomarkers

Poste, G., Jan 13 2011, In : Nature. 469, 7329, p. 156-157 2 p.

Research output: Contribution to journalArticle

Biological Specimen Banks
Specimen Handling
Precision Medicine
Pharmacogenetics
Medical Genetics
2009
35 Citations (Scopus)

What's in a name?

Arkin, A., Berry, D., Church, G., Arnold, F., Boldt, J., Müller, O., Ellington, A. D., Endy, D., Fussenegger, M., Gold, E. R., Greenwood, J., Lee, S. Y., Lim, W., Minshull, J., Murray, T. H., Poste, G., Prather, K. L. J., El-Samad, H., Smolke, C. & Weiss, R., Dec 2009, In : Nature Biotechnology. 27, 12, p. 1071-1073 3 p.

Research output: Contribution to journalArticle

2008
134 Citations (Scopus)

The "seed and soil" hypothesis revisited

Fidler, I. J. & Poste, G., Aug 2008, In : The Lancet Oncology. 9, 8, p. 808 1 p.

Research output: Contribution to journalArticle

Neoplasm Seeding
19th Century History
20th Century History
Medical Oncology
Seeds
2007
28 Citations (Scopus)

Nullomers: Really a matter of natural selection?

Acquisti, C., Poste, G., Curtiss, D. & Kumar, S., Oct 10 2007, In : PLoS One. 2, 10, e1022.

Research output: Contribution to journalArticle

Genetic Selection
natural selection
Genes
DNA sequences
Pesticides
2006
7 Citations (Scopus)

Incorporating appropriate technology into North American schools of public health

Hotez, P., Gupta, R., Mahoney, R. & Poste, G., 2006, In : Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 19, 2, p. 118-123 6 p.

Research output: Contribution to journalArticle

Public Health Schools
Tropical Medicine
Cost of Illness
Latin America
Biotechnology
2003
11 Citations (Scopus)

Sharing publication-related data and materials: Responsibilities of authorship in the life sciences

Cech, T. R., Eddy, S. R., Eisenberg, D., Hersey, K., Holtzman, S. H., Poste, G., Raikhel, N. V., Scheller, R. H., Singer, D. B. & Waltham, M. C., May 1 2003, In : Plant Physiology. 132, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Authorship
Biological Science Disciplines
Publications
committees
Information Dissemination
41 Citations (Scopus)

Statement on scientific publication and security.

Atlas, R., Campbell, P., Cozzarelli, N. R., Curfman, G., Enquist, L., Fink, G., Flanagin, A., Fletcher, J., George, E., Hammes, G., Heyman, D., Inglesby, T., Kaplan, S., Kennedy, D., Krug, J., Levinson, R., Marcus, E., Metzger, H., Morse, S. S., O'Brien, A. & 12 others, Onderdonk, A., Poste, G., Renault, B., Rich, R., Rosengard, A., Salzburg, S., Scanlan, M., Shenk, T., Tabor, H., Varmus, H., Wimmer, E. & Yamamoto, K., Feb 21 2003, In : Science. 299, 5610, p. 1149 1 p.

Research output: Contribution to journalArticle

2002
2 Citations (Scopus)
warfare
conversation
interview
2001

Biotechnology and the evolution of molecular medicine

Poste, G., 2001, In : Journal of Biolaw and Business. 4, 3, p. 12-16 5 p.

Research output: Contribution to journalArticle

Molecular Medicine
Biotechnology
15 Citations (Scopus)
Molecular Diagnostic Techniques
Molecular Pathology
Pharmacogenetics
Genotype
Delivery of Health Care
2000
10 Citations (Scopus)

Rational or rationed medicine? The promise of genetics for improved clinical practice

Fears, R., Roberts, D. & Poste, G., Apr 1 2000, In : British Medical Journal. 320, 7239, p. 933-935 3 p.

Research output: Contribution to journalArticle

Medicine
Genomics
Delivery of Health Care
Public-Private Sector Partnerships
Genetic Research
1999
26 Citations (Scopus)

Building population genetics resources using the U.K. NHS

Fears, R. & Poste, G., Apr 9 1999, In : Science. 284, 5412, p. 267-268 2 p.

Research output: Contribution to journalArticle

Factual Databases
Genetic Privacy
Computerized Medical Records Systems
State Medicine
Research Subjects
7 Citations (Scopus)

Privacy and confidentiality in the age of genetic engineering.

Poste, G., 1999, In : Texas review of law & politics. 4, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Genetic Privacy
Genetic Research
Genetic Engineering
Privacy
Confidentiality
16 Citations (Scopus)

The impact of genetics on medical education and training

Fears, R., Weatherall, D. & Poste, G., 1999, In : British Medical Bulletin. 55, 2, p. 460-470 11 p.

Research output: Contribution to journalArticle

Medical Education
Research
Genetic Services
Technology
Policy Making
1998
11 Citations (Scopus)

Molecular medicine and information-based targeted healthcare.

Poste, G., May 1998, In : Nature Biotechnology. 16 Suppl, p. 19-21 3 p.

Research output: Contribution to journalArticle

Factual Databases
Entrepreneurship
Molecular Medicine
Computer Communication Networks
Medical Informatics
227 Citations (Scopus)

Possible involvement of stress-activated protein kinase signaling pathway and fas receptor expression in prevention of ischemia/reperfusion- induced cardiomyocyte apoptosis by carvedilol

Yue, T. L., Ma, X. L., Wang, X., Romanic, A. M., Liu, G. L., Louden, C., Gu, J. L., Kumar, S., Poste, G., Ruffolo, R. R. & Feuerstein, G. Z., Feb 9 1998, In : Circulation Research. 82, 2, p. 166-174 9 p.

Research output: Contribution to journalArticle

CD95 Antigens
Heat-Shock Proteins
Cardiac Myocytes
Protein Kinases
Reperfusion
1997
3 Citations (Scopus)

Life-sciences R and D, national prosperity, and industrial competitiveness

Fears, R., Ferguson, M. W. J., Stewart, W. & Poste, G., May 2 1997, In : Science. 276, 5313, p. 759-760 2 p.

Research output: Contribution to journalArticle

Technology Transfer
Biological Science Disciplines
European Union
Industry
Research
84 Citations (Scopus)

Parkinson's disease: Prospects for improved drug therapy

Hagan, J. J., Middlemiss, D. N., Sharpe, P. C. & Poste, G., May 1 1997, In : Trends in Pharmacological Sciences. 18, 5, p. 156-163 8 p.

Research output: Contribution to journalArticle

Drug therapy
Parkinson Disease
Levodopa
Drug Therapy
Selegiline
1 Citation (Scopus)

Patents, ethics and improving healthcare.

Poste, G., Roberts, D. & Gentry, S., 1997, In : Bulletin of Medical Ethics. No. 124, p. 29-31 3 p.

Research output: Contribution to journalArticle

International Cooperation
Internationality
Patents
Drug Industry
Jurisprudence

Re-classification of NSAIDs (multiple letters) [2]

Griswold, D. E., Ruffolo, R. R., Poste, G. & Torphy, T. J., 1997, In : Trends in Pharmacological Sciences. 18, 9, p. 311-312 2 p.

Research output: Contribution to journalArticle

Cyclooxygenase Inhibitors
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
159 Citations (Scopus)

The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics

Chopra, I., Hodgson, J., Metcalf, B. & Poste, G., Mar 1997, In : Antimicrobial Agents and Chemotherapy. 41, 3, p. 497-503 7 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Anti-Infective Agents
Anti-Bacterial Agents
Bacteria
1996
55 Citations (Scopus)

New approaches to the control of infections caused by antibiotic-resistant bacteria: An industry perspective

Chopra, I., Hodgson, J., Metcalf, B. & Poste, G., 1996, In : Journal of the American Medical Association. 275, 5, p. 401-403 3 p.

Research output: Contribution to journalArticle

Bacterial Vaccines
Communicable Disease Control
Bacterial Genes
Drug Design
Drug Industry
64 Citations (Scopus)

Tumor heterogeneity and progression: Conceptual foundations for modeling

Greller, L. D., Tobin, F. L. & Poste, G., 1996, In : Invasion and Metastasis. 16, 4-5, p. 177-208 32 p.

Research output: Contribution to journalArticle

Neoplasms
Growth
Theoretical Models
Language
Population
1995
32 Citations (Scopus)

Carvedilol update III: Rationale for use in congestive heart failure

Feuerstein, G. Z., Poste, G. & Ruffolo, R. R., 1995, In : Drugs of Today. 31, 5, p. 307-326 20 p.

Research output: Contribution to journalArticle

Heart Failure
Placebos
Cardiovascular Agents
Mortality
Digitalis
8 Citations (Scopus)

Carvedilol update III: Rationale for use in congestive heart failure

Feuerstein, G. Z., Poste, G. & Ruffolo, R. R., 1995, In : Drugs of Today. 31, SUPPL. F, p. 1-23 23 p.

Research output: Contribution to journalArticle

Heart Failure
Mortality
carvedilol
Reactive Oxygen Species
Myocardium
15 Citations (Scopus)

The case for genomic patenting

Poste, G., 1995, In : Nature. 378, 6557, p. 534-536 3 p.

Research output: Contribution to journalArticle

Intellectual Property
Ownership
Routine Diagnostic Tests
Vaccines
Research
1994
12 Citations (Scopus)

Circumvention of multidrug resistance in murine fibrosarcoma and colon carcinoma cells by treatment with the α-adrenoceptor antagonist furobenzazepine

Fan, D., Poste, G., Ruffolo, R. R., Dong, Z., Seid, C., Earnest, L. E., Campbell, T. E., Clyne, R. K., Beltran, P. J. & Fidler, I. J., 1994, In : International Journal of Oncology. 4, 4, p. 789-798 10 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Multiple Drug Resistance
Adrenergic Receptors
Colon
Carcinoma
1 Citation (Scopus)

Novel agents in the treatment of atherosclerosis

Fears, R., Suckling, K. & Poste, G., May 1 1994, In : Expert Opinion on Investigational Drugs. 3, 5, p. 481-491 11 p.

Research output: Contribution to journalArticle

Atherosclerosis
Research
Fibric Acids
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
2 Citations (Scopus)
Fibrinolytic Agents
Creativity
Plasminogen Activators
Biomarkers
Myocardial Infarction
23 Citations (Scopus)

Reversal of multidrug resistance in murine fibrosarcoma cells by thioxanthene flupentixol

Fan, D., Poste, G., Seid, C., Earnest, L. E., Bull, T., Clyne, R. K. & Fidler, I. J., Sep 1994, In : Investigational New Drugs. 12, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

Thioxanthenes
Flupenthixol
Fibrosarcoma
Multiple Drug Resistance
Pharmaceutical Preparations
175 Citations (Scopus)

SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist

Ohlstein, E. H., Nambi, P., Douglas, S. A., Edwards, R. M., Gellai, M., Lago, A., Leber, J. D., Cousins, R. D., Gao, A., Frazee, J. S., Peishoff, C. E., Bean, J. W., Eggleston, D. S., Elshourbagy, N. A., Kumar, C., Lee, J. A., Yue, T. L., Louden, C., Brooks, D. P., Weinstock, J. & 5 others, Feuerstein, G., Poste, G., Ruffolo, R. R., Gleason, J. G. & Elliott, J. D., Aug 16 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 17, p. 8052-8056 5 p.

Research output: Contribution to journalArticle

Endothelins
Endothelin-1
Neointima
Endothelin Receptors
Balloon Angioplasty
1993
155 Citations (Scopus)

Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury

Ohlstein, E. H., Douglas, S. A., Sung, C. P., Yue, T. L., Louden, C., Arleth, A., Poste, G., Ruffolo, R. R. & Feuerstein, G. Z., Jul 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 6189-6193 5 p.

Research output: Contribution to journalArticle

Cardiovascular Agents
Vascular System Injuries
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement
14 Citations (Scopus)

Chemical derivatization of therapeutic proteins

Smith, R. A. G., Dewdney, J. M., Fears, R. & Poste, G., 1993, In : Trends in Biotechnology. 11, 9, p. 397-403 7 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Proteins
Protein Engineering
Chemical modification
Biological Availability
1992
68 Citations (Scopus)

Carvedilol: A novel cardiovascular drug with multiple actions

Ruffolo, R. R., Boyle, D. A., Brooks, D. P., Feuerstein, G. Z., Venuti, R. P., Lukas, M. A. & Poste, G., 1992, In : Cardiovascular Drug Reviews. 10, 2, p. 127-157 31 p.

Research output: Contribution to journalArticle

Cardiovascular Agents
Adrenergic Receptors
Antihypertensive Agents
Pharmaceutical Preparations
Vascular Resistance
70 Citations (Scopus)

Development of GPIIb/IIIa antagonists as antithrombotic drugs

Nichols, A. J., Ruffolo, R. R., Huffman, W. F., Poste, G. & Samanen, J., 1992, In : Trends in Pharmacological Sciences. 13, C, p. 413-417 5 p.

Research output: Contribution to journalArticle

Platelets
Thrombosis
Adhesion
Agglomeration
Cerebrovascular Disorders
1991
21 Citations (Scopus)

From vasopressin antagonist to agonist: A saga of surprise!

Ruffolo, R., Brooks, D. P., Huffman, W. F. & Poste, G., 1991, In : Drug News and Perspectives. 4, 4, p. 217-222 6 p.

Research output: Contribution to journalArticle

Antidiuretic Hormone Receptor Antagonists