Dorothy Banks

Professor

  • 2137 Citations
  • 27 h-Index
1991 …2020
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Research Output 1991 2019

  • 2137 Citations
  • 27 h-Index
  • 50 Article
  • 2 Review article
  • 1 Letter
  • 1 Short survey
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Article
2019

A novel biomarker of cardiometabolic pathology in schizophrenia?

Lee, E. E., Sears, D. D., Liu, J., Jin, H., Tu, X. M., Eyler, L. T. & Jeste, D. V., Oct 2019, In : Journal of Psychiatric Research. 117, p. 31-37 7 p.

Research output: Contribution to journalArticle

Adiponectin
Schizophrenia
Biomarkers
Pathology
Molecular Weight

Arriba por la Vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas

Takemoto, M., Schechtman, M., Villa, N., Talavera, G., Sears, D. D., Natarajan, L., Owen, N., Rosenberg, D. E., Dunstan, D., Allison, M. & Kerr, J., Apr 2019, In : Contemporary Clinical Trials. 79, p. 66-72 7 p.

Research output: Contribution to journalArticle

Hispanic Americans
Cardiovascular Diseases
Motivational Interviewing
House Calls
Thigh

Association of low fasting glucose and HbA1c with cardiovascular disease and mortality: The MESA study

Mongraw-Chaffin, M., Bertoni, A. G., Golden, S. H., Mathioudakis, N., Sears, D. D., Szklo, M. & Anderson, C. A. M., May 1 2019, In : Journal of the Endocrine Society. 3, 5, p. 892-901 10 p.

Research output: Contribution to journalArticle

Open Access
Fasting
Hemoglobins
Cardiovascular Diseases
Glucose
Mortality

Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

Weiner, L. S., Takemoto, M., Godbole, S., Nelson, S. H., Natarajan, L., Sears, D. D. & Hartman, S. J., Jan 1 2019, (Accepted/In press) In : Journal of Cancer Survivorship.

Research output: Contribution to journalArticle

Survivors
Exercise
Breast Neoplasms
Light
Neoplasms

Modeling Temporal Variation in Physical Activity Using Functional Principal Components Analysis

Xu, S. Y., Nelson, S., Kerr, J., Godbole, S., Johnson, E., Patterson, R. E., Rock, C. L., Sears, D. D., Abramson, I. & Natarajan, L., Jul 15 2019, In : Statistics in Biosciences. 11, 2, p. 403-421 19 p.

Research output: Contribution to journalArticle

Open Access
Functional Principal Component Analysis
Principal Component Analysis
Principal component analysis
Health
Exercise

Protocol for a cross sectional study of cancer risk, environmental exposures and lifestyle behaviors in a diverse community sample: The Community of Mine study

Jankowska, M. M., Sears, D. D., Natarajan, L., Martinez, E., Anderson, C. A. M., Sallis, J. F., Matthews, S. A., Crist, K., Dillon, L., Johnson, E., Barrera-Ng, A., Full, K., Godbole, S. & Kerr, J., Feb 13 2019, In : BMC public health. 19, 1, 186.

Research output: Contribution to journalArticle

Open Access
Environmental Exposure
Life Style
Cross-Sectional Studies
Tumor Biomarkers
Exercise

Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study

Pacheco, L. S., Anderson, C. A. M., Lacey, J. V., Giovannucci, E. L., Lemus, H., Araneta, M. R. G., Sears, D. D., Talavera, G. A. & Martinez, M. E., Jan 1 2019, In : PloS one. 14, 10, e0223638.

Research output: Contribution to journalArticle

Open Access
Beverages
teachers
colorectal neoplasms
Sugars
beverages
55 Citations (Scopus)

The NASA twins study: A multidimensional analysis of a year-long human spaceflight

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A. & 62 others, Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. & Turek, F. W., Jan 1 2019, In : Science. 364, 6436, eaau8650.

Research output: Contribution to journalArticle

United States National Aeronautics and Space Administration
Space Flight
Twin Studies
Telomere
Astronauts
2018
4 Citations (Scopus)

AIBP protects against metabolic abnormalities and atherosclerosis

Schneider, D. A., Choi, S. H., Agatisa-Boyle, C., Zhu, L., Kim, J., Pattison, J., Sears, D. D., Gordts, P. L. S. M., Fang, L. & Miller, Y. I., Jan 1 2018, In : Journal of Lipid Research. 59, 5, p. 854-863 10 p.

Research output: Contribution to journalArticle

Atherosclerosis
Carrier Proteins
Nutrition
Cholesterol
High Fat Diet
1 Citation (Scopus)

Associations of sedentary behavior and abdominal muscle density: The multi-ethnic study of atherosclerosis

Vella, C. A., Michos, E. D., Sears, D. D., Cushman, M., Van Hollebeke, R. B., Wiest, M. M. & Allison, M. A., Nov 2018, In : Journal of Physical Activity and Health. 15, 11, p. 827-833 7 p.

Research output: Contribution to journalArticle

Abdominal Muscles
Metabolic Equivalent
Atherosclerosis
Muscles
Exercise

Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks

Xu, S., Thompson, W., Kerr, J., Godbole, S., Sears, D. D., Patterson, R. & Natarajan, L., Sep 2018, In : PloS one. 13, 9, e0202923.

Research output: Contribution to journalArticle

Open Access
Health Behavior
Bayesian networks
sleep
breast neoplasms
body mass index
6 Citations (Scopus)

Obesity-induced changes in lipid mediators persist after weight loss

Hernandez-Carretero, A., Weber, N., La Frano, M. R., Ying, W., Lantero Rodriguez, J., Sears, D. D., Wallenius, V., Börgeson, E., Newman, J. W. & Osborn, O., Apr 1 2018, In : International Journal of Obesity. 42, 4, p. 728-736 9 p.

Research output: Contribution to journalArticle

prostaglandin R2 D-isomerase
Weight Loss
Obesity
Lipids
Prostaglandins D
31 Citations (Scopus)

Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study

Hartman, S. J., Nelson, S. H., Myers, E., Natarajan, L., Sears, D. D., Palmer, B. W., Weiner, L. S., Parker, B. A. & Patterson, R. E., Jan 1 2018, In : Cancer. 124, 1, p. 192-202 11 p.

Research output: Contribution to journalArticle

Survivors
Randomized Controlled Trials
Exercise
Cognition
Breast Neoplasms
5 Citations (Scopus)

Sedentary behaviors and biomarkers among breast cancer survivors

Hartman, S. J., Marinac, C. R., Cadmus-Bertram, L., Kerr, J., Natarajan, L., Godbole, S., Patterson, R. E., Morey, B. & Sears, D. D., Jan 2018, In : Journal of Physical Activity and Health. 15, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Biomarkers
Insulin Resistance
Breast Neoplasms
C-Reactive Protein
Linear Models
7 Citations (Scopus)

The effects of metformin and weight loss on biomarkers associated with breast cancer outcomes

Patterson, R. E., Marinac, C. R., Sears, D. D., Kerr, J., Hartman, S. J., Cadmus-Bertram, L., Villaseñor, A., Flatt, S. W., Godbole, S., Li, H., Laughlin, G. A., Oratowski-Coleman, J., Parker, B. A. & Natarajan, L., Jan 1 2018, In : Journal of the National Cancer Institute. 110, 11, djy040.

Research output: Contribution to journalArticle

Metformin
Weight Loss
Biomarkers
Confidence Intervals
Breast Neoplasms
2017
3 Citations (Scopus)

Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial

Kerr, J., Crist, K., Vital, D. G., Dillon, L., Aden, S. A., Trivedi, M., Castellanos, L. R., Godbole, S., Li, H., Allison, M. A., Khemlina, G. L., Takemoto, M. L., Schenk, S., Sallis, J. F., Grace, M., Dunstan, D. W., Natarajan, L., LaCroix, A. Z. & Sears, D. D., Nov 2017, In : PloS one. 12, 11, e0188544.

Research output: Contribution to journalArticle

Open Access
meals (menu)
blood vessels
Cross-Over Studies
Area Under Curve
Blood Vessels
6 Citations (Scopus)

A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative

Mongraw-Chaffin, M., LaCroix, A. Z., Sears, D. D., Garcia, L., Phillips, L. S., Salmoirago-Blotcher, E., Zaslavsky, O. & Anderson, C. A. M., May 1 2017, In : Metabolism: Clinical and Experimental. 70, p. 116-124 9 p.

Research output: Contribution to journalArticle

Women's Health
Fasting
Cardiovascular Diseases
Prospective Studies
Glucose
2 Citations (Scopus)

Research article kernel density estimation as a measure of environmental exposure related to insulin resistance in breast cancer survivors

Jankowska, M. M., Natarajan, L., Godbole, S., Meseck, K., Sears, D. D., Patterson, R. E. & Kerr, J., Jul 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 7, p. 1078-1084 7 p.

Research output: Contribution to journalArticle

Open Access
Spatial Analysis
Environmental Exposure
Recreation
Geographic Information Systems
Survivors
2016
23 Citations (Scopus)

Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress

Eguchi, A., Lazic, M., Armando, A. M., Phillips, S. A., Katebian, R., Maraka, S., Quehenberger, O., Sears, D. D. & Feldstein, A. E., Nov 1 2016, In : Journal of Molecular Medicine. 94, 11, p. 1241-1253 13 p.

Research output: Contribution to journalArticle

Physiological Stress
Adipocytes
Obese Mice
Diet
Obesity
73 Citations (Scopus)

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

Li, P., Liu, S., Lu, M., Bandyopadhyay, G., Oh, D., Imamura, T., Johnson, A. M. F., Sears, D., Shen, Z., Cui, B., Kong, L., Hou, S., Liang, X., Iovino, S., Watkins, S. M., Ying, W., Osborn, O., Wollam, J., Brenner, M. & Olefsky, J. M., Nov 3 2016, In : Cell. 167, 4, p. 973-984.e12

Research output: Contribution to journalArticle

Open Access
Galectin 3
Insulin Resistance
Insulin
Macrophages
Obese Mice
28 Citations (Scopus)

Prolonged nightly fasting and breast cancer prognosis

Marinac, C. R., Nelson, S. H., Breen, C. I., Hartman, S. J., Natarajan, L., Pierce, J. P., Flatt, S. W., Sears, D. D. & Patterson, R. E., Aug 2016, In : JAMA Oncology. 2, 8, p. 1049-1055 7 p.

Research output: Contribution to journalArticle

Open Access
Fasting
Breast Neoplasms
Sleep
Recurrence
C-Reactive Protein
21 Citations (Scopus)

Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity

Chung, H., Chou, W., Sears, D. D., Patterson, R. E., Webster, N. J. G. & Ellies, L. G., Dec 1 2016, In : Metabolism: Clinical and Experimental. 65, 12, p. 1743-1754 12 p.

Research output: Contribution to journalArticle

Insulin Resistance
Obesity
Liver
Fasting
Gluconeogenesis
2015
6 Citations (Scopus)

Evaluation of the synuclein-γ (sncg) gene as a PPARγ target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue

Dunn, T. N., Akiyama, T., Lee, H. W., Kim, J. B., Knotts, T. A., Smith, S. R., Sears, D. D., Carstens, E. & Adams, S. H., Mar 1 2015, In : PloS one. 10, 3, e0115830.

Research output: Contribution to journalArticle

Open Access
Synucleins
Peroxisome Proliferator-Activated Receptors
Spinal Ganglia
adipocytes
Adipocytes
26 Citations (Scopus)

Frequency and circadian timing of eating may influence biomarkers of inflammation and insulin resistance associated with breast cancer risk

Marinac, C. R., Sears, D. D., Natarajan, L., Gallo, L. C., Breen, C. I. & Patterson, R. E., Aug 25 2015, In : PloS one. 10, 8, e0136240.

Research output: Contribution to journalArticle

Open Access
Biomarkers
insulin resistance
breast neoplasms
C-Reactive Protein
Insulin Resistance
27 Citations (Scopus)

Gender and age differences in hourly and daily patterns of sedentary time in older adults living in retirement communities

Bellettiere, J., Carlson, J. A., Rosenberg, D., Singhania, A., Natarajan, L., Berardi, V., LaCroix, A. Z., Sears, D. D., Moran, K., Crist, K. & Kerr, J., Aug 21 2015, In : PloS one. 10, 8, e0136161.

Research output: Contribution to journalArticle

Open Access
retirement communities
Retirement
Health risks
Accelerometers
gender differences
15 Citations (Scopus)

Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion

Hartman, S. J., Natarajan, L., Palmer, B. W., Parker, B., Patterson, R. E. & Sears, D. D., Nov 1 2015, In : Contemporary Clinical Trials. 45, p. 371-376 6 p.

Research output: Contribution to journalArticle

Survivors
Exercise
Breast Neoplasms
Arm
Cognition
53 Citations (Scopus)

Intermittent Fasting and Human Metabolic Health

Patterson, R. E., Laughlin, G. A., LaCroix, A. Z., Hartman, S. J., Natarajan, L., Senger, C. M., Martínez, M. E., Villaseñor, A., Sears, D. D., Marinac, C. R. & Gallo, L. C., Aug 1 2015, In : Journal of the Academy of Nutrition and Dietetics. 115, 8, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer

Chung, H., Lee, Y. S., Mayoral, R., Oh, D. Y., Siu, J. T., Webster, N. J., Sears, D. D., Olefsky, J. M. & Ellies, L. G., Jul 1 2015, In : Oncogene. 34, 27, p. 3504-3513 10 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
G-Protein-Coupled Receptors
Obesity
Breast Neoplasms
Breast
25 Citations (Scopus)

Prolonged nightly fasting and breast cancer risk: Findings from NHANES (2009-2010)

Marinac, C. R., Natarajan, L., Sears, D. D., Gallo, L. C., Hartman, S. J., Arredondo, E. & Patterson, R. E., May 1 2015, In : Cancer Epidemiology Biomarkers and Prevention. 24, 5, p. 783-789 7 p.

Research output: Contribution to journalArticle

Open Access
Nutrition Surveys
Fasting
Breast Neoplasms
Glucose
Logistic Models
2014
27 Citations (Scopus)

Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis

Lazic, M., Inzaugarat, M. E., Povero, D., Zhao, I. C., Chen, M., Nalbandian, M., Miller, Y. I., Cherñavsky, A. C., Feldstein, A. E. & Sears, D. D., Sep 24 2014, In : PloS one. 9, 9, e107658.

Research output: Contribution to journalArticle

Open Access
Omega-3 Fatty Acids
High Fat Diet
Fatty Liver
high fat diet
Nutrition
75 Citations (Scopus)

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

Inokuchi-Shimizu, S., Park, E. J., Roh, Y. S., Yang, L., Zhang, B., Song, J., Liang, S., Pimienta, M., Taniguchi, K., Wu, X., Asahina, K., Lagakos, W., Mackey, M. R., Akira, S., Ellisman, M. H., Sears, D. D., Olefsky, J. M., Karin, M., Brenner, D. A. & Seki, E., Aug 1 2014, In : Journal of Clinical Investigation. 124, 8, p. 3566-3578 13 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Carcinogenesis
Phosphotransferases
Fatty Acids
AMP-Activated Protein Kinases
2013
28 Citations (Scopus)

Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients

Qatanani, M., Tan, Y., Dobrin, R., Greenawalt, D. M., Hu, G., Zhao, W., Olefsky, J. M., Sears, D. D., Kaplan, L. M. & Kemp, D. M., Mar 1 2013, In : Diabetes. 62, 3, p. 855-863 9 p.

Research output: Contribution to journalArticle

Open Access
Insulin Resistance
Adipose Tissue
Insulin
Inflammation
Citric Acid Cycle
35 Citations (Scopus)

Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress

Ham, M., Lee, J. W., Choi, A. H., Jang, H., Choi, G., Park, J., Kozuka, C., Sears, D. D., Masuzaki, H. & Kima, J. B., Jun 1 2013, In : Molecular and cellular biology. 33, 12, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Glucosephosphate Dehydrogenase
Oxidative Stress
Macrophages
Lipopolysaccharides
Adipose Tissue
32 Citations (Scopus)

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Patterson, R. E., Colditz, G. A., Hu, F. B., Schmitz, K. H., Ahima, R. S., Brownson, R. C., Carson, K. R., Chavarro, J. E., Chodosh, L. A., Gehlert, S., Gill, J., Glanz, K., Haire-Joshu, D., Herbst, K. L., Hoehner, C. M., Hovmand, P. S., Irwin, M. L., Jacobs, L. A., James, A. S., Jones, L. W. & 25 others, Kerr, J., Kibel, A. S., King, I. B., Ligibel, J. A., Meyerhardt, J. A., Natarajan, L., Neuhouser, M. L., Olefsky, J. M., Proctor, E. K., Redline, S., Rock, C. L., Rosner, B., Sarwer, D. B., Schwartz, J. S., Sears, D. D., Sesso, H. D., Stampfer, M. J., Subramanian, S. V., Taveras, E. M., Tchou, J., Thompson, B., Troxel, A. B., Wessling-Resnick, M., Wolin, K. Y. & Thornquist, M. D., Apr 1 2013, In : Cancer Causes and Control. 24, 4, p. 695-704 10 p.

Research output: Contribution to journalArticle

Research
Neoplasms
Organized Financing
Exercise
Survivors
2011
173 Citations (Scopus)

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity

Li, P., Fan, W., Xu, J., Lu, M., Yamamoto, H., Auwerx, J., Sears, D. D., Talukdar, S., Oh, D., Chen, A., Bandyopadhyay, G., Scadeng, M., Ofrecio, J. M., Nalbandian, S. & Olefsky, J. M., Nov 11 2011, In : Cell. 147, 4, p. 815-826 12 p.

Research output: Contribution to journalArticle

Open Access
Co-Repressor Proteins
Peroxisome Proliferator-Activated Receptors
Phosphorylation
Adipocytes
Insulin Resistance
52 Citations (Scopus)

Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

Hsiao, G., Chapman, J., Ofrecio, J. M., Wilkes, J., Resnik, J. L., Thapar, D., Subramaniam, S. & Sears, D. D., Jan 1 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 300, 1, p. E164-E174

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolic Networks and Pathways
Insulin Resistance
Ligands
Insulin
162 Citations (Scopus)

SirT1 regulates adipose tissue inflammation

Gillum, M. P., Kotas, M. E., Erion, D. M., Kursawe, R., Chatterjee, P., Nead, K. T., Muise, E. S., Hsiao, J. J., Frederick, D. W., Yonemitsu, S., Banks, A. S., Qiang, L., Bhanot, S., Olefsky, J. M., Sears, D. D., Caprio, S. & Shulman, G. I., Dec 1 2011, In : Diabetes. 60, 12, p. 3235-3245 11 p.

Research output: Contribution to journalArticle

Sirtuin 1
Adipose Tissue
Inflammation
Macrophages
Overnutrition
2010
145 Citations (Scopus)

Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

Li, P., Lu, M., Nguyen, M. T. A., Bae, E. J., Chapman, J., Feng, D., Hawkins, M., Pessin, J. E., Sears, D. D., Nguyen, A. K., Amidi, A., Watkins, S. M., Nguyen, U. & Olefsky, J. M., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15333-15345 13 p.

Research output: Contribution to journalArticle

Open Access
Obese Mice
Macrophages
Nutrition
Adipose Tissue
Tissue
53 Citations (Scopus)

Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice

Chapman, J., Miles, P. D., Ofrecio, J. M., Neels, J. G., Yu, J. G., Resnik, J. L., Wilkes, J., Talukdar, S., Thapar, D., Johnson, K. & Sears, D. D., Dec 9 2010, In : PloS one. 5, 11, e13959.

Research output: Contribution to journalArticle

Open Access
osteopontin
Osteopontin
High Fat Diet
high fat diet
Nutrition
2009
86 Citations (Scopus)

12/15-Lipoxygenase is equired for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice

Sears, D. D., Miles, P. D., Chapman, J., Ofrecio, J. M., Almazan, F., Thapar, D. & Miller, Y. I., Sep 29 2009, In : PloS one. 4, 9, e7250.

Research output: Contribution to journalArticle

Open Access
High Fat Diet
high fat diet
Nutrition
lipoxygenase
insulin resistance
67 Citations (Scopus)

FOXO1 transrepresses peroxisome proliferator-activated receptor γ transactivation, coordinating an insulin-induced feed-forward response in adipocytes

Fan, W. Q., Imamura, T., Sonoda, N., Sears, D. D., Patsouris, D., Kim, J. J. & Olefsky, J. M., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12188-12197 10 p.

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
Adipocytes
Transcriptional Activation
Insulin
Phosphorylation
65 Citations (Scopus)

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema

Gregoire, F. M., Zhang, F., Clarke, H. J., Gustafson, T. A., Sears, D. D., Favelyukis, S., Lenhard, J., Rentzeperis, D., Clemens, L. E., Mu, Y. & Lavan, B. E., Jul 1 2009, In : Molecular Endocrinology. 23, 7, p. 975-988 14 p.

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
Hypoglycemic Agents
Transcriptional Activation
Weight Gain
Edema
117 Citations (Scopus)

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

Sears, D. D., Hsiao, G., Hsiao, A., Yu, J. G., Courtney, C. H., Ofrecio, J. M., Chapman, J. & Subramaniam, S., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18745-18750 6 p.

Research output: Contribution to journalArticle

Open Access
Insulin Resistance
Insulin
Adipose Tissue
HLA-DRB1 Chains
Peroxisome Proliferator-Activated Receptors
168 Citations (Scopus)

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

Sugii, S., Olson, P., Sears, D. D., Saberi, M., Atkins, A. R., Barish, G. D., Hong, S. H., Castro, G. L., Yin, Y. Q., Nelson, M. C., Hsiao, G., Greaves, D. R., Downes, M., Yu, R. T., Olefsky, J. M. & Evans, R. M., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22504-22509 6 p.

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferators
Adipocytes
Insulin
Thiazolidinediones
Macrophages
2007
56 Citations (Scopus)

Selective modulation of promoter recruitment and transcriptional activity of PPARγ

Sears, D. D., Hsiao, A., Ofrecio, J. M., Chapman, J., He, W. & Olefsky, J. M., Dec 21 2007, In : Biochemical and Biophysical Research Communications. 364, 3, p. 515-521 7 p.

Research output: Contribution to journalArticle

Personnel Selection
Thiazolidinediones
PPAR gamma
Modulation
rosiglitazone
1999
29 Citations (Scopus)

Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis

Cohen, H., Sears, D. D., Zenvirth, D., Hieter, P. & Simchen, G., Jun 1999, In : Molecular and cellular biology. 19, 6, p. 4153-4158 6 p.

Research output: Contribution to journalArticle

Open Access
Yeast Artificial Chromosomes
Gametogenesis
Meiosis
Trinucleotide Repeat Expansion
Trinucleotide Repeats
1995
34 Citations (Scopus)

Cis-acting determinants affecting centromere function, sister-chromatid cohesion and reciprocal recombination during meiosis in Saccharomyces cerevisiae

Sears, D. D., Hegemann, J. H., Shero, J. H. & Hieter, P., Jan 1 1995, In : Genetics. 139, 3, p. 1159-1173 15 p.

Research output: Contribution to journalArticle

Chromatids
Centromere
Meiosis
Genetic Recombination
Saccharomyces cerevisiae
1994
18 Citations (Scopus)

An implanted recombination hot spot stimulates recombination and enhances sister chromatid cohesion of heterologous YACs during yeast meiosis

Sears, D. D., Hieter, P. & Simchen, G., Jan 1 1994, In : Genetics. 138, 4, p. 1055-1065 11 p.

Research output: Contribution to journalArticle

Yeast Artificial Chromosomes
Chromatids
Meiosis
Genetic Recombination
Yeasts
1992
44 Citations (Scopus)
Open Access
Human Artificial Chromosomes
Yeast Artificial Chromosomes
Genetic Recombination
Saccharomyces cerevisiae
Meiosis
1991
39 Citations (Scopus)

High-efficiency yeast artificial chromosome fragmentation vectors

Pavan, W. J., Hieter, P., Sears, D., Burkhoff, A. & Reeves, R. H., Sep 30 1991, In : Gene. 106, 1, p. 125-127 3 p.

Research output: Contribution to journalArticle

Yeast Artificial Chromosomes
Chromosomes
Alu Elements
Homologous Recombination
DNA