George Pettit

Regents Professor

  • 31556 Citations
  • 89 h-Index
1954 …2020

Research output per year

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Research Output

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Article
2020

Interaction of diazonamide A with tubulin

Bai, R., Cruz-Monserrate, Z., Fenical, W., Pettit, G. R. & Hamel, E., Feb 15 2020, In : Archives of Biochemistry and Biophysics. 680, 108217.

Research output: Contribution to journalArticle

2018

Antineoplastic Agents. 605. Isoquinstatins

Pettit, G., Melody, N. & Chapuis, J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 451-457 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Antineoplastic Agents. 606. the Betulastatins

Pettit, G., Melody, N. & Chapuis, J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 458-464 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Antineoplastic Agents. 604. the Path of Quinstatin Derivatives to Antibody Drug Conjugates

Pettit, G., Melody, N. & Chapuis, J., Jan 1 2017, In : Journal of Natural Products. 80, 9, p. 2447-2452 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications

Pettit, G., Searcy, J. D., Tan, R., Cragg, G. M., Melody, N., Knight, J. C. & Chapuis, J., Mar 25 2016, In : Journal of Natural Products. 79, 3, p. 507-518 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

Pettit, G., Ye, Q., Herald, D. L., Knight, J. C., Hogan, F., Melody, N., Mukku, V. J. R. V., Doubek, D. L. & Chapuis, J., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1598-1603 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Antineoplastic agents. 599. Total synthesis of dolastatin 16

Pettit, G., Smith, T. H., Arce, P. M., Flahive, E. J., Anderson, C. R., Chapuis, J., Xu, J-P., Groy, T. L., Belcher, P. E. & Macdonald, C. B., Mar 27 2015, In : Journal of Natural Products. 78, 3, p. 476-485 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Antineoplastic agents. 600. from the south pacific ocean to the silstatins

Pettit, G., Arce, P. M., Chapuis, J. & Macdonald, C. B., Mar 27 2015, In : Journal of Natural Products. 78, 3, p. 510-523 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

Pettit, G., Tan, R., Pettit, R., Doubek, D. L., Chapuis, J. & Weber, C. A., 2015, In : RSC Advances. 5, 12, p. 9116-9122 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure-Function Relationships

Kedei, N., Kraft, M. B., Keck, G. E., Herald, C. L., Melody, N., Pettit, G. & Blumberg, P. M., Apr 24 2015, In : Journal of Natural Products. 78, 4, p. 896-900 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

The cephalostatins. 23. Conversion of hecogenin to a steroidal 1,6-dioxaspiro[5.5]nonane analogue for cephalostatin 11

Pettit, G., Moser, B. R., Herald, D. L., Knight, J. C., Chapuis, J. & Zheng, X., May 22 2015, In : Journal of Natural Products. 78, 5, p. 1067-1072 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

Pettit, G., Xu, J-P., Chapuis, J. & Melody, N., Jun 26 2015, In : Journal of Natural Products. 78, 6, p. 1446-1450 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Antineoplastic agents. 595. structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer1

Pettit, G., Melody, N., Hempenstall, F., Chapuis, J., Groy, T. L. & Williams, L., Apr 25 2014, In : Journal of Natural Products. 77, 4, p. 863-872 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

Pettit, G., Tang, Y., Zhang, Q., Bourne, G. T., Arm, C. A., Leet, J. E., Knight, J. C., Pettit, R., Chapuis, J., Doubek, D. L., Ward, F. J., Weber, C. & Hooper, J. N. A., Mar 22 2013, In : Journal of Natural Products. 76, 3, p. 420-424 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

Hadimani, M. B., MacDonough, M. T., Ghatak, A., Strecker, T. E., Lopez, R., Sriram, M., Nguyen, B. L., Hall, J. J., Kessler, R. J., Shirali, A. R., Liu, L., Garner, C. M., Pettit, G., Hamel, E., Chaplin, D. J., Mason, R. P., Trawick, M. L. & Pinney, K. G., Sep 27 2013, In : Journal of Natural Products. 76, 9, p. 1668-1678 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012

Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs

Pettit, G., Rosenberg, H. J., Dixon, R., Knight, J. C., Hamel, E., Chapuis, J., Pettit, R., Hogan, F., Sumner, B., Ain, K. B. & Trickey-Platt, B., Mar 23 2012, In : Journal of Natural Products. 75, 3, p. 385-393 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies(1)

Pettit, G., Tan, R., Bao, G. H., Melody, N., Doubek, D. L., Gao, S., Chapuis, J. & Williams, L., Apr 27 2012, In : Journal of Natural Products. 75, 4, p. 771-773 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis

Lubahn, C., Schaller, J. A., Shewmacker, E., Wood, C., Bellinger, D. L., Byron, D., Melody, N., Pettit, G. & Lorton, D., Dec 1 2012, In : Rheumatology International. 32, 12, p. 3751-3760 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Cephalostatins. 22. Synthesis of bis-steroidal pyrazine pyrones

Pettit, G., Moser, B. R., Mendonça, R. F., Knight, J. C. & Hogan, F., Jun 22 2012, In : Journal of Natural Products. 75, 6, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids

Abi-Ghanem, D., Lai, X., Berghman, L. R., Horvat, D., Li, J., Romo, D., Uddin, M. N., Kamano, Y., Nogawa, T., Xu, J-P., Pettit, G. & Puschett, J. B., Jan 1 2011, In : Journal of Immunoassay and Immunochemistry. 32, 1, p. 31-46 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units

Pettit, G., Smith, T. H., Xu, J-P., Herald, D. L., Flahive, E. J., Anderson, C. R., Belcher, P. E. & Knight, J. C., May 27 2011, In : Journal of Natural Products. 74, 5, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10

Pettit, G., Hogan, F. & Toms, S., May 27 2011, In : Journal of Natural Products. 74, 5, p. 962-968 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Interactions of halichondrin B and eribulin with tubulin

Bai, R., Nguyen, T. L., Burnett, J. C., Atasoylu, O., Munro, M. H. G., Pettit, G., Smith, A. B., Gussio, R. & Hamel, E., Jun 27 2011, In : Journal of Chemical Information and Modeling. 51, 6, p. 1393-1404 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1

Tanpure, R. P., Nguyen, B. L., Strecker, T. E., Aguirre, S., Sharma, S., Chaplin, D. J., Siim, B. G., Hamel, E., Lippert, J. W., Pettit, G., Trawick, M. L. & Pinney, K. G., Jul 22 2011, In : Journal of Natural Products. 74, 7, p. 1568-1574 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1)

Pettit, G., Mendonca, R. F., Knight, J. C. & Pettit, R., Sep 23 2011, In : Journal of Natural Products. 74, 9, p. 1922-1930 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin a-4 phosphate and other Z-combretastatins

Pettit, G., Minardi, M. D., Hogan, F. & Price, P. M., Mar 26 2010, In : Journal of Natural Products. 73, 3, p. 399-403 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antineoplastic agents. 556. Isolation and structure of coprinastatin 1 from coprinus cinereus

Pettit, G., Meng, Y., Pettit, R., Herald, D. L., Cichacz, Z., Doubek, D. L. & Richert, L., Mar 26 2010, In : Journal of Natural Products. 73, 3, p. 388-392 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

Pettit, G., Ye, Q., Herald, D. L., Hogan, F. & Pettit, R., Feb 26 2010, In : Journal of Natural Products. 73, 2, p. 164-166 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae)

Pettit, G., Meng, Y., Pettit, R., Herald, D. L., Hogan, F. & Cichacz, Z., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 4879-4883 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cytotoxic lipid esters from Peucedanum ledebourielloides

Zheng, X., Du, J., Xu, Y., Liao, D. & Pettit, G., May 1 2010, In : Medicinal Chemistry Research. 19, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture

Pettit, R., Pettit, G., Xu, J-P., Weber, C. A. & Richert, L. A., Apr 5 2010, In : Planta Medica. 76, 5, p. 500-501 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10

Prokopiou, E. M., Cooper, P. A., Pettit, G., Bibby, M. C. & Stevend, S. D., Mar 1 2010, In : Molecular Medicine Reports. 3, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine

Pettit, G., Ducki, S., Eastham, S. A. & Melody, N., Jul 24 2009, In : Journal of Natural Products. 72, 7, p. 1279-1282 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2

Pettit, G., Quistorf, P. D., Fry, J. A., Herald, D. L., Hamel, E. & Chapuis, J., May 22 2009, In : Journal of Natural Products. 72, 5, p. 876-883 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

Pettit, G., Knight, J. C., Herald, D. L., Pettit, R., Hogan, F., Mukku, V. J. R. V., Hamblin, J. S., Dodson, M. J. & Chapuis, J., Mar 27 2009, In : Journal of Natural Products. 72, 3, p. 366-371 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Antineoplastic agents. 571. total synthesis of bacillistatin 2

Pettit, G., Hu, S., Knight, J. C. & Chapuis, J., Mar 27 2009, In : Journal of Natural Products. 72, 3, p. 372-379 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Antineoplastic agents. 575. The fungus Aspergillus phoenicis

Pettit, G., Du, J., Pettit, R., Knight, J. C. & Doubek, D. L., Jul 29 2009, In : Heterocycles. 79, C, p. 909-916 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Antineoplastic agents. 578. synthesis of stilstatins 1 and 2 and their water-soluble prodrugs

Pettit, G., Thornhill, A., Melody, N. & Knight, J. C., Mar 27 2009, In : Journal of Natural Products. 72, 3, p. 380-388 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: A resveratrol structural modification

Pettit, G., Melody, N., Thornhill, A., Knight, J. C., Groy, T. L. & Herald, C. L., Sep 25 2009, In : Journal of Natural Products. 72, 9, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
49 Scopus citations

Density functional study on the structural conformations and intramolecular charge transfer from the vibrational spectra of the anticancer drug combretastatin-A2

Padmaja, L., Ravikumar, C., Sajan, D., Joe, I. H., Jayakumar, V. S., Pettit, G. & Nielsen, O. F., Apr 1 2009, In : Journal of Raman Spectroscopy. 40, 4, p. 419-428 10 p.

Research output: Contribution to journalArticle

183 Scopus citations

E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory β-E-nitrostyrenes

Pettit, R., Pettit, G., Hamel, E., Hogan, F., Moser, B. R., Wolf, S., Pon, S., Chapuis, J. & Schmidt, J. M., Sep 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 18, p. 6606-6612 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: Correlation with cytotoxicity

Bai, R., Edler, M. C., Bonate, P. L., Copeland, T. D., Pettit, G., Ludueña, R. F. & Hamel, E., Jan 1 2009, In : Molecular Pharmacology. 75, 1, p. 218-226 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms

Pettit, R., Weber, C. A., Lawrence, S. B., Pettit, G., Kean, M. J. & Cage, G. D., Sep 1 2009, In : Journal of Medical Microbiology. 58, 9, p. 1203-1206 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms

Pettit, G., Hogan, F., Xu, J-P., Tan, R., Nogawa, T., Cichacz, Z., Pettit, R., Du, J., Ye, Q. H., Cragg, G. M., Herald, C. L., Hoard, M. S., Goswami, A., Searcy, J., Tackett, L., Doubek, D. L., Williams, L., Hooper, J. N. A., Schmidt, J. M., Chapuis, J. & 2 others, Tackett, D. N. & Craciunescu, F., Mar 1 2008, In : Journal of Natural Products. 71, 3, p. 438-444 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Antineoplastic agents. 552. Oxidation of combretastatin A-1: Trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug

Pettit, G., Thornhill, A. J., Moser, B. R. & Hogan, F., Sep 1 2008, In : Journal of Natural Products. 71, 9, p. 1561-1563 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

Pettit, G., Mukku, V. J. R. V., Cragg, G., Herald, D. L., Knight, J. C., Herald, C. L. & Chapuis, J., Jan 1 2008, In : Journal of Natural Products. 71, 1, p. 130-133 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents

Siles, R., Ackley, J. F., Hadimani, M. B., Hall, J. J., Mugabe, B. E., Guddneppanavar, R., Monk, K. A., Chapuis, J., Pettit, G., Chaplin, D. J., Edvardsen, K., Trawick, M. L., Garner, C. M. & Pinney, K. G., Mar 1 2008, In : Journal of Natural Products. 71, 3, p. 313-320 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4

Hall, J. J., Sriram, M., Strecker, T. E., Tidmore, J. K., Jelinek, C. J., Kumar, G. D. K., Hadimani, M. B., Pettit, G., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., Sep 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 18, p. 5146-5149 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vitro interactions of approved and experimental drugs against Candida albicans and Aspergillus spp.

Repp, K. K., Hogan, F., Pettit, G. & Pettit, R., Feb 2008, In : Journal of Chemotherapy. 20, 1, p. 137-139 3 p.

Research output: Contribution to journalArticle