Diego Mastroeni

Assistant Research Professor

  • 3337 Citations
  • 25 h-Index
20052019

Research output per year

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Research Output

  • 3337 Citations
  • 25 h-Index
  • 40 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter
2019

Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood

Lardenoije, R., Roubroeks, J. A. Y., Pishva, E., Leber, M., Wagner, H., Iatrou, A., Smith, A. R., Smith, R. G., Eijssen, L. M. T., Kleineidam, L., Kawalia, A., Hoffmann, P., Luck, T., Riedel-Heller, S., Jessen, F., Maier, W., Wagner, M., Hurlemann, R., Kenis, G., Ali, M. & 9 others, Del Sol, A., Mastroeni, D., Delvaux, E., Coleman, P. D., Mill, J., Rutten, B. P. F., Lunnon, K., Ramirez, A. & Van Den Hove, D. L. A., Nov 27 2019, In : Clinical Epigenetics. 11, 1, 164.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: Comparison of single cell versus neuron pools

Deng, W., Xing, C., David, R., Mastroeni, D., Ning, M. M., Lo, E. H. & Coleman, P. D., Jan 1 2019, In : Aging and Disease. 10, 6, p. 1146-1158 13 p.

Research output: Contribution to journalArticle

Open Access

Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., De Both, M. D., Mastroeni, D., Serrano, G. E., Sue, L. I., Beach, T. G., Coleman, P. & Huentelman, M. J., Sep 15 2019, In : Brain Research. 1719, p. 217-224 8 p.

Research output: Contribution to journalArticle

Tau positron-emission tomography in former national football league players

Stern, R. A., Adler, C. H., Chen, K., Navitsky, M., Luo, J., Dodick, D. W., Alosco, M. L., Tripodis, Y., Goradia, D. D., Martin, B., Mastroeni, D., Fritts, N. G., Jarnagin, J., Devous, M. D., Mintun, M. A., Pontecorvo, M. J., Shenton, M. E. & Reiman, E. M., May 2 2019, In : New England Journal of Medicine. 380, 18, p. 1716-1725 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., Mastroeni, D. F., Persico, A. M., Jepsen, W. M., Beach, T. G., Huentelman, M. J., Coleman, P. D. & Combs, C., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 3, p. 691-713 23 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Age-related disturbances in DNA (hydroxy)methylation in APP/PS1 mice

Chouliaras, L., Lardenoije, R., Kenis, G., Mastroeni, DI., Hof, P. R., Os, J. V., Steinbusch, H. W. M., Van Leeuwen, F. W., Rutten, B. P. F. & Van Den Hove, D. L. A., Dec 31 2018, In : Translational Neuroscience. 9, 1, p. 190-202 13 p.

Research output: Contribution to journalArticle

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J. & Coleman, P., Mar 1 2018, In : Neurobiology of Aging. 63, p. 12-21 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

Johansson, J. U., Brubaker, W. D., Javitz, H., Bergen, A. W., Nishita, D., Trigunaite, A., Crane, A., Ceballos, J., Mastroeni, D., Tenner, A. J., Sabbagh, M. & Rogers, J., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease

Tan, Y., Delvaux, E., Nolz, J., Coleman, P., Chen, S. & Mastroeni, D., Aug 1 2018, In : Neurobiology of Aging. 68, p. 134-141 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

A call for new approaches to Alzheimer's disease research

Coleman, P. & Mastroeni, D., Sep 1 2017, In : Neurobiology of Aging. 57, p. iii-iv

Research output: Contribution to journalComment/debate

6 Scopus citations

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

Mastroeni, D., Sekar, S., Nolz, J., Delvaux, E., Lunnon, K., Mill, J., Liang, W. S. & Coleman, P., Jul 2017, In : PloS one. 12, 7, e0177814.

Research output: Contribution to journalArticle

15 Scopus citations

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's

Delvaux, E., Mastroeni, D., Nolz, J., Chow, N., Sabbagh, M., Caselli, R. J., Reiman, E. M., Marshall, F. J. & Coleman, P., Oct 1 2017, In : Neurobiology of Aging. 58, p. 225-237 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms

Brubaker, W. D., Crane, A., Johansson, J. U., Yen, K., Garfinkel, K., Mastroeni, D., Asok, P., Bradt, B., Sabbagh, M., Wallace, T. L., Glavis-Bloom, C., Tenner, A. J. & Rogers, J., Dec 2017, In : Alzheimer's and Dementia. 13, 12, p. 1397-1409 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Analysis of the putative role of CR1 in Alzheimer's disease: Genetic association, expression and function

Fonseca, M. I., Chu, S., Pierce, A. L., Brubaker, W. D., Hauhart, R. E., Mastroeni, D., Clarke, E. V., Rogers, J., Atkinson, J. P. & Tenner, A. J., Feb 2016, In : PloS one. 11, 2, e0149792.

Research output: Contribution to journalArticle

35 Scopus citations

Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

Mastroeni, D., Chouliaras, L., Van den Hove, D. L., Nolz, J., Rutten, B. P. F., Delvaux, E. & Coleman, P., Jun 1 2016, In : Neuroepigenetics. 6, p. 26-31 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

Mastroeni, D., Delvaux, E., Nolz, J., Tan, Y., Grover, A., Oddo, S. & Coleman, P., Dec 1 2015, In : Neurobiology of Aging. 36, 12, p. 3121-3129 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
10 Scopus citations

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A. & Rutten, B. P. F., Aug 1 2015, In : Progress in Neurobiology. 131, p. 21-64 44 p.

Research output: Contribution to journalReview article

151 Scopus citations
2014

Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease

Fitzsimons, C. P., Van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., Van Den Hurk, M., Boks, M. P., Biojone, C., Joca, S., Steinbusch, H. W. M., Lunnon, K., Mastroeni, D. F., Mill, J., Lucassen, P. J., Coleman, P. D., Van Den Hove, D. L. A. & Rutten, B. P. F., Jun 25 2014, In : Molecular Neurodegeneration. 9, 1, 25.

Research output: Contribution to journalReview article

39 Scopus citations

HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Nural-Guvener, H. F., Zakharova, L., Nimlos, J., Popovic, S., Mastroeni, D. & Gaballa, M. A., Jul 2 2014, In : Fibrogenesis and Tissue Repair. 7, 1, 10.

Research output: Contribution to journalArticle

61 Scopus citations
2013

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P. D., Rutten, B. P. F. & van den Hove, D. L. A., Sep 1 2013, In : Neurobiology of Aging. 34, 9, p. 2091-2099 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease

Lucin, K. M., O'Brien, C. E., Bieri, G., Czirr, E., Mosher, K. I., Abbey, R. J., Mastroeni, D. F., Rogers, J., Spencer, B., Masliah, E. & Wyss-Coray, T., Sep 4 2013, In : Neuron. 79, 5, p. 873-886 14 p.

Research output: Contribution to journalArticle

169 Scopus citations

P53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D. & Scrable, H., Jun 27 2013, In : Oncogene. 32, 26, p. 3165-3174 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology

Mastroeni, D., Chouliaras, L., Grover, A., Liang, W. S., Hauns, K., Rogers, J. & Coleman, P. D., Jan 8 2013, In : PloS one. 8, 1, e53349.

Research output: Contribution to journalArticle

32 Scopus citations
2011

Epigenetic mechanisms in Alzheimer's disease

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. D. & Rogers, J., Jul 1 2011, In : Neurobiology of Aging. 32, 7, p. 1161-1180 20 p.

Research output: Contribution to journalReview article

168 Scopus citations

The epigenetics of Alzheimer's disease - additional considerations

Rogers, J., Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C. & Coleman, P. D., Jul 1 2011, In : Neurobiology of Aging. 32, 7, p. 1196-1197 2 p.

Research output: Contribution to journalComment/debate

7 Scopus citations
2010

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. D. & Rogers, J., Dec 1 2010, In : Neurobiology of Aging. 31, 12, p. 2025-2037 13 p.

Research output: Contribution to journalArticle

216 Scopus citations

Evidence for an association between KIBRA and late-onset Alzheimer's disease

Corneveaux, J. J., Liang, W. S., Reiman, E. M., Webster, J. A., Myers, A. J., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Craig, D. W., Coon, K. D., Dunckley, T., Bandy, D., Lee, W., Chen, K., Beach, T. G., Mastroeni, D., Grover, A., Ravid, R., Sando, S. B. & 13 others, Aasly, J. O., Heun, R., Jessen, F., Kölsch, H., Rogers, J., Hutton, M. L., Melquist, S., Petersen, R. C., Alexander, G. E., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A. & Huentelman, M. J., Jun 1 2010, In : Neurobiology of Aging. 31, 6, p. 901-909 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-δ

van den Berge, S. A., Middeldorp, J., Eleana Zhang, C., Curtis, M. A., Leonard, B. W., Mastroeni, D., Voorn, P., van de Berg, W. D. J., Huitinga, I. & Hol, E. M., Jun 1 2010, In : Aging Cell. 9, 3, p. 313-326 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C. M., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Apr 1 2010, In : Neurobiology of Aging. 31, 4, p. 549-566 18 p.

Research output: Contribution to journalArticle

50 Scopus citations

Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function

Zakharova, L., Mastroeni, D., Mutlu, N., Molina, M., Goldman, S., Diethrich, E. & Gaballa, M. A., Jul 1 2010, In : Cardiovascular research. 87, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

84 Scopus citations

Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from meta-analysis

Webster, J., Reiman, E. M., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Huentelman, M. J., Craig, D. W., Coon, K. D., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L., Kaleem, M., Mastroeni, D., Grover, A., Rogers, J., Heun, R. & 12 others, Jessen, F., Kölsch, H., Heward, C. B., Ravid, R., Hutton, M. L., Melquist, S., Petersen, R. C., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A., Hardy, J. & Myers, A., Jul 21 2010, In : International Journal of Molecular Epidemiology and Genetics. 1, 1, p. 19-30 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2009

Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

Mastroeni, D., McKee, A., Grover, A., Rogers, J. & Coleman, P. D., Aug 12 2009, In : PloS one. 4, 8, e6617.

Research output: Contribution to journalArticle

196 Scopus citations

Microglial responses to dopamine in a cell culture model of Parkinson's disease

Mastroeni, D., Grover, A., Leonard, B., Joyce, J. N., Coleman, P. D., Kozik, B., Bellinger, D. L. & Rogers, J., Nov 1 2009, In : Neurobiology of Aging. 30, 11, p. 1805-1817 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease

Leonard, B. W., Mastroeni, D., Grover, A., Liu, Q., Yang, K., Gao, M., Wu, J., Pootrakul, D., van den Berge, S. A., Hol, E. M. & Rogers, J., Jul 20 2009, In : Journal of Comparative Neurology. 515, 3, p. 269-294 26 p.

Research output: Contribution to journalArticle

34 Scopus citations
2008

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: A reference data set

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C. M., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Apr 22 2008, In : Physiological genomics. 33, 2, p. 240-256 17 p.

Research output: Contribution to journalArticle

175 Scopus citations

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

Liang, W. S., Reiman, E. M., Valla, J., Dunckley, T., Beach, T. G., Grover, A., Niedzielko, T. L., Schneider, L. E., Mastroeni, D., Caselli, R., Kukull, W., Morris, J. C., Hulette, C. M., Schmechel, D., Rogers, J. & Stephan, D. A., Mar 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 11, p. 4441-4446 6 p.

Research output: Contribution to journalArticle

323 Scopus citations
2007

GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers

Reiman, E. M., Webster, J. A., Myers, A. J., Hardy, J., Dunckley, T., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Huentelman, MJ. J., Craig, D. W., Coon, K. D., Liang, W. S., Herbert, R. L. H., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L. & 14 others, Kaleem, M., Mastroeni, D., Grover, A., Heward, C. B., Ravid, R., Rogers, J., Hutton, M. L., Melquist, S., Petersen, R. C., Alexander, G. E., Caselli, RJ. J., Kukull, W., Papassotiropoulos, A. & Stephan, D. A., Jun 7 2007, In : Neuron. 54, 5, p. 713-720 8 p.

Research output: Contribution to journalArticle

392 Scopus citations

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C., Schmechel, D., Alexander, G. E., Reiman, E. M., Rogers, J. & Stephan, D. A., Feb 12 2007, In : Physiological genomics. 28, 3, p. 311-322 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder?

Rogers, J., Mastroeni, D., Leonard, B., Joyce, J. & Grover, A., Aug 2 2007, Neuroinflation in Neuronal Death and Repair. Bagetta, G., Corasaniti, T. & Lipton, S. (eds.). p. 235-246 12 p. (International Review of Neurobiology; vol. 82).

Research output: Chapter in Book/Report/Conference proceedingChapter

187 Scopus citations
2006

Gene expression correlates of neurofibrillary tangles in Alzheimer's disease

Dunckley, T., Beach, T. G., Ramsey, K. E., Grover, A., Mastroeni, D., Walker, D. G., LaFleur, B. J., Coon, K. D., Brown, K. M., Caselli, R., Kukull, W., Higdon, R., McKeel, D., Morris, J. C., Hulette, C., Schmechel, D., Reiman, E. M., Rogers, J. & Stephan, D. A., Oct 1 2006, In : Neurobiology of Aging. 27, 10, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

96 Scopus citations

Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes

Rogers, J., Li, R., Mastroeni, D., Grover, A., Leonard, B., Ahern, G., Cao, P., Kolody, H., Vedders, L., Kolb, W. P. & Sabbagh, M., Dec 1 2006, In : Neurobiology of Aging. 27, 12, p. 1733-1739 7 p.

Research output: Contribution to journalArticle

117 Scopus citations
2005

Microglial responses to amyloid β peptide opsonization and indomethacin treatment

Strohmeyer, R., Kovelowski, C. J., Mastroeni, D., Leonard, B., Grover, A. & Rogers, J., Aug 19 2005, In : Journal of Neuroinflammation. 2, 18.

Research output: Contribution to journalArticle

25 Scopus citations