Diego Mastroeni

Assistant Research Professor

  • 3153 Citations
  • 24 h-Index
20052023
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Research Output 2005 2019

  • 3153 Citations
  • 24 h-Index
  • 38 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter
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Article
2019

Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., De Both, M. D., Mastroeni, D., Serrano, G. E., Sue, L. I., Beach, T. G., Coleman, P. & Huentelman, M. J., Sep 15 2019, In : Brain Research. 1719, p. 217-224 8 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Temporal Lobe
Alzheimer Disease
RNA
Untranslated RNA
12 Citations (Scopus)

Tau positron-emission tomography in former national football league players

Stern, R. A., Adler, C. H., Chen, K., Navitsky, M., Luo, J., Dodick, D. W., Alosco, M. L., Tripodis, Y., Goradia, D. D., Martin, B., Mastroeni, D., Fritts, N. G., Jarnagin, J., Devous, M. D., Mintun, M. A., Pontecorvo, M. J., Shenton, M. E. & Reiman, E. M., May 2 2019, In : New England Journal of Medicine. 380, 18, p. 1716-1725 10 p.

Research output: Contribution to journalArticle

Football
Positron-Emission Tomography
Amyloid
Confidence Intervals
Neurobehavioral Manifestations
2 Citations (Scopus)

Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., Mastroeni, D. F., Persico, A. M., Jepsen, W. M., Beach, T. G., Huentelman, M. J., Coleman, P. D. & Combs, C., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 3, p. 691-713 23 p.

Research output: Contribution to journalArticle

Temporal Lobe
Transcriptome
Alzheimer Disease
Mitochondria
RNA
2018

Age-related disturbances in DNA (hydroxy)methylation in APP/PS1 mice

Chouliaras, L., Lardenoije, R., Kenis, G., Mastroeni, D., Hof, P. R., Os, J. V., Steinbusch, H. W. M., Van Leeuwen, F. W., Rutten, B. P. F. & Van Den Hove, D. L. A., Dec 31 2018, In : Translational Neuroscience. 9, 1, p. 190-202 13 p.

Research output: Contribution to journalArticle

5-Methylcytosine
DNA Methylation
Hippocampus
Alzheimer Disease
Brain Diseases
11 Citations (Scopus)

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J. & Coleman, P., Mar 1 2018, In : Neurobiology of Aging. 63, p. 12-21 10 p.

Research output: Contribution to journalArticle

Microglia
Hepatitis B
Lasers
Hepatitis B virus
Alzheimer Disease
6 Citations (Scopus)

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

coenzyme Q10
Amyloid
Neuroglia
Neurons
Alzheimer Disease
6 Citations (Scopus)

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

Johansson, J. U., Brubaker, W. D., Javitz, H., Bergen, A. W., Nishita, D., Trigunaite, A., Crane, A., Ceballos, J., Mastroeni, D., Tenner, A. J., Sabbagh, M. & Rogers, J., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Complement C1
Complement Receptors
Amyloid
Alzheimer Disease
Peptides
3 Citations (Scopus)

Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease

Tan, Y., Delvaux, E., Nolz, J., Coleman, P., Chen, S. & Mastroeni, D., Aug 1 2018, In : Neurobiology of Aging. 68, p. 134-141 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase 2
Microglia
Substantia Nigra
Parkinson Disease
Lasers
2017
12 Citations (Scopus)

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

Mastroeni, D., Sekar, S., Nolz, J., Delvaux, E., Lunnon, K., Mill, J., Liang, W. S. & Coleman, P., Jul 1 2017, In : PLoS One. 12, 7, e0177814.

Research output: Contribution to journalArticle

neuroglia
Microglia
Alzheimer disease
lasers
Brain
4 Citations (Scopus)

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's

Delvaux, E., Mastroeni, D., Nolz, J., Chow, N., Sabbagh, M., Caselli, R. J., Reiman, E. M., Marshall, F. J. & Coleman, P., Oct 1 2017, In : Neurobiology of Aging. 58, p. 225-237 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Leukocytes
Multivariate Analysis
Hematologic Tests
Parkinson Disease
13 Citations (Scopus)

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms

Brubaker, W. D., Crane, A., Johansson, J. U., Yen, K., Garfinkel, K., Mastroeni, D., Asok, P., Bradt, B., Sabbagh, M., Wallace, T. L., Glavis-Bloom, C., Tenner, A. J. & Rogers, J., Dec 1 2017, In : Alzheimer's and Dementia. 13, 12, p. 1397-1409 13 p.

Research output: Contribution to journalArticle

Amyloid
Complement C1
Complement Receptors
Erythrocytes
Peptides
2016
35 Citations (Scopus)

Analysis of the putative role of CR1 in Alzheimer's disease: Genetic association, expression and function

Fonseca, M. I., Chu, S., Pierce, A. L., Brubaker, W. D., Hauhart, R. E., Mastroeni, D., Clarke, E. V., Rogers, J., Atkinson, J. P. & Tenner, A. J., Feb 1 2016, In : PLoS One. 11, 2, e0149792.

Research output: Contribution to journalArticle

Alzheimer disease
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Alzheimer Disease
5 Citations (Scopus)

Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

Mastroeni, D., Chouliaras, L., Van den Hove, D. L., Nolz, J., Rutten, B. P. F., Delvaux, E. & Coleman, P., Jun 1 2016, In : Neuroepigenetics. 6, p. 26-31 6 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Brain
Alzheimer Disease
Normal distribution
Cell Proliferation
Chromatin
Brain
Lasers
Genes
Serratia marcescens nuclease
21 Citations (Scopus)

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Alzheimer Disease
Genes
Mitochondrial DNA
Disease Progression
2015
23 Citations (Scopus)

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

Mastroeni, D., Delvaux, E., Nolz, J., Tan, Y., Grover, A., Oddo, S. & Coleman, P., Dec 1 2015, In : Neurobiology of Aging. 36, 12, p. 3121-3129 9 p.

Research output: Contribution to journalArticle

Epigenomics
Alzheimer Disease
Cell Nucleus
Histones
Lysine
10 Citations (Scopus)
Mitochondria
Amyloid
Epigenomics
Antioxidants
Maintenance
2014
54 Citations (Scopus)

HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Nural-Guvener, H. F., Zakharova, L., Nimlos, J., Popovic, S., Mastroeni, D. & Gaballa, M. A., Jul 2 2014, In : Fibrogenesis and Tissue Repair. 7, 1, 10.

Research output: Contribution to journalArticle

Histone Deacetylases
Myofibroblasts
Fibrosis
Heart Failure
Myocardial Infarction
2013
209 Citations (Scopus)

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P., Rutten, B. P. F. & van den Hove, D. L. A., Sep 1 2013, In : Neurobiology of Aging. 34, 9, p. 2091-2099 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Hippocampus
Alzheimer Disease
Epigenomics
Amyloid Plaques
154 Citations (Scopus)

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease

Lucin, K. M., O'Brien, C. E., Bieri, G., Czirr, E., Mosher, K. I., Abbey, R. J., Mastroeni, D., Rogers, J., Spencer, B., Masliah, E. & Wyss-Coray, T., Sep 4 2013, In : Neuron. 79, 5, p. 873-886 14 p.

Research output: Contribution to journalArticle

Phagocytosis
Alzheimer Disease
Autophagy
Brain
Microglia
16 Citations (Scopus)

P53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D. & Scrable, H., Jun 27 2013, In : Oncogene. 32, 26, p. 3165-3174 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Protein Isoforms
Brain
Neoplasms
Gliosis
31 Citations (Scopus)

Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology

Mastroeni, D., Chouliaras, L., Grover, A., Liang, W. S., Hauns, K., Rogers, J. & Coleman, P., Jan 8 2013, In : PLoS One. 8, 1, e53349.

Research output: Contribution to journalArticle

nuclear proteins
Transcription
Alzheimer disease
Nuclear Proteins
pathophysiology
2010
204 Citations (Scopus)

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. & Rogers, J., Dec 1 2010, In : Neurobiology of Aging. 31, 12, p. 2025-2037 13 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Alzheimer Disease
Neurons
Ribosomes
76 Citations (Scopus)

Evidence for an association between KIBRA and late-onset Alzheimer's disease

Corneveaux, J. J., Liang, W. S., Reiman, E. M., Webster, J. A., Myers, A. J., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Craig, D. W., Coon, K. D., Dunckley, T., Bandy, D., Lee, W., Chen, K., Beach, T. G., Mastroeni, D., Grover, A., Ravid, R., Sando, S. B. & 13 others, Aasly, J. O., Heun, R., Jessen, F., Kölsch, H., Rogers, J., Hutton, M. L., Melquist, S., Petersen, R. C., Alexander, G. E., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A. & Huentelman, M. J., Jun 1 2010, In : Neurobiology of Aging. 31, 6, p. 901-909 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Episodic Memory
Gyrus Cinguli
Temporal Lobe
Alleles
80 Citations (Scopus)

Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-δ

van den Berge, S. A., Middeldorp, J., Eleana Zhang, C., Curtis, M. A., Leonard, B. W., Mastroeni, D., Voorn, P., van de Berg, W. D. J., Huitinga, I. & Hol, E. M., Jun 1 2010, In : Aging Cell. 9, 3, p. 313-326 14 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Glial Fibrillary Acidic Protein
Olfactory Bulb
Proliferating Cell Nuclear Antigen
Brain
47 Citations (Scopus)

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C. M., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Apr 1 2010, In : Neurobiology of Aging. 31, 4, p. 549-566 18 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Gene Expression
Brain
Neuropathology
Disease Progression
84 Citations (Scopus)

Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function

Zakharova, L., Mastroeni, D., Mutlu, N., Molina, M., Goldman, S., Diethrich, E. & Gaballa, M. A., Jul 1 2010, In : Cardiovascular Research. 87, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

Heart Transplantation
Stem Cells
Myocardial Infarction
Myocardium
Cell Transplantation
5 Citations (Scopus)

Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from meta-analysis

Webster, J., Reiman, E. M., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Huentelman, M. J., Craig, D. W., Coon, K. D., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L., Kaleem, M., Mastroeni, D., Grover, A., Rogers, J., Heun, R. & 12 others, Jessen, F., Kölsch, H., Heward, C. B., Ravid, R., Hutton, M. L., Melquist, S., Petersen, R. C., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A., Hardy, J. & Myers, A., Jul 21 2010, In : International Journal of Molecular Epidemiology and Genetics. 1, 1, p. 19-30 12 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Peptidyl-Dipeptidase A
Single Nucleotide Polymorphism
Meta-Analysis
Alzheimer Disease
2009
193 Citations (Scopus)

Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

Mastroeni, D., McKee, A., Grover, A., Rogers, J. & Coleman, P., Aug 12 2009, In : PLoS One. 4, 8, e6617.

Research output: Contribution to journalArticle

Monozygotic Twins
Alzheimer disease
Epigenomics
epigenetics
Neurons
58 Citations (Scopus)

Microglial responses to dopamine in a cell culture model of Parkinson's disease

Mastroeni, D., Grover, A., Leonard, B., Joyce, J. N., Coleman, P., Kozik, B., Bellinger, D. L. & Rogers, J., Nov 1 2009, In : Neurobiology of Aging. 30, 11, p. 1805-1817 13 p.

Research output: Contribution to journalArticle

Microglia
Parkinson Disease
Tretinoin
Dopamine
Cell Culture Techniques
33 Citations (Scopus)

Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease

Leonard, B. W., Mastroeni, D., Grover, A., Liu, Q., Yang, K., Gao, M., Wu, J., Pootrakul, D., van den Berge, S. A., Hol, E. M. & Rogers, J., Jul 20 2009, In : Journal of Comparative Neurology. 515, 3, p. 269-294 26 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Neurodegenerative Diseases
Autopsy
Astrocytes
Brain
2008
162 Citations (Scopus)

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: A reference data set

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C. M., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Apr 22 2008, In : Physiological Genomics. 33, 2, p. 240-256 17 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Gene Expression
Brain
Laser Capture Microdissection
Datasets
306 Citations (Scopus)

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

Liang, W. S., Reiman, E. M., Valla, J., Dunckley, T., Beach, T. G., Grover, A., Niedzielko, T. L., Schneider, L. E., Mastroeni, D., Caselli, R., Kukull, W., Morris, J. C., Hulette, C. M., Schmechel, D., Rogers, J. & Stephan, D. A., Mar 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 11, p. 4441-4446 6 p.

Research output: Contribution to journalArticle

Gyrus Cinguli
Energy Metabolism
Alzheimer Disease
Neurons
Genes
2007
391 Citations (Scopus)

GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers

Reiman, E. M., Webster, J. A., Myers, A. J., Hardy, J., Dunckley, T., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Huentelman, MJ. J., Craig, D. W., Coon, K. D., Liang, W. S., Herbert, R. L. H., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L. & 14 others, Kaleem, M., Mastroeni, D., Grover, A., Heward, C. B., Ravid, R., Rogers, J., Hutton, M. L., Melquist, S., Petersen, R. C., Alexander, G. E., Caselli, RJ. J., Kukull, W., Papassotiropoulos, A. & Stephan, D. A., Jun 7 2007, In : Neuron. 54, 5, p. 713-720 8 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Carrier Proteins
Alleles
Single Nucleotide Polymorphism
Alzheimer Disease
134 Citations (Scopus)

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C., Schmechel, D., Alexander, G. E., Reiman, E. M., Rogers, J. & Stephan, D. A., Feb 12 2007, In : Physiological Genomics. 28, 3, p. 311-322 12 p.

Research output: Contribution to journalArticle

Transcriptome
Alzheimer Disease
Brain
Visual Cortex
Pathology
2006
90 Citations (Scopus)

Gene expression correlates of neurofibrillary tangles in Alzheimer's disease

Dunckley, T., Beach, T. G., Ramsey, K. E., Grover, A., Mastroeni, D., Walker, D. G., LaFleur, B. J., Coon, K. D., Brown, K. M., Caselli, R., Kukull, W., Higdon, R., McKeel, D., Morris, J. C., Hulette, C., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Oct 1 2006, In : Neurobiology of Aging. 27, 10, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Alzheimer Disease
Gene Expression
Neurons
Entorhinal Cortex
111 Citations (Scopus)

Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes

Rogers, J., Li, R., Mastroeni, D., Grover, A., Leonard, B., Ahern, G., Cao, P., Kolody, H., Vedders, L., Kolb, W. P. & Sabbagh, M., Dec 1 2006, In : Neurobiology of Aging. 27, 12, p. 1733-1739 7 p.

Research output: Contribution to journalArticle

Complement C3
Amyloid
Alzheimer Disease
Erythrocytes
Complement C3b
2005
25 Citations (Scopus)

Microglial responses to amyloid β peptide opsonization and indomethacin treatment

Strohmeyer, R., Kovelowski, C. J., Mastroeni, D., Leonard, B., Grover, A. & Rogers, J., Aug 19 2005, In : Journal of Neuroinflammation. 2, 18.

Research output: Contribution to journalArticle

Amyloid
Indomethacin
Anti-Inflammatory Agents
Chemotaxis
Phagocytosis