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Research Output 1985 2018

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2018

Integrating fluorescence computed tomography with optical sheet illumination for imaging of live single cells

Cao, B., Shetty, R., Smith, D., Kelbauskas, L. & Meldrum, D., Sep 3 2018, In : Optics Express. 26, 18, p. 24020-24030 11 p.

Research output: Contribution to journalArticle

tomography
illumination
fluorescence
cells
spatial resolution
6 Citations (Scopus)

Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging

Su, F., Agarwal, S., Pan, T., Qiao, Y., Zhang, L., Shi, Z., Kong, X., Day, K., Chen, M., Meldrum, D., Kodibagkar, V. & Tian, Y., Jan 17 2018, In : ACS Applied Materials and Interfaces. 10, 2, p. 1556-1565 10 p.

Research output: Contribution to journalArticle

Polymers
Fluorescence
Imaging techniques
Magnetic resonance
Relaxation time

Parallel fabrication of macroporous scaffolds

Dobos, A., Grandhi, T. S. P., Godeshala, S., Meldrum, D. & Rege, K., Jan 1 2018, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalArticle

Scaffolds
Hydrogel
Fabrication
Equipment and Supplies
Aminoglycosides
2 Citations (Scopus)

Simultaneous multiparameter cellular energy metabolism profiling of small populations of cells

Kelbauskas, L., Ashili, S. P., Lee, K. B., Zhu, H., Tian, Y. & Meldrum, D., Dec 1 2018, In : Scientific Reports. 8, 1, 4359.

Research output: Contribution to journalArticle

Energy Metabolism
Population
Technology
Mitochondrial Membrane Potential
Oxygen Consumption

Unlocking the photobiological conversion of CO2 to (: R)-3-hydroxybutyrate in cyanobacteria

Wang, B., Xiong, W., Yu, J., Maness, P. C. & Meldrum, D., Jan 1 2018, In : Green Chemistry. 20, 16, p. 3772-3782 11 p.

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
cyanobacterium
Plastics
plastic
Polyhydroxyalkanoates
2017
5 Citations (Scopus)

A platform for high-throughput bioenergy production phenotype characterization in single cells

Kelbauskas, L., Glenn, H., Anderson, C., Messner, J., Lee, K. B., Song, G., Houkal, J., Su, F., Zhang, L., Tian, Y., Wang, H., Bussey, K., Johnson, R. H. & Meldrum, D., Mar 28 2017, In : Scientific Reports. 7, 45399.

Research output: Contribution to journalArticle

Phenotype
Single-Cell Analysis
Oxygen Consumption
Cell Survival
Electrons
2 Citations (Scopus)

A versatile method for dynamically controlled patterning of small populations of epithelial cells on substrates via non-contact piezoelectric inkjet printing

Lee, K. B., Kelbauskas, L., Brunner, A. & Meldrum, D., Apr 1 2017, In : PLoS One. 12, 4, e0176079.

Research output: Contribution to journalArticle

Printing
Extracellular Matrix Proteins
epithelial cells
Epithelial Cells
Substrates
5 Citations (Scopus)

Characterization and comparison of three microfabrication methods to generate out-of-plane microvortices for single cell rotation and 3D imaging

Shetty, R. M., Myers, J. R., Sreenivasulu, M., Teller, W., Vela, J., Houkal, J., Chao, S-H., Johnson, R. H., Kelbauskas, L., Wang, H. & Meldrum, D., Jan 1 2017, In : Journal of Micromechanics and Microengineering. 27, 1, 015004.

Research output: Contribution to journalArticle

Microfabrication
Photolithography
Vortex flow
Imaging techniques
Fluidics
9 Citations (Scopus)

Improved Performance of Loop-Mediated Isothermal Amplification Assays via Swarm Priming

Martineau, R. L., Murray, S. A., Ci, S., Gao, W., Chao, S-H. & Meldrum, D., Jan 3 2017, In : Analytical Chemistry. 89, 1, p. 625-632 8 p.

Research output: Contribution to journalArticle

Amplification
Assays
Speed indicators
Bacteriophages
Reaction products

Laser-fabricated cell patterning stencil for single cell analysis

Messner, J. J., Glenn, H. L. & Meldrum, D., Dec 19 2017, In : BMC Biotechnology. 17, 1, 89.

Research output: Contribution to journalArticle

Single-Cell Analysis
Lasers
Bioengineering
Cell Separation
Polymers
1 Citation (Scopus)

Optical computed tomography for spatially isotropic four-dimensional imaging of live single cells

Kelbauskas, L., Shetty, R., Cao, B., Wang, K. C., Smith, D., Wang, H., Chao, S-H., Gangaraju, S., Ashcroft, B., Kritzer, M., Glenn, H., Johnson, R. H. & Meldrum, D., Dec 1 2017, In : Science advances. 3, 12, e1602580.

Research output: Contribution to journalArticle

Optical Tomography
Tomography
X-Rays
Mitochondrial Dynamics
Myeloid Leukemia
2 Citations (Scopus)

Platform for combined analysis of functional and biomolecular phenotypes of the same cell

Kelbauskas, L., Ashili, S., Zeng, J., Rezaie, A., Lee, K., Derkach, D., Ueberroth, B., Gao, W., Paulson, T., Wang, H., Tian, Y., Smith, D., Reid, B. & Meldrum, D., Mar 16 2017, In : Scientific Reports. 7, 44636.

Research output: Contribution to journalArticle

Phenotype
Cell Respiration
Disease Progression
Gene Expression
5 Citations (Scopus)

Ratiometric glucose sensing based on fluorescent oxygen films and glucose oxidase

Su, F., Zhang, L., Kong, X., Lee, F., Tian, Y. & Meldrum, D., Jun 1 2017, In : Sensing and Bio-Sensing Research. 14, p. 1-6 6 p.

Research output: Contribution to journalArticle

Glucose Oxidase
Glucose oxidase
Glucose
Oxygen
Oxygen sensors
9 Citations (Scopus)

Rotation of single live mammalian cells using dynamic holographic optical tweezers

Bin Cao, C., Kelbauskas, L., Chan, S., Shetty, R. M., Smith, D. & Meldrum, D., May 1 2017, In : Optics and Lasers in Engineering. 92, p. 70-75 6 p.

Research output: Contribution to journalArticle

Optical tweezers
Cells
Imaging techniques
cells
circumferences
2016
7 Citations (Scopus)

1,8-Naphthalimide Derivative Dyes with Large Stokes Shifts for Targeting Live-Cell Mitochondria

Zhang, L., Su, F., Kong, X., Lee, F., Sher, S., Day, K., Tian, Y. & Meldrum, D., 2016, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Naphthalimides
Mitochondria
Coloring Agents
Derivatives
Fluorophores
9 Citations (Scopus)

A simple non-perturbing cell migration assay insensitive to proliferation effects

Glenn, H. L., Messner, J. & Meldrum, D., Aug 18 2016, In : Scientific Reports. 6, 31694.

Research output: Contribution to journalArticle

Cell Migration Assays
Cell Movement
Cell Line
Emigration and Immigration
Neoplasms
13 Citations (Scopus)

Ratiometric fluorescent pH-sensitive polymers for high-throughput monitoring of extracellular pH

Zhang, L., Su, F., Kong, X., Lee, F., Day, K., Gao, W., Vecera, M. E., Sohr, J. M., Buizer, S., Tian, Y. & Meldrum, D., 2016, In : RSC Advances. 6, 52, p. 46134-46142 9 p.

Research output: Contribution to journalArticle

Polymers
Throughput
Monitoring
Metabolism
Sensors
5 Citations (Scopus)

The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux

Yaron, J. R., Rao, M. Y., Gangaraju, S., Zhang, L., Kong, X., Su, F., Tian, Y., Glenn, H. L. & Meldrum, D., Feb 11 2016, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Nigericin
Inflammasomes
Potassium
Caspase 1
Chemical activation
1 Citation (Scopus)

Transcriptional regulation by normal epithelium of premalignant to malignant progression in Barrett's esophagus

Zeng, J., Kelbauskas, L., Rezaie, A., Lee, K., Ueberroth, B., Gao, W., Derkach, D., Tran, T., Smith, D., Bussey, K. J. & Meldrum, D., Oct 12 2016, In : Scientific Reports. 6, 35227.

Research output: Contribution to journalArticle

Barrett Esophagus
Epithelium
Epithelial Cells
Gene Expression Profiling
Transforming Growth Factor beta
1 Citation (Scopus)

Vorinostat differentially alters 3D nuclear structure of cancer and non-cancerous esophageal cells

Nandakumar, V., Hansen, N., Glenn, H. L., Han, J. H., Helland, S., Hernandez, K., Senechal, P., Johnson, R. H., Bussey, K. J. & Meldrum, D., Sep 8 2016, In : Scientific Reports. 6, 30593.

Research output: Contribution to journalArticle

Neoplasms
Optical Tomography
Confocal Microscopy
Pharmaceutical Preparations
Euchromatin
2015
45 Citations (Scopus)

A Highly Selective Mitochondria-Targeting Fluorescent K+ Sensor

Kong, X., Su, F., Zhang, L., Yaron, J., Lee, F., Shi, Z., Tian, Y. & Meldrum, D., Oct 1 2015, In : Angewandte Chemie - International Edition. 54, 41, p. 12053-12057 5 p.

Research output: Contribution to journalArticle

Mitochondria
Potassium
Sensors
Nigericin
Ionophores
44 Citations (Scopus)

K+ regulates Ca2+ to drive inflammasome signaling: Dynamic visualization of ion flux in live cells

Yaron, J. R., Gangaraju, S., Rao, M. Y., Kong, X., Zhang, L., Su, F., Tian, Y., Glenn, H. L. & Meldrum, D., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1954.

Research output: Contribution to journalArticle

Inflammasomes
Potassium
Ions
Calcium
Adenosine Triphosphate
6 Citations (Scopus)

Measuring gene expression in single bacterial cells: Recent advances in methods and micro-devices

Shi, X., Gao, W., Wang, J., Chao, S-H., Zhang, W. & Meldrum, D., Jan 1 2015, In : Critical Reviews in Biotechnology. 35, 4, p. 448-460 13 p.

Research output: Contribution to journalArticle

Gene Expression
Equipment and Supplies
Lab-On-A-Chip Devices
Population
Bacterial Genes
16 Citations (Scopus)

Parallel RNA extraction using magnetic beads and a droplet array

Shi, X., Chen, C. H., Gao, W., Chao, S-H. & Meldrum, D., Feb 21 2015, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 15, 4, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

RNA
Diatoms
Microtechnology
Messenger RNA
Lab-on-a-chip
6 Citations (Scopus)

Premethylation of foreign DNA improves integrative transformation efficiency in Synechocystis sp. strain PCC 6803

Wang, B., Yu, J., Zhang, W. & Meldrum, D., 2015, In : Applied and Environmental Microbiology. 81, 24, p. 8500-8506 7 p.

Research output: Contribution to journalArticle

Synechocystis
DNA
methyltransferases
plasmid
Methyltransferases
2014
2 Citations (Scopus)

A convenient, optimized pipeline for isolation, fluorescence microscopy and molecular analysis of live single cells

Yaron, J. R., Ziegler, C. P., Tran, T. H., Glenn, H. L. & Meldrum, D., May 8 2014, In : Biological Procedures Online. 16, 1, 9.

Research output: Contribution to journalArticle

Single-Cell Analysis
Fluorescence microscopy
Fluorescence Microscopy
Gene expression
Pipelines
7 Citations (Scopus)

A minimally invasive method for retrieving single adherent cells of different types from cultures

Zeng, J., Mohammadreza, A., Gao, W., Merza, S., Smith, D., Kelbauskas, L. & Meldrum, D., Jun 24 2014, In : Scientific Reports. 4, 5424.

Research output: Contribution to journalArticle

Single-Cell Analysis
Cell Culture Techniques
Cell Separation
Trypsin
Digestion
17 Citations (Scopus)

A polymer-based ratiometric intracellular glucose sensor

Zhang, L., Su, F., Buizer, S., Kong, X., Lee, F., Day, K., Tian, Y. & Meldrum, D., Jul 4 2014, In : Chemical Communications. 50, 52, p. 6920-6922 3 p.

Research output: Contribution to journalArticle

Glucose sensors
Glucose
Polymers
Glucans
HeLa Cells

Automated cell counting in a high density, polymer-coated, live single cell sandwich microarray

Yaron, J. R., Pan, J., Borkar, T., Lee, K. B., Wang, K. C., Anderson, C. L., Glenn, H. L. & Meldrum, D., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1438-1439 2 p.

Research output: Contribution to journalArticle

Microarrays
counting
polymers
Polymers
cells
3-Hydroxybutyric Acid
Cyanobacteria
corrigendum
13 Citations (Scopus)

Dually fluorescent core-shell microgels for ratiometric imaging in live antigen-presenting cells

Zhou, X., Su, F., Tian, Y. & Meldrum, D., Feb 4 2014, In : PLoS One. 9, 2, e88185.

Research output: Contribution to journalArticle

antigen-presenting cells
Antigen-Presenting Cells
image analysis
Imaging techniques
Molecular Imaging
5 Citations (Scopus)

Sensitizing cancer cells to TRAIL-induced death by micellar delivery of mitoxantrone

Grandhi, T. S. P., Potta, T., Taylor, D. J., Tian, Y., Johnson, R. H., Meldrum, D. & Rege, K., Aug 1 2014, In : Nanomedicine. 9, 12, p. 1774-1788 15 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Mitoxantrone
apoptosis
Cell death
ligand
2013
21 Citations (Scopus)

A dual sensor for real-time monitoring of glucose and oxygen

Zhang, L., Su, F., Buizer, S., Lu, H., Gao, W., Tian, Y. & Meldrum, D., Dec 2013, In : Biomaterials. 34, 38, p. 9779-9788 10 p.

Research output: Contribution to journalArticle

Glucose
Oxygen
Monitoring
Sensors
Polyacrylates
19 Citations (Scopus)

A fluorescent colorimetric pH sensor and the influences of matrices on sensing performances

Tian, Y., Fuller, E., Klug, S., Lee, F., Su, F., Zhang, L., Chao, S-H. & Meldrum, D., 2013, In : Sensors and Actuators, B: Chemical. 188, p. 1-10 10 p.

Research output: Contribution to journalArticle

pH sensors
Color
Polymer matrix
sensors
matrices
84 Citations (Scopus)

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 othersFerrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., 2013, In : Scientific Reports. 3, 1449.

Research output: Contribution to journalArticle

Natural Science Disciplines
Neoplasm Metastasis
Cell Line
Mechanics
Proteomics
91 Citations (Scopus)

Engineering cyanobacteria for photosynthetic production of 3-hydroxybutyrate directly from CO2

Wang, B., Pugh, S., Nielsen, D., Zhang, W. & Meldrum, D., Mar 2013, In : Metabolic Engineering. 16, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
Cyanobacteria
Synechocystis
Biosynthesis
Chemical industry
15 Citations (Scopus)

Integrated metagenomic and metatranscriptomic analyses of microbial communities in the meso- and bathypelagic realm of north Pacific ocean

Wu, J., Gao, W., Johnson, R. H., Zhang, W. & Meldrum, D., Oct 2013, In : Marine Drugs. 11, 10, p. 3777-3801 25 p.

Research output: Contribution to journalArticle

Pacific Ocean
Metagenomics
Oceans and Seas
Seawater
Crenarchaeota
5 Citations (Scopus)

Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota

Gao, W., Navarroli, D., Naimark, J., Zhang, W., Chao, S-H. & Meldrum, D., Jan 9 2013, In : Microbiome. 1, 1, 4.

Research output: Contribution to journalArticle

Microbiota
Observation
Growth
Bacteria
Metagenomics
17 Citations (Scopus)
Diatoms
Bacillariophyceae
Thalassiosira
Reverse Transcription
gene expression
14 Citations (Scopus)

On-chip isotachophoresis separation of functional DNA origami capture nanoarrays from cell lysate

Mei, Q., Johnson, R. H., Wei, X., Su, F., Liu, Y., Kelbauskas, L., Lindsay, S., Meldrum, D. & Yan, H., Oct 2013, In : Nano Research. 6, 10, p. 712-719 8 p.

Research output: Contribution to journalArticle

DNA
Thrombin
Nanostructures
Structural integrity
Fused silica
2 Citations (Scopus)

Single-Cell Analysis Reveals Early Manifestation of Cancerous Phenotype in Pre-Malignant Esophageal Cells

Wang, J., Shi, X., Johnson, R. H., Kelbauskas, L., Zhang, W. & Meldrum, D., Oct 8 2013, In : PLoS One. 8, 10, e75365.

Research output: Contribution to journalArticle

Single-Cell Analysis
Mitochondrial DNA
Genes
Phenotype
phenotype
2012
121 Citations (Scopus)

An FRET-based ratiometric chemosensor for in vitro cellular fluorescence analyses of pH

Zhou, X., Su, F., Lu, H., Senechal-Willis, P., Tian, Y., Johnson, R. H. & Meldrum, D., Jan 2012, In : Biomaterials. 33, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Fluorescence
Naphthalimides
pH sensors
Fluorophores
101 Citations (Scopus)

Application of synthetic biology in cyanobacteria and algae

Wang, B., Wang, J. & Meldrum, D., 2012, In : Frontiers in Microbiology. 3, SEP, Article 344.

Research output: Contribution to journalArticle

Synthetic Biology
Cyanobacteria
Biofuels
Solar Energy
Research
38 Citations (Scopus)

A series of poly[N-(2-hydroxypropyl)methacrylamide] copolymers with anthracene-derived fluorophores showing aggregation-induced emission properties for bioimaging

Lu, H., Su, F., Mei, Q., Zhou, X., Tian, Y., Tian, W., Johnson, R. H. & Meldrum, D., Mar 1 2012, In : Journal of Polymer Science, Part A: Polymer Chemistry. 50, 5, p. 890-899 10 p.

Research output: Contribution to journalArticle

Fluorophores
Anthracene
Agglomeration
Copolymers
Polymers
2 Citations (Scopus)

A statistical framework for multiparameter analysis at the single-cell level

Torres-García, W., Ashili, S., Kelbauskas, L., Johnson, R. H., Zhang, W., Runger, G. & Meldrum, D., Mar 2012, In : Molecular BioSystems. 8, 3, p. 804-817 14 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Oxygen Consumption
Access to Information
Barrett Esophagus
8 Citations (Scopus)

High throughput micropatterning of optical oxygen sensor for single cell analysis

Zhu, H., Tian, Y., Bhushan, S., Su, F. & Meldrum, D., 2012, In : IEEE Sensors Journal. 12, 6, p. 1668-1672 5 p., 6086560.

Research output: Contribution to journalArticle

Oxygen sensors
Optical sensors
Throughput
sensors
Sensors
33 Citations (Scopus)

Isotropic 3D nuclear morphometry of normal, fibrocystic and malignant breast epithelial cells reveals new structural alterations

Nandakumar, V., Kelbauskas, L., Hernandez, K. F., Lintecum, K. M., Senechal, P., Bussey, K. J., Davies, P., Johnson, R. H. & Meldrum, D., Jan 5 2012, In : PLoS One. 7, 1, e29230.

Research output: Contribution to journalArticle

morphometry
breasts
Breast
epithelial cells
Epithelial Cells
17 Citations (Scopus)

Method for physiologic phenotype characterization at the single-cell level in non-interacting and interacting cells

Kelbauskas, L., Ashili, S. P., Houkal, J., Smith, D., Mohammadreza, A., Lee, K. B., Forrester, J., Kumar, A., Anis, Y. H., Paulson, T. G., Youngbull, C. A., Tian, Y., Holl, M. R., Johnson, R. H. & Meldrum, D., Mar 2012, In : Journal of Biomedical Optics. 17, 3, 037008.

Research output: Contribution to journalArticle

phenotype
cells
Oxygen
Optical sensors
Metabolites
11 Citations (Scopus)

Micro-patterning and characterization of PHEMA-co-PAM-based optical chemical sensors for lab-on-a-chip applications

Zhu, H., Zhou, X., Su, F., Tian, Y., Ashili, S., Holl, M. R. & Meldrum, D., Oct 2012, In : Sensors and Actuators, B: Chemical. 173, p. 817-823 7 p.

Research output: Contribution to journalArticle

Lab-on-a-chip
Methacrylates
Optical sensors
Polyacrylates
Chemical sensors
32 Citations (Scopus)

Nanostructured oxygen sensor - using micelles to incorporate a hydrophobic platinum porphyrin

Su, F., Alam, R., Mei, Q., Tian, Y., Youngbull, C., Johnson, R. H. & Meldrum, D., Mar 22 2012, In : PLoS One. 7, 3, e33390.

Research output: Contribution to journalArticle

Oxygen sensors
platinum
porphyrins
Porphyrins
Micelles